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Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang pan-quan luo Zhi-Jian Wei A-Man Xu Tao Guo Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laboratory of Digestive Disease Hefei 230031Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230000Anhui ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor,long non-coding RNA and microRNA(miRNA)are important regulators that affect tumor proliferation,metastasis and chemotherapy resistance,and thus participate in tumor ***19 is a new bio-marker which can promote tumor invasion and ***,the mechanism by which CASC19 affects the progression of GC through miRNA is not *** To explore the role of the CASC19/miR-491-5p/HMGA2 regulatory axis in *** To explore the expression and prognosis of CASC19 in GC through clinical samples,and investigate the effects of inhibiting CASC19 on the proliferation,migration,invasion and other functions of GC cells through cell counting Kit-8(CCK-8),ethynyldeoxyuridine,Wound healing assay,Transwell,Western blot and flow cytometry *** effect of miR-491-5p and HMGA2 in GC were also *** regulatory relationship between CASC19 and miR-491-5p,miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transcription *** CCK-8,Transwell,Wound healing assay,flow cytometry and animal experiments verify the role of CASC19/miR-491-5p/HMGA2 regulatory *** The expression level of CASC19 is related to the T stage,N stage,and tumor size of *** of the expression of CASC19 can inhibit the ability of proliferation,migration,invasion and EMT conversion of GC cells,and knocking down the expression of CASC19 can promote the apoptosis of GC *** the expression of miR-491-5p can inhibit the proliferation of GC cells,miR-491-5p mimics can inhibit EMT conversion,and promote the apoptosis of GC cells,while decreasing the expression of miR-491-5p can promote the proliferation and EMT conversion and inhibit the apoptosis of GC *** expression of HMGA2 in GC tissues is higher than that in adjacent *** the same time,the expression level of HMGA2 is related to the N and T stages of the *** the level of HMGA2 can pr

关键词： Gastric cancer Long non-coding RNA CASC19 miR-491-5p HMGA2 Prognosis

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Prognostic factors for disease-free survival in postoperative patients with hepatocellular carcinoma and construction of a nomogram model

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World Journal of Clinical Cases 2022年第36期10卷 13250-13263页

作者： pan-quan luo Zheng-Hui Ye Li-Xiang Zhang En-Dong Song Zhi-Jian Wei A-Man Xu Zhen Lu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230011Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230011Anhui ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common type of liver cancer and has a high risk of invasion and metastasis along with a poor *** To investigate the independent predictive markers for disease-free survival(DFS)in patients with HCC and establish a trustworthy *** In this study,445 patients who were hospitalized in The First Affiliated Hospital of Anhui Medical College between December 2009 and December 2014 were retrospectively *** survival curve was plotted using the Kaplan–Meier method and survival was determined using the log-rank *** identify the prognostic variables,multivariate Cox regression analyses were carried *** predict the DFS in patients with HCC,a nomogram was created.C-indices and receiver operator characteristic curves were used to evaluate the nomogram’s *** curve analysis(DCA)was used to evaluate the clinical application value of the *** Longer DFS was observed in patients with the following characteristics:elderly,I–II stage,and no history of hepatitis *** calibration curve showed that this nomogram was reliable and had a higher area under the curve value than the tumor node metastasis(TNM)***,the DCA curve revealed that the nomogram had good clinical applicability in predicting 3-and 5-year DFS in HCC patients after *** Age,TNM stage,and history of hepatitis B infection were independent factors for DFS in HCC patients,and a novel nomogram for DFS of HCC patients was created and validated.

关键词： Hepatocellular carcinoma Disease-free survival Prognosis Nomogram

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Sequential Inverse Optimal Control of Discrete-Time Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 608-621页

作者： Sheng Cao Zhiwei luo Changqin quan the Graduate School of System Informatics Kobe University Kobe 657-8501Japan

This paper presents a novel sequential inverse optimal control(SIOC)method for discrete-time systems,which calculates the unknown weight vectors of the cost function in real time using the input and output of an optimally controlled discrete-time *** proposed method overcomes the limitations of previous approaches by eliminating the need for the invertible Jacobian *** calculates the possible-solution spaces and their intersections sequentially until the dimension of the intersection space decreases to *** remaining one-dimensional vector of the possible-solution space’s intersection represents the SIOC *** paper presents clear conditions for convergence and addresses the issue of noisy data by clarifying the conditions for the singular values of the matrices that relate to the possible-solution *** effectiveness of the proposed method is demonstrated through simulation results.

关键词： Inverse optimal control promised calculation step sequential calculation

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Shape optimisation of basin insulator for DC gas insulated switchgear/gas insulated transmission lines based on artificial bee colony algorithm

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High Voltage 2024年第2期9卷 275-286页

作者： Yi luo Shiyi Mao Ju Tang Zijun pan Cheng pan State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityWuhanChina

The surface charge accumulation on the basin insulator is a particular problem in high-voltage direct current(HVDC)gas insulated switchgears(GIS)and gas insulated trans-mission lines(GIL),which restricts the development and application of extra/ultra high-voltage(EHV/UHV)*** surface charge distribution and anti-flashover performance are closely related to the insulator *** obtain the optimal basin insulator,a shape optimisation model based on artificial bee colony algorithm was established,and the minimisation objective functions based on capacitive(initial)electric field distribution and resistive(steady-state)electric field distribution were respectively *** optimisation results of the two objective functions were calculated,and the electric field and charge distribution on the surface of the insulator before and after optimisation were evaluated and compared using the simulation *** results indicated that the optimisation based on the capacitive electric field can significantly inhibit the surface charge accumulation,and the optimised insulator can significantly reduce the surface normal electric field and make the distribution of the tangential electric field more uniform,and the maximum tangential electric field can be reduced by 10%;the optimisation based on resistive electric field can achieve similar results,but requires more computational *** on the results,the‘anti-charge’basin insulator structure suitable for the DC field was given.

关键词： insulator artificial charge

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Development and validation of a novel nomogram for predicting overall survival in gastric cancer based on inflammatory markers

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 49-59页

作者： pan-quan luo En-Dong Song Fei Liu Abigail N Rankine Li-Xiang Zhang Zhi-Jian Wei Wen-Xiu Han A-Man Xu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Faculty of Medical Technology Ophthalmology LaboratoryAnhui Medical CollegeHefei 230601Anhui ProvinceChina Department of Clinical Medicine Anhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND Nearly 66%of occurrences of gastric cancer(GC),which has the second-highest death rate of all cancers,arise in developing *** several cancers,the predictive significance of inflammatory markers has been *** To identify clinical characteristics and develop a specific nomogram to determine overall survival for GC *** Nine hundred and four GC patients treated at the First Affiliated Hospital of Anhui Medical University between January 2010 and January 2013 were *** risk variables were screened for Cox *** C index,receiver operator characteristic(ROC)curve,and decision curve analysis were used to evaluate the *** Tumor node metastasis stage,carcinoembryonic antigen,systemic immuneinflammation index,and age were identified as independent predictive variables by multivariate *** immune-inflammation index value was superior to that of other inflammatory *** ROC indicated the nomogram had a higher area under the curve than other factors,and its C-index for assessing the validation and training groups of GC patients was extremely *** created a novel nomogram to forecast the prognosis of GC patients following curativegastrectomy based on blood markers and other characteristics. Both surgeons and patients canbenefit significantly from this new scoring system.

关键词： Gastric cancer Nomogram Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Systemic immune-inflammation index

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Model established based on blood markers predicts overall survival in patients after radical resection of types Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction

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World Journal of Gastrointestinal Surgery 2022年第8期14卷 788-798页

作者： Zhi-Jian Wei Ya-Ting Qiao Bai-Chuan Zhou Abigail N Rankine Li-Xiang Zhang Ye-Zhou Su A-Man Xu Wen-Xiu Han pan-quan luo Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastrointestinal Surgery Affiliated Hospital of HeBei UniversityBaoding 071000Hebei ProvinceChina Department of Clinical Medicine Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Gastroenterology Anhui Provincial Key Laboratory of Digestive DiseaseThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND In recent years, the incidence of types Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction(AEG) has shown an obvious upward trend worldwide. The prognostic prediction after radical resection of AEG has not been well *** To establish a prognostic model for AEG(types II and III) based on routine *** A total of 355 patients who underwent curative AEG at The First Affiliated Hospital of Anhui Medical University from January 2014 to June 2015 were retrospectively included in this study. Univariate and multivariate analyses were performed to identify the independent risk factors. A nomogram was constructed based on Cox proportional hazards models. The new score models was analyzed by C index and calibration curves. The receiver operating characteristic(ROC) curve was used to compare the predictive accuracy of the scoring system and tumor-node-metastasis(TNM) stage. Overall survival was calculated using the Kaplan-Meier curve amongst different risk AEG *** Multivariate analysis showed that TNM stage(hazard ratio [HR] = 2.286, P = 0.008), neutrophil-tolymphocyte ratio(HR = 2.979, P = 0.001), and body mass index(HR = 0.626, P = 0.026) were independent prognostic factors. The new scoring system had a higher concordance index(0.697),and the calibration curves of the nomogram were reliable. The area under the ROC curve of the new score model(3-year: 0.725, 95% confidence interval [CI]: 0.676-0.777;5-year: 0.758, 95%CI:0.708-0.807) was larger than that of TNM staging(3-year: 0.630, 95%CI: 0.585-0.684;5-year: 0.665,95%CI: 0.616-0.715).CONCLUSION Based on the serum markers and other clinical indicators, we have developed a precise model to predict the prognosis of patients with AEG(types II and III). The new prognostic nomogram could effectively enhance the predictive value of the TNM staging system. This scoring system can be advantageous and helpful for surgeons and patients.

关键词： Adenocarcinomas of the esophagogastric junction Neutrophil-to-lymphocyte ratio Platelet-tolymphocyte ratio Prognosis Tumor-node-metastasis

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Coalbursts in China: Theory, practice and management

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 1-25页

作者： Yishan pan Yimin Song Hao luo Yonghui Xiao Institute of Disaster Rock Mechanics Liaoning UniversityShenyang110036China School of Civil Engineering North China University of TechnologyBeijing100144China College of Computer Science Liaoning UniversityShenyang110036China School of Physics Liaoning UniversityShenyang110036China

Coalburst is one of the most serious disasters that threaten the safe production of coal mines, and this disaster is particularly serious in China. This paper presents an overview of coalbursts in China since 1980s. From the "stress and energy" and "regional and local" perspectives, the achievements in the theory, practice and management of coalbursts in China are systematically summarized. A theoretical system of coalbursts has been formed to reveal the deformational behavior of coalbursts and explain the mechanism of coalbursts. The occurrence conditions of coalbursts are put forward and the critical stress is obtained. The stress index method for risk evaluation of coalbursts before mining is proposed, and the deformation localization prediction method of coalbursts is put forward. The relationship between energy release and absorption in the process of coalbursts is found, and the prevention and control methods of coalbursts, including the regional method, the local method and support, are presented. The safety evaluation index of coalburst prevention and control is put forward. The integrated prevention and control method for coal and gas outbursts is proposed. The prevention and control technology and equipment of coalbursts have also been developed. Amongst them, the distribution law of the critical stress in China coalburst mines is discovered. The technology and equipment for monitoring, prevention and control of coalbursts, as well as for integrated prevention and control of combined coalbursts and other disasters, have been developed. The energy-absorbing and coalburst-preventing support technology for roadways is invented, and key engineering parameters of coalburst prevention and control are pointed out. In China, coalburst prevention and control laws and standards have been developed. Technical standards for coalbursts are formulated, statute and regulations for coal mines are established, and regulatory documents are promoted.

关键词： Coalbursts Rockbursts Dynamic disaster Energy-absorbing support Monitoring and early warning

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Nomogram established using risk factors of early gastric cancer for predicting the lymph node metastasis

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 665-676页

作者： Xiao-Cong Jiang Xiao-Bing Yao Heng-Bo Xia Ye-Zhou Su pan-quan luo Jian-Ran Sun En-Dong Song Zhi-Jian Wei A-Man Xu Li-Xiang Zhang Yu-Hong Lan Department of Radiotherapy Oncology Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina Emergency Surgery Shanghai Seventh People’s HospitalShanghai 200137China Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Department of Obstetrics and Gynecology First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Department of Endocrinology The First Affiliated Hospital of USTCDivision of Life Science and MedicineHefei 230031Anhui ProvinceChina Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina

BACKGROUND For the prognosis of patients with early gastric cancer(EGC),lymph node metastasis(LNM)plays a crucial role.A thorough and precise evaluation of the patient for LNM is now *** To determine the factors influencing LNM and to construct a prediction model of LNM for EGC *** Clinical information and pathology data of 2217 EGC patients downloaded from the Surveillance,Epidemiology,and End Results database were collected and *** on a 7:3 ratio,1550 people were categorized into training sets and 667 people were assigned to testing sets,*** on the factors influencing LNM determined by the training sets,the nomogram was drawn and *** Based on multivariate analysis,age at diagnosis,histology type,grade,T-stage,and size were risk factors of LNM for ***,nomogram was drawn to predict the risk of LNM for EGC *** the categorical variables,the effect of grade(well,moderate,and poor)was the most significant prognosis *** training sets and testing sets,respectively,area under the receiver-operating characteristic curve of nomograms were 0.751[95%confidence interval(CI):0.721-0.782]and 0.786(95%CI:0.742-0.830).In addition,the calibration curves showed that the prediction model of LNM had good *** Age at diagnosis,histology type,grade,T-stage,and tumor size were independent variables for LNM in *** on the above risk factors,prediction model may offer some guiding implications for the choice of subsequent therapeutic approaches for EGC.

关键词： SEER Early gastric cancer Lymph node metastasis Risk factors Nomogram

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Atomically dispersed Ni electrocatalyst for superior urea-assisted water splitting

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Journal of Energy Chemistry 2024年第3期90卷 1-6,I0002页

作者： Fang luo Shuyuan pan Yuhua Xie Chen Li Yingjie Yu Zehui Yang College of Materials Science and Engineering State Key Laboratory of New Textile Materials&Advanced Processing TechnologyWuhan Textile UniversityWuhan 430200China Hubei Hydrogen Energy Technology Innovation Center Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074HubeiChina

Urea oxidation reaction(UOR) has been selected as substitution for oxygen evolution reaction ascribing to its low thermodynamic voltage as well as utilization of nickel as ***,we report the formation of nickel single atoms(Ni-SAs) as exceptional bifunctional electrocatalyst toward UOR and hydrogen evolution reaction(HER) in urea-assisted water *** UOR catalysis,Ni-SAs perform a superior catalytic performance than Ni-NP/NC and Pt/C ascribing to the formation of HOO-Ni-N_(4) structure evidenced by in-situ Raman spectroscopy,corresponding to a boosted mass activity by 175-fold at 1.4 V *** than Ni-NP/***,Ni-SAs requires only 450 mV overpotential to obtain HER current density of 500 mA cm^(-2).136 mA cm^(-2) is achieved in urea-assisted water splitting at1.7 V for Ni-SAs,boosted by 5.7 times than Pt/C-IrO_(2) driven water splitting.

关键词： Urea oxidation reaction Hydrogen evolution reaction Nickel single atoms Water splitting

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Experimental study on temperature fluctuations on plate surface induced by coaxial-jet flow

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Nuclear Science and Techniques 2024年第5期35卷 139-153页

作者： Xue-Yao Xiong Zun-quan Liu Guo-Yan Zhou Xing luo Shan-Tung Tu Key Laboratory of Pressure Systems and Safety(MOE) East China University of Science and TechnologyShanghai 200237China Institute of Thermodynamics Gottfried Wilhelm Leibniz University Hannover30823 GarbsenGermany

In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal *** on thermal striping in the upper plenum has mainly focused on fluid *** experimental studies have been reported on solid structures in a fluid field with a coaxial *** study entailed an experimental study of the temperature fluctuations in the fluid and on a plate surface caused by a coaxial *** temperature fluctuations of the fluid and plate surfaces located at different heights were *** cause of the temperature fluctuation was analyzed using a transient temperature *** results show that the mixing of the hot and cold fluids gradually becomes uniform in the positive axial *** average surface temperatures tended to be *** the jet reaches the plate surface,the swing of the jet center,contraction and expansion of the cold jet,and changes in the jet shape result in temperature *** intensity of the temperature fluctuation was affected by the *** attention should be paid when the plate is located at a lower height,and between the hot and cold-fluid nozzles.

关键词： Temperature fluctuation Thermal striping Coaxial jet Thermal mixing The upper plenum of nuclear reactor

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