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Lie Group Analysis for the Effects of Variable Fluid Viscosity and Thermal Radiation on Free Convective Heat and Mass Transfer with Variable Stream Condition

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Engineering（科研） 2010年第8期2卷 625-634页

作者： p. Loganathan p. puvi arasu 不详

Natural convective boundary layer flow and heat and mass transfer of a fluid with variable viscosity and thermal radiation over a vertical stretching surface in the presence of suction/injection is investigated by Lie group analysis. Fluid viscosity is assumed to vary as a linear function of temperature. The symmetry groups admitted by the corresponding boundary value problem are obtained by using a special form of Lie group transformations viz. scaling group of transformations. An exact solution is obtained for translation symmetry and numerical solutions for scaling symmetry. The effects of fluid viscosity and thermal radiation on the dimensionless velocity, temperature and concentration profiles are shown graphically. Comparisons with previously published works are performed and excellent agreement between the results is obtained. The conclusion is drawn that the flow field and temperature profiles are significantly influenced by these parameters.

关键词： Scaling Group of Transformations Free Convective Flow Temperature-Dependent Fluid Viscosity Suction/Blowing Thermal Radiation

Life cycle cost analysis of new FRp based solar parabolic trough collector hot water generation system

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Journal of Zhejiang University-Science A(Applied physics & Engineering) 2008年第3期9卷 416-422页

作者： A. VALAN arasu T. SORNAKUMAR Faculty of Mechanical Engineering Thiagarajar College of Engineering Madurai 625 015 India

parabolic trough collectors （pTCs） are employed for a variety of applications including steam generation and hot water generation. This paper deals with the experimental results and an economic analysis of a new fibre reinforced plastic （FRp） based solar pTC with an embedded electronic controlled tracking system designed and developed for hot water generation in a restaurant in Madurai, India. The new collector performance has been tested according to ASHRAE Standard 93 （1986）. The performance of a new pTC hot water generation system with a well mixed hot water storage tank is investigated by a series of extensive tests over ten months period. The average maximum storage tank water temperature observed was 74.91℃, when no energy is withdrawn from the tank to the load during the collection period. The total cost of the new economic FRp based solar pTC for hot water generation with an embedded electronic controlled tracking system is Rs. 25000 （US$ 573） only. In the present work, life cycle savings （LCS） method is employed for a detailed economic analysis of the pTC system. A computer program is used as a tool for the economic analysis. The present worth of life cycle solar savings is evaluated for the new solar pTC hot water generation system that replaces an existing electric water heating system in the restaurant and attains a value of Rs. 23171.66 after 15 years, which is a significant saving. The LCS method and the MATLAB computer simulation program presented in this paper can be used to estimate the LCS of other renewable energy systems.

关键词： Economic analysis Life cycle savings Life cycle cost (LCS) parabolic trough collector (pTC) Solar water heating system (SWHS)

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

The dielectric studies on sol–gel routed molybdenum oxide thin film

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Journal of Advanced Dielectrics 2017年第2期7卷 21-27页

作者： p.Adal arasu R.Victor Williams Department of physics St.Joseph's CollegeTrichyIndia

The influence of temperature on the dielectric properties of sol-gel routed spin-coated molybdenum trioxide(MoO_(3)) thin film has been *** films were annealed at temperatures 250℃,350℃ and 400℃.The phase transformation from amorphous to-orthorhombic phase with preferential orientation(022)has been found by XRD for the film annealed above 250℃.The vibration modes of-orthorhombic MoO_(3) have been examined by Raman *** predominant Raman's band of-orthorhombic MoO_(3) thin film has been found at the frequency range 1000–600 cm^(-1).Using the UV–Vis spectrum,the band gap of the film is found to be 3.3–3.8 *** surface morphology of the MoO_(3) films has been examined by scanning electron *** AC conductivity measurement of the MoO_(3) film has been carried out in the frequency range 10–10^(6) *** frequency dependence of the impedance has been plotted in the complex *** variation of the capacitance and dielectric constant of MoO_(3) film with respect to temperature and frequency has been *** of capacitance and figure of merit of the film are also determined.

关键词： Sol-gel dielectric constant capacitance tunability Curie-temperature figure-of-merit

Heat Transfer Analysis of an Elevated Linear Absorber with Trapezoidal Cavity in the Linear Fresnel Reflector Solar Concentrator System

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Journal of Thermal Science 2015年第1期24卷 90-98页

作者： R.Manikumar R.palanichamy A.Valan arasu Department of Automobile Engineering SSM Institute of Engineering and Technology SSM Institute of Engineering and Technology Department of Mechanical Engineering Thiagarajar College of Engineering

This paper describes various aspects of the design methodology and heat transfer calculations for an elevated linear absorber. The absorber is a part of the linear Fresnel reflector solar concentrator system, in which hot fluid is generated. The design of the absorber is an inverted trapezoidal air cavity with a glass cover enclosing a multi tube absorber. In a trapezoidal cavity absorber, a set of linear multi tube absorber with plate(named as "plane surface") and without plate(named as "tube surface") underneath are considered. An analytical simulation is done for different gaps between the tubes and for different depths of the cavity. A better design of the absorber is found out to maximize the heat transfer rate supplied to the absorber tube fluid. Also, the experimentally obtained overall heat loss coefficients are compared with the analytical values for the considered arrangements of absorber set up and results are discussed in details.

关键词： LFRSC trapezoidal cavity absorber overall heat loss coefficient concentrated radiation

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Adding new dimension to non-directed C（sp3）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective Oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Aliphatic C–H groups are among the most abundant yet least reactive functional groups in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p450 superfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp3）–H bonds in complex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic applications [2].

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SpAST spastin