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Advances and controversies in the management of early stage nonsmall cell lung cancer

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World Journal of Clinical Oncology 2021年第12期12卷 1089-1100页

作者： Angel Cilleruelo-Ramos Esther Cladellas-Gutiérrez Carolina de la Pinta Laura Quintana-Cortés paloma Sosa-Fajardo Felipe Couñago Xabier Mielgo-Rubio Juan Carlos Trujillo-Reyes Department of Thoracic Surgery Clinic Universitary HospitalValladolid 47005Spain Department of Surgery Universidad de ValladolidValladolid 47001Spain Department of Thoracic Surgery Hospital de la Santa Creu i Sant PauBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Medical Oncology Hospital Don Benito-VillanuevaBadajoz 06400Spain Department of Radiation Therapy Complejo Hospitalario UniversitarioSantiago de CompostelaLa Coruña 15706Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28223Spain Department of Medicine School of Biomedical SciencesUniversidad EuropeaMadrid 28223Spain Department of Medical Oncology Unit Hospital Universitario Fundación AlcorcónMadrid 28922Spain Department of Surgery Universitat AutónomaBarcelona 08029Spain

Complete resection continues to be the gold standard for the treatment of earlystage lung *** landmark Lung Cancer Study Group trial in 1995 established lobectomy as the minimum intervention necessary for the management of early-stage non-small cell lung cancer,as it was associated with lower recurrence and metastasis rates than sublobar resection and lower postoperative morbidity and mortality than *** is a growing tendency to perform sublobar resection in selected cases,as,depending on factors such as tumor size,histologic subtype,lymph node involvement,and resection margins,it can produce similar oncological results to *** treatments such as stereotactic body radiotherapy and radiofrequency ablation can also produce good outcomes in inoperable patients or patients who refuse surgery.

关键词： Video-assisted thoracoscopic surgery Sublobar resection Radiofrequency ablation Stereotactic radiosurgery Early stage Lung cancer

Populational Description of Patients with Diabetes Mellitus Attended in a Family Health Center in Cuiabá, Mato Grosso

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Open Journal of Endocrine and Metabolic Diseases 2017年第1期7卷 1-11页

作者： Erick Tiago de Jesus Assunç ã o Ana Paula Brianezi Danyelle Mariaca de Melo paloma de Oliveira Luciana Graciela de Oliveira Boiç a Larissa Bianca Paiva Cunha de Sá Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School S&atilde o Paulo Brazil Family and Community Health Cuiabá Brazil Diabetology Department Malteser Krankenhaus St. Franziskus-Hospital Flensburg Germany

Diabetes mellitus (DM) represents one of the most serious current health problems nowadays, considering the number of people affected, its complications and morbidities. A broad analysis was performed among diabetic patients attended in the Family Health Center from the district of Baú, in Cuiabá, Mato Grosso State (Center-east Brazil), to examine the patterns of occurrence of overweight or obesity, values of glycated hemoglobin and the diagnostic of metabolic syndrome. The results show ahead a wide work that is necessary to prevent and early diagnose concerning DM, since only an intensive control will make it possible to alter the reality of the unfavorable prognosis documented.

关键词： Diabetes Mellitus Obesity Metabolic Syndrome

Benefits of laptop computer ergonomics education to graduate students

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Open Journal of Therapy and Rehabilitation 2014年第1期2卷 25-32页

作者： Peter J. Bowman Katharine D. Braswell Jessica R. Cohen Jenna L. Funke Hannah L. Landon paloma I. Martinez Julie N. Mossbarger Division of Occupational Therapy College of Health Professions Medical University of South Carolina Charleston USA

Laptop computers are used more often than desktop computers, especially among graduate students. Many common laptop habits can have severe physiological effects on the user ranging from eye strain, poor posture, upper extremity pain, and overuse injuries. Thus, it is important to educate students on the best ergonomic position to use laptops. This study investigates the efficacy of a laptop ergonomic education session and its effects on graduate students’ knowledge and behaviors regarding proper laptop use. A convenience sample of control and experimental groups was used and consisted of 83 occupational therapy (OT), 63 physical therapy (PT), and 26 nurse anesthesia (NA) graduate students. The sample size was 172, with 94 graduate students in the control group and 78 graduate students in the experimental. All study participants completed an initial ergonomics questionnaire. The experimental group was given an ergonomics education session following the questionnaire. Approximately 4 weeks after both groups completed the initial questionnaire;a follow up questionnaire was administered. Results showed that subjects demonstrated a statistically significant improvement in ergonomics knowledge after they completed the ergonomic educational session. Some participants reported making adaptations to laptop positioning and equipment use following the educational session. Thus, participating in ergonomic education can positively influence awareness of body mechanics relative to laptop workstation design.

关键词： Laptop Ergonomics Education Posture

Sustainable Urbanization in a Medium-Sized City in Southern Brazil

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Journal of Civil Engineering and Architecture 2021年第4期15卷 181-185页

作者： Alcindo Neckel Laercio Stolfo Maculan Georgea Marthina Pedott Julian Grub Henrique Aniceto Kujawa Leila Dal Moro Eliane Thaines Bodah Brian William Bodah Paula Polese paloma Toscan Postgraduate Program in Architecture and Urbanism(PPGArq-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS 99070-220Brazil Postgraduate Program in Architecture and Urbanism(PPG Arq e Urb—UNISINOS) São Leopoldo/RS 93022-750Brazil University of Perugia Piazza Universita1Perugia 06123Italy Stricto Sensu Postgraduate Program in Administration of IMED Faculty(PPGA-IMED) Passo Fundo/RS 99070-220Brazil Onondaga Community College State University of New York4585 West Seneca TurnpikeSyracuseNY 13215USA Thaines and Bodah Center for Education and Development 840 South Meadowlark LaneOthelloWA 99344USA

Urbanization in Brazil is increasing,mainly in medium-sized *** expansion causes varying degrees of environmental *** general objective of this manuscript is to analyze the resultant impacts that urbanization has had on soil morphology in and around developing areas of the Brazilian city of Passo Fundo/*** of the methodology laid out in the Leopold Matrix allowed the location of data for the analysis of the characteristics present in the use of the soil of the study *** showed high levels of vegetative loss around the City of Passo Fundo,due to a high degree of urban expansion driven by real estate *** research suggests monitoring the degree of pollution of water resources in addition to regional air quality due to the marked intensity of vehicular flow.

关键词： Urban design environmental impacts environmental analysis public policies

Urban Cemeteries in Southern Brazil: An Analysis of Planimetric Variations, Vegetation Indices and Temperature

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Journal of Civil Engineering and Architecture 2020年第11期14卷 617-624页

作者： paloma Carollo Toscan Alcindo Neckel Cleiton Korcelski Laércio Stolfo Maculan Daniela Maroni Tania Michel Fuga Laura Pasa Cambrussi Henrique Aniceto Kujawa Eliane Thaines Bodah Brian William Bodah Stricto Sensu Postgraduate Program in Architecture and Urbanism of IMED(PPGARQ-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS 99070-220Brazil University of Perugia Piazza Università1Perugia 06123Italy State University of New York Onondaga Community College4585 West Seneca TurnpikeSyracuseNY 13215USA Thaines and Bodah Center for Education and Development 840 South Meadowlark LaneOthelloWA 99344USA

Urban cemeteries have the potential to negatively impact the quality of health of populations in their immediate ***,it becomes important to understand the factors influencing the potential to disperse *** study examined the altimetry,Normalized Difference Vegetation Index(NDVI)and Land Surface Temperature(LST)in five urban cemeteries in the City of Passo Fundo/RS,in the south of Brazil,and the possible potential for the proliferation of contaminating agents present in these cemetery spaces in relation to a radius of 300 meters(m).The methodologies used Landsat 8 satellite images to sample the altimetry,NDVI and LST,applied to a regression model,to analyze the dispersion factors of the correlation of collected *** results showed a trend of contamination of the environment by urban cemeteries in Passo Fundo,in the regions with the highest population density and the lowest vegetative cover.

关键词： Contamination potential remote sensing urban cemeteries urban population

Geoctenologies Applied to Evolution in Urban Design in a City in Southern Brazil

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Journal of Civil Engineering and Architecture 2021年第10期15卷 541-545页

作者： Michele Bianchini Alcindo Neckel Maria Eduarda Cargnin Bade Laura Pasa Cambrussi Emanuela Brandelero Siqueira Julian Grub Luana Pasquetti paloma Toscan Henrique Aniceto Kujawa Isadora Cezar Caino Postgraduate Program in Architecture and Urbanism(PPGArq-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS 99070-220Brazil Postgraduate Program in Architecture and Urbanism(PPG Arq e Urb-UNISINOS) São Leopoldo/RS 93022-750Brazil University of Perugia Piazza Università1Perugia 06123Italy

The evolution process of urban design is the result of transformations due to population increase along the expansion of cities on a global *** applied to forms of mapping make it possible to understand the changes that have occurred in urban spaces in relation to temporal *** general objective of this study is to analyze the change that occurred from the year 2010 to 2021,in the evolution of urban design,in the city of Marau(southern Brazil).The identification of urban evolution in the years 2010 and 2021 was carried *** data were modeled using the QGIS software,in the SIRGAS(Geocentric Reference System for the Americas)database,related to the evolution of urban design in *** results demonstrate the need to apply geotechnologies not only in the city of Marau,but in other cities worldwide,because city halls need precision maps,avoiding the fragmentation of the urban fabric,a result of population expansion not projected in the built environment.

关键词： Urban evolution urban grid remote sensing urban design

Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin paloma Munoz de Rueda Rosa Quiles CIBERehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Unit for Clinical Management of Digestive Diseases Complejo Hospitalario Universitario de Granada Instituto de Investigacion Biosanitaria de Granada University Hospital Politecnico La Fe Unit for Clinical Management of Digestive Diseases University Hospital Virgen Del Rocio Hospital Toledo University Clinic Hospital of Valencia University General Hospital of Valencia Unit for Clinical Management of Digestive Diseases University Hospital Nuestra Senora de Valme Department of Gastroenterology and Hepatology Agencia Sanitaria Costa del Sol University Hospital Cruces Gastroenterology Unit University Hospital Fundacion Alcorcon University Hospital Virgen Macarena University Hospital Virgen de la Arrixaca Hospital of Leon University General Hospital Reina Sofia Department Gastroenterology and Hepatology University Hospital Central de Asturias University Hospital Reina Sofia University Hospital De Gran Canaria Dr. Negrin Hospital San Pedro de Alcantara

AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow ***:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was

关键词： Hepatitis C Boceprevir Telaprevir First-generation protease inhibitors Advanced fibrosis

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采薇的汉语学习之路

孔子学院（中法文对照版） 2023年第5期 76-78页

作者：陈采薇白洁(翻译) 不详

她来自巴西圣保罗州立大学孔子学院,中文名叫陈采薇,目前是一名建筑专业的大学生。“采薇”来源于中国最古老的诗歌总集《诗经·小雅》:“采薇采薇,薇亦作止。”“采薇”,作为一个充满诗意的名字,在春风里唤起了对远方友人的思念。

关键词：采薇《诗经·小雅》诗歌总集巴西圣保罗汉语学习孔子学院

Isolated Autoimmune Orchitis Due to IgG4 Hypersecretion Presenting as Tumor-Like Mass: Case Report and Review of Literature

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Open Journal of Urology 2022年第1期12卷 51-56页

作者： Francisco Marcos da Silva Barroso Flavio Antunes de Sousa paloma Menezes de Souza Gustavo Lopes de Castro Katia Ramos Moreira Leite Monique Freire Santana Roger Arthur da Cunha Alves Gabriela Ayumi Owada Borges Juan Eduardo Rios rodriguez Urology Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil General Surgery Service Santa Casa de Ribeir&#227 o Preto Ribeir&#227 o Preto Brazil Sã o Paulo University (USP) Ribeir&#227 o Preto Brazil Faculty of Medicine Federal University of Amazonas (UFAM) Manaus Amazonas Brazil Pathology Department Sírio-Libanes Hospital S&#227 o Paulo Brazil Faculty of Medicine S&#227 o Paulo University (USP) S&#227 o Paulo Brazil Patholgy Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil Dr. Heitor Vieira Dourado Tropical Medicine Foundation Manaus Amazonas Brazil Teaching and Research Department Oncology Center Control Foundation (FCECON) Manaus Amazonas Brazil Urology Service Hospital Pronto-Socorro 28 de Agosto Manaus Amazonas Brazil General Surgery Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil

Background: IgG4-related disease is a rare autoimmune condition that presents with lymphoplasmacytic infiltrate and fibrosis in the organ affected. Isolated testicle involvement is uncommon and there are only a few cases reported in the literature. Case Presentation: We report a case of isolated chronic orchitis due to IgG4 hypersecretion in a 61-year-old patient that evolved with asymptomatic tumor-like mass growth and was treated with left orchiectomy. Histopathological study revealed orchitis related to IgG4 hypersecretion disease. Conclusion: IgG4-related disease can be manifested as a multi or single-organ disorder. Most diagnoses are made after surgery with histopathological analysis. Most of the cases in literature stand out the difficulty in diagnosis and necessity of high suspicion due to this condition’s similarity with neoplasm presentation.

关键词： Orchitis IgG4-Related Disease Autoimmune Testicle Inflammatory