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Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: A randomized controlled trial

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World Journal of Gastroenterology 2008年第12期14卷 1908-1913页

作者： Binay k de deep Dutta Rimi Som pranab k Biswas Subrata k pal Anirban Biswas department of Medicine Medical College Calcutta 88 College Street Calcutta 700073 and Institute of Cardiovascular Sciences RG Kar Medical College Calcutta 32 Gorachand Road Kolkata 700014 India

AIM: To study the hemodynamic effects of spironolactone with propranolol vs propranolol alone in the secondary prophylaxis of variceal bleeding. METHODS: Thirty-five cirrhotics with variceal bleeding randomly received propranolol (n = 17: Group A) or spironolactone plus propranolol (n = 18: Group B). Hemodynamic assessment was performed at baseline and on the eighth day. RESULTS: Spironolactone with propranolol caused a greater reduction in the hepatic venous pressure gradient than propranolol alone (26.94% vs 10.2%; p patients on the combination treatment had a reduction in hepatic venous pressure gradient to ≤ 12 mmHg or a 20% reduction from baseline in contrast to only six out of seventeen (6/17) on propranolol alone (p pironolactone with propranolol results in a better response with a greater reduction in hepatic venous pressure gradient in the secondary prophylaxis of variceal bleeding. A greater number of patients may be protected by this combination therapy than by propranolol alone. Hence, this combination may be recommended for secondary prophylaxis in patients with variceal bleeding.

关键词： Hepatic venous pressure gradient Secondary prophylaxis Spironolactone propranolol Varicealbleeding

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Spruce forest stands in a stationary state

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Journal of Forestry Research 2019年第4期30卷 1167-1178页

作者： petri p.k?renlampi University of Eastern Finland

We present stationarity criteria for forest stands,and establish embodiments using a Norwegian empirical stand development *** natural stationary states only slightly differ from the outcome of long-term simulations previously implemented using the same empirical *** interference in terms of diameter-limit cutting is ***,stationary states differing from the natural one *** volume,growth and monetary value appear low but the financial return rate may be *** yield and financial return clearly contradict each other,the former arising from harvesting large trees,the latter from frequent removal of small *** exponential tree size distribution does not appear to comply with the stationarity criterion.

关键词： Growth plenterwald(selection cutting) Recruitment Stand development Yield

Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第32期11卷 5015-5018页

作者： Dénes Grg János Regly-Mérei Sándor paku László kopper p.ter Nagy department of Transplantation and SurgerySemmelweis University BudapestHungary Third department of SurgerySemmelweis University BudapestHungary Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis UniversityBudapest Hungary First department of pathology and Experimental Cancer ResearchSemmelweis University BudapestHungary

AIM： To characterize the alpha-fetoprotein （AFp） positive and negative hepatocellular carcinoma （HCC） samples. METHODS： Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens： AFp,β-catenin, p53, CD44, MSH-2, MLH-1, and HNF-4. The tumors were divided into two groups based on the AFp expression. The immunophenotypic data and important clinical parameters were studied between the two groups. RESULTS： Twenty-one of the thirty-seven examined HCCs were AFp positive. Seven with nudear p53 staining were AFp positive, while seven tumors with nuclear β-catenin staining were AFp negative. CD44 staining and high histological tumor grade were more frequent among the AFp-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFp positive and negative samples. CONCLUSION： AFp expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFp-negative liver tumors. This observation supports the microarray data on in vivo human tumors.

关键词： Hepatocellular carcinoma Alpha-fetoprotein p53 β-catenin CD44

Surface roughness measurements in NFMQL assisted turning of titanium alloys: An optimization approach

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Friction 2017年第2期5卷 155-170页

作者： Munish k.GUpTA p.k.SOOD MED NIT Hamirpur(H.P.)177005 India

The prediction and optimization of surface roughness values remain a critical concern in nano-fluids based minimum quantity lubrication (NFMQL) turning of titanium (grade-2) ***,we discuss an application of response surface methodology with Box-Cox transformation to determine the optimal cutting parameters for three surface roughness values,i.e.,Ra,Rq,and Rz,in turning of titanium alloy under the NFMQL *** surface roughness prediction model has been established based on the selected input parameters such as cutting speed,feed rate,approach angle,and different nano-fluids *** the multiple regression technique is used to find the relationship between the given responses and input ***,the experimental data were optimized through the desirability function *** findings from the current investigation showed that feed rate is the most effective parameter followed by cutting speed,different nano-fluids,and approach angle on Ra and Rq values,whereas cutting speed is more effective in the case of Rz under NFMQL ***,the predicted results are comparatively near to the experimental values and hence,the established models of RSM using Box-Cox transformation can be used for prediction satisfactorily.

关键词： nano-fluids optimization surface roughness turning titanium alloy

Short term Wind Speed prediction Using Multiple kernel pseudo Inverse Neural Network

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International Journal of Automation and computing 2018年第1期15卷 66-83页

作者： S.p.Mishra p.k.Dash Multi-disciplinary Research Centre (MDRC) Department of Electrical EngineeringSiksha "O" Anusandhan University

An accurate short-term wind speed prediction algorithm based on the efficient kernel ridge pseudo inverse neural network （kRpINN） variants is proposed in this paper. The use of nonlinear kernel functions in pseudo inverse neural networks eliminates the trial and error approach of choosing the number of hidden layer neurons and their activation functions. The robustness of the proposed method has been validated in comparison with other models such as pseudo inverse radial basis function （pIRBF） and Legendre tanh activation function based neural network, i.e., pILNNT, whose input weights to the hidden layer weights are optimized using an adaptive firefly algorithm, i.e., FFA. However, since the individual kernel functions based kRpINN may not be able to produce accurate forecasts under chaotically varying wind speed conditions, a linear combination of individual kernel functions is used to build the multi kernel ridge pseudo inverse neural network （Mk-RpINN） for providing improved forecasting accuracy, generalization, and stability of the wind speed prediction model. Several case studies have been presented to validate the accuracy of the short-term wind speed prediction models using the real world wind speed data from a wind farm in the Wyoming State of USA over time horizons varying from 10 minutes to 5 hours.

关键词： Wind speed prediction pseudo inverse neural network kernel ridge regression nonlinear kernels firefly optimizatiotl.

On the Epochal Variability in the Frequency of Cyclones during the pre-Onset and Onset phases of the Monsoon over the North Indian Ocean

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Advances in Atmospheric Sciences 2020年第6期37卷 634-651页

作者： p.p.BABURAJ S.ABHILASH k.MOHANkUMAR A.k.SAHAI department of Atmospheric Sciences Cochin University of Science and TechnologyCochin 682016India Regional Meteorological Center India Meteorological DepartmentChennai 600006India Advanced Center for Atmospheric Radar Research Cochin University of Science and TechnologyCochin 682022India Indian Institute of Tropical Meteorology Dr.Homi Bhabha RoadPashanPune 411008India

In this paper we examine the epochal changes in the frequency of cyclones over the North Indian Ocean during the pre-onset and onset phases of the *** consider three epochs;namely,the early(1955-74),middle(1975-94)and recent(1995-2014)*** is found that the number of cyclones in the Bay of Bengal(BOB)decreases throughout the three *** the Arabian Sea(ARB),however,there is a decrease in the early epoch,before then reaching a minimum in the middle epoch followed by an increase in the recent epoch,thus exhibiting epochal *** and thermodynamic parameters along with Genesis potential Index(GpI)are examined to understand the frequency variation in cyclogenesis over the ARB and *** the ARB,thermodynamic factors such as mid-level moisture,surface latent heat flux and sensible heat flux,and dynamic parameters such as lower-level convergence and upper-level divergence,are favorable during the early and recent epochs but unfavorable during the middle epoch,and these results are found to be consistent with the observed epochal variability in the frequency of ***,all these influential parameters are found to have decreased over the BOB during the entire 60-year period.

关键词： epoch Indian moisture

deformation-based support design for highly stressed ground with a focus on rockburst damage mitigation

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 50-66页

作者： p.k.kaiser A.Moss Laurentian University SudburyONP3E 2C6Canada Geok Inc.680 Ramsey Lake Road SudburyONP3E 6H5Canada Sonal Mining Technology Inc. 2488 Shadbolt LaneWest VancouverBCV7S 3J1Canada

As mines go deeper,mine designs become more fragile and effective rock support becomes a strategic element for ground control to facilitate timely construction and cost-effective access for uninterrupted *** article focuses on the design of integrated support systems for brittle ground when large displacements due to gradual bulking of stress-fractured rock or sudden violent bulking during rockbursts are induced by static and dynamic *** provides an overview of support design principles for a rational approach to ground control in deep mines when large deformations are anticipated near *** designs must not only account for load equilibrium but also for deformation *** importantly,the design approach must account for the fact that the support’s displacement capacity is being consumed as it is deformed after support *** is therefore necessary to design for the remnant support capacity,*** capacity remaining when the support is ***,if the support capacity can be consumed,it can also be restored by means of preventive support maintenance(pSM).The pSM concept for cost-effective ground control is introduced and illustrated by quantitative and operational *** to other design approaches,the deformation-based support design(DBSD)approach provides the capacity of an integrated support system as a function of imposed *** in this support capacity due to mininginduced deformation renders excavations increasingly more vulnerable if located within the influence of active mining and seismic *** deformation measurements are robust indicators of the decay in support capacity,scanning and other displacement monitoring technologies enable measurements to verify the DBSD approach,to assess the remnant safety margin of the deformed support,and to make operational support maintenance decisions.

关键词： deep mining deformation-based support design(DBSD) Cost-effective support Support consumption preventive support maintenance(pSM)

Tribological and vibrational characteristics of AISI 316L tested at elevated temperature and 600 Torr vacuum

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defence Technology（防务技术） 2019年第1期15卷 58-64页

作者： k.Arul Raj M.p.Arunkumar p.k.C.kanigalpula M.karthikeyan department of Mechanical Engineering Koneru Lakshmaiah Education Foundation department of Mechanical Engineering RajaRajeswari College of Engineering

Friction and wear studies enable the investigation of material interaction between two sliding surfaces in contact. In the present investigation, the coefficient of friction and the wear resistance of AISI 316 L parts were studied under self-mating, dry sliding conditions using a pin-on-disc type configuration. The experiments were conducted at vacuum based high temperature pin-on-disc tribometer. The 4 mm diameter pin and 180 mm diameter disc were subjected to varying sliding velocities(0.5, 0.75 and 1.5 m/s) and were operated in 200, 400, 500 and 580 ℃ temperature at 600 Torr vacuum. The variation of specific wear rates with sliding velocities and different environmental conditions was studied. The morphology of sliding/rubbed surfaces was observed using Scanning Electron Microscope. In summary, it was found that a severe to mild wear transition occurred in sliding under operating conditions. Increased wear rates have been observed for 500 and 580 ℃ with increasing sliding velocity. Adhesive wear has been found to be predominant at 500 and 580 ℃ where as de-lamination has been observed at ambient temperature,200 and 400 ℃ in vacuum. The present paper also carried out the numerical analysis of the vibration behavior of AISI 316 L under thermal environment. Results revealed that at high temperature vibrational amplitude and natural frequency is significantly reduced. This can be attributed to the reduction in stiffness of the material at elevated temperatures. This high amplitude vibration during service can lead to high wear rate.

关键词： pin-on-disc Sliding wear Vacuum de-lamination Scanning electron microscope Vibration