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Tc17细胞在中性粒细胞哮喘小鼠的表达及意义

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中国当代儿科杂志 2016年第2期18卷 172-176页

作者：张敏农光民蒋敏詹文杰广西医科大学第一附属医院儿科广西南宁530021 孝感市中心医院儿科湖北孝感432100

目的检测中性粒细胞(NEU)哮喘小鼠肺脏Tc17细胞比例,初步探讨Tc17细胞在NEU哮喘发病机制中的作用。方法 32只清洁级C57B/6小鼠,随机分成NEU哮喘组和对照组。NEU哮喘组用卵蛋白(OVA)和脂多糖(LPS)气道滴入致敏,予OVA雾化激发,对照组用生... 详细信息

目的检测中性粒细胞(NEU)哮喘小鼠肺脏Tc17细胞比例,初步探讨Tc17细胞在NEU哮喘发病机制中的作用。方法 32只清洁级C57B/6小鼠,随机分成NEU哮喘组和对照组。NEU哮喘组用卵蛋白(OVA)和脂多糖(LPS)气道滴入致敏,予OVA雾化激发,对照组用生理盐水致敏和激发。在最后一次雾化结束后24 h,收集支气管肺泡灌洗液(BALF)并检测其有核细胞总数及分类比例,分离肺组织行HE染色,流式细胞术检测小鼠肺脏Tc17细胞与Th17细胞百分比,酶联免疫吸附试验(ELISA)检测BALF中IL-6、TGF-β、IL-17水平。结果 NEU哮喘组小鼠BALF中有核细胞总数、嗜酸性粒细胞(EOS)及中性粒细胞百分比均明显高于对照组(P<0.01),其肺脏Tc17细胞与Th17细胞百分比高于对照组(P<0.01);NEU哮喘组小鼠肺脏Tc17细胞比例与Th17细胞比例呈正相关性(r=0.7932,P<0.05);NEU哮喘组BALF的IL-6、TGF-β、IL-17浓度高于对照组(P<0.05)。结论 NEU哮喘组肺脏Tc17细胞表达增高,Tc17细胞可能参与了中性粒细胞哮喘的发病,IL-17很可能是Tc17细胞在NEU哮喘中发挥作用的方式之一。

关键词：中性粒细胞哮喘 Tc17细胞小鼠

Al_(2)O_(3)对超高碱度连铸保护渣理化性能的影响

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工程科学学报 2023年第2期45卷 234-242页

作者：李刚潘伟杰李民朱礼龙何生平重庆大学材料科学工程学院重庆400044 重庆科技学院重庆401331

Al_(2)O_(3)是一种两性氧化物,在高碱度条件下呈现酸性氧化物特征,而在低碱度条件下表现出碱性氧化物的行为,是冶金熔渣中常见的一种组元.以超高碱度保护渣(综合碱度R=1.75)为研究对象,分析了Al_(2)O_(3)对保护渣流动特性、熔化特性和... 详细信息

Al_(2)O_(3)是一种两性氧化物,在高碱度条件下呈现酸性氧化物特征,而在低碱度条件下表现出碱性氧化物的行为,是冶金熔渣中常见的一种组元.以超高碱度保护渣(综合碱度R=1.75)为研究对象,分析了Al_(2)O_(3)对保护渣流动特性、熔化特性和凝固特性的影响规律.研究结果显示:渣中Al_(2)O_(3)质量分数每增加1%,熔化温度上升5℃左右,转折温度下降12℃左右,开始结晶温度平均下降11℃左右.平均结晶速率随渣中Al_(2)O_(3)质量分数的增加而减小.且随着Al_(2)O_(3)质量分数的增加,保护渣结晶矿相中晶体比例逐渐降低,但晶体保持枪晶石的种类不变.

关键词： Al_(2)O_(3) 保护渣超高碱度凝固特性结晶性能

Numerical simulation of a thermal-bubble actuated diffuser-nozzle valveless pump

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Science China(Technological Sciences) 2009年第10期52卷 2967-2972页

作者： pan Liangming DENG jieWen YUAN DeWen CHEN DeQi ZHANG JunQi School of Power Engineering Chongqing UniversityChongqing 400044China

A valveless micropump actuated by thermal bubbles which are generated by an electrode heater mounted with a pair of diffuser nozzles has been numerically studied by commercial CFD software FLUENT. The relationships between the net flow rate and the superheating and heat supplying frequency have been investigated. The depth of the diffuser-nozzle micropump is 200 μm, the diameter of the actuating chamber is 1 mm, and a pair of diffuser nozzles whose gap has been expanded from 30 μm to 274 μm with an open angle of 7° are connected to the actuating chamber. The working fluid is methanol. In the numerical simulation, the flow pattern is laminar. The results show that the pump has different optimal driving frequencies at different superheating. A cycle resulting from bubble growth and shrinking costs more time at higher superheating temperature; different superheating has different optimal driving frequency; when the superheating increases, the maximum volume flow rate and the maximum pump pressure will increase simultaneously, and the optimal driving frequency decreases as well, the maximum volume flow rate and pump pressure also have the same tendency; in the condition of uncontrolled condensing, the bubble shrinking process is longer than the growth process, thus it is the determining factor to affect the pump performance. The maximum volume flow rate is 9.02 μL/min at ΔT = 15°C, and the maximum pump pressure is 680 Pa. With the increase of wall superheat, cycle including the bubble growth and condensation will become longer, resulting in a significant impact on the pumping flow; different wall superheat has different optimized frequency, increasing superheat will bring increased pumping flow and pump pressure, the optimized driving frequency will be reduced; liquid supply phase is longer than pumping phase.

关键词： thermal bubble actuating valveless diffuser-nozzle micropump numerical simulation

Effective Components of Dried Ginger in Warming Lung to Reduce Watery Phlegm and In vivo Tissue Distribution Based on the“Syndrome-Efficacy-Biological Sample Analysis”Method

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World Journal of Traditional Chinese Medicine 2018年第3期4卷 105-111页

作者： Ying Cui Zheng Wang Ling-Ling Li Rui-jie Li Jing Feng Kai Ma Bei pan Yuan-Fei Niu Xing-Han Guo Yuan-Yuan Li Henan University of Chinese Medicine Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province Henan Province Chinese Medical Research Institute

Objective: This study aimed to investigate effective components of dried ginger(DG) in warming lung to reduce watery phlegm and in vivo tissue distribution on the syndrome of cold fluid retained in lung of rats with chronic obstructive pulmonary disease(COPD) by means of the "syndrome?efficacy?biological sample analysis" method and then to explore its meridian tropism. Methods: Wistar rats were given nasal drops of 200-μL lipopolysaccharide and smoke 30 min two times a day, then put the appropriate dose of ice water, and freeze for an hour to build model rats. On the 16 th day, the drug group was orally administered of DG(500 mg/mL) until the 30 th day. Blood samples and biological tissues were collected from the orbital venous plexus into heparinized hemostasis tubes at 5, 10, 15, 30, 45, 60, 90, 120, 180, 240, and 360 min after the last administration. Using ultraviolet-high-performance liquid chromatography(Waters, USA) method, the effective components were tested, and DAS 3.0 software(Mathematical Pharmacology Professional Committee of China, Shanghai, China) was used to analyze the results. Results: The compounds of DG entering into blood were 6-gingerol, 6-shogaol, and 8-gingerol. Tissue distribution analysis indicates that three active ingredients are widely present in the lung, spleen, kidney, liver, heart, large intestine, stomach, small intestine, and other organs of rats with COPD. Conclusions: 6?gingerol, 6?shogaol, and 8?gingerol belong to effective components of DG in curing the syndrome of cold fluid retained in lung of rats with COPD and mainly distributed in organs including the spleen, stomach, lung, kidney, liver, and heart.

关键词： Dried ginger effective components meridian tropism syndrome of cold fluid retained in lung syndrome-efficacy-biological sample analysis tissue distribution

AE waveform characteristics of rock mass under uniaxial loading based on Hilbert-Huang transform

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Journal of Central South University 2021年第6期28卷 1843-1856页

作者： LI Xue-long CHEN Shao-jie LIU Shu-min LI Zhong-hui mine Disaster Prevention and Control-ministry of State Key Laboratory Breeding Base Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Coal Resources and Safe mining China University of Mining and TechnologyXuzhou 221116China College of Energy and mining Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Coal mine Disaster Dynamics and Control College of Resource and Safety EngineeringChongqing UniversityChongqing 400030China

Acoustic Emission(AE)waveforms contain information on microscopic structural features that can be related with damage of coal rock *** this paper,the Hilbert-Huang transform(HHT)method is used to obtain detailed structural characteristics of coal rock masses associated with damage,at different loading stages,from the analyses of the characteristics of AE *** results show that the HHT method can be used to decompose the target waveform into multiple intrinsic mode function(IMF)components,with the energy mainly concentrated in the c1−c4 IMF components,where the c1 component has the highest frequency and the largest amount of *** the loading continues,the proportion of energy occupied by the low-frequency IMF component shows an increasing *** the initial compaction stage,the Hilbert marginal spectrum is mainly concentrated in the low frequency range of 0−40 *** plastic deformation stage is associated to energy accumulation in the frequency range of 0−25 kHz and 200−350 kHz,while the instability damage stage is mainly concentrated in the frequency range of 0−25 *** 20 kHz,the instability damage reaches its maximum *** is a relatively clear instantaneous energy peak at each stage,albeit being more distinct at the beginning and at the end of the compaction *** the effective duration of the waveform is short,its resulting energy is small,and so there is a relatively high value from the instantaneous energy *** waveform lasts a relatively long time after the peak that coincides with failure,which is the period where the waveform reaches its maximum energy *** Hilbert three-dimensional energy spectrum is generally zero in the region where the real energy is *** addition,its energy spectrum is intermittent rather than *** is therefore consistent with the characteristics of the several dynamic ranges mentioned above,and it indicates more clearly the low-frequency energy concentration in the critical sta

关键词： acoustic emission waveform Hilbert-Huang transform coal rock

Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive Materials 2021年第2期6卷 503-519页

作者： jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo pan Paul K.Chu Kenneth M.C.Cheung Kelvin W.K.Yeung Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and Engineering Nankai UniversityTianjinChina School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite Magnesium ion Microenvironment 3D scaffold Bone tissue regeneration

Predicting Quantum Many-Body Dynamics with Transferable Neural Net works

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Chinese Physics Letters 2020年第1期37卷 101-104页

作者： Ze-Wang Zhang Shuo Yang Yi-Hang Wu Chen-Xi Liu Yi-min Han Ching-Hua Lee Zheng Sun Guang-jie Li Xiao Zhang School of Physics Sun Yat-sen UniversityGuangzhou 510275 State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084 Department of Physics National University of Singapore117542Singapore Institute of High Performance Computing 138632Singapore

Advanced machine learning(ML)approaches such as transfer learning have seldom been applied to approximate quantum many-body *** we demonstrate that a simple recurrent unit(SRU)based efficient and transferable sequence learning framework is capable of learning and accurately predicting the time evolution of the one-dimensional(ID)Ising model with simultaneous transverse and parallel magnetic fields,as quantitatively corroborated by relative entropy measurements between the predicted and exact state *** a cost of constant computational complexity,a larger many-body state evolution is predicted in an autoregressive way from just one initial state,without any guidance or knowledge of any *** work paves the way for future applications of advanced ML methods in quantum many-body dynamics with knowledge only from a smaller system.

关键词： quantum exact entropy

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我国灾害防减基本法的框架设计

江苏社会科学 2010年第1期 155-160页

作者：钮敏蒋洁南京信息工程大学法律系副教授210044

本文认为,灾害防减基本法的立法宗旨是及时发现突变征兆、尽量减慢量的积累以及全力弥补突变损耗;并以实证研究与比较分析的方法探求灾害防减立法框架,指出该框架应包括常设双重多级防灾组织体系、多元定期直列防灾方案系统、临时应急... 详细信息

本文认为,灾害防减基本法的立法宗旨是及时发现突变征兆、尽量减慢量的积累以及全力弥补突变损耗;并以实证研究与比较分析的方法探求灾害防减立法框架,指出该框架应包括常设双重多级防灾组织体系、多元定期直列防灾方案系统、临时应急联动统筹指挥机制等,其重点应放在明确各级政府与国内企业的社会责任,保障灾害防减行动特别牺牲者的合法利益,从而形成国家统一领导、综合协调、分类管理、分级负责以及属地管理为主的灾害管理体制。

关键词：灾害防减基本法框架设计直列式灾害防减计划多级灾害防减组织企业社会责任

Synthesis and characterization of imide modified poly(dimethylsiloxane) with maleopimaric acid as raw material

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Chinese Chemical Letters 2015年第5期26卷 572-574页

作者： Tao Xu He Liu jie Song Shi-Bin Shang Zhan-Qian Song Xiu-jie Chen Chong Yang Institute of Chemical Industry of Forestry Products Chinese Academy of ForestryKey Laboratory of Biomass Energy and MaterialNational Engineering Laboratory for Biomass Chemical UtilizationKey and Open Laboratory on Forest Chemical EngineeringSFA Shenzhen Guanheng New Materials Technology Co. Ltd. Department of Chemistry and Biochemistry University of Michigan-Flint

With the natural rosin derivative （maleopimaric acid, MPA） as the raw material, imide modified vinyl poly（dimethylsiloxane）（MP-VMS） was synthesized and characterized by ^1H NMR and ^13C NMR. The curing kinetic parameters of MP-VMS were determined by differential scanning calorimetry （DSC） at various heating rates （5, 8, 10, 15 ℃/min） from the Kissingner, Ozawa and Crane methods. The activation energy （Ea）, pre-exponential factor （A） and reaction order （n） were respectively 18.6 kJ/mol, 71,108 and 0.902. The low-temperature and high-temperature resistance of its curing product were respectively investigated by DSC and thermogravimetric analysis. The results showed that incorporation of MPA could significantly improve the thermal stability of silicone while had no effect on the low-temperature resistance, and the Tmax （the temperature corresponding to the maximum weight loss rate） increased by 70.7 ℃.

关键词： Maleopimaric acid lmide Polysiloxane Curing kinetics Differential scanning calorimetry (DSC)