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Asian Journal of Andrology 2006年第4期8卷 463-467,516-517页

作者： T.pushpalatha p.RamachandraReddy p.sreenivasulareddy Department of Biotechnology Sri Venkateswara University Tirupati 517502India

Aim:To investigate the effect of in utero exposure to hydroxyprogesterone(Hp)on liver metabolism in adult male albino ***:pregnant Wistar strain albino rats were exposed to supra-normal levels(10 mg/kg and 25 mg/kg)of Hp on days 1,7 and 14 of *** male pups were maintained under controlled conditions and the rats were killed 90 days after *** liver tissue was immediately excised,weighed and used for biochemical assays. Results:The activity levels of succinate dehydrogenase(SDH),glutamate dehydrogenase(GDH),glucose-6-phosphate dehydrogenase(G-6-pDH),malate dehydrogenase(MDH)and aminotransaminases were significantly increased in the livers of rats exposed to Hp during embryonic *** lactate dehydrogenase(LDH)activity level was significantly decreased in the liver of experimental ***,there was a significant elevation of activity levels of antioxidant enzymes(glutathione S-transferase[GST] and catalase[CAT])with an increased lipid peroxidation in the hepatic tissue of experimental rats compared with the control ***:The results of the present study suggest that there is an increase in the oxidative metabolism,antioxidative mechanism and levels of lipid peroxidation in rats exposed to Hp during embryonic *** increased aminotransaminase activities in these rats reveal tissue damage and disruption of mitochondrial integrity.(Asian J Androl 2006 Jul;8:463-467)

关键词： hydroxyprogesterone liver oxidative enzymes antioxidants lipid peroxidation embryonic development

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