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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/sTAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang shenghua Lu Qianqian ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous system Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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煤矿井下水泵房巡检机器人系统设计与应用

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煤矿现代化 2025年第1期34卷 117-122页

作者：孙歌山西煤炭运销集团蒲县昊锦塬煤业有限公司山西临汾041206

针对煤矿井下水泵房传统工人巡检存在劳动强度大、巡检耗时较长、成本较高、检测结果不准确等问题,本文对煤矿井下水泵房智能巡检机器人系统进行研究,采用模块化和轻量化设计思想,在分析水泵房巡检内容和要求的基础上,提出了一种履带式... 详细信息

针对煤矿井下水泵房传统工人巡检存在劳动强度大、巡检耗时较长、成本较高、检测结果不准确等问题,本文对煤矿井下水泵房智能巡检机器人系统进行研究,采用模块化和轻量化设计思想,在分析水泵房巡检内容和要求的基础上,提出了一种履带式水泵房智能巡检机器人系统,实时采集井下水泵房现场被参数信息,代替工人完成井下水泵房的巡检任务。完成了智能巡检机器人硬件系统设计,利用模块化思想编写了控制系统程序,并且编写了巡检轨迹程序,可根据设定的轨迹自主巡检。经在山西某煤矿进行现场调试和试运行表明,井下水泵房智能巡检机器人系统可代替4~6名工人实施巡检,降低了工人劳动强度,巡检周期从单日1次增加到单日3次,巡检效率大大提高,机器人本体移动定位误差≤5 cm,能准确获取设备运行异常特征并报警。

关键词：煤矿水泵房智能巡检机器人远程运维路径规划

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中国儿童道德情感发展的动态演变及生态系统模型建构——基于三轮大样本实证调查

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华东师范大学学报（教育科学版） 2025年第1期43卷 96-112页

作者：孙彩平葛丹丹南京师范大学道德教育研究所南京210024 南京工程学院学生工作处南京211167

道德情感是品德现实化的动力因素,是考察儿童知行统一性的关键点。基于2016、2019、2022年中国儿童道德发展的大样本整体动态数据(77953,77367,79914),采用回归分析、夏普里值分解发现中国儿童道德情感的发展:(1)类型不均衡,同情心表现... 详细信息

道德情感是品德现实化的动力因素,是考察儿童知行统一性的关键点。基于2016、2019、2022年中国儿童道德发展的大样本整体动态数据(77953,77367,79914),采用回归分析、夏普里值分解发现中国儿童道德情感的发展:(1)类型不均衡,同情心表现需要关注;(2)水平随年龄的增高呈现先增高后降低的发展趋势,10岁为儿童道德情感发展的关键点;(3)存在性别和城乡区域的结构差异;(4)按因素影响强度呈现独特的生态系统逻辑,从高到低排列为“个体-学校-社会支持-家庭”;生活满意度、了解儿童的人、学校和家庭心理环境是高影响因素;不同因素对不同性别和学段儿童的道德情感发展影响存在差异。由上发现提出,中国儿童道德情感培育要重视道德情感类型的发展失衡、群体发展的差异和关键影响因素,优化儿童道德情感发展的生态系统,抓住发展的关键期,进一步明确教育的侧重点,提升针对性和时效性。

关键词：中国儿童道德情感发展动态影响因素生态系统

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of parkinson's disease.A defined systematic search of the pubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells parkinson's disease survival transplant

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Controllability of singular Distributed parameter systems in the sense of Mild solution

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Journal of systems science & Complexity 2020年第5期33卷 1485-1496页

作者： ge Zhaoqiang ge Xiaochi school of Mathematics and statistics Xi'an Jiaotong UniversitgyXi'an 710049China Cass Business school CityUniversity of LondonLondonEC1Y 8TEUK

Necessary and sufficient conditions for the exact controllability and approximate controllability of a singular distributed parameter system are *** general results are used to examine the exact controllability and ap... 详细信息

关键词： Approximate controllability exact controllability Hilbert space mild solution singular distributed parameter systems

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Atomic Evolutions of a single Atom in a High-Q Cavity

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Chinese physics Letters 2001年第11期18卷 1463-1466页

作者： ge Guo-Qing p.T.Leung Department of physics Huazhong University of Science and TechnologyWuhan 430074 Department of physics The Chinese University of Hong KongShatinHong KongChina

Atomic evolutions in a single atom laser system are studied for different preparations of the initial atomic state and cavity field. Both the analytical and the numerical results are in very good agreement with the experiment carried out by Brune et al. [phys. Rev. Lett. 76 (1996) 1800], if we choose the same parameters as the experiment. The research justified that the spontaneous emission rates are enhanced in the high-Q cavity.

关键词： experiment. field. system

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine program and Department of pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Controllability and Observability of stochastic singular systems in Banach spaces

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Journal of systems science & Complexity 2022年第1期35卷 194-204页

作者： ge Zhaoqiang school of Mathematics and statistics Xi’an Jiaotong UniversityXi'an 710049China.

Exact(approximate)controllability and exact(approximate)observability of stochastic singular systems in Banach spaces are ***,the condition for the existence and uniqueness of the mild solution to stochastic singular systems is given by ge-semigroup in Banach ***,the necessary and sufficient conditions for the exact(approximate)controllability and exact(approximate)observability of the systems considered are derived in terms of ge-semigroup,and the dual principle is ***,an illustrative example is given.

关键词： Banach space controllability ge-semigroup observability stochastic singular systems

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