检索结果-南通市图书馆

Controversies regarding transplantation of mesenchymal stem cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Transplantation 2024年第2期14卷 48-61页

作者： Tsvetelina Velikova Tereza Dekova Dimitrina georgieva Miteva Department of Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Genetics Faculty of BiologySofia University St.Kliment OhridskiSofia 1164Bulgaria

Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical *** comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and *** delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface *** heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety ***,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine *** also assess the current status of clinical trials and the ever-evolving regulatory *** we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery *** review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation.

关键词： Mesenchymal stem cells Transplantation controversies Regenerative medicine Autoimmune diseases Chronic inflammatory illnesses Tumor growth Metastasis Therapeutic potential Clinical use of mesenchymal stem cell

Genetic screening of liver cancer:State of the art

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第5期16卷 716-730页

作者： Milena peruhova Sonya Banova-Chakarova Dimitrina georgieva Miteva Tsvetelina Velikova Department of Gastroenterology University Hospital"Heart and Brain"Burgas 8000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment OhridskiSofia 1164Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria

Liver cancer,primarily hepatocellular carcinoma,remains a global health challenge with rising incidence and limited therapeutic *** factors play a pivotal role in the development and progression of liver *** state-of-the-art paper provides a comprehensive review of the current landscape of genetic screening strategies for liver *** discuss the genetic underpinnings of liver cancer,emphasizing the critical role of risk-associated genetic variants,somatic mutations,and epigenetic *** also explore the intricate interplay between environmental factors and genetics,highlighting how genetic screening can aid in risk stratification and early detection via using liquid biopsy,and advancements in high-throughput sequencing *** synthesizing the latest research findings,we aim to provide a comprehensive overview of the state-of-the-art genetic screening methods for liver cancer,shedding light on their potential to revolutionize early detection,risk assessment,and targeted therapies in the fight against this devastating disease.

关键词： Hepatocellular carcinoma Liver cancer Genetic screening Risk-associated genetic variants Epigenetic alterations Genetic biomarkers Circulating tumor DNA Next-generation sequencing

Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第12期12卷 2031-2039页

作者： Tsvetelina Velikova Georgi Vasilev Russka Shumnalieva Lyubomir Chervenkov Dimitrina georgieva Miteva Milena Gulinac Stamatios priftis Snezhina Lazova Medical Faculty Sofia University"St.Kliment Ohridski"Sofia 1407Bulgaria Clinic of Neurology and Department of Emergency Medicine UMHAT"Sv.Georgi"Plovdiv 4000Bulgaria Department of Rheumatology Clinic of RheumatologyUniversity Hospital"St.Ivan Rilski"Medical University-SofiaSofia 1612Bulgaria Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment Ohridski"Sofia 1164Bulgaria Department of General and Clinical pathology Medical University of PlovdivPlovdiv 4002Bulgaria Department of Healthcare Faculty of Public Health“Prof.Tsekomir VodenicharovMDDSc”Medical University of SofiaSofia 1407Bulgaria Department of pediatric University Hospital"N.I.Pirogov"Sofia 1606Bulgaria

Gluten ataxia and other central nervous system disorders could be linked to gluten enteropathy and related *** this narrative review,we focus on the various neuro-logical manifestations in patients with gluten sensitivity/celiac disease,immunological and autoimmune mechanisms of ataxia in connection to gluten sensitivity and the autoantibodies that could be used as a biomarker for diagnosing and *** focused on the anti-gliadin antibodies,antibodies to different isoforms of tissue transglutaminase(TG)(anti-TG2,3,and 6 antibodies),anti-glycine receptor antibodies,anti-glutamine acid decarboxylase antibodies,anti-deamidated gliadin peptides antibodies,*** studies found a higher prevalence of these antibodies in patients with gluten sensitivity and neurological dysfunction,presented as different neurological *** also discuss the role of a gluten-free diet on the clinical improvement of patients and also on imaging of these disorders.

关键词： Gluten ataxia Celiac disease Gluten enteropathy Autoantibodies Anti-gliadin antibodies Anti-bodies to tissue transglutaminase Anti-tissue transglutaminase antibodies Anti-transglutaminase 6 antibodies Anti-glycine receptor antibodies Anti-glutamine acid decarboxylase antibodies

Artificial intelligence as a tool in drug discovery and development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Experimental Medicine 2024年第3期14卷 11-19页

作者： Maria Kokudeva Mincho Vichev Emilia Naseva Dimitrina georgieva Miteva Tsvetelina Velikova Department of pharmacology and Toxicology Faculty of PharmacyMedical University of SofiaSofia 1000Bulgaria Healthcare Solutions Sofia 1404Bulgaria Faculty of public Health Medical University of SofiaSofia 1431Bulgaria Department of Genetics Faculty of BiologySofia University St.Kliment OhridskiSofia 1164Bulgaria Tsvetelina Velikova Medical FacultySofia University St.Kliment OhridskiSofia 1407Bulgaria

The rapidly advancing field of artificial intelligence(AI)has garnered substantial attention for its potential application in drug discovery and *** opinion review critically examined the feasibility and prospects of integrating AI as a transformative tool in the pharmaceutical ***,encompassing machine learning algorithms,deep learning,and data analytics,offers unprecedented opportunities to streamline and enhance various stages of drug *** opinion review delved into the current landscape of AI-driven approaches,discussing their utilization in target identification,lead optimization,and predictive modeling of pharmacokinetics and *** aimed to scrutinize the integration of large-scale omics data,electronic health records,and chemical informatics,highlighting the power of AI in uncovering novel therapeutic targets and accelerating drug repurposing *** the considerable potential of AI,the review also addressed inherent challenges,including data privacy concerns,interpretability of AI models,and the need for robust validation in realworld clinical ***,we explored ethical considerations surrounding AI-driven decision-making in drug *** opinion review provided a nuanced perspective on the transformative role of AI in drug discovery by discussing the existing literature and emerging trends,presenting critical insights and addressing potential *** conclusion,this study aimed to stimulate discourse within the scientific community and guide future endeavors to harness the full potential of AI in drug development.

关键词： Artificial intelligence Drug discovery Drug development Decision-making AI-driven medicine Healthcare public health

physical-Chemical Characterization of Nanodispersed powders produced by a plasma-Chemical Technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

plasma Science and Technology 2007年第3期9卷 273-279页

作者： M.georgieva G.VISSOKOV Iv.GRANCHAROV Department of Technology of Inorganic Substances University of Chemical Technology and Metallurgy8St.Kliment Ohridski Blvd.1756 SofiaBulgaria

This article presents a review on the physical-chemical properties and characteristics of plasma-chemically produced nanodispersed powders （NDp）, such as metals, oxides, nitrides, carbides, and catalysts. The plasma-chemical preparatior~ of the powders was carried out in thermal plasma （Tp） created by means of high-current electric arcs, plasma jets, high-frequency （HF） discharges, etc. We also discuss certain properties and characteristics of the NDps, which are determined largely by the conditions of preparation.

关键词： plasma-chemical treatment nitrides thermodynamic analysis

Detection of CO2 and O2 by iron loaded LTL zeolite films

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2018年第1期12卷 94-102页

作者： Veselina georgieva Richard Retoux Valerie Ruaux Valentin Valtchev Svetlana Mintova Laboratoire Catalyse et Spectrochimie (LCS) ENSICAEN CNRS Normandy University 14000 Caen France Laboratoire de Cristallographie et Sciences des Matériaux (CRISMAT) ENSICAEN CNRS Normandy University 14000 Caen France

Detection of oxygen and carbon dioxide is important in the field of chemical and biosensors for atmosphere and biosystem monitoring and fermentation processes. The present study reports on the preparation of zeolite films doped with iron nanoparticles for detection of CO2 and O2 in gas phase. pure nanosized LTL type zeolite with monomodal particle size distribution loaded with iron （Fe-LTL） was prepared under hydrothermal condition from colloidal precursor suspensions. The zeolite was loaded with iron to different levels by ion exchange. The Fe-LTL suspensions were used for preparation of thin films on silicon wafers via spin coating method. The reduction of the iron in the zeolite films was carried out under H2 flow （50% H2 in Ar） at 300 ℃. The presence of iron nanoparticles is proved by in situ ultra-violet-visible spectroscopy. The properties of the films including surface roughness, thickness, porosity, and mechanical stability were studied. In addition, the loading and distribution of iron in the zeolite films were investigated. The Fe-LTL zeolite films were used to detect O2 and CO2 in a concentration dependent mode, followed by IR spectroscopy. The changes in the IR bands at 855 and 642 cm^-1 （Fe O-H and Fe-O bending vibrations） and at 2363 and 2333 cm^-1 （CO2 asymmetric stretching） corresponding to the presence of O2 and CO2, respectively, were evaluated. The response to O2 and CO2 was instant, which was attributed to great accessibility of the iron in the nanosized zeolite crystals. The saturation of the Fe-LTL films with CO2 and O2 at each concentration was reached within less than a minute. The Fe-LTL films detected both oxygen and carbon dioxide in contrast, to the pure LTL zeolite film.

关键词： zeolite films detection of CO2 and O2 adsorption

Dual-polarization multiplexing amorphous Si:H grating couplers for silicon photonic transmitters in the photonic BiCMOS backend of line

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2022年第1期15卷 143-155页

作者： Galina georgieva Christian Mai pascal M.Seiler Anna peczek Lars Zimmermann Hochfrequenztechnik-photonik/Siliziumphotonik Technische Universität BerlinStraße des 17.Juni 13510623 BerlinGermany IHp-Leibnitz Institut für innovative Mikroelektronik Im Technologiepark 2515236 Frankfurt(Oder)Germany IHp Solutions GmbH Im Technologiepark 715236 Frankfurt(Oder)Germany

In this paper,we report on polarization combining two-dimensional grating couplers(2D GCs)on amorphous Si:H,fabricated in the backend of line of a photonic BiCMOS *** 2D GCs can be used as an interface of a hybrid silicon photonic coherent transmitter,which can be implemented on bulk Si *** fabricated 2D GCs operate in the telecom C-band and show an experimental coupling efficiency of−5 dB with a wafer variation of±1.2 *** for efficiency enhancement and improved performance stability in future design generations are outlined and extension toward O-band devices is also investigated.

关键词： Hybrid integration photonic BiCMOS Amorphous silicon Two-dimensional grating coupler(2D GC) Dual-polarization coherent communication Silicon photonics

High-Temperature Thermodynamic Investigation of Nano-Dispersed Nitrides Obtained in Thermal plasma

在线全文

学校读者我要写书评

暂无评论

plasma Science and Technology 2007年第2期9卷 174-176页

作者： M. georgieva G. VISSOKOV Iv. GRANCHAROV L. BRAKALOV Department of Technology of Inorganic Substances University of Chemical Technology andMetal|urgy 8 K. Okhridski Blvd. 1756 Sofia Bulgaria

The nitrides of transient metals have a high hardness, thermal stability, remarkable wear resistance in aggressive chemical mediums, melted metals and alloys, high corrosion resistance, and low coefficient of electric resistance. Under the conditions of low-temperature argon plasma （LTp）, thermodynamic investigations were conducted in the process of obtaining of A1N, TiN and Si3N4 in a temperature range of 1000 K to 6000 K. To investigate the thermodynamic possibility of obtaining nitrides, a computer model was used which provided the equilibrium composition of gaseous and solid phases at different temperatures. The conditions for chemical equilibrium of the system were based on the minimization of Gibbs＇ energy.

关键词： plasma-chemical treatment nitrides thermodynamic analysis

preliminary in vitro evaluation of neuroprotective and monoamine oxidase type B inhibitory effects of newly synthesized 8-aminocaffeines

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第6期14卷 971-972页

作者： Magdalena Kondeva-Burdina Maya georgieva Alexandra Kasabova-Angelova Virginia Tzankova Alexander Zlatkov Laboratory of Drug Metabolism and Drug Toxicity Department of PharmacologyPharmacotherapy and ToxicologyFaculty of PharmacyMedical University of Sofia Department of pharmaceutical Chemistry Faculty of PharmacyMedical University of Sofia

The expected growth of the elderly population at highest risk for parkinson’s disease(pD)in the next decades makes the identification of factors that promote or prevent the disease an important *** addition,new therapies-aiming to delay the progression of pD are also needed(prediger,2010).However,there have been few clinical trials designed to investigate *** the application of an appropriate in vitro model such as the neuroblastoma SH-SY5Y cell line is extremely *** cells were selected due to its human origin,catecholaminergic neuronal properties,and ease of maintenance(Xicoy et al.,2017).

关键词： preliminary neuroprotective monoamine oxidase