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Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets

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Journal of pharmaceutical Analysis 2022年第3期12卷 365-379页

作者： Divya S.parimi Yamini Gupta Sreekar Marpu Chandra S.Bhatt Tharun K.bollu Anil K.Suresh Bionanotechnology&Sustainable Laboratory Department of Biological SciencesSchool of Engineering and Applied SciencesSri Ramaswamy Memorial(SRM)UniversityAmaravati522503India Department of Chemistry University of North TexasDentonTX76201USA Department of Biotechnology Faculty of Science and HumanitiesSri Ramaswamy Memorial(SRM)Institute of Science and TechnologyChennai603203India

Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic potential of a nanovector for identification,monitoring,targeting,and post-treatment response *** of superparamagnetic iron oxide nanoparticles(SpION)are of tremendous significance in cancer therapy because of their inherited high surface area,high reactivity,biocompatibility,superior contrast,and magnetic and photo-inducibility *** addition to a brief introduction,we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic ***-synthesis particulate and surface alterations in terms of pharmaco-affinity,liquid accessibility,and biocompatibility to facilitate cancer therapy are *** parameters including particle contrast,core-fusions,surface area,reactivity,photosensitivity,photodynamics,and photothermal properties,which facilitate diverse cancer diagnostics,are *** also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors,cell sorting,purification of bioentities,and elimination of ***,while addressing the toxicity of nanomaterials,the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular interactions is *** summary,these discussions spotlight the versatility and integration of multitasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics.

关键词： Nanomagnets Biomimetics Utrasmall-SpIONs Magnetization Core-fusion Cancer theragnostics

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A pilot study on maternal oral health and birth weight of twins

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Open Journal of Epidemiology 2014年第1期4卷 7-13页

作者： Ye Shen Chao Li Aura Heimonen Jukka H. Meurman Martha E. Nunn Donald R. Miller Thomas E. Van Dyke p.ashanti bollu Risto Kaaja Sok-Ja Janket Center for periodontology The Forsyth Institute Boston USA College of Dental Medicine Roseman University of Health Sciences Henderson USA Department of Epidemiology and Biostatistics University of Georgia Athens USA Department of Epidemiology Boston University School of Public Health Boston USA Department of General Dentistry Boston University School of Dental Medicine Boston USA Department of periodontics Creighton University School of Dentistry Omaha USA Institute of Dentistry University of Helsinki and Helsinki University Central Hospital Helsinki Finland Satakunta Central Hospital and Turku University Turku Finland

Background: Oral health has been implicated in low birth weight or preterm birth. However, this relationship has not yet been studied in twins. We investigated whether maternal oral health was associated with the birth weights of twins by a cross-sectional study conducted at Helsinki University Central Hospital. Methods: Utilizing linear mixed effect models to recognize the correlation between twins from the same mothers and the independence between different mothers. 40 birth weights of twins were modeled as main outcomes. In model 1, poor periodontal health (ppH) was fitted as the main explanatory variable. In model 2, presence of non-specific oral mucositis (NSOM) was fitted as the main predictor. Results: In model 1, babies from mothers with ppH weighed approximately 158.2 grams less than babies of mothers without ppH. However, this association was not statistically significant (p = 0.11). When a stricter criterion for ppH (3 sites of pocket depth > 4 mm) was used, p-value decreased to 0.09 showing a dose response to ppH. In model 2, mothers with NSOM had babies weighing 224.9 grams less than mothers without these lesions. This was nearly significant (p = 0.08). Conclusion: Although not significant, the results from this small data of twins suggest that maternal oral health may be associated with birth weight of twin neonates. Our results are appropriate to generate hypothesis for future studies.

关键词： Twins Birth Weights Oral Health Correlated Data Linear Mixed Effect Models

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