Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets

作     者：Divya S.Parimi Yamini Gupta Sreekar Marpu Chandra S.Bhatt Tharun K.Bollu Anil K.Suresh Divya S.Parimi;Yamini Gupta;Sreekar Marpu;Chandra S.Bhatt;Tharun K.Bollu;Anil K.Suresh

作者机构：Bionanotechnology&Sustainable LaboratoryDepartment of Biological SciencesSchool of Engineering and Applied SciencesSri Ramaswamy Memorial(SRM)UniversityAmaravati522503India Department of ChemistryUniversity of North TexasDentonTX76201USA Department of BiotechnologyFaculty of Science and HumanitiesSri Ramaswamy Memorial(SRM)Institute of Science and TechnologyChennai603203India 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2022年第12卷第3期

页      面：365-379页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Department of Science and Technology Government of India NewDelhi for financial support through Early Career Research Award(Grant No.:ECR/2017/000339) 

主　　题：Nanomagnets Biomimetics Utrasmall-SPIONs Magnetization Core-fusion Cancer theragnostics 

摘      要：Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic potential of a nanovector for identification,monitoring,targeting,and post-treatment response *** of superparamagnetic iron oxide nanoparticles(SPION)are of tremendous significance in cancer therapy because of their inherited high surface area,high reactivity,biocompatibility,superior contrast,and magnetic and photo-inducibility *** addition to a brief introduction,we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic ***-synthesis particulate and surface alterations in terms of pharmaco-affinity,liquid accessibility,and biocompatibility to facilitate cancer therapy are *** parameters including particle contrast,core-fusions,surface area,reactivity,photosensitivity,photodynamics,and photothermal properties,which facilitate diverse cancer diagnostics,are *** also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors,cell sorting,purification of bioentities,and elimination of ***,while addressing the toxicity of nanomaterials,the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular interactions is *** summary,these discussions spotlight the versatility and integration of multitasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics.