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中国惯性技术学报 2013年第3期21卷 341-346页

作者： S.V.Ivanov V.M.Теut p.b.оliynyk National Technical University of Ukraine Kiev 03056Ukraine

研究了一种大风浪中舰船模型和扰动参数的识别方法。通过对舰船角速率信号进行谱分析,确定舰船模型参数和静态扰动力矩的大小。所获得参数的精度可以满足自动驾驶仪控制系统综合和整定的要求。

关键词：舰船模型扰动参数谱分析静态扰动力矩

Structure of Some 4f Rare Earth Liquid Metals --A Charged Hard Sphere Approach

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Communications in Theoretical physics 2006年第2X期46卷 337-342页

作者： p.b. Thakor p.N. Gajjar A.R. Jani Department of physics Veer Nazmad South Gujarat University Udhana Magdalla Road Surat 395 007 Gujarat India Department of physics Oujarat University Ahmedabd Oujarat India Department of physics Sardar Patel University Vallabh Vidyanagar 388 120 Gujarat India

A well-established pseodopotential is used to study the structure of some 4f rare earth liquid metals （Ce, pr, Eu, Gd, Tb, and Yb）. The structure factor S（q）, pair distribution function g（r）, interatomic distance r1, and coordination number n1 are calculated using Charged Hard Sphere （CHS） reference system. To introduce the exchange and correlation effects, the local field correction due to Sarkar et al. （S） is applied. The present investigation is successful in generating the structural information of Ce, pr, Eu, Gd, Tb, and Yb 4f rare earth liquid metals.

关键词： pseudopotential structure factor pair distribution function interatomic distance

Impacts of pI3K/protein kinase b pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(pI3K)/protein kinase b(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κb serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the pI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/pI3K/AKT/connexin 43,and Notch/pI3K/AKT *** targeting the inactivation of the pI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the pI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship.b.tween neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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外贸进出口英语对话

作者： p.b.鲁宾逊

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平等与分配公正

世界社会科学 1992年第9期 3-7页

作者： p.b.纳雅克 ,侯宏勋

导言亚里士多德在其《伦理学》一书中写道:“‘公正即平等’这一人人都坚信不移的命题是完全不成立的。”不错,在希腊语中,“平等”一词与“公正”同义。然而,亚里士多德和他的老师

关键词：劳动权利机会平等收入财富政治就业权利财政管理共产主义社会思维形式概念不平等

Application of QUAL2K for Water Quality Modeling of River Ghataprabha （India）

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Journal of Environmental Science and Engineering 2010年第12期4卷 6-11页

作者： p.b. Kalburgi C.b. Shivayogimath b.K. purandara Department of biotechnology Basaveshwar Engineering College Vidyagiri Bagalkot 58 7102 India Department of Civil Engineering Basaveshwar Engineering College Vidyagiri Bagalkot 587102 India National Institute of Hydrology Hunuman Nagar Belgaum 590001 India

River Ghataprabha, during its course through belgaum district in Karnataka state （India）, receives untreated domestic waste from Gokak town and other neighboring villages situated on the bank of the river. The present study involves the application of water quality model QUAL2K to predict the water quality of this polluted segment of the river. The model was calibrated and validated for biochemical oxygen demand （bOD）, dissolved oxygen （DO） and total nitrogen （TN） in pre-monsoon season. Data for calibration and validation were obtained after the field and laboratory measurements. The performance of the model was evaluated using statistics based on standard errors （SE） and mean multiplicative errors （MME）. The model represented the field data quite well with some exceptions. In spite of some differences between the measured and simulated data sets at some points, the calibration and validation results are acceptable especially for the developing countries where the financial resources are often limited for frequent monitoring campaigns and higher accuracy data analysis.

关键词： Water quality modeling QUAL2K river pollution river Ghataprabha bOD modeling DO modelling

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俄罗斯社会的影子化:原因和后果

世界社会科学 2001年第5期 100-102页

作者： p.b.雷弗基娜,华

perturbative Quantum Chromodynamics α_(s)^(4)-Order Corrections to the Ratio R for τ Decay

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Chinese physics Letters 1998年第10期15卷 711-712页

作者： b.p.Nigam Department of physics&Astronomy Box 871504Arizona State University TempeArizonaUSA 85287-1504

The perturbative quantum chromodynamics correction to the semihadronic decay rate R of the heavy leptonτwas expressed by braaten as an expansion in powers ofαs to orderα*** had found theα_(s)^(4)order correction to be significant and conjectured that theα_(s)^(4)order corrections might also be *** et *** corrected theα_(s)^(4)-order *** have extended the analytic calculations to orderαs4;it involves an unknown constant K3 which occurs inαs4 *** order to estimate the effect ofα_(s)^(4)order correction,we have chosen K3 to range from-1000 to+1000 and we find that the value of R changes by about-11%to+10%,respectively,compared to the value of R=3.5 obtained toα_(s)^(4)-order result.

关键词： correction α dynamics

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氟喹诺酮类构效关系

国外医药（抗生素分册） 1990年第2期11卷 122-125,121页

作者： Fernandes p.b. 田治明

前言自1977年发表了一篇有关萘啶羧酸类抗菌剂的构效关系、微生物学和化学合成的综述之后,各种文献又报道5000多种新的类似物。近年来,发现了许多临床上有重要价值的抗菌剂,它们的化学结构中皆含有1-取代-1,4-二氢-4-氧-吡啶-3-羧酸,即... 详细信息

前言自1977年发表了一篇有关萘啶羧酸类抗菌剂的构效关系、微生物学和化学合成的综述之后,各种文献又报道5000多种新的类似物。近年来,发现了许多临床上有重要价值的抗菌剂,它们的化学结构中皆含有1-取代-1,4-二氢-4-氧-吡啶-3-羧酸,即通常称作喹诺酮类。这些新抗菌剂包括氟哌酸(Norfloxacin,1)、甲氟哌酸(pefloxacin,2)、氟嗪酸(Ofloxacin,3)、环丙氟哌酸(Ciprofloxacin,4)、氟啶酸(Enoxacin,5)、双氟哌酸(Difloxacin,6)Temafloxacin(7)、Lomefloxacin(8)、Fleroxacin(9)、Tosu floxacin(10)和氨氟哌酸(Amifloxacin,

关键词：氟喹诺酮构效关系