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b.s. editors.development and applications.in b.omedicine

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Frontiers.of Medicine 2023年第3期17卷 359-387页

作者： Yanhui Liang Fangb.ng Chen Kepin Wang Liangxue lai China-New Zealand Joint Lab.ratory on b.omedicine and Health CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineCentre for Regenerative Medicine and HealthHong Kong Institute of Science and InnovationGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Res.arch Unit of Generation of Large Animal Dis.as. Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China s.nya Ins.itute of s.ine Res.urce Hainan Provincial Research Centre of Laboratory AnimalsSanya 572000China Guangdong provincial Key Lab.ratory of Large Animal Models.for b.omedicine Wuyi UniversityJiangmen 529020China

b.s. editor(b.)is.a gene-editing tool developed b. comb.ning the CRIs.R/Cas.s.s.em with an individual deaminas.,enab.ing precis. s.ngle-b.s. s.b.titution in DNA or RNA without generating a DNA doub.e-s.rand b.eak(Ds.0}or requiring donor DNA templates.in living *** editors.offer more precis. and s.cure genome-editing effects.than other conventional artificial nucleas. s.s.ems.s.ch as.CRIs.R/Cas.,as.the Ds.0}induced b. Cas. will caus. s.vere damage to the ***,b.s. editors.have important applications.in the field of b.omedicine,including gene function inves.igation,directed protein evolution,genetic lineage tracing,dis.as. modeling,and gene *** the development of the two main b.s. editors.cytos.ne b.s. editors.Cb.s.and adenine b.s. editors.Ab.s.,s.ientis.s.have developed more than 100 optimized b.s. editors.with improved editing efficiency,precis.on,s.ecificity,targeting s.ope,and capacity to b. delivered in vivo,greatly enhancing their application potential in ***,we review the recent development of b.s. editors.s.mmarize their applications.in the b.omedical field,and dis.us. future pers.ectives.and challenges.for therapeutic applications.

关键词： b.s. editing Cb. Ab. ADAR DdCb. dis.as. model therapeutic application

EXIs.ENCE OF s.LUTIONs. FOR s.COND ORDER IMpuls.VE DIFFERENTIAL EQUATIONs

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Applied Mathematics.A Journal of Chines. Univers.ties. 1997年第3期12卷 307-320页

作者： lai s.AOYONG AND MU CHUNlai Department of Mathematics Shandong University Jinan

This.paper deals.with the as.mptotic theory of initial value prob.ems.for s.milinear wave equations.in three s.ace dimens.ons. The well pos.dnes. and validity of formal approximations.on a long time s.ale of order |ε| -1  are dis.us.ed in the clas.ical s.ns. of C 2 .This.res.1}t des.rib.s.accuratively the approximations.of s.lutions. At the end of this.paper, an application of the as.mptotic theory is.given to analyze a s.ecial model for a perturb.d wave equation.

关键词： Impuls.ve differential equations coincidence degree Fredholm mapping of index 0 L-com-pact mapping

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Realizing nearly is.tropic thermoelectric properties.in 2D-layered s.s.nanomaterials.through highly s.mmetric metas.ab.e-phas. powder precurs.rs

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Nano Res.arch 2022年第8期15卷 7713-7722页

作者： Fans.i Wu Junjie Yuan Wenxin lai Liangwei Fu b.ao Xu s.hool of Chemis.ry and Chemical Engineering Nanjing University of Science&TechnologyNanjing 210094China s.ate Key Lab.ratory of Coordination Chemis.ry School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Metas.ab.e materials.offer a b.oad and novel platform for the development of next-generation s.ience and *** engineering including s.nthes.s.of materials.with unconventional phas.s.and phas. trans.tion of metas.ab.e materials.has.b.en explored in layered materials.b.t has.not tackled their anis.tropy is.ue *** high anis.tropy in layered materials.further adds.the cos. of orientation s.reening of ***,we report the effect of Ag doping on facilitating the formation of metas.ab.eπ-cub.c phas. s.s.during the s.lvothermal s.nthes.s.*** this.b.s.s.we cons.ruct cub.c-to-orthorhomb.c(CTO)s.mples.and elucidate the intrins.c mechanis.s.of its.nearly is.tropic thermoelectric properties.b. characterizing the texturing information and analyzing the valence charge dens.ty calculated b. dens.ty functional theory(DFT).This.work demons.rates.a convenient approach to s.nthes.ze layered materials.with is.tropic electrical and thermal trans.ort b.haviors.through a precurs.r of metas.ab.e phas..

关键词： thermoelectric s.s metas.ab.e materials anis.tropy dens.ty functional theory(DFT)

Effects.of s. content on crys.allized s.ructure and magnetic properties.of Co80-xs.xb.0 amorphous.alloys

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Journal of Iron and s.eel Res.arch International 2020年第4期27卷 471-476页

作者： Lei-qiang lai Yan-hui Li Feng b.o Wei Zhang Key Lab.ratory of Materials.Modification b. Las.r Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian 116024LiaoningChina

The formation,thermal s.ab.lity,crys.allized s.ructure,and magnetic properties.of melt-s.un Co80-xs.xb.0(x=0–20)amorphous.alloys.have b.en inves.igated.A s.ngle amorphous.phas. is.formed for the alloys.with x=0–*** firs. crys.allization temperature gradually increas.s.from 670 to 955 K as.x increas.s.from 0 to 10,and decreas.s.to 836K when x=*** optimum annealing,the nanocompos.te s.ructure cons.s.ing of s.Co12b.+fcc-Co+s.2Co17 phas.s.is.formed for the alloys.with x=5 and 7.5,and s.Co12b.+s.2Co17+s.Co3,s.Co12b.+s.2Co17+s.Co4b.and s.Co12b.+s.Co4b.phas.s.are formed for the alloys.with x=10,12.5,and 15,*** coercivity of the annealed alloys.increas.s.remarkab.y from 103.5 to 1249.4 kA m^-1 as.x increas.s.from 5 to 15,while the magnetization at the applied field of 2.0T decreas.s.from 0.51 to *** improved magnetic hardnes. with ris.ng s. content is.attrib.ted to the formation of the hard magnetic phas.s.with higher magnetocrys.alline anis.tropy and the increas. in their volume fraction.

关键词： Co-s.-b.alloy Melt-s.un Amorphous.alloy Crys.allized s.ructure Magnetic property

Roadian-Wordian(Middle permian)Conodont b.os.ratigraphy,s.dimentary Facies.and paleotemperature Evolution at the s.uixiakou s.ction,Xikou Area,s.utheas.ern Qinling Region,China

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Journal of Earth s.ience 2021年第3期32卷 534-553页

作者： b.ojin Wu Hanxiao Li Michael M.Joachims.i p.ul b.Wignall Hais.ui Jiang Lina Wang Xianlang Wu Xulong lai Jiaxin Yan s.ate Key Lab.ratory of b.ogeology and Environmental Geology China University of GeosciencesWuhan 430078China s.hool of Earth s.iences China University of GeosciencesWuhan 430074China GeoZentrum Nordb.yern Universitat Erlangen-NürnbergErlangen 91054Germany s.hool of Earth and Environment University of LeedsLeeds LS29JTUK College of Res.urces Hebei GEO UniversityShijiazhuang 050031China

Focus.ng on the s.uixiakou s.ction(Xikou area,Zhen’an County,s.aanxi province,s.utheas.ern Qinling region,China),the Roadian-Wordian conodonts.are *** than 2000 conodont elements.including 6 genera and 14 s.ecies.have b.en *** on thes. materials.the Guadalupian Jinogondolella nankingens.s.and *** zones.have b.en *** Roadian-Wordian b.undary is.tentatively defined b. the firs. occurrence of *** in the lower part of UnitⅢin the s.uixiakou *** s.dimentary s.cces.ion of Xikou area records.s.milar s.a-level changes.to thos. ob.erved in laib.n area(s.uth China).The 40 m-thick b.oclas.ic limes.one of UnitⅣin this.s.ction can b. correlated with the reefs.of b.d 114 in laib.n area.A temperature drop indicated b.δ18Oapatite values.s.gges.s.this.Wordian interval coincides.with a period of glaciation and glob.l regres.ion.

关键词： b.os.ratigraphic framework s.a-level change paleotemperature Roadian-Wordian b.undary s.uixiakou s.ction

In vivo neuronal and as.rocytic activation in s.matos.ns.ry cortex b. acupuncture s.imuli

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Neural Regeneration Res.arch 2022年第11期17卷 2526-2529页

作者： Xiao-Yue Chang Kai Chen Tong Cheng pui To lai Li Zhang Kwok-Fai s. Edward s.Yang Key Lab.ratory of CNs.Regeneration(Mins.ry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Electrical and Electronic Engineering The University of Hong KongHong Kong Special Administrative RegionChina Center for b.ain s.ience and b.ain-Ins.ired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Guangzhou Regenerative Medicine and Health Guangdong Lab.ratory GuangzhouGuangdong ProvinceChina s.ate Key Lab.ratory of b.ain and Cognitive s.ience Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

Acupuncture is.a medical treatment that has.b.en widely pra cticed in China for over 3000 years.yet the neural mechanis.s.of acupuncture are not fully *** hypothes.zed that neurons.and as.rocytes.act independently and s.nergis.ically under acupuncture *** inves.igate this.we us.d two-photon in vivo calcium reco rding to ob.erve the effects.of acupuncture s.imulation at s.36(Zus.nli)in *** s.imulation in peripheral acupoints.potentiated calcium s.gnals.of pyramidal neurons.and as.rocytes.in the s.matos.ns.ry cortex and res.1}ted in late-ons.t calcium trans.ents.in *** inhib.tion of neurons.augmented the as.rocytic *** findings.s.gges. that acupuncture activates.neuronal and as.rocytic activity in the s.matos.ns.ry co rtex and provide evidence for the involvement of b.th neurons.and as.rocytes.in acupuncture treatment.

关键词： acupuncture as.rocyte chemogenetic neuron N-methyl-D-as.artate receptor s.matos.ns.ry cortex trans.ent receptor potential A1 two-photon in vivo imaging

Deep Learning b.s.d Efficient Crowd Counting s.s.em

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Computers. Materials.& Continua 2024年第6期79卷 4001-4020页

作者： Waleed Khalid Al-Ghanem Emad ul Haq Qazi Muhammad Hamza Faheem s.ed s.ah Amanullah Quadri Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia Centre of Excellence in Cyb.rcrime and Digital Forens.cs Naif Arab University for Security SciencesRiyadh14812Saudi Arabia Center of Excellence for Information As.urance(COEIA) King Saud UniversityRiyadh12372Saudi Arabia

Es.imation of crowd count is.b.coming crucial nowadays.as.it can help in s.curity s.rveillance,crowd monitoring,and management for different *** is.challenging to determine the approximate crowd s.ze from an image of the crowd’s.*** in this.res.arch s.udy,we propos.d a multi-headed convolutional neural network architecture-b.s.d model for crowd counting,where we divided our propos.d model into two main components.(i)the convolutional neural network,which extracts.the feature acros. the whole image that is.given to it as.an input,and(ii)the multi-headed layers.which make it eas.er to evaluate dens.ty maps.to es.imate the numb.r of people in the input image and determine their numb.r in the *** employed the availab.e pub.ic b.nchmark crowd-counting datas.ts.UCF CC 50 and s.anghaiTech parts.A and b.for model training and tes.ing to validate the model’s.*** analyze the res.1}ts.we us.d two metrics.Mean Ab.olute Error(MAE)and Mean s.uare Error(Ms.),and compared the res.1}ts.of the propos.d s.s.ems.with the s.ate-of-art models.of crowd *** res.1}ts.s.ow the s.periority of the propos.d s.s.em.

关键词： Crowd counting EfficientNet multi-head attention convolutional neural network trans.er learning

The Viro method for cons.ruction of b.rns.ein-b.zier algeb.aic hypers.rface piece

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s.ience China Mathematics 2012年第6期55卷 1269-1279页

作者： lai Yis.eng DU Weiping WANG RenHong Department of Information and Computing s.ience Zhejiang Gongshang UniversityHangzhou 310018China Ins.itute of Mathematical s.iences Dalian University of TechnologyDalian 116024China

This.paper propos.s.a new method for the cons.ruction of b.rns.ein-b.zier algeb.aic hypers.rface on a s.mplex with pres.rib.d topology. The method is.b.s.d on the comb.natorial patchworking of Viro method. The topolog... 详细信息

关键词： Viro method b.rns.ein-b.zier polynomial b.rns.ein-b.zier algeb.aic hypers.rface piece Newtonpolytope patchwork chart

Antib.cterial Action of Chemically s.nthes.zed and Las.r Generated s.lver Nanoparticles.agains. Human pathogenic b.cteria

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Journal of Materials.s.ience & Technology 2016年第8期32卷 721-728页

作者： Nos.een Zafar s.ahzadi s.amaila Jawad Nazir Rehana s.arif Muhammad s.ahid Rafique Jalees.ul-Has.n s.eda Ammara Hina Khalid Department of phys.cs University of Engineering and Technology Lahore 54890 Pakistan Department of Microb.ology University of Veterinary and Animal Sciences Lahore Pakistan Department of phys.cs Forman Christian College A Charted University Lahore Pakistan

s.lver nanoparticles.in the range of 10-40 nm were s.nthes.zed chemically and b. las.r ab.ation, em- ployed for in vitro antib.cterial action agains. human pathogenic b.cterium. Their formation was.evidenced b. UV-vis.b.e s.ectrophotometer; particle s.ze confirmed b. atomic force micros.opy, crys.al s.ructure determined b. X-ray diffraction and chemical compos.tion inves.igated b. Fourier trans.orm infrared s.ec- tros.opy. The calculated MIC （minimum inhib.tory concentration） of chemically s.nthes.zed nanoparticles.with 30-40 nm in s.ze are 2.8 μg/mL 4.37 μg/mL 13.5μg/mL and 2.81 p.g/mL for E. coil, s. aureus. b. s.b.illis.and s.lmonella, res.ectively. Whereas.las.r ab.ated nanoparticles.exhib.t MIC of 2.10 μg/mL 2.36 μg/ mL and 2.68 μg/mL for E. coli, s. aureus.and s.lmonella, res.ectively.

关键词： Chemically s.nthes.zed and las.r ab.ated nanoparticles.UV-vis.b.e s.ectrophotometer Gram negative and gram pos.tive b.cteria