检索结果-南通市图书馆

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第2期11卷 322-339页

作者： david Dolivo pamela Weathers Tanja Dominko Department of Surgery Northwestern University-Feinberg School of MedicineChicagoIL 60611USA Department of Biology and Biotechnology Worcester Polytechnic InstituteWorcesterMA 01609USA

Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed *** considerable research,few therapies have proven effective and been approved clinically for treatment of *** compounds are best known as antimalarial therapeutics,but they also demonstrate antiparasitic,antibacterial,anticancer,and antifibrotic *** we summarize literature describing anti-fibrotic effects of artemisinin compounds in in vivo and in vitro models of tissue fibrosis,and we describe the likely mechanisms by which artemisinin compounds appear to inhibit cellular and tissue processes that lead to *** consider alternative routes of administration of artemisinin for treatment of internal organ fibrosis,we also discuss the potential for more direct oral delivery of Artemisia plant material to enhance bioavailability and efficacy of artemisinin compared to administration of purified artemisinin drugs at comparable *** is our hope that greater understanding of the broad anti-fibrotic effects of artemisinin drugs will enable and promote their use as therapeutics for treatment of fibrotic diseases.

关键词： Fibrosis Artemisia Artemisinin Artesunate Fibroblast Myofibroblast Scar TGF-β

Sensory Phenotypic and Molecular Identification of Aromatic Rice Accessions Cultivated in Benin

在线全文

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2024年第3期15卷 195-206页

作者： Chimène Nadège Mahoussi Nanoukon Koffi david Montcho Hambada Deless Edmond Fulgence Thiémélé Bignon Meyrix pamela Franzel Loumedjinon Babatoundé Franel Carel Wenceslas Affolabi Amed Sèmèvo Havivi Kéllya Laurinzo Déguénon Grâce Finagnon Vitoekpon Arielle Bankole Lambert Gustave Djedatin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Bio-technologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Biotechnologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Plant Horticultural and Forestry Sciences National University of Agriculture Kétou Benin Genetics Teaching and Research Unit Department of Biochemistry-Genetics Peleforo GON COULIBALY University Korhogo C&#244te d’Ivoire

Rice is one of the most widely cultivated cereals in the world, and its aroma is increasingly in demand. With the advancement of research, a major rice flavor gene has been identified on rice chromosome 8. It encodes non-functional betaine aldehyde dehydrogenase leading to the accumulation of 2-acetyl-1-pyrroline which is the major olfactory compound that confers the fragrant character to rice. The aroma of rice is considered a special trait of enormous economic importance that determines the prime price in world trade. To satisfy the needs of the population and reduce rice imports into Benin, we conducted this study to identify aromatic rice accessions grown in Benin. Seventy-two rice accessions collected across Benin were PCR amplified with three SSR markers RM 7049, Aro 7, and RM 223, linked to the fgr (fragrance of rice) aroma gene. Molecular analysis revealed that 12 of the 72 accessions, namely Bagou 19, Bagou 22, Tchaka 34, Foun 15, Tchaka 41, Nana 32, Kan 61, Kung 69, Kung 67, Bagou 20, Agbab 101 and Koum 55 possess the fgr gene and can be considered as aromatic rice accessions. A sensory phenotypic test using KOH was carried out on rice accessions carrying fgr gene. Of the twelve positives, only one had the smell of aromatic rice, like the Azucena control. These results show that Benin also has aromatic rice varieties that can be sold on national and international markets.

关键词： Aromatic Rice 2-Acetyl-1-Pyrroline SSR Markers Benin

Recent Advances in Dissecting Stress-Regulatory Crosstalk in Rice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第2期6卷 250-260页

作者： Rita Sharma david De Vleesschauwer Manoj K. Sharma pamela C. Ronald Department of Plant Pathology and Genome Center University of California Davis CA 95616 USA Joint BioEnergy Institute Emeryville CA 94710 USA Laboratory of Phytopathology Faculty of Bioscience Engineering Ghent University B-9000 Ghent Belgium Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea

Biotic and abiotic stresses impose a serious limitation on crop productivity worldwide. Prior or simultaneous exposure to one type of stress often affects the plant response to other stresses, indicating extensive overlap and cross-talk between stress-response signaling pathways. Systems biology approaches that integrate large genomic and prot-eomic data sets have facilitated identification of candidate genes that govern this stress-regulatory crosstalk. Recently, we constructed a yeast two-hybrid map around three rice proteins that control the response to biotic and abiotic stresses, namely the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae; NH1, the rice ortholog of NPR1, a key regulator of systemic acquired resistance; and the ethylene-responsive transcription factor, SUBIA, which confers tolerance to submergence stress. These studies coupled with transcriptional profiling and co-expression analyses identified a suite of proteins that are positioned at the interface of biotic and abiotic stress responses, including mitogen-activated protein kinase 5 （OsMPK5）, wall-associated kinase 25 （WAK25）, sucrose non-fermenting-l-related protein kinase-1 （SnRK1）, SUBIA binding protein 23 （SAB23）, and several WRKY family tran- scription factors. Emerging evidence suggests that these genes orchestrate crosstalk between biotic and abiotic stresses through a variety of mechanisms, including regulation of cellular energy homeostasis and modification of synergistic and/or antagonistic interactions between the stress hormones salicylic acid, ethylene, jasmonic acid, and abscisic acid.

关键词： abiotic biotic crosstalk defense response hormone systems biology stress.

Down-regulation of IL-8 expression in human airway epithelial cells through helper-dependent adenoviral-mediated RNA interference

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2005年第2期15卷 111-119页

作者： Bernard MARTIN,david R.KOEHLER,pamela L.ZEITLIN,A.Keith TANAWELL,Jim HU Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung Development Hospitalfor Sick Children Toronto Canada M5G 1X8 Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung Development Hospitalfor Sick Children Toronto Canada M5G 1X8 Laboratory Medicine and Pathobiology University of Toronto Toronto Canada M5S 1A1 Departments of Pediatrics The Johns Hopkins University School of Medicine Baltimore MD 21287 USA. Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung Development Hospitalfor Sick Children Toronto Canada M5G 1X8Department of Paediatrics University of Toronto Toronto Canada M5S 1A1 Department of Physiology University of Toronto Toronto Canada M5S 1A1 Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung Development Hospitalfor Sick Children Toronto Canada M5G 1X8Department of Paediatrics University of Toronto Toronto Canada M5S 1A1 Laboratory Medicine and Pathobiology University of Toronto Toronto Canada M5S 1A1

Interleukin (IL)-8 is a potent neutrophil chemotactic factor and a crucial mediator in neutrophil-dependent *** cell types produce IL-8, either in response to external stimuli such as cytokines or bacterial infection, or aftermalignant transformation. Anti-IL-8 strategies have been considered for anti-inflammatory therapy. In this paper wedemonstrate that the RNA interference technique can be used to efficiently down-regulate IL-8 protein expression inairway epithelial cells. We used a helper-dependent adenoviral vector to express a small hairpin (sh)RNA targetinghuman IL-8 in cultured airway epithelial cells (IB3-1, Cftr-/-; C38, Cftr-corrected) stimulated with TNF-α, IL-1β orheat-inactivated Burkholderia cenocepacia. Stimulated IL-8 expression in IB3-1 and C38 cells was significantly reducedby shRNA expression. The shRNA targeting IL-8 had no effect on the activation of NF-κB, or on the protein levels ofIκB or IL-6, suggesting that this anti-IL-8 strategy was highly specific, and therefore may offer potential for thetreatment of inflammatory diseases.

关键词： Interleukin-8 RNA interference helper-dependent adenoviral vector inflammation chemokine neutrophil cystic fibrosis.

Patient perceptions of stool DNA testing for pan-digestive cancer screening:A survey questionnaire

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第17期20卷 4972-4979页

作者： Dennis Yang Shauna L Hillman Ann M Harris pamela S Sinicrope Mary E Devens david A Ahlquist Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Division of Biostatistics Mayo ClinicRochesterMN 55902United States Survey Research Center Mayo ClinicRochesterMN 55902United States Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55902United States

AIM: To explore patient interest in a potential multi-organ stool-DNA test (MUST) for pan-digestive cancer screening.

关键词： Stool-DNA testing Colorectal cancer screening Gastrointestinal cancer screening Patient perceptions

Time trend and seasonality in medically attended respiratory syncytial virus (RSV) infections in US children aged 0-5 years, January 2010-January 2023

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2023年第4期11卷 36-44页

作者： Lindsey Wang Nathan Berger pamela B Davis david C Kaelber Nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for Artificial Intelligence in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective The long-term time trend and seasonality variations of first-time medically attended respiratory syncytial virus(RSV)infections among young children are *** aim to examine the time trend of medically attended first-time RSV infections among young children in the USA from January 2010 through January *** This is a population-based cohort study using electronic health records(EHRs).Monthly incidence rate of medically attended first-time RSV infection(cases per 10000000 person-days).A time-series regression model was used to model and predict time trends and *** Multicenter and nationwide TriNetX Network in the *** The study population comprised children aged 0–5 years who had medical visits during the period of January 2010 to January *** The data included 29013937 medical visits for children aged 0–5 years(46.5%girls and 53.5%boys)from January 2010 through January *** 2010 through 2019,the monthly incidence rate of first-time medically attended RSV infection in children aged 0–5 years followed a consistent seasonal *** patterns of medically attended RSV infections were significantly disrupted during the COVID-19 *** 2020,the seasonal variation disappeared with a peak incidence rate of 20 cases per 1000000 person-days,a decrease of 97.4%from the expected peak rate(rate ratio or RR:0.026,95%CI 0.017 to 0.040).In 2021,the seasonality returned but started 4 months earlier,lasted for 9 months,and peaked in August at a rate of 753 cases per 1000000 person-days,a decrease of 9.6%from the expected peak rate(RR:0.90,95%CI 0.82 to 0.99).In 2022,the seasonal pattern is similar to prepandemic years but reached a historically high rate of 2182 cases per 10000000 person-days in November,an increase of 143%from the expected peak rate(RR:2.43,95%CI 2.25 to 2.63).The time trend and seasonality of the EHR-based medically attended RSV infections are consistent with those of RSV-associated hospital

关键词： infections trend attended

Association of COVID- 19 with respiratory syncytial virus (RSV) infections in children aged 0-5 years in the USA in 2022: a multicentre retrospective cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2023年第4期11卷 45-55页

作者： Lindsey Wang pamela B Davis Nathan Berger david C Kaelber Nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for AI in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective To investigate whether COVID-19 infection was associated with increased risk for incident respiratory syncytial virus(RSV)infections and associated diseases among young children that might have contributed to the 2022 surge of severe paediatric RSV cases in the *** This is a retrospective population-based cohort *** outcomes were examined,including overall RSV infection,positive lab test-confirmed RSV infection,clinically diagnosed RSV diseases,RSV-associated bronchiolitis and unspecified *** ratio(RR)and 95%CI of the outcomes that occurred during the 2022 and 2021 RSV seasons were calculated by comparing propensity-score matched *** Nationwide multicentre database of electronic health records(EHRs)of 61.4million patients in the USA including 1.7million children 0–5 years of age,which was accessed through TriNetX Analytics that provides web-based and secure access to patient EHR data from hospitals,primary care and specialty treatment *** The study population consisted of 228940 children of 0–5 years with no prior RSV infection who had medical encounters in October *** were replicated in a separate study population of 370919 children of 0–5 years with no prior RSV infection who had medical encounters in July 2021–August 2021 during a non-overlapping time *** For the 2022 study population(average age 2.4 years,46.8%girls,61%white,16%black),the risk for incident RSV infection during October 2022–December 2022 was 6.40%for children with prior COVID-19 infection,higher than 4.30%for the matched children without COVID-19(RR 1.40,95%CI 1.27 to 1.55);and among children aged 0–1year,the overall risk was 7.90%for those with prior COVID-19 infection,higher than 5.64%for matched children without(RR 1.40,95%CI 1.21 to 1.62).For the 2021 study population(average age 2.2 years,46%girls,57%white,20%black),the risk for incident RSV infection during July 2021–December 2021 was 4.85%for childre

关键词： infections matched centre

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

强制结构理论及实验检验

社会 2013年第4期33卷 176-192页

作者：刘军 david Willer pamela Emanuelson 哈尔滨工程大学社会学系美国南卡罗来纳大学社会学系美国北达科他州立大学社会学与人类学系

学术界对强制关系的研究较少,尽管它无处不在。本文基于要素论探讨强制结构的含义、分类及模型,重点探讨了间接强制结构的效应。间接强制是涉及至少三个行动者的一类"不给钱就制裁,给钱就‘保护’你"的结构关系。实验研究结果表明,在边... 详细信息

学术界对强制关系的研究较少,尽管它无处不在。本文基于要素论探讨强制结构的含义、分类及模型,重点探讨了间接强制结构的效应。间接强制是涉及至少三个行动者的一类"不给钱就制裁,给钱就‘保护’你"的结构关系。实验研究结果表明,在边界条件内,间接强制结构与直接强制结构一样有效力,即有类似的强制幅度和力度,二者都使强制者获得最大的剥夺率。本文最后讨论了影响强制效果的因素,包括强制者的贪欲与策略、强—强联盟及受制者联盟的效应等。

关键词：强制社会网络三方关系网络交换论

在线全文

学校读者我要写书评

暂无评论

网络结构与权力分配:要素论的解释

社会学研究 2011年第2期25卷 134-166,245页

作者：刘军 david Willer pamela Emanuelson 哈尔滨工程大学社会学系美国南卡罗来纳大学社会学系美国北达科他州立大学社会学系

中国的社会网研究很少关注网络结构与权力分配之间的关系,这恰是要素论的贡献。在介绍影响、社会关系、社会行动者等基本"要素"之后,本文分析了要素论的建模原理及多种结构条件,并简析其优势所在。要素论研究发现,权力的分配取决于行动... 详细信息

中国的社会网研究很少关注网络结构与权力分配之间的关系,这恰是要素论的贡献。在介绍影响、社会关系、社会行动者等基本"要素"之后,本文分析了要素论的建模原理及多种结构条件,并简析其优势所在。要素论研究发现,权力的分配取决于行动者的偏好、信念、关系类型及诸多结构条件,因此,核心点未必有权。要素论根据网络结构预测权力的分配,这是其独特之处。该理论的其他优势有:坚持理论导向的实验研究,揭示了权力来源于"排除"机制,运用分析—组合法,可用于研究大型的、复杂的社会历史结构。本文最后讨论了要素论的未来方向,包括考虑到行动者的属性和结构的转换以及关系的要素论研究会加深对中国社会的认识等。

关键词：权力要素论网络结构关系研究网络交换论社会网络分析