Development and validation of a novel nomogram for predicting overall survival in gastric cancer based on inflammatory markers

作     者：Pan-Quan Luo En-Dong Song Fei Liu Abigail N Rankine Li-Xiang Zhang Zhi-Jian Wei Wen-Xiu Han A-Man Xu 

作者机构：Department of General SurgeryThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Faculty of Medical TechnologyOphthalmology LaboratoryAnhui Medical CollegeHefei 230601Anhui ProvinceChina Department of Clinical MedicineAnhui Medical UniversityHefei 230032Anhui ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第1期

页      面：49-59页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Natural Science Foundation of Anhui Province No.2108085QH337 

主　　题：Gastric cancer Nomogram Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Systemic immune-inflammation index 

摘      要：BACKGROUND Nearly 66%of occurrences of gastric cancer(GC),which has the second-highest death rate of all cancers,arise in developing *** several cancers,the predictive significance of inflammatory markers has been *** To identify clinical characteristics and develop a specific nomogram to determine overall survival for GC *** Nine hundred and four GC patients treated at the First Affiliated Hospital of Anhui Medical University between January 2010 and January 2013 were *** risk variables were screened for Cox *** C index,receiver operator characteristic(ROC)curve,and decision curve analysis were used to evaluate the *** Tumor node metastasis stage,carcinoembryonic antigen,systemic immuneinflammation index,and age were identified as independent predictive variables by multivariate *** immune-inflammation index value was superior to that of other inflammatory *** ROC indicated the nomogram had a higher area under the curve than other factors,and its C-index for assessing the validation and training groups of GC patients was extremely *** created a novel nomogram to forecast the prognosis of GC patients following curativegastrectomy based on blood markers and other characteristics. Both surgeons and patients canbenefit significantly from this new scoring system.