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glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning Li Yong Wang Chun Li Xu Chen Xue-Feng Zhang Nan Nan Tan Yi-Qin Hong Ming-Yan Shao Bing-Hua Tang Dong-Qing Guo School of Life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

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glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling

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Animal Nutrition 2022年第1期8卷 1-9页

作者： Ying Yang Xiaoxiao Fan Yun Ji Ju Li Zhaolai Dai Zhenlong Wu State Key Laboratory of Animal Nutrition China Agricultural UniversityBeijing100193China Henan Yinfa Animal Husbandry Co. XinzhengHenan451100China

Endoplasmic reticulum(ER)stress has been associated with the dysfunction of intestinal barrier in humans and *** have previously shown that oral administration of glycine to suckling-piglets improves ER stress-related intestinal mucosal barrier impairment and jejunal epithelial ***,the underlying mechanism remains *** this study,the protective effect and the mechanism of glycine on apoptosis and dysfunction in intestinal barrier induced by brefeldin A(BFA),an ER stress inducer,was explored in porcine intestinal epithelial cells(IPEC-1).The results showed that BFA treatment led to enhanced apoptosis and upregulation of proteins involved in ER stress signaling,including inositol-requiring enzyme 1a(IRE1a),activating transcription factor 6a(ATF6a),c-Jun N-terminal kinase(JNK),and C/EBP-homologous protein(CHOP).In addition,BFA induced a dysfunction in intestinal epithelial barrier,as evidenced by the increased paracellular permeability,decreased transepithelial electrical resistance(TEER),and reduced abundance of tight junction proteins(occludin,claudin-1,zonula occludens[ZO]-1,and ZO-2).These alterations triggered by BFA were significantly abolished by glycine treatment(Pglycine on barrier function impaired by ER ***,we found that the regulatory effect of glycine on intestinal permeability,proteins implicated in ER stress and apoptosis,as well as the morphological alterations of the ER were reversed by *** summary,our results indicated that glycine alleviates ER stress-induced apoptosis and intestinal barrier dysfunction in IPEC-1 cells in a mammalian target of rapamycin complex 1(mTORC1)-dependent *** data provides in vitro evidence and a mechanism for the protective effect of glycine against the disruption of intestinal barrier integrity induced by ER stress.

关键词： glycine ER stress Apoptosis mTORC1 Intestinal barrier

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Functionalization of diatomite with glycine and amino silane for formaldehyde removal

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International Journal of Minerals,Metallurgy and Materials 2022年第2期29卷 356-367页

作者： Yonghao Di Fang Yuan Xiaotian Ning Hongwei Jia Yangyu Liu Xiangwei Zhang Chunquan Li Shuilin Zheng Zhiming Sun School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China

Two amino-functionalized diatomite(DE)composites modified by 3-aminopropyltriethoxysilane(APTS)or glycine(GLY)(i.e.,APTS/DE and GLY/DE)were successfully synthesized via the wet chemical method for the time-and cost-efficient removal of indoor formaldehyde(HCHO).First,the optimal preparation conditions of the two composites were determined,and then their microstructures and morphologies were characterized and *** HCHO adsorption experiments with the two types of amino-modified DE composites were also conducted to compare their adsorption *** results indicated that the pseudo-second-order kinetic and Langmuir isotherm models could well describe the adsorption process,and the maximum adsorption capacities of APTS/DE and GLY/DE prepared under optimal conditions at 20°C were 5.83 and 1.14 mg·g^(-1),*** thermodynamic parameters of the composites indicated that the adsorption process was spontaneous and *** abundant amine groups grafted on the surface of DE were derived from the Schiff base reaction and were essential for the high-efficient adsorption performance toward HCHO.

关键词： diatomite 3-aminopropyltriethoxysilane glycine adsorption formaldehyde

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glycine receptors contribute to cytoprotection of glycine in myocardial cells

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Chinese Medical Journal 2007年第10期120卷 915-921页

作者： QI Ren-bin ZHANG Jun-yan LU Da-xiang WANG Hua-dong WANG Hai-hua LI Chu-jie Department of Pathophysiology Medical College of Jinan University Guangzhou 510632 China Department of Respiratory Diseases Children＇s Hospital of Shanxi Province Taiyuan 030013 China Department of Physiology Wannan Medical College Wuhu 241001 China

Background The classic glycine receptor （GlyR） in the central nervous system is a ligand-gated membrane-spanning ion channel. Recent studies have provided evidence for the existence of GlyR in endothelial cells, renal proximal tubular cells and most leukocytes. In contrast, no evidence for GlyR in myocardial cells has been found so far. Our recent researches have showed that glycine could protect myocardial cells from the damage induced by lipopolysaccharide （LPS）. Further studies suggest that myocardial cells could contain GlyR or binding site of glycine. Methods In isolated rat heart damaged by LPS, the myocardial monophasic action potential （MAP）, the heart rate （HR） the myocardial tension and the activities of lactate dehydrogenase （LDH） from the coronary effluent were determined. The concentration of intracellular free calcium （[Ca^2＋]i） was measured in cardiomyocytes injured by LPS and by hypoxia/reoxygenation （H/R）, which excludes the possibility that reduced calcium influx because of LPS neutralized by glycine. Immunohistochemistry was used to detect the GlyR in myocardial tissue. GlyR and its subunit in the purified cultured cardiomyocytes were identified by Western blotting. Results Although significant improvement in the MAP/MAPD20, HR, and reduction in LDH release were observed in glycine ＋ LPS hearts, myocardial tension did not recover. Further studies demonstrated that glycine could prevent rat mycordial cells from LPS and hypoxia/reoxygenation injury （no endotoxin） by attenuating calcium influx. Immunohistochemistry exhibited a positive green-fluorescence signaling along the cardiac muscle fibers. Western blotting shows that the purified cultured cardiomyocytes express GlyR β subunit, but GlyR α1 subunit could not be detected. Conclusions The results suggest that glycine receptor is expressed in cardiomyocytes and participates in cytoprotection from LPS and hypoxia/reoxygenation injury. glycine could directly activate GlyR on the cardiomyocytes

关键词： glycine glycine receptor myocardial cell cardiomyocyte

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glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4

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Acta Pharmacologica Sinica 2006年第11期27卷 1479-1486页

作者： Zuo-jin LIU~2 Lu-nan YAN~3 Shen-wei LI~2 Hai-bo YOU~2 Jian-ping GONG~2 2 Department of Hepatobiliary Surgery,Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China 3 Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China Department of Hepatobiliary Surgery Second Affiliated Hospital Chongqing University of Medical Sciences Chongqing China Department of General Surgery West China Hospital Sichuan University Chengdu China

Aim:To determine whether glycine could downregulate interleukin 1 receptorassociated kinase-4(IRAK-4)expression to interfere with lipopolysaccharides(LPS)signal transduction and blunt transplantative liver ischemia-reperfusioninjury(I/RI).Methods:SD rats were randomly divided into two groups:donoranimals of the glycine group(n=40)were given glycine(1.5 mL;300 mmol/L,iv)1h before harvest,and the control group were treated with 1.5 mL physiologicalsaline(n=40).Orthotropic liver transplantation was then performed according tothe Kamada *** animals in each group were followed up for 7 d aftersurgery to assess *** remaining animals in each group were dividedinto 3 subgroups(n=10)at 1h,2h and 6 h after portal vein *** ofLPS,serum aspartate aminotransferase(AST),alanine aminotransferase(ALT)and total bilirubin in portal circulation,as well as IRAK-4 and TNF-α expression,NF-κB transcriptional activity and morphological study of liver tissues ***:Reperfusion resulted in a significant elevation of LPS concen-trations in each group persisting to the end of our ***,glycine,whichled to improved survival rate and liver function,significantly alleviated liver pa-renchyma cell damage by downregulating 1RAK-4,TNF-α expression and NF-κBtranscriptional activity compared with the control ***:glycinecan attenuate hepatic I/RI by downregulating IRAK-4 to interfere with LPS signaltransduction.

关键词： liver transplantation reperfusion injury glycine lipopolysaccharides IRAK-4

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Cyclic voltammetry and potentiodynamic polarization studies of chalcopyrite concentrate in glycine medium

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Transactions of Nonferrous Metals Society of China 2021年第2期31卷 545-554页

作者： Maryam KHEZRI Bahram REZAI Ali Akbar ABDOLLAHZADEH Benjamin PWILSON Mehdi MOLAEINASAB Mari LUNDSTRÖM Department of Mining and Metallurgical Engineering Amirkabir University of Technology(Tehran Polytechnic)TehranIran Department of Mining Engineering University of KashanKashanIran Department of Chemical and Metallurgical Engineering(CMET) School of Chemical EngineeringAalto UniversityP.O.Box 16200EspooFinland Sarcheshmeh Copper Complex National Iranian Copper Industries CompanyRafsanjanIran

Cyclic voltammetry and potentiodynamic polarization analyses were utilized to investigate the mechanism and kinetics of glycine leaching reactions for *** effects of pH(9−12),temperature(30−90℃)and glycine concentration(0−2 mol/L)on corrosion current density,corrosion potential and cyclic voltammograms were investigated using chalcopyrite concentrate−carbon paste *** showed that an increase in the glycine concentration from 0 to 2 mol/L led to an increased oxidation peak current *** the same conditions,corrosion current density was found to change from approximately 28 to 89μA/cm2,whereas corrosion potential was decreased from−80 to−130 *** temperatures enhanced the measured current densities up to 60℃;however,above this level,current density was observed to decrease.A similar current density behavior was determined with pH.A pH change from 9 to 10.5 resulted in an increase in current density and pH higher than 10.5 gave rise to a reduced current *** addition,the thermodynamic stability of copper and iron oxides was found to increase at higher temperatures.

关键词： glycine corrosion current density corrosion potential electrochemical behaior chalcopyrite concentrate

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Evaluation of solvent-mediated phase transformation of glycine using oleic acid: Morphology and characterization study

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Chinese Journal of Chemical Engineering 2018年第9期26卷 1829-1836页

作者： Sevgi Polat Perviz Sayan Department of Chemical Engineering Faculty of Engineering Marmara University

The polymorphic phase transformation of β-glycine to α-glycine was carried out both in the absence and presence of various concentrations of oleic acid used as additive at 25 ℃ in a water/ethanol medium. The effects of oleic acid and its concentration on phase transformation time were determined by continuously measuring the ultrasonic velocity. The crystals obtained by the completion of the phase transformation were characterized by XRD, SEM, and TG/DTG. The XRD and SEM results indicated that oleic acid significantly impacted phase transformation time and the morphological characteristics of the crystals. In addition to SEM analysis, detailed crystal shape analysis was performed and the circularity, elongation, and convexity parameters were determined quantitatively. TG/DTG analyses were performed to investigate thermal decomposition behavior and to calculate the activation energies based on different kinetic models such as FWO, KAS, Starink, and Tang kinetic models. With the addition of oleic acid to the medium, the calculated activation energy values increased from 89.63–90.63 to153.8–155.4 kJ·mol^（-1）. The activation energy values showed that oleic acid was adsorbed on the crystal surface;this result was supported by FTIR, elemental, and Kjeldahl analyses.

关键词： glycine Oleic acid Crystallization Isoconversional methods Phase transformation

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Palladium-catalyzed asymmetric allylic C–H alkylation of 1,4-dienes and glycine Schiff bases

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Science China Chemistry 2020年第4期63卷 454-459页

作者： Tian-Ci Wang Pu-Sheng Wang Liu-Zhu Gong Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026China Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences Hefei 230026China

A highly regio-and enantioselective allylic C–H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes,delivering structurally diverse chiral β-branched α-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo-and enantioselectivities.

关键词： asymmetric catalysis palladium allylic C–H alkylation 1,4-diene glycine Schiff base

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Influence of glycine additive on corrosion and wear performance of electroplated trivalent chromium coating

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 544-554页

作者： Navid Mehdipour Milad Rezaei Zeynab Mahidashti Department of Materials and Metallurgical Engineering Amirkabir University of Technology(Tehran Polytechnic)Hafez Ave.P.O.Box 15875-4413TehranIran

The aim of this study is to evaluate the effect of various molar ratios of glycine to chromium salt(Gly:Cr)and different current densities on the corrosion and wear behaviors of Cr(III)electroplated *** morphology and thickness of the coatings were investigated by scanning electron *** wear properties of the coatings were studied using pin on disk and hardness tests,while corrosion behavior of the coatings was identified using linear polarization,small amplitude cyclic voltammetry,and electrochemical impedance spectroscopy *** increasing the glycine concentration,a structure with low crack density was *** all molar ratios,maximum thickness and current efficiency was observed at a current density of 150 mA·cm?*** the electrochemical methods had a consistent result,and maximum corrosion resistance of approximately 16000Ω·cm2 was obtained in the case of Gly:Cr=3:1 and current density of 200 mA·cm?2.

关键词： electrodeposition trivalent chromium glycine corrosion resistance

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High-level theoretical study of the evolution of abundances and interconversion of glycine conformers

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Chinese Physics B 2018年第4期27卷 264-271页

作者： Fan Liu Jing Yu Yan-Ru Huang College of Science Liaoning Shihua University Fushun 113001 China

The relative conformer energies of glycine are evaluated by using a focal point analysis expressed as（HF→MP2→MP3→CCSD→CCSD（T））.The conformer abundances at various temperatures（298–500 K） are calculated based on the relative energies and Boltzmann statistical thermostatistical analysis with and without considering internal hindered rotations.A comparison between the available Raman spectrum and the electron momentum spectrum confirms that the influence of rigid-rotor hindered rotation on the conformational proportions of glycine is considerable,especially for the IIIp *** conformational interconversions are *** is found that with increasing temperature,the mole fraction of IIn keeps constant and Ip structure can convert into IVn and IIIp,leading to the decrease in the weight of Ip and the increase in the weights of IVn and IIIp conformers,which is in accordance with experimental observations.

关键词： glycine conformation abundance interconversion

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