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28例猫高血压眼病的回顾性分析

中国兽医杂志 2024年第7期60卷 124-128页

作者：吕迪辛良徐焕明胡瑭琦刘玥李晶庞茉刘畅石磊金艺鹏中国农业大学动物医院北京海淀100093 中国农业大学动物医学院北京海淀100193

为了探究猫高血压眼病的临床病例特征、治疗方法和转归,本文对2018年1月—2022年12月在中国农业大学动物医院就诊的28例猫高血压眼病病例进行了回顾性分析,归纳总结了患猫的发病年龄、品种、性别、眼部症状、初诊血压、伴发疾病、治疗... 详细信息

为了探究猫高血压眼病的临床病例特征、治疗方法和转归,本文对2018年1月—2022年12月在中国农业大学动物医院就诊的28例猫高血压眼病病例进行了回顾性分析,归纳总结了患猫的发病年龄、品种、性别、眼部症状、初诊血压、伴发疾病、治疗方法、治疗后血压和眼部症状转归。结果显示,所纳入患猫71.4%(20/28)为家养短毛猫和家养长毛猫,平均诊断年龄为16岁,其中英国短毛猫和异国短毛猫确诊年龄显著小于家养短毛猫和家养长毛猫(P<0.05);雄性和雌性患猫占比均为50.0%(14/28);75.0%(21/28)患猫首诊时双眼失明,眼科检查异常表现包括:视网膜脱离(64.3%,18/28)、视网膜出血(57.1%,16/28)、眼内炎(57.1%,16/28)、玻璃体溢出(3.6%,1/28)和前房积血(3.6%,1/28),患猫出现失明至就诊的平均时间为43 d(范围:2~365 d);初诊时平均收缩压为238 mmHg(范围:186~300 mmHg);患猫系统性高血压的病因调查结果显示,11.5%(3/26)为特发性高血压,69.2%(18/26)继发于慢性肾病,15.4%(4/26)继发于甲状腺机能亢进,3.8%(1/26)继发于肾上腺肿物。18只患猫口服氨氯地平进行治疗,2只患猫口服甲巯咪唑进行治疗。15只患猫进行了眼科复查,5只患猫视网膜重新贴附,其中3只患猫双眼和1只患猫单眼威胁反应恢复阳性,视网膜重新贴附比例随着眼部异常持续时间增加而降低,其中视网膜重新贴附患猫的初诊收缩压显著高于视网膜未贴附患猫(P<0.05)。由于老年猫高血压发病率高,眼睛是高血压损伤的靶器官,因此建议老年猫定期体检(包括眼科检查),以对该类疾病起到良好的预防作用。

关键词：猫系统性高血压眼底检查回顾性分析高血压眼病

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共享充电桩交易管理平台中的区块链技术应用

制造业自动化 2024年第7期46卷 115-120页

作者：周奕冯庆燎余飞鸥庞建军潘浩森广东电网有限责任公司广州供电局广东广州510620

针对电动汽车共享充电桩的共享交易以及充电管理等需求,在对区块链技术应用在共享充电桩交易中的适用性分析基础上,提出并设计基于区块链的充电桩共享交易平台。构建了区块链中的智能合约和共识机制,设计了系统总体架构和交易流程,搭建... 详细信息

针对电动汽车共享充电桩的共享交易以及充电管理等需求,在对区块链技术应用在共享充电桩交易中的适用性分析基础上,提出并设计基于区块链的充电桩共享交易平台。构建了区块链中的智能合约和共识机制,设计了系统总体架构和交易流程,搭建了基于区块链的共享充电桩交易管理系统。以电动汽车用户、综合楼宇和光伏用户、其他充电桩用户为共享主体构建应用场景开展实例分析,以验证系统的有效性。

关键词：区块链充电交易共享充电桩交易平台

Progress towards understanding the pathogenesis of dengue hemorrhagic fever

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Virologica Sinica 2017年第1期32卷 16-22页

作者： Xiaojing pang Rudian Zhang Gong Cheng Tsinghua-Peking Center for Life Sciences School of Medicine Tsinghua University Beijing 100084 China School of Life Science Tsinghua University Beijing 100084 China

Dengue virus(DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever(DHF), the latter of which can progress to dengue shock syndrome(DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future.

关键词： DENV dengue hemorrhagic fever (DHF) NS1 genome antibody-dependent enhancement (ADE) T cell

温度和CO_2环境对玻璃钢腐蚀形貌及力学性能的影响

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材料热处理学报 2016年第10期37卷 109-114页

作者：杨丽颖聂百胜董小平庞艳荣王修云中国矿业大学资源与安全工程学院北京100083 河北大学质量技术监督学院河北保定071002 安科工程技术研究院(北京)有限公司北京100083

为了研究温度和CO_2环境对玻璃钢的腐蚀形貌及力学性能的影响,采用扫描电镜(SEM)、红外光谱(IR)分别观察并测试了40、55、70和90℃下腐蚀后试样腐蚀表面与断口形貌、透光率,用力学分析法测试了腐蚀后试样的环向拉伸性能、巴氏硬度以及... 详细信息

为了研究温度和CO_2环境对玻璃钢的腐蚀形貌及力学性能的影响,采用扫描电镜(SEM)、红外光谱(IR)分别观察并测试了40、55、70和90℃下腐蚀后试样腐蚀表面与断口形貌、透光率,用力学分析法测试了腐蚀后试样的环向拉伸性能、巴氏硬度以及爆破压力等。结果表明,随温度升高,玻璃钢受CO_2腐蚀后,试样表面腐蚀坑增多,粉化严重。玻璃钢断口由40℃时的浅层碳纤维的机械拉断发展到由90℃时的浅层碳纤维拉断、碳纤维分层和脱粘组成。当温度从40℃增加到90℃时,试样的峰值拉力、断裂时的拉力、变形分别从33.312 kN、32.403 kN、5.750 mm减小到29.812 kN、26.999 kN、5.101 mm,巴氏硬度从64.667HBa减小到61.333 HBa;试样中C-O、C-Cl官能团的透光率分别从75.9%、91.4%减小到59.3%、82.6%,玻璃钢随温度升高因腐蚀造成的老化加速。

关键词：温度玻璃钢形貌力学性能

基于肾小管形态学变化的供肾损伤程度对早期移植效果的影响

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郑州大学学报（医学版） 2024年第5期59卷 697-701页

作者：刘磊朱昆仑邱阳李新强罗振宇庞新路王军祥丰贵文郑州大学第一附属医院肾移植科郑州450052 郑州大学第一附属医院病理科郑州450052

目的:探讨基于肾小管形态学变化的供肾损伤程度分级方法,及基于该分级的损伤程度对移植效果的影响。方法:回顾性收集郑州大学第一附属医院2019年5月1日至2022年9月30日实施肾移植的70例ATI供者和139例受者资料。将肾小管上皮细胞存在形... 详细信息

目的:探讨基于肾小管形态学变化的供肾损伤程度分级方法,及基于该分级的损伤程度对移植效果的影响。方法:回顾性收集郑州大学第一附属医院2019年5月1日至2022年9月30日实施肾移植的70例ATI供者和139例受者资料。将肾小管上皮细胞存在形态学改变及基底膜裸露范围50%为重度损伤,不用作供肾。比较两组术后第7天,1、3、6、12、18、24个月时的肾功能(eGFR)以及肾功能延迟恢复(DGF)发生率。结果:两组eGFR随时间延长而增高(P<0.05),但组间eGFR差异无统计学意义(P=0.058)。中度损伤组DGF发生率为51.9%,DGF持续时间的中位数(四分位数)为30.0(20.5,43.0)d,高于轻度损伤组[21.7%,18.0(16.5,21.5)](P<0.05)。结论:供肾移植前基于肾小管形态学变化进行损伤程度分级评估能够预测受者移植效果;轻、中度供肾损伤均可用于供肾移植,但中度损伤的供肾有更大DGF和肾功能损害的风险。

关键词：肾移植移植前活检急性肾小管损伤肾功能延迟恢复

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Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments

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Integrative Zoology 2016年第2期11卷 86-97页

作者： Xinyi GUO Ling XIE Xuze ZHANG Yinfa JI Juan CHEN Bo pang Yongtao XU Delin QI Songchang GUO Key laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyCASXiningChina University of Chinese Academy of Sciences BeijingChina Qinghai University for Nationalities XiningChina Qinghai Normal University XiningChina Animal Science Department of Agriculture and Animal Husbandry College Qinghai UniversityXiningChina

Fishes harbor a huge resource of phenotypic diversity and are useful for understanding the genetic basis of morphological ***,it is difficult to transfer classical genetic mapping to most non-model *** this study,we performed a comparative sequence analysis of Fgfr1a to first interpret the evolution of this candidate scale-loss gene in 15 schizothoracine fishes with various scale *** considerable amino acid(AA)substitutions were observed,molecular evolution analysis indicates that the overall coding regions were subject to functional *** also identified extra copies of Fgfr1a in 4 scale-loss fishes and detected accelerated evolution in one AA substitution specific to these *** speculate that Fgfr1a had accumulated mutations in the ancestral lineage of scale-loss schizothoracine fishes before experiencing duplication events,which was further followed by the diversification of *** silico mutation analysis predicted deleterious effects of the mutations while no disruptive molecular mechanism was ***,our results highlight the important role of Fgfr1a gene in the adaptive evolution of schizothoracine fishes during their radiation in the Qinghai-Tibetan Plateau.

关键词： adaptive evolution Fgfr1a scale loss Schizothoracine

Therapeutic effects of EGF-modified curcumin/ chitosan nano-spray on wound healing

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Regenerative Biomaterials 2021年第2期8卷 140-148页

作者： Yue Li QingQing Leng XianLun pang Huan Shi yanLin Liu SuSu Xiao Ling Zhao Ping Zhou ShaoZhi Fu Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China Health Management Center Traditional Chinese Medicine Hospital Affiliated to Southwest Medical UniversityLuzhou 646000China Department of Pharmaceutics School of Pharmacy of Southwest Medical UniversityLuzhou 646000China Department of Radiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Dermal injury,including trauma,surgical incisions,and burns,remain the most prevalent socio-economical health care issue in the *** represents a reliable administration strategy that can promote the healing of skin lesions,but the lack of effective drug delivery methods can limit its *** this study,we developed a novel nano-drug delivery system to treat skin defects through *** prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor(EGF)to develop an aqueous EGF-modified spray(EGF@CCN)for the treatment of dermal *** vitro assays showed that the EGF@CCN displayed low cytotoxicity,and that curcumin was continuously and slowly released from the EGF@*** vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats,showing that the EGF@CCN had significant advantages in promoting wound *** day 12 post-operation,skin defects in the rats of the EGF@CCN group were almost completely *** effects were related to the activity of curcumin and EGF on skin healing,and the high compatibility of the nano *** therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.

关键词： curcumin chitosan EGF skin regeneration wound healing

广西防城港近岸表层沉积物重金属分布特征及污染评价

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中国地质调查 2022年第1期9卷 82-90页

作者：庞国涛阎琨李伟中国地质调查局烟台海岸带地质调查中心山东烟台264000 中国地质大学(武汉)环境学院湖北武汉430074

为了解防城港近岸海域表层沉积物重金属分布及污染特征,系统采集了19件研究区的表层沉积物样品,检测了7种重金属元素的含量。测试结果表明研究区表层沉积物中Cu、Pb、Zn、Cd、Cr、Hg和As含量均符合政府制定的海洋功能区划要求。单因子... 详细信息

为了解防城港近岸海域表层沉积物重金属分布及污染特征,系统采集了19件研究区的表层沉积物样品,检测了7种重金属元素的含量。测试结果表明研究区表层沉积物中Cu、Pb、Zn、Cd、Cr、Hg和As含量均符合政府制定的海洋功能区划要求。单因子潜在生态危害指数法评价结果显示,不同重金属潜在生态危害排序为Hg>Cu>Cd>As>Pb>Cr>Zn,除Hg外均属于低生态风险。综合潜在风险评价指数显示除F17和F19站位潜在生态风险等级为高外,其他站位潜在生态风险等级为中或低,其中Hg是潜在风险的主要控制元素。地质累积指数评价表明企沙半岛南部区域存在轻微的Cu、Hg污染,且这2种元素含量在部分站位处于阈值效应含量和可能效应含量之间,存在一定的概率引发毒性。相关性分析和主成分分析综合显示,Pb、Cr和As主要受陆源输入沉积的影响;Cu和Zn主要来自船体防腐涂料和工业污水;Cd和Hg的来源相对多元,既有陆源河流汇入,也有来自电镀、石油燃烧、生活工业污水和海水养殖的影响。

关键词：防城港表层沉积物重金属地质累积指数潜在生态风险

Achievements and challenges of primate conservation in China

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Zoological Research(Diversity and Conservation) 2024年第1期1卷 66-74页

作者： Bao-Guo Li He Zhang Ming Li Xue-Long Jiang Peng-Fei Fan Jiang Zhou Song-Tao Guo Xiao-Guang Qi Jin-Hua Li Ji-Qi Lu Dong-Po Xia Liang-Wei Cui Zuo-Fu Xiang Qi-Hai Zhou Zhi-pang Huang Cheng-Ming Huang Wen Xiao Hui-Jian Hu Zhi-Xin Zhou Ming-Yong Chen Da-Yong Li Peng-Lai Fan Yin yang Ru-Liang Pan Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi’anShaanxi 710069China Jiangxi Provincial Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchangJiangxi 330045China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China School of Karst Science Guizhou Normal UniversityGuiyangGuizhou 550025China International Collaborative Research Center for Huangshan Biodiversity and Tibetan Macaque Behavioral Ecology Anhui UniversityHefeiAnhui 230601China Institute of Biodiversity and Ecology Zhengzhou UniversityZhengzhouHenan 450001China Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunmingYunnan 650224China College of Life Sciences and Technology Central South University of Forestry and TechnologyChangshaHunan 410004China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Ministry of Education) Guangxi Normal UniversityGuilinGuangxi 541004China International Centre of Biodiversity and Primate Conservation Centre Dali UniversityDaliYunnan 671003China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Institute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510663China School of Life Sciences Yunnan UniversityKunmingYunnan 650500China Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchongSichuan 637001China Institute of International Rivers and Eco-security Yunnan UniversityKunmingYunnan 650500China School of Human Sciences The University of Western AustraliaPerthWA 6009Australia

The dual impact of climate change and human activities has precipitated a sharp decline in primate biodiversity *** is home to the most diverse primate species in the Northern hemisphere,which face severe ecological threats due to the expansion of modern agriculture,extensive exploitation and consumption of natural resources,and excessive land development during its transition from an agricultural to a modern *** response,China has implemented various ecological conservation measures,including habitat restoration and *** efforts have made substantial strides in biodiversity conservation,with certain regions witnessing an increase in primate *** the current study,we conducted a systematic review of historical documents and field research data related to Chinese primates,evaluating the endangered status of primate species in *** improvements in the habitats of most primate species and some population growth,many species still face severe threats,including declining and small *** such as the Myanmar snub-nosed monkey(Rhinopithecus strykeri),eastern black crested gibbon(Nomascus nasutus),and Hainan gibbon(***)remain particularly vulnerable due to their limited distribution ranges and extremely small *** scientific data,fragmented information,and not enough studies in conservation biology further compound the ***,there is a notable lack of detailed population monitoring data for species such as the Bengal slow loris(Nycticebus bengalensis),pygmy slow loris(***),Indochinese gray langur(Trachypithecus crepusculus),Shortridge’s langur(***),and capped langur(***),which hinders the development of practical and targeted conservation management ***,for national biodiversity conservation,there is an urgent need for specialized primate surveys,enhancing habitat protection and restoration,and increasing focus on cross-border conse

关键词： Primates Biodiversity Habitat fragmentation Habitat restoration Conservation strategies