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Differential effect of biotin on carboxylase activity and mice skeletal muscle metabolism

Advances in Bioscience and Biotechnology 2013年第7期4卷 43-50页

作者： Marco Antonio Parra Montes de Oca Gabriel Gutierrez-Ospina pablo hofmann salcedo Alma Lilia Fuentes-Farias Esperanza Melendez-Herrera Margarita Gomez-Chavarin Armida Baez-Saldana Departamento de Biologia Celular y Fisiologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoCiudad UniversitariaD.F.Mexico Laboratorio de Eco-fisiologia Animal Instituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico

In mammalian skeletal muscle there are four carboxylases involved in several biochemical processes like gluconeogenesis, tricarboxylic acid cycle anaplerosis, metabolism of fatty acids and metabolism of various amino acids. It has been shown that biotin deficiency reduces body weight at the expense of muscular mass. When necessary, the liver uses skeletal muscle protein to provide glucose and amino acids to organs in need of such compounds. In this paper we analyzed carboxylase specific activities in hind limb skeletal muscle of 3 weeks old BALB/c male mice, at 0, 1, 4, 7, and 14 days of a specific diet with different biotin concentrations. Biotin was used at 0.0, 1.8 or 98.2 mg per kg of food;and was referred to as biotin deficient, sufficient and supplemented, respectively. Water and food supply and consumption by the three groups of mice were the same. Therefore, the observed effects were directly related to biotin ingestion. The body weight of biotin supplemented mice was the same as the body weight of mice in the biotin sufficient group, while biotin deficiency caused body weight reduction after 7 days of biotin depletion. We found that the total protein concentration in the vastus lateralis muscle is associated with the biotin content in the diet. After 7 days, the muscle total protein content was lower in mice of the biotin deficient group while it was higher in the mice from the biotin supplemented group

关键词： Biotin Deficiency Biotin Supplementation Biotin Sufficiency Skeletal Muscle Carboxylases Body Growth

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Hybrid multi-chip assembly of optical communication engines by in situ 3D nanolithography

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Light(Science & Applications) 2020年第1期9卷 1340-1350页

作者： Matthias Blaicher Muhammad Rodlin Billah Juned Kemal Tobias Hoose pablo Marin-Palomo Andreas hofmann Yasar Kutuvantavida Clemens Kieninger Philipp-Immanuel Dietrich Matthias Lauermann Stefan Wolf Ute Troppenz Martin Moehrle Florian Merget Sebastian Skacel Jeremy Witzens Sebastian Randel Wolfgang Freude Christian Koos Institute of Photonics and Quantum Electronics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstraße 576131 KarlsruheGermany Institute for Microstructure Technology(IMT) KITHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Institute for Automation and Applied Informatics(IAI) KITHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Vanguard Automation GmbH Gablonzer StraBe 1076185 KarlsruheGermany Fraunhofer Institute for Telecommunications Heinrich Hertz Institute(HHI)Einsteinufer 3710587 BerlinGermany Institute of Integrated Photonics(IPH) RWTH AachenSommerfeldstraße 18/2452074 AachenGermany

Three-dimensional(3D)nano-printing of freeform optical waveguides,also referred to as photonic wire bonding,allows for efficient coupling between photonic chips and can greatly simplify optical system *** a key advantage,the shape and the trajectory of photonic wire bonds can be adapted to the mode-field profiles and the positions of the chips,thereby offering an attractive alternative to conventional optical assembly techniques that rely on technically complex and costly high-precision ***,while the fundamental advantages of the photonic wire bonding concept have been shown in proof-of-concept experiments,it has so far been unclear whether the technique can also be leveraged for practically relevant use cases with stringent reproducibility and reliability *** this paper,we demonstrate optical communication engines that rely on photonic wire bonding for connecting arrays of silicon photonic modulators to InP lasers and single-mode *** a first experiment,we show an eight-channel transmitter offering an aggregate line rate of 448 Gbit/s by low-complexity intensity modulation.A second experiment is dedicated to a four-channel coherent transmitter,operating at a net data rate of 732.7 Gbit/s-a record for coherent silicon photonic transmitters with co-packaged *** dedicated test chips,we further demonstrate automated mass production of photonic wire bonds with insertion losses of(0.7±0.15)dB,and we show their resilience in environmental-stability tests and at high optical *** results might form the basis for simplified assembly of advanced photonic multi-chip systems that combine the distinct advantages of different integration platforms.

关键词： communication lithography bonding

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独特的牙科之旅瓦伦西亚某牙科诊所

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室内设计与装修 2020年第3期 14-15页

作者： [西班牙]FRAN SILVESTRE ARQUITECTOS COCO(编译) Jesus Orrico(摄) ALFARO hofmann Fran Silvestre pablo Camarasa 不详

该牙科诊所位于瓦伦西亚市中心,是一家为客户提供个性化治疗方案的私人牙科诊所。诊所所在建筑建于20世纪初,狭小紧凑的建筑布局影响了诊所的功能分区。为解决这一不利因素,设计团队统一了墙壁、地板和天花板的颜色,并将这三部分设计成... 详细信息

该牙科诊所位于瓦伦西亚市中心,是一家为客户提供个性化治疗方案的私人牙科诊所。诊所所在建筑建于20世纪初,狭小紧凑的建筑布局影响了诊所的功能分区。为解决这一不利因素,设计团队统一了墙壁、地板和天花板的颜色,并将这三部分设计成连续的铺面。

关键词：牙科诊所瓦伦西亚建筑布局功能分区设计团队天花板不利因素市中心

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