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Brain targeted delivery of paclitaxel using endogenous ligand

Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 427-438页

作者： Sanjeev r.Acharya padmanabha r.v.reddy Department of Pharmacognosy Nirma University Department of Pharmacy Institute of Pharmacy Nirma University

The objective of the present investigation was to formulate nanoparticles constructed using PLGA polymer for the effective targeted delivery to brain via nasal route. The PLGA nanoparticles were optimized using novel design of experiment technique by 23 full factorial design. Drug: polymer ratio（X1）, surfactant concentration（X2） and stirring speed（X3） were identified as critical process parameters, and its impact on particle size（Y1） and % entrapment efficiency（Y2） was studied. The optimized nanoparticle formulation was conjugated with glutathione as an endogenous ligand by using carbodiimide chemistry using(1-Ethyl-3-（3-dimethylaminopropyl）carbodiimide)（EDAC） as linker molecule. From Ellman's assay,it was found that a total of 691.27 ± 151 units of glutathione were conjugated upon each PLGA nanoparticle. The in vitro release studies as well as ex vivo studies revealed biphasic pattern of drug release with initial burst release followed by slow exponential release of drug over a period of 24 h. The in vivo biodistribution studies were conducted on rat following nasal administration of the nanoparticle formulation（conjugated and unconjugated）and were compared with plain paclitaxel suspension. The results clearly demonstrated that the brain targeting efficiency was enhanced with the glutathione conjugated formulation（387.474%） as compared to the unconjugated nanoparticle formulation（224.327%）. Further,the in vitro in vivo correlation studies revealed good relationship（r2> 0.95） as obtained from the levy plot. Glutathione proves to be an efficient vector for the successful transport of poor bioavailable drug to the brain.

关键词： Biodistribution Glutathione In vitro in vivo correlation (IvIvC) PLGA nanoparticles

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Multilocular thymic cysts-a diagnostic challenge on computed tomography

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World Journal of Clinical Cases 2025年第3期13卷 61-65页

作者： Nirmal Kumar reddy Onteddu Naga Sai rasagna Mareddy Sai Swarupa r vulasala Jayabharath Onteddu Mayur virarkar Department of Internal Medicine University of Florida College of MedicineJacksonvilleFL 32209United States Department of Diagnostic radiology University of AlabamaBirminghamAL 35294United States Department of Diagnostic radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Public Health Sciences University of FloridaGainesvilleFL 32611United States

A recent case report provided a patient scenario,wherein,a 39-year-old male patient presented with occasional palpitations,headache,and *** of tumor markers did not show any abnormal ***,a computed tomography(CT)scan was undertaken,and its findings were affirmative of thymic ***,the postoperative histopathological assessment of the mass,after its resection,confirmed it as an anterior mediastinal multilocular thymic cyst(MTC),with concurrent acute upper respiratory tract infection and acute ***,this case report advocates the need for a preoperative histopathological examination with CT imaging to minimize the risk of confusing an MTC with a malignant thymic tumor.

关键词： Imaging findings Multilocular thymic cyst Histopathology Thymic cancer Mediastinal mass

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Chiral N-phosphonyl imine chemistry:asymmetric additions of glycine enolate to diphenyl diamine-based phosphonyl imines

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Science China Chemistry 2010年第1期53卷 125-129页

作者： PINDI Suresh KATTAMUrI padmanabha v. Department of Chemistry and Biochemistry Texas Tech University

Diphenyl diamine-based phosphonyl imines attached by the N-isopropyl group in the auxiliary have been synthesized in good yields under convenient reaction *** new chiral N-phosphonyl imines can react with glycine enolate smoothly to give chiral α-β diamino esters in good yields(72%-90%) and up to excellent diastereoselectivity(>99:1 dr).By treatment with HBr,the chiral auxiliary can be readily *** absolute structure has been unambiguously determined by converting a product to a known sample.

关键词： chiral N-phosphonyl imine chiral phosphoramide glycine enolate α-β diamino ester

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An Efficient Long Short-Term Memory Model for Digital Cross-Language Summarization

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Computers, Materials & Continua 2023年第3期74卷 6389-6409页

作者： Y.C.A.padmanabha reddy Shyam Sunder reddy Kasireddy Nageswara rao Sirisala ramu Kuchipudi Purnachand Kollapudi Department of CSE B V Raju Institute of TechnologyNarsapurMedakT.S502313India Department of IT Vasavi College of EngineeringHyderabadT.S500089India Department of CSE K.S.R.M College of EngineeringKadapaA.P516003India Department of IT C.B.I.TGandipetHyderabadTelangana500075India

The rise of social networking enables the development of multilingual Internet-accessible digital documents in several *** digital document needs to be evaluated physically through the Cross-Language Text Summarization(CLTS)involved in the disparate and generation of the source ***-language document processing is involved in the generation of documents from disparate language sources toward targeted *** digital documents need to be processed with the contextual semantic data with the decoding *** paper presented a multilingual crosslanguage processing of the documents with the abstractive and summarising of the *** proposed model is represented as the Hidden Markov Model LSTM reinforcement Learning(HMMlstmrL).First,the developed model uses the Hidden Markov model for the computation of keywords in the cross-language words for the *** the second stage,bi-directional long-short-term memory networks are used for key word extraction in the cross-language ***,the proposed HMMlstmrL uses the voting concept in reinforcement learning for the identification and extraction of the *** performance of the proposed HMMlstmrL is 2%better than that of the conventional bi-direction LSTM model.

关键词： Text summarization reinforcement learning hidden markov model cross-language multilingual

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Stability of stratified shear flows in channels with variable cross sections

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Applied Mathematics and Mechanics(English Edition) 2015年第11期36卷 1459-1480页

作者： v.r.reddy M.SUBBIAH Department of Mathematics Pondicherry University

For the instability problem of density stratified shear flows in sea straits with variable cross sections, a new semielliptical instability region is found. rurthermore, the instability of the bounded shear layer is studied in two cases：（i） the density which takes two different constant values in two layers and （ii） the density which takes three different constant values in three layers. In both cases, the dispersion relation is found to be a quartic equation in the complex phase velocity. It is found that there are two unstable modes in a range of the wave numbers in the first case, whereas there is only one unstable mode in the second case.

关键词： hydrodynamic stability shear flow variable density sea strait variablecross section

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ZrB_(2)-SiC based composites for thermal protection by reaction sintering of ZrO_(2)+B_(4)C+Si

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Journal of Advanced Ceramics 2017年第4期6卷 320-329页

作者： r.v.KrISHNArAO v.v.BHANUPrASAD G.MADHUSUDHAN reddy Defence Metallurgical research Laboratory KanchanbaghHyderabad-500058India

Synthesis and sintering of ZrB_(2)-SiC based composites have been carried out in a single-step pressureless reaction sintering(PLrS)of ZrO_(2),B_(4)C,and Si.Y_(2)O_(3) and Al_(2)O_(3) were used as sintering *** effect of ratios of ZrO_(2)/B_(4)C,ZrO_(2)/Si,and sintering additives(Y_(2)O_(3) and Al_(2)O_(3)),was studied by sintering at different temperatures between 1500 and 1680℃in argon ***_(2),SiC,and YAG phases were identified in the sintered *** as high as 4.2 g/cm^(3),micro hardness of 12.7 GPa,and flexural strength of 117.6 MPa were obtained for PLrS *** material was also prepared by PLrS for tungsten inert gas(TIG)welding of the ZrB_(2)-SiC based *** shear strength of the weld was 63.5 *** PLrS ZrB_(2)-SiC composites exhibited:(i)resistance to oxidation and thermal shock upon exposure to plasma flame at 2700℃for 600 s,(ii)thermal protection for Cf-SiC composites upon exposure to oxy-propane flame at 2300℃for 600 s.

关键词： ZrB_(2) SiC reactive sintering synthesis composites

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Joining and machining of(ZrB2-SiC)and(Cf-SiC)based composites

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Defence Technology（防务技术） 2018年第5期14卷 385-395页

作者： r.v.Krishnarao G.Madhusudan reddy v.v.Bhanuprasad Defence Metallurgical research Laboratory KanchanbaghHyderabad500058India

Filler materials of(ZrB_2-SiC-B_4C-YAG) composite were developed for gas tungsten arc welding(GTAW) of the ZrB_2-SiC and Cf-SiC based composites to themselves and to each other. reaction with filler material,porosity and cracks were not observed at weld interfaces of all the joints. Penetration of filler material in to voids and pores existing in the Cf-SiC composites was observed. Average shear strength of 25.7 MPa was achieved for joints of Cf-SiC composites. By incorporation of Cf-SiC(CvD) ground short fibre reinforcement the(ZrB_2-SiC-B_4C-YAG) composite was machinable with tungsten carbide tool. The joint and machined composites were resistance to oxidation and thermal shock when exposed to the oxy-propane flame at 2300℃ for 300s. The combination of(ZrB_2-SiC-B_4C-YAG) and Cf-SiC based composites can be used for making parts like thermal protection system or nozzles for high temperature applications.

关键词： ZrB2-SiC Composite Sintering Machining Gas tungsten arc welding

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Gas tungsten arc welding of ZrB_2-SiC based ultra high temperature ceramic composites

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Defence Technology（防务技术） 2015年第3期11卷 188-196页

作者： r.v.KrISHNArAO G.MADHUSUDHAN reddy Defence Metallurgical research Laboratory

The difficulty in fabricating the large size or complex shape limits the application of ZrB2-SiC composites. Joining them by fusion welding without or with preheating, controlled cooling under protective gas shield leads to thermal shock failure or porosity at the weld interface. In the present work, a filler material of(ZrB2-SiC-B4C-YAG) composite with oxidation resistance and thermal shock resistance was produced in the form of welding wire. Using the filler, gas tungsten arc welding(GTAW) was performed without employing preheating, post controlled cooling and extraneous protective gas shield to join hot pressed ZrB2-SiC(ZS), and pressureless sintered ZrB2-SiC-B4C-YAG(ZSBY) composites to themselves. The fusion welding resulted in cracking and non-uniform joining without any filler material. The weld interfaces of the composites were very clean and coherent. The vickers micro-hardness across the weld interface was found to increase due to the increase in the volume % of both SiC and B4C in the filler material. The shear strength of the weld was about 50% of the flextural strength of the parent composite.

关键词：陶瓷基复合材料焊接界面钨极氩弧焊气体保护超高温填充材料 ZrB2 形状复杂

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Mathematical modelling of couple stresses on fluid flow in constricted tapered artery in presence of slip velocity-effects of catheter

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Applied Mathematics and Mechanics(English Edition) 2014年第8期35卷 947-958页

作者： J.v.r.reddy D.SrIKANTH S.K.MUrTHY Department of Applied Mathematics Defence Institute of Advanced Technology Deemed UniversityPune 411025MaharastraIndia

This paper explores the mathematical model for couple stress fluid flow through an annular region. The above model is used for studying the blood flow be-tween the clogged （stenotic） artery and the catheter. The asymmetric nature of the stenosis is considered. The closed form expressions for the physiological parameters such as impedance and shear stress at the wall are obtained. The effects of various geomet-ric parameters and the parameters arising out of the fluid considered are discussed by considering the slip velocity and tapering angle. The study of the above model is very significant as it has direct applications in the treatment of cardiovascular diseases.

关键词： blood flow couple stress fluid stenosed artery tapered artery catheter

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Measurements of atmospheric turbulence parameters at vainu Bappu Observatory using short-exposure CCD images

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research in Astronomy and Astrophysics 2019年第5期19卷 123-132页

作者： Sreekanth reddy v. ravinder Kumar Banyal Sridharan r. Aishwarya Selvaraj Indian Institute of Astrophysics

We report atmospheric turbulence parameters, namely atmospheric seeing, tilt-anisoplanatic angle(θ_0) and coherence time(Τ_0), measured under various sky conditions, at vainu Bappu Observatory in Kavalur. Bursts of short exposure images of selected stars were recorded with a high-speed, frame-transfer CCD mounted on the Cassegrain focus of a newly commissioned 1.3 m telescope. The estimated median seeing is ≈ 1.85 " at wavelength of ～ 600 nm, the image motion correlation between different pairs of stars is ～44% for θ0≈ 36" and mean Τ_0 is ≈ 2.4 ms. This work was motivated by the design considerations and expected performance of an adaptive optics system that is currently being planned for the telescope.

关键词： atmospheric effects turbulence instrumentation:adaptive optics catalogs methods:observational

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