Chiral N-phosphonyl imine chemistry:asymmetric additions of glycine enolate to diphenyl diamine-based phosphonyl imines

作     者：PINDI Suresh KATTAMURI Padmanabha V. 

作者机构：Department of Chemistry and BiochemistryTexas Tech University 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2010年第53卷第1期

页      面：125-129页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Institutes of Health (Grant Nos.1 RO3 DA026960-01) Robert Welch Foundation (Grant No.D-1361) 

主　　题：chiral N-phosphonyl imine chiral phosphoramide glycine enolate α-β diamino ester 

摘      要：Diphenyl diamine-based phosphonyl imines attached by the N-isopropyl group in the auxiliary have been synthesized in good yields under convenient reaction *** new chiral N-phosphonyl imines can react with glycine enolate smoothly to give chiral α-β diamino esters in good yields(72%-90%) and up to excellent diastereoselectivity(99:1 dr).By treatment with HBr,the chiral auxiliary can be readily *** absolute structure has been unambiguously determined by converting a product to a known sample.