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Navigating medial patellotibial ligament reconstruction:Clinical perspectives and surgical strategies

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World Journal of Clinical Cases 2025年第1期13卷 6-10页

作者： Juan pablo Zicaro Ignacio Garcia-Mansilla Division of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when *** medial patellotibial ligament and the medial patellomeniscal ligament are secondary stabilizers of the *** this,both the medial patellotibial and patellofemoral ligaments aid in patellar rotation and tilt when the knee is flexed beyond 45°.The medial patellotibial ligament plays a particularly important role in the final stages of stretching in extension and between 40 degrees to 90 degrees of *** clinical relevance and surgical indications for medial patellotibial ligament reconstruction associated with medial patellofemoral ligament reconstruction are still *** editorial explores the surgical indications and clinical results for medial patellotibial ligament reconstruction to improve readers’understanding of this technique,especially because reported clinical outcomes have remained sparse.

关键词： Medial patellotibial ligament Patellar instability Reconstruction Surgical

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Main environmental variables influencing the abundance of plant species under risk category

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Journal of Forestry Research 2022年第4期33卷 1209-1217页

作者： pablo Antúnez División de Estudios de Posgrado Universidad de la Sierra Juárez68725 Oax.México

Determining climatic and physiographic variables in Mexico’s major ecoregions that are limiting to biodiversity and species of high conservation concern is essential for their ***,at the national level to date,few studies have been performed with large data sets and crossconfirmation using multiple statistical ***,we used 25 endemic,rare and endangered species from 3610 sampling points throughout Mexico and 25 environmental attributes,including average precipitation for different seasons of the year,annual dryness index,slope of the terrain;and maximum,minimum and average temperatures to test our hypothesis that these species could be assessed with the same weight among all variables,showing similar indices of *** results using principal component analysis,covariation analysis by permutations,and random forest regression showed that summer precipitation,length of the frost-free period,spring precipitation,winter precipitation and growing season precipitation all strongly influence the abundance of tropical *** contrast,annual precipitation and the balance at different seasons(summer and growing season)were the most relevant variables on the temperate region *** dry areas,the minimum temperature of the coldest month and the maximum temperature of the warmest month were the most significant *** these different associations in different climatic regions could support a more precise management and conservation plan for the preservation of plant species diversity in forests under different global warming scenarios.

关键词： Correlative models Climate change Effect of topography Endemic species IUCN list Machine learning algorithms

On the interaction of a donepezil-huprine hybrid with synthetic membrane models

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Neural Regeneration Research 2023年第2期18卷 333-334页

作者： pablo Zambrano Max Planck Institute of Biochemistry Cellular and Molecular BiophysicsMunichGermany

Alzheimer's disease is the most prevalent type of dementia today,discovered and described by Alois Alzheimer in *** to the World Alzheimer Report 2021,75%of people with dementia worldwide are undiagnosed,equivalent to 41 million people(Gauthier et al.,2021).With each passing year,the number of people affected by these diseases is increasing,and the estimates of suffering from them in the future are growing.

关键词： Alzheimer diseases

Chemokines and Chemokine Receptors:Their Manifold Roles in Homeostasis and Disease

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Cellular & Molecular Immunology 2004年第2期1卷 95-104页

作者： pablo Iribarren Laboratory of Molecular Immunoregulation Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMarylandUSA

Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and *** recent years,it has become clear that the function of chemokines extends well beyond the role in leukocyte *** participate in organ development,angiogenesis/angiostasis,leukocyte trafficking and homing,tumorigenesis and metastasis,as well as in immune responses to microbial ***, chemokines and their receptors are important targets for modulation of host responses in pathophysiologicai conditions and for therapeutic intervention of human *** & Molecular Immunology.2004;1(2): 95-104.

关键词： chemokine receptor development leukocyte homing angiogenesis metastasis

Asymptotic of Eigenvalues and Lattice Points

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1645-1650页

作者： Juan pablo PINASCO Instituto de Ciencias Universidad Nacional de General Sarmiento

dimension. elementary domains of In this work we study the spectral counting function for the p-Laplace operator in one We show the existence of a two-term Weyl-type asymptote. The method of proof is rather based on ... 详细信息

关键词： p-Laplacian eigenvalues lattice points

Human-Exoskeleton Joint Coordination Assessment:A Case Study on the Shoulder and Elbow Joints

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Journal of Bionic Engineering 2022年第6期19卷 1712-1721页

作者： pablo Delgado Clarissa Rincon Yimesker Yihun Mechanical Engineering Wichita State University1845 FairmountWichitaKS67260USA Biomedical Engineering Wichita State University1845 FairmountWichitaKS67260USA

This study is aimed at developing a methodology to assess and quantify the human limb motions and interactions with the exoskeleton in relation to *** different basic and common upper arm joint movements and their interaction with a joint-based exoskeleton are considered:shoulder vertical and horizontal abduction-adduction,and elbow *** exoskeleton and the human model are aligned to the respective joints inside a Musculoskeletal Modeling *** the range of motion,the linear and angular displacement errors were analyzed,and the effect of those errors on the length of the associated tendons was *** have shown a noticeable variation of the muscle-tendon lengths up to 65.7 mm and a change in the pattern on different muscle groups of the ***,about 4 mm muscle-tendon length changes observed particularly at the elbow anconeus *** changes of length could cause unwanted stresses at the joints,specially for people with disabilities due to stroke that might not have the flexibility to accommodate those extra pose variations imposed by the exoskeleton.

关键词： Exoskeleton Upper limb Rehabilitation Misalignment OpenSim Computational modeling Bioinspiration

Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： Beatriz Gonzalez pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

THE BLOCH SPACE ON THE UNIT BALL OF A HILBERT SPACE: MAXIMALITY AND MULTIPLIERS

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Acta Mathematica Scientia 2021年第3期41卷 899-906页

作者： pablo GALINDO Mikael LINDSTRÖM Departamento de Análisis Matemático Universidad de Valencia.C/Dr.Moliner 50.46.100BurjasotValenciaSpain Department of Mathematics Abo Akademi University.FI-20500ÅboFinland

We prove that, as in the finite dimensional case, the space of Bloch functions on the unit ball of a Hilbert space contains, under very mild conditions, any semi-Banach space of analytic functions invariant under automorphisms. The multipliers for such Bloch space are characterized and some of their spectral properties are described.

关键词： Analytic functions on Hilbert space invariance under automorphisms multiplier