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effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores espinosa Isabel Carmona Jose Antonio pons Francisco Jorquera Francisco Javier Rodriguez Ramon perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen martin paloma Munoz de Rueda Rosa Quiles CIBeRehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Unit for Clinical Management of Digestive Diseases Complejo Hospitalario Universitario de Granada Instituto de Investigacion Biosanitaria de Granada University Hospital politecnico La Fe Unit for Clinical Management of Digestive Diseases University Hospital Virgen Del Rocio Hospital Toledo University Clinic Hospital of Valencia University General Hospital of Valencia Unit for Clinical Management of Digestive Diseases University Hospital Nuestra Senora de Valme Department of Gastroenterology and Hepatology Agencia Sanitaria Costa del Sol University Hospital Cruces Gastroenterology Unit University Hospital Fundacion Alcorcon University Hospital Virgen Macarena University Hospital Virgen de la Arrixaca Hospital of Leon University General Hospital Reina Sofia Department Gastroenterology and Hepatology University Hospital Central de Asturias University Hospital Reina Sofia University Hospital De Gran Canaria Dr. Negrin Hospital San pedro de Alcantara

AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(pIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. MeTHODS:prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(Te),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow ***:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were Te:28%(n = 298) relapsers,12%(n = 123) partial responders(pR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(p ereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and Te. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(p = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was

关键词： Hepatitis C Boceprevir Telaprevir First-generation protease inhibitors Advanced fibrosis

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全结肠的先天性巨结肠:28年的治疗经验

世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 54-55页

作者： Wildhaber B. e. Teitelbaum D. H. Coran A. G. 肖莉 Section of pediatric Surgery CS Mott Children’s Hospital Univ. Michigan Med. Sch. Hlth. S. Ann Arbor MI 48109-0245 United States

The aim of this study was to review outcomes after surgical treatment of total colonic Hirschsprung’s disease (TCH). Twenty-five records of patients with TCH treated between 1974 and 2002 were reviewed. Follow-up data were collected using a standardized questionnaire. Objective functional outcome was assessed using a scoring system. Twenty patients had aganglionosis of the colon and distal ileum, 5 of whom had a more extensive condition. One of these 5 patients underwent an endorectal pull-through (eRpT), 1 underwent intestinal transplantation, and 3 died. Four of the remaining 20 patients underwent a primary eRpT, 16 received a stoma as neonates followed by eRpT in 12, and a martin-Duhamel procedure or Swenson’s operation in 3 (median age, 10.5months); 1 remains with an ostomy. postoperative complications included enterocolitis (55%), anal stricture (25%), and perineal excoriation (20%). Mean follow-up were 17.5 years (±11.1 years). eightynine percent were free of recurrent enterocolitis. Frequency of bowel movements is 1 to 5 per day in 82%of the patients, 18%have 6 or more bowel movements per day. Occasional soiling is noted in 40%(one third of those requiring nighttime diapers). Overall functional outcome was good in 83%. Those patients with the longest follow-up periods had the best stooling scores (p =.04). Surgical treatment of TCH is associated with a number of complications including recurrent enterocolitis and anal strictures. Long-term outcome is quite favorable.

关键词：先天性巨结肠全结肠拖出术造瘘术小肠结肠炎肛门狭窄外科手术肠蠕动术后并发症神经节细胞

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采用实际气体状态方程的制冷压缩机计算模拟

压缩机技术 1984年第4期 18-22页

作者： e.H.Ng ,A.B.Tramschek ,J.F.T.Maclaren ,熊则男西安交通大学

本文描述了模拟制冷压缩机的模型,工作流体的热力性质由实际气体状态方程表示。对于制冷剂为R12的制冷机,采用martin-Downing状态方程计算获得的性能参数,与模拟分析获得的相应结果进行了比较。在模拟分析中工作流体是用理想气体方程进... 详细信息

本文描述了模拟制冷压缩机的模型,工作流体的热力性质由实际气体状态方程表示。对于制冷剂为R12的制冷机,采用martin-Downing状态方程计算获得的性能参数,与模拟分析获得的相应结果进行了比较。在模拟分析中工作流体是用理想气体方程进行描述的。从一种类型的制冷压缩机得到的结果,揭示了许多设计者有兴趣的参数:如:p-V图、气阀升程曲线、质量流动率、阀摩擦系数、循环功、各种损失等等,仅仅在压缩机吸入孔口的制冷剂有着少量的过热,而压缩比较大的时候,证实了使用实际气体状态方程的合理性。

关键词：实际气体状态方程制冷剂热力性质设计者兴趣流体冷冻剂制冷材料个性心理特征制冷压缩机理想气体方程

ULTRAMAFIC XeNOLITHS FROM A KAMAFUGITe LAVA IN CeNOZOIC VOLCANIC FIeLD OF WeST QINLING, CHINA AND ITS GeOLOGICAL IMpLICATION

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地学前缘 2000年第S1期7卷 371-371页

作者： Yu Xuehui 1,Cao Yongqing 2,Mo Xuanxue 1,martin F.J.Flower 2,Deng Jingfu 1 [WT5,5”BX](1.Department of Geology, China University of Geosciences Beijing 100083,China 2.Department of earth and environment Sciences, University of Illinois at Chicago, 8

Cenozoic potassic mafic volcanism (kamafugite magamtism) in West Qinling, Gansu province of China is a important section of Cenozoic volcanic belt of Qingzang (Tibet) plateau and adjacent area. The kamafugite magma show near\|primary magma characteristics. Strong incompatible elements concentrations in the volcanic rocks infer the kamafugite magmas may be origined from a enrichment mantle sources *** groups of deep\|seated xenoliths were collected from a kamafugite lava in West Qinling, Gansu province, China: (1)spinel Iherzolite and garnet Iherzolite; (2) harzburgite; (3) dunite and (4) clinopyroxenite. All suite of peridotite xenoliths are Cr\|diopside series. The main textures of peridotite xenoliths are granoblastic, porphyroclastic and granular, but the textures of clinopyroxenite are mainly poikilitic. The textural characteristics, mineral chemical variations and mineral geothermometric data show that the mantle source region of the Cenozoic kamafugite magam are very complex and undertook partial melting and enrichment associated with alkaline metasomatism by fluid and carbonatite melts. Geothermometry indicates the equilibration p and T conditions of the spinel lherzolite and garnet lherzolite are 970℃, 18 9Gpa and 1219℃,27 61Gpa corresponding to depth of 62km and 92km representatively. We suggest, combining with geophysical data, the spinel lherzolite formed at the top of upper mantle, the garnet lherzolite represent the base of lithosphere or the top of asthenosphere, but the clinopyroxenite is formed by cumulation in shallower magma reservoir. Kamafugite magmas formed within the stability field of garnet lherzolite by partial melting, the partial melting degree is only about 1%～2%. There is a superheating condition in Cenozoic mantle of West Qinling, which may be related to strong uplift of Qingzang (Tibet) plateau since cenozoic and extrusion east forward of asthenosphere beneath the Qingzang (Tibet) plateau.

关键词： Ultramafic Xenoliths Cenozoic Kamafugite West Qin liag

Accretion in strong field gravity with eXTp

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Science China(physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni emanuele Berti Stefano Bianchi Ilaria Caiazzo piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen paolo pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue Yupeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti emanuele Nardini paul T.O'Brien Julian p.Osborne pierre Olivier petrucci Andrea possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e planetologie Spaziali Via Fosso del Cavaliere Anton pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High energy physics Chinese Academy of Science Center for Field Theory and particle physics and Department of physics Fudan University IRAp Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of physics Anhui Normal University Department of Astronomy and Institute of Theoretical physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of physics and Research Centre for Computational physics and Data processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di padova INFN-TIFpA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and polarimetry(eXTp) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTp has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

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肛裂临床诊治指南（第三次修订）

中华胃肠外科杂志 2013年第7期16卷 689-690页

作者： Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson p. Terry phang Feza Remzi David Rivadeneira Howard Ross peter Senatore elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) 美国结直肠外科医师协会不详

“美国结直肠外科医师协会（American Societyof ColonandRectal ***）”（协会）致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高，给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成... 详细信息

“美国结直肠外科医师协会（American Societyof ColonandRectal ***）”（协会）致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高，给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展，以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的，非指令性的，目的是为临床决策提供信息，而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。

关键词：诊治指南临床决策结直肠外科修订肛裂医师协会肛门疾病循证医学证据

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青钱柳内生真菌多样性及其代谢产物的特性

福建农林大学学报（自然科学版） 2019年第4期48卷 493-500页

作者：寇晓琳谢楠吴彩娥范龚健洑香香南京林业大学轻工与食品学院江苏南京210037 南方现代林业协同创新中心江苏南京210037

为揭示青钱柳内生真菌的分布、多样性及其代谢产物的抑菌活性,并筛选产黄酮的内生真菌,挖掘植物内生真菌新资源,采用组织分离的方法对青钱柳的枝、皮、叶、根部位的内生真菌进行分离,用马丁氏培养基、察氏培养基、pDA培养基对内生真菌... 详细信息

为揭示青钱柳内生真菌的分布、多样性及其代谢产物的抑菌活性,并筛选产黄酮的内生真菌,挖掘植物内生真菌新资源,采用组织分离的方法对青钱柳的枝、皮、叶、根部位的内生真菌进行分离,用马丁氏培养基、察氏培养基、pDA培养基对内生真菌进行培养,通过观察内生真菌的形态特征进行初步分类,同时提取其发酵产物,并以金黄色葡萄球菌、大肠杆菌、白色念珠菌为供试病原菌对分离的内生真菌进行抑菌活性试验,通过显色试验和薄层层析试验筛选出产黄酮的内生真菌.试验共分离得到67株内生真菌,通过菌落形态和显微形态对分离得到的青钱柳内生真菌进行分类,其分别隶属于3纲4目6科10属;青钱柳不同组织中内生真菌的分离结果不同,其中根部分布的内生真菌从数量和种属上都占优势;马丁氏培养基培养的菌株种类少、数量多,而察氏培养基和pDA培养基培养的菌株种类较多、菌株较少;抑菌试验共得到13株具有抑菌作用的内生真菌,其中有2株内生真菌的发酵产物对供试菌株均表现出较强的抑菌活性,分别属于青霉属和链格孢属;并且筛选出7株菌株(pp03、pY01、pG11、pZ06、pY12、pp12和pp06)具有稳定的产生黄酮类化合物的能力.

关键词：青钱柳内生真菌代谢产物抑菌活性黄酮

肾源性系统性纤维化的危险因素:4所美国大学评估钆螯合物对比剂

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国际医学放射学杂志 2008年第A6期31卷 484-484页

作者： R.Wertman e.Altun D.R.martin D.G.Mitchell J.R.Leyendecker R.B.O’Malley 王文娟 School of Medicine University of North Carolina at Chapel Hill101Manning DrCB7510Chapel HillNC27599-7510USA.

目的回顾性研究4所美国大学三级保健中心应用不同钆螯合物对比剂相关的肾源性系统性纤维化(NSF)的基准发生率。

关键词：对比剂肾源性螯合物大学评估钆双胺马根维显保健中心检查单病理学确诊精确检验法

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评价理论视角下《春望》的评价意义及英译

牡丹江教育学院学报 2011年第3期 70-71页

作者：徐灵香姜娥江西师范大学外国语学院江西南昌330022

评价意义涉及人们对世界的看法和态度,存在于各类语篇,但目前应用于诗歌的却很少。本文运用martin的评价理论,从态度和级差资源来解析杜甫《春望》中所表达的评价意义及其在四种译文中的体现,看看译者使用的翻译策略在评价意义表达上是... 详细信息

评价意义涉及人们对世界的看法和态度,存在于各类语篇,但目前应用于诗歌的却很少。本文运用martin的评价理论,从态度和级差资源来解析杜甫《春望》中所表达的评价意义及其在四种译文中的体现,看看译者使用的翻译策略在评价意义表达上是否"忠实"于原文,从而对译文质量进行评估。

关键词：评价理论《春望》英译评价意义