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In vitro Effect of dithiocarbamate Pesticides and of CaNa_2EDTA on Human Serum Dopamine-β-hydroxylase

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Biomedical and Environmental Sciences 1995年第2期8卷 114-121页

作者： paola DE PARIS AND STEFANO CAROLdi(Istituto di Medicina del Lavoro, Universita’ di Padova, Padova, Italy)(Send correspondence to: Dr. Stefano Caroldi. Istituto di Medicina del Lavoro, Via Facciolati 71,I-35127, Padova, Italy. Tel: 3949-8216652, Fax: 3949- Istituto di Medicina del Lavoro Università di Padova Italy.

Serum dopamine-β-hydroxylase (DBH) inhibition has been reported in lead workers treated with CaNa2EDTA and in alcoholic patients repeatedly treated with the alcohol aversive drug disulfiram. The mechanism of inhibition involves Cu-chelation at the active site of DBH. The effect of CaNa2EDTA and disulfiram on serum DBH has been compared to the effect of dithiocarbamate pesticides in vitro for the possible use of serum DBH determination for the biological monitoring of workers exposed to these *** dithiocarbamates inhibit human serum DBH at micromoIar concentrations (range of I50, 0.027-1.6 μmol/L). The inhibitory potency increased from methyl- and dimethyl dithiocarbamates to diethyl dithiocarbamates up to the most potent ethylene bisdithiocarbamates. The I50 of *** was 3.8 mol/L, higher than those of dithiocarbamates. Copper addition to the test system rcactivated at stoichiometric concentrations dithiocarbamaie-inhibited DBH indicating that both base line values and percent of inhibition can be calculated in a single blood sample. Results suggest that serum DBH determination couId be useful in case of acute poisoning involving high doses of dithiocarbamate pesticides

关键词： EDTA 络合试剂 hydroxylase

Laser ablation of liver tumors:An ancillary technique,or an alternative to radiofrequency and microwave?

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World Journal of Radiology 2017年第3期9卷 91-96页

作者： Sergio Sartori Francesca di Vece Francesca Ermili paola Tombesi Section of Interventional Ultrasound St Anna Hospital44100 FerraraItaly

Radiofrequency ablation(RFA) is currently the most popular and used ablation modality for the treatment ofnon surgical patients with primary and secondary liver tumors, but in the last years microwave ablation(MWA) is being technically improved and widely rediscovered for clinical use. Laser thermal ablation(LTA) is by far less investigated and used than RFA and MWA, but the available data on its effectiveness and safety are quite good and comparable to those of RFA and MWA. All the three hyperthermia-based ablative techniques, when performed by skilled operators, can successfully treat all liver tumors eligible for thermal ablation, and to date in most centers of interventional oncology or interventional radiology the choice of the technique usually depends on the physician's preference and experience, or technical availability. However, RFA, MWA, and LTA have peculiar advantages and limitations that can make each of them more suitable than the other ones to treat patients and tumors with different characteristics. When all the three thermal ablation techniques are available, the choice among RFA, MWA, and LTA should be guided by their advantages and disadvantages, number, size, and location of the liver nodules, and cost-saving considerations, in order to give patients the best treatment option.

关键词： Radiofrequency ablation Liver neoplasm Laser ablation Microwave ablation Hepatocellular carcinoma Liver metastases

disaster Tales as Communication Tool for Increasing Risk Resilience

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International Journal of disaster Risk Science 2021年第3期12卷 341-354页

作者： paola Mazzoglio Stefano Macchia Enrico Gallo Julia Winter Pierluigi Claps Department of Environment Land and Infrastructure Engineering(DIATI-Dipartimento di Ingegneria dell’Ambientedel Territorio e delle Infrastrutture)Politecnico di Torino10129 TorinoItaly Comune di Torino 10152 TorinoItaly PwC(PricewaterhouseCoopers)Italy 10122 TorinoItaly

Agencies in charge of flood management use disaster reports(DRs)as the preferred source of information on past flooding events.A systematic survey of DRs prepared by Italian agencies suggests that DRs could be widely enhanced in view of targeting more effective communication to citizens,reinforcing the communication pillar in civil protection planning and management,and improving the resilience of the population to extreme *** loss of the rigor and details required for all the usual technical uses of DRs,we suggest recompiling them in the form of"disaster tales"(DTs),as tools that offer wider knowledge of the events to improve people’s preparedness and self-protection *** major flooding events have demonstrated the communication potential that videos and pictures taken by citizens have for risk perception and disaster *** watching and listening to what has happened the communication recipient can better understand the feelings of the people experiencing an *** structure of the improved reports,we suggest,will finally integrate data,graphs,and maps with interactive tools and be able to present handier multimedia views of the *** to three case studies of flooding in Italy illustrates how to concretely implement the suggested disaster reports to create more readily accessible disaster tales.

关键词： disaster communication disaster narratives Flood risk perception Italy Storytelling

Fragile to strong crossover and Widom line in supercooled water： A comparative study

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Frontiers of physics 2018年第1期13卷 75-83页

作者： Margherita De Marzio Gaia Camisasca Maurro Rovere paola Gallo dipartimento di Matematica e Fisica Universita Roma Tre Italia

The aim of this paper is to discuss the relationship between the dynamics and thermodynamics of water in the supercooled region. Reviewed case studies comprehend bulk water simulated with the SPC/E, TIP4P and TIP4P/2005 potentials, water at protein interfaces, and water in solution with electrolytes. Upon supercooling, the fragile to strong crossover in the s-relaxation of water is found to occur when the Widom line emanating from the liquid-liquid critical point is crossed. This appears to be a general characteristic of supercooled water, not depending on the applied interaction potential and/or different local environments.

关键词： molecular dynamics simulation supercooled water slow dynamics hydration water,aqueous solutions

Comment on “Preliminary outcome of microwave ablation of hepatocellular carcinoma: breaking the 3-cm barrier?”

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Hepatoma Research 2016年第1期2卷 237-238页

作者： paola Tombesi Francesca di Vece Francesca Ermili Sergio Sartori Section of Interventional Ultrasound St.Anna Hospital44100 FerraraItaly

Thamtorawat S,Hicks R,Yu J,Siripongsakun S,Lin WC,Raman S,McWilliams JP,Douek M,Bahrami S,Lu *** outcome of Microwave ablation of hepatocellular carcinoma:breaking the 3-cm barrier?

关键词： hepatocellular breaking barrier

Two-Level Schwarz Preconditioners for Super Penalty discontinuous Galerkin Methods

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Communications in Computational Physics 2009年第2期5卷 398-412页

作者： paola F.Antonietti Blanca Ayuso MOX–Laboratory for Modeling and Scientific Computing Dipartimento di Matematica”F.Brioschi”Politecnico di Milanovia Bonardi 920133 MilanoItaly Departamento de Matematicas Universidad Autonoma de MadridCampus de CantoblancoCtra.de Colmenar Viejo28049 MadridSpain

We extend the construction and analysis of the non-overlapping Schwarz preconditioners proposed in[2,3]to the(non-consistent)super penalty discontinuous Galerkin methods introduced in[5]and[8].We show that the resulting preconditioners are scalable,and we provide the convergence *** also present numerical experiments confirming the sharpness of the theoretical results.

关键词： Schwarz preconditioners super penalty discontinuous Galerkin methods

Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent

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World Journal of Gastroenterology 2006年第14期12卷 2187-2194页

作者： Nicola dioguardi Fabio Grizzi Barbara Franceschini paola Bossi Carlo Russo Laboratori di Medicina Quantitativa Istituto Clinico Humanitas IRCCS RozzanoMilanand "Michele Rodriguez" FoundationInstitute for Quantitative Methods in MedicineMilanItaly Department of Pathology Istituto Clinico Humanitas IRCCS RozzanoMilanItaly

AIM： To provide the accurate alternative metrical means of monitoring the effects of new antiviral drugs on the reversal of newly formed collagen. METHODS： digitized histological biopsy sections taken from 209 patients with chronic C virus hepatitis with different grade of fibrosis or cirrhosis, were measured by means of a new, rapid, user-friendly, fully computeraided method based on the international system meter rectified using fractal principles. RESULTS： The following were described： geometric perimeter, area and wrinkledness of fibrosis; the collation of the Knodell, Sheuer, Ishak and METAVIR scores with fractal-rectified metric measurements; the meaning of the physical composition of fibrosis in relation to the magnitude of collagen islets; the intra- and inter-biopsy sample variability of these parameters; the ＂staging＂ of biopsy sections indicating the pathway covered by fibrosis formation towards its maximum known value; the quantitative liver tissue architectural changes with the Hurst exponent. CONCLUSION： Our model provides the first metrical evaluations of the geometric properties of fibrosis and the quantitative architectural changes of the liver tissue. The representativeness of histological sections of the whole liver is also discussed in the light of the results obtained with the Hurst coefficient.

关键词： Liver Fibrosis Cirrhosis Staging Image analysis Fractals

Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors

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World Journal of Pediatrics 2019年第5期15卷 465-470页

作者： paola Muggeo Vito Michele Rosario Muggeo paola Giordano Maurizio Delvecchio Maria Altomare Chiara Novielli Marco Matteo Ciccone Gabriele D'Amato Maria Felicia Faienza Nicola Santoro Department of Pediatric Oncology and Hematology University Hospital of PoliclinicoPiazza G.Cesare 1170124 BariItaly Department of Economical Business and Statistical SciencesUniversity of PalermoPalermoItaly Department of Biomedicine and Human Oncology Pediatric SectionUniversity"A.Moro"BariItaly Pediatric and Neonatology Unit Mother and Children Health Care Department"Madonna delle Grazie"HospitalASL MateraMateraItaly Cardiovascular diseases Section Department of Emergency and Organ TransplantationUniversity"A.Moro"BariItaly Neonatal Intensive Care Unit Di Venere HospitalBariItaly

Background Vitamin D(25-OHD)has a role in bone health after treatment for cancer.25-OHD deficiency has been associated with risk factors for cardiovascular disease,but no data focusing on this topic in childhood cancer survivors have been *** investigated the 25-OHD status in children treated for acute lymphoblastic leukemia(ALL),and evaluated its influence on vascular *** 25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy *** were grouped according to 25-OHD level(dimers,Fbg,and hs-CRP),ultrasound markers of vascular endothelial function(flow-mediated dilatation,FMD,common carotid intima-media thickness,C-IMT,and antero-posterior diameter of infra-renal abdominal aorta,APAO)were evaluated in the *** Cases showed higher prevalence of 25-OHD deficiency than controls(p=0.002).In univariate analysis via mean comparisons,25-OHD deficient(differences were also found for ET-1(P=0.035)and AD-HMW(P=0.015).In the multiple regression models controlling for some confounders,25-OHD still was associated with C-IMT(P=0.0163),ET-1(P=0.0077),and AD-HMW(P=0.0008).Conclusions Childhood ALL survivors show higher prevalence of 25-OHD deficiency as compared to *** 25-OHD levels appear to be linked to indicators of endothelial and vascular *** monitoring of 25-OHD balance may help to prevent cardiovascular diseases in childhood ALL survivors,characterized by high cardiovascular risk.

关键词： Acute lymphoblastic leukemia Cardiovascular disease C-IMT Vascular ultrasound studies Vitamin D

Risk of Upper Extremity Biomechanical Overload in Automotive Facility

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Biomedical and Environmental Sciences 2013年第1期26卷 70-75页

作者： Angela SANCINI Assunta CAPOZZELLA Tiziana CACIAR Francesco TOMEI Nadia NARDONE Barbara SCALA Maria FIASCHETTI Carlotta CETICA Lara SCIMITTO PierAgostino GIOFFRè Federica SINIBALdi Claudia di PASTENA paola CORBOSIERO Maria Pia SCHIFANO Gianfranco TOMEI Manuela CIARROCCA University of Rome "Sapienza" Department of AnatomyHistologyMedical-Legal and OrthopedicsUnit of Occupational MedicineViale Regina Elena 33600161 RomeItaly University of Rome "Sapienza" Department of Psychiatric and Psychological SciencePiazzale Aldo Moro 500185 RomeItaly

Objective To assess the risk factors for upper extremity-work-related musculoskeletal disorders（UE-WMSD） on 13 prod ucti on lines in an airbag factory using the threshold limit values-American conference of industrial hygienists-hand activity level（TLV-ACGIH-HAL） method and introduce the ergonomic improvement to reduce the repe titi veness and the peak force（Pf）.Methods Professional exposure level on 13 production lines in a automobile factory was measured using the TLV-ACGIH-HAL method and a further risk was assessed according to the ergonomic *** The first assessment of 9 produc tion lines showed that the professional exposure level was above the TLV or HAL *** second assessment showed that the professional exposure level was below the AL limit on all production lines except 1,in which the professional exposure level was between TLV and *** The assessment of UE-WMSD-related risk can ide ntif y the riskiest emplacements and evaluate the reduc tion of risk in professional exposure through interventi ons of structuralorganizati onal type.

关键词： Repe titi ve acti vity Work-related musculoskeletal disorders Assessment of work-related risk Threshold limit values-American conference of industrial hygienists Hand activity level.