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Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic dysfunction-Associated Steatotic Liver disease-induced cirrhosis

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World Journal of Gastroenterology 2024年第7期30卷 685-704页

作者： Marcello dallio Mario Romeo paolo Vaia Salvatore Auletta Simone Mammone Marina Cipullo Luigi Sapio Angela Ragone Marco Niosi Silvio Naviglio Alessandro Federico department of Precision Medicine Hepatogastroenterology DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy department of Precision Medicine Clinical Biochemistry DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy

BACKGROUNd For compensated advanced chronic liver disease(cACLd)patients,the first decompensation represents a dramatically worsening prognostic *** on the first decompensation event(dE),the transition to decompensated advanced chronic liver disease(dACLd)can occur through two modalities referred to as acute decompensation(Ad)and non-Ad(NAd),*** Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these ***,due to its invasiveness and costs,CSPH is almost never evaluated in clinical ***,recognizing noninvasively predicting tools still have more appeal across healthcare *** red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic dysfunction-Associated Steatotic Liver disease(MASLd).However,its predictive role for the decompensation has never been *** In this observational study,we investigated the clinical usage of RPR in predicting dEs in MASLd-related cACLd *** Fourty controls and 150 MASLd-cACLd patients were consecutively enrolled and followed up(FUP)semiannually for 3 *** baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver disease(MELd),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were *** FUP,dEs(timing and modaities)were *** was assessed at the baseline and on dE occurrence according to the available Clinical Practice *** Of 150 MASLd-related cACLd patients,43(28.6%)progressed to dACLd at a median time of 28.9 months(29 NAd and 14 Ad).Baseline RPR values were significantly higher in cACLd in comparison to controls,as well as MELd,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLd-progressing compared to cACLd individuals[all Pd ALBI(P:0.011)].Receiving operator curve a

关键词： Liver cirrhosis Red blood cell distribution width Red blood cell distribution width to platelet ratio Translational Medicine Prognostic biomarker

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结合区域引导和双注意力机制的高光谱目标检测判别式学习网络

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电子学报 2024年第5期52卷 1716-1729页

作者：钟佳平李云松谢卫莹雷杰 paolo Gamba 西安电子科技大学综合业务网全国重点实验室陕西西安710071 帕维亚大学意大利帕维亚27100

高光谱图像(HyperSpectral Images,HSIs)具有高光谱分辨率和丰富的光谱信息,其具有的大量窄波段电磁波有利于获取感兴趣目标的理化信息,并根据对应的光谱特征对不同物质进行有效区分,从而完成目标检测任务.然而有限样本、少量先验信息... 详细信息

高光谱图像(HyperSpectral Images,HSIs)具有高光谱分辨率和丰富的光谱信息,其具有的大量窄波段电磁波有利于获取感兴趣目标的理化信息,并根据对应的光谱特征对不同物质进行有效区分,从而完成目标检测任务.然而有限样本、少量先验信息、高维相似背景及不同类别差异小所导致的目标和背景混淆问题使得高光谱目标检测(Hyperspectral Target detection,HTd)面临挑战.为此,本文提出结合区域引导和双注意力机制的高光谱目标检测判别式学习网络(Region-guided and dual-Attention discriminative learning Network,RAdN),以缓解标记样本少的条件下不同类别相似度高和相同类别差异性大导致的背景和目标不易区分的问题,减少高维冗余特征带来的计算复杂度,同时提升检测精度.本文使用经验性区域引导网络训练,采用光谱约束的无监督聚类方法确定网络输入,选择性地关注高光谱图像中的显著性特征和感兴趣区域.此外,本文在网络中添加双通道注意力机制来辅助复杂背景分布的估计,并在网络中引入不同类别光谱先验损失函数,进一步减少高维复杂背景以及光谱变化对于目标的干扰.实验结果和分析表明,RAdN在不同数据集上的性能优于现有先进的算法.

关键词：高光谱目标检测无监督聚类通道注意力机制感兴趣区域光谱分辨率

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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： Gian Luca Rampioni Vinciguerra Marina Capece Luca Reggiani Bonetti Giovanni Nigita Federica Calore Sydney Rentsch paolo Magistri Roberto Ballarin Fabrizio di Benedetto Rosario distefano Roberto Cirombella Andrea Vecchione Barbara Belletti Gustavo Baldassarre Francesca Lovat Carlo M.Croce department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA department of Clinical and Molecular Medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy department of diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy division of Molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PdAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient *** aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor *** of the onco-suppressor miR-15a has been extensively documented in ***,we identified the transcription factor Fos-related antigen-2(Fra-2)as a miR-15a target mediating the adaptive mechanism of PdAC to nutrient *** report that the IGF1 signaling pathway was enhanced in nutrient deprived PdAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PdAC ***,we discovered that miR-15a repressed IGF1R expression via Fra-2 *** miR-15a-low context,IGF1R hyperactivated mTOR,modulated the autophagic flux and sustained PdAC growth in nutrient *** a genetic mouse model,Mir15aKO PdAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet ***,nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent ***,our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PdAC.

关键词： IGF1R Fra miR

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Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer:A meta-analysis and systematic review

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Asian Journal of Urology 2024年第2期11卷 191-207页

作者： Stefano Salciccia Marco Frisenda Giulio Bevilacqua Pietro Viscuso paolo Casale Ettore de Berardinis Giovanni Battista di Pierro Susanna Cattarino Gloria Giorgino davide Rosati Francesco del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci department of Urology Sapienza Rome UniversityPoliclinico Umberto I00161 RomeItaly department of Urology Humanitas20089 RozzanoMIItaly

Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic ***: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect ***: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78-1.88) and between high and low PLR was 1.47 (95% CI: 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44-2.13) and between high and low PLR was 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.

关键词： Prostatic neoplasm Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyteratio Meta-analysis Radical prostatectomy Metastatic

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data trustworthiness and user reputation as indicators of VGI quality

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Geo-Spatial Information Science 2018年第3期21卷 213-233页

作者： paolo Fogliaroni Fausto d’Antonio Eliseo Clementini department for Geodesy and Geoinformation Vienna University of TechnologyViennaAustria department of Industrial and Information Engineering and Economics University of L’AquilaL’AquilaItaly

Volunteered geographic information(VGI)has entered a phase where there are both a substantial amount of crowdsourced information available and a big interest in using it by *** the issue of deciding the quality of VGI without resorting to a comparison with authoritative data remains an open *** article first formulates the problem of quality assessment of VGI *** presents a model to measure trustworthiness of information and reputation of contributors by analyzing geometric,qualitative,and semantic aspects of edits over *** implementation of the model is running on a small data-set for a preliminary empirical *** results indicate that the computed trustworthiness provides a valid approximation of VGI quality.

关键词： Volunteered geographic information data quality trustworthiness reputation

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Quantifying the contribution of the root system of alpine vegetation in the soil aggregate stability of moraine

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International Soil and Water Conservation Research 2017年第1期5卷 36-42页

作者： Csilla Hudek Silvia Stanchi Michele d’amico Michele Freppaz University of Torino DISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly Train2Move Fellowship University of TorinoDISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly

One fifth of the world's population is living in mountains or in their surrounding *** anthropogenic pressure continues to grow with the increasing number of settlements,especially in areas connected to touristic activities,such as the Italian *** process of soil formation on high mountains is particularly slow and these soils are particularly vulnerable to soil *** alpine regions,extreme meteorological events are increasingly frequent due to climate change,speeding up the process of soil degradation and increasing the number of severe erosion processes,shallow landslides and debris *** cover plays a crucial role in the stabilization of mountain soils thereby reducing the risk of natural hazards effecting downslope *** aggregate stability is one of the main soil properties that can be linked to soil loss *** developed on moraines in recently deglaciated areas typically have low levels of soil aggregation,and a limited or discontinuous vegetation cover making them more susceptible to ***,soil structure can be influenced by the root system of the *** are actively involved in the formation of water-stable soil aggregation,increasing the stability of the soil and its nutrient *** the present study,we aim to quantify the effect of the root system of alpine vegetation on the soil aggregate stability of the forefield of the Lys glacier,in the Aosta Valley(NW-Italy).This proglacial area provides the opportunity to study how the root system of ten pioneer alpine species from different successional stages can contribute to soil development and soil *** quantify the aggregate stability of root permeated soils,a modified wet sieving method was *** root length per soil volume of the different species was also determined and later correlated with the aggregate stability *** results showed that soil aggregate stability was significantly increased by the presence

关键词： Soil aggregate stability Root length density Pioneer alpine species Glacier forefield

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Quantum cellular automata and free quantum field theory

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Frontiers of physics 2017年第1期12卷 65-75页

作者： Giacomo Mauro d'Ariano paolo Perinottit QUIT Group Dipartimento di Fisica via Bassi 6 1-27100 Pavia Italy

In a series of recent papers [1-4] it has been shown how free quantum field theory can be derived without using mechanical primitives （including space-time, special relativity, quantization rules, etc.）, but only considering the easiest quantum algorithm encompassing a countable set of quantum systems whose network of interactions satisfies the simple principles of unitarity, homogeneity, locality, and isotropy. This has opened the route to extending the axiomatic information-theoretic derivation of the quantum theory of abstract systems [5, 6] to include quantum field theory. The inherent discrete nature of the informational axiomatization leads to an extension of quantum field theory to a quantum cellular automata theory, where the usual field theory is recovered in a regime where the discrete structure of the automata cannot be probed. A simple heuristic argument sets the scale of discreteness to the Planck scale, and the customary physical regime where discreteness is not visible is the relativistic one of small waveveetors. In this paper we provide a thorough derivation from principles that in the most general case the graph of the quantum cellular automaton is the Cayley graph of a finitely presented group, and showing how for the case corresponding to Euclidean emergent space （where the group resorts to an Abelian one） the automata leads to Weyl, dirac and Maxwell field dynamics in the relativistic limit. We conclude with some perspectives towards the more general scenario of non-linear automata for interacting quantum field theory.

关键词： quantum automata quantum walks quantum fields axiomatics Planck scale

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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano de Rienzo paolo destefanis danilo di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini debora Marchiori Hugo davila Pasquale ditonno paolo Gontero Gennaro Iapicca Theo M de Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni Francesco Sessa department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly department of Urology San Carlo di Nancy HospitalRomeItaly department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly department of diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland department of Urology University of CataniaItaly department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. during two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). during the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia delphi consensus

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Challenges and advancing strategies of endoscopic submucosal dissection for early gastric cancer:The puzzle of eCura C1

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 439-444页

作者： Giulio Calabrese Guido Manfredi Marcello F Maida Francesco V Mandarino Endrit Shahini Francesco Pugliese paolo Cecinato Liboria Laterza Emanuele Sinagra Sandro Sferrazza department of Gastroenterology and Endoscopy ARNAS Civico–Di Cristina–BenfratelliPalermo 90127SiciliaItaly department of Gastroenterology and digestive Endoscopy Ospedale MaggioreCrema 26013Italy department of Medicine and Surgery University of Enna"Kore"Enna 94100SiciliaItaly department of Gastroenterology and digestive Endoscopy IRCCS Ospedale San RaffaeleMilan 20132LombardyItaly department of Gastroenterology National Institute of Gastroenterology-IRCCS“Saverio de Bellis”Castellana GrotteBari 70013Italy department of digestive and Interventional Endoscopy Niguarda HospitalASST NiguardaMilan 20162LombardyItaly department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’OrsolaBologna 40138Emilia-RomagnaItaly department of Gastroenterology and Endoscopy Fondazione Instituto San Raffaele GiglioCefalù90015PalermoItaly

In this editorial,we explore the challenges of managing noncurative resections in early gastric cancer after endoscopic submucosal dissection(ESd),starting from the consideration recently made by Zhu et ***,we evaluate the management of eCura C1 lesions,where decisions regarding further interventions are pivotal yet *** among endoscopists,surgeons,and pathologists is underscored to refine risk assessment and personalize therapeutic *** advancements in ESd techniques and interdisciplinary collaboration offer opportunities for outcome optimization in managing eCura C1 ***,despite needing further clinical validation,molecular biomarkers have emerged as promising tools for enhancing *** manuscript highlights the ongoing research attempts to define treatment paradigms effectively and evaluates the potential of emerging options,ultimately aiming to improve patient care and outcomes in this complex clinical scenario.

关键词： Early gastric cancer Endoscopic submucosal dissection eCura Non-curative resection Multidisciplinary approach

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Physical insights into trapping effects on vertical GaN-on-Si trench MOSFETs from TCAd

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Journal of Semiconductors 2024年第3期45卷 45-52页

作者： NicolòZagni Manuel Fregolent Andrea del Fiol davide Favero Francesco Bergamin Giovanni Verzellesi Carlo de Santi Gaudenzio Meneghesso Enrico Zanoni Christian Huber Matteo Meneghini paolo Pavan department of Engineering“Enzo Ferrari” University of Modena and Reggio EmiliaModena 41125Italy department of Information Engineering University of PadovaPadova 35131Italy department of Sciences and Methods for Engineering(dISMI) University of Modena and Reggio EmiliaReggio Emilia 42122Italy EN&TECH Center University of Modena and Reggio EmiliaReggio Emilia 42122Italy Advanced Technologies and Micro Systems department Robert Bosch GmbHRenningen 71272Germany

Vertical GaN power MOSFET is a novel technology that offers great potential for power switching *** still in an early development phase,vertical GaN devices are yet to be fully optimized and require careful studies to foster their *** this work,we report on the physical insights into device performance improvements obtained during the development of vertical GaN-on-Si trench MOSFETs(TMOS’s)provided by TCAd simulations,enhancing the dependability of the adopted process optimization ***,two different TMOS devices are compared in terms of transfer-curve hysteresis(H)and subthreshold slope(SS),showing a≈75%H reduction along with a≈30%SS *** allow attributing the achieved improvements to a decrease in the border and interface traps,respectively.A sensitivity analysis is also carried out,allowing to quantify the additional trap density reduction required to minimize both figures of merit.

关键词： vertical GaN trench MOSFET SiO_(2) interface traps border traps hysteresis BTI

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