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Assessment of Cardiac Autonomic Function by Using Heart Rate Turbulence in Behcet’s Disease

World Journal of Cardiovascular Surgery 2014年第11期4卷 193-199页

作者： Onder Akci Mustafa Aldemir Fatma Yaman ozlem Solak Sadik Volkan Emren Ersel Onrat Alaeddin Avsar Cardiology Department School of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Cardiovascular Surgery Department School of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Physical Medicine and Rehabilitation Department School of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Cardiology Department Afyon State HospitalAfyonkarahisarTurkey

Behcet’s disease (BD) is a chronic inflammatory disorder that can affect many systems in the body. Cardiac involvement increases the risk of cardiovascular mortality and occurs in 1%-5% of patients with BD. Ventricular arrythmias are believed to be the cause of this increased risk of cardiovascular mortality and it is also thought to be related with cardiac autonomic dysfunction. Heart rate turbulence (HRT) is a new predictor of cardiac autonomic activity. HRT is an independent and powerful predictor of mortality. In this study, we investigated the cardiac autonomic activity which can be determined by HRT in patients with BD. Forty patients with BD (20 men, mean age: 40 ± 9 years, range: 27-55 years) were diagnosed according to the International Study Group Criteria (ISGC) and gender and age matched healthy volunteers (20 men, mean age: 39 ± 8 years, range: 26-56 years) were included in this study. All of the participants (patients and controls) underwent 24 hours Holter electrocardiogram. HRT parameters, turbulence onset (TO) and turbulence slope (TS) were calculated with HRT (View Version 0.60-0.1 of Software Program). There were no significant differences in TO and TS values between patients with BD and control subject (TO-BD: 0.014 ± 0.03, TO-Control: 0.011 ± 0.04;TS-BD: 7.88 ± 4.9, TS-Control: 9.42 ± 6.7 respectively). Although increased cardiovascular mortality rates in BD have been shown in many studies, HRT values—detecting the risk of sudden death—do not seem to be altered in this disease.

关键词： Behcet’s Disease Heart Rate Turbulence Sudden Cardiac Death Cardiac Autonomic Activity

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Current state and clinical outcome in Turkish patients with hepatocellular carcinoma

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World Journal of Hepatology 2018年第1期10卷 51-61页

作者： Omer Ekinci Bulent Baran Asli Cifcibasi Ormeci ozlem Mutluay Soyer Suut Gokturk Sami Evirgen Arzu Poyanli Mine Gulluoglu Filiz Akyuz Cetin Karaca Kadir Demir Fatih Besisik Sabahattin Kaymakoglu Department of Gastroenterohepatology Istanbul Faculty of Medicine Istanbul University Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Department of Gastroenterology Ko? University Hospital Department of Radiology Istanbul Faculty of Medicine Istanbul University Department of Pathology Istanbul Faculty of Medicine Istanbul University

AIM To investigate clinical, etiological, and prognostic features in patients with hepatocellular *** Patients with hepatocellular carcinoma who were followed-up from 2001 to 2011 were included in the study. The diagnosis was established by histopathological and/or radiological criteria. We retrospectively reviewed clinical and laboratory data, etiology of primary liver disease, imaging characteristics and treatments. ChildPugh and Barcelona Clinic Liver Cancer stage was determined at initial diagnosis. Kaplan-Meier survival analysis was done to find out treatment effect on survival. Risk factors for vascular invasion and overall survival were investigated by multivariate Cox regression analyses. RESULTS Five hundred and forty-five patients with hepatocellular carcinoma were included in the study. Viral hepatitis was prevalent and 68 patients either had normal liver or were non-cirrhotic. Overall median survival was 16(13-19) mo. Presence of extrahepatic metastasis was associated with larger tumor size(OR = 3.19, 95%CI: 1.14-10.6). Independent predictor variables of vascular invasion were AFP(OR = 2.95, 95%CI: 1.38-6.31), total tumor diameter(OR = 3.14, 95%CI: 1.01-9.77), and hepatitis B infection( OR = 5.37, 95 % CI : 1.23-23.39). Liver functional reserve, tumor size/extension, AFP level and primary treatment modality were independent predictors of overall survival. Transarterial chemoembolization(HR = 0.38, 95%CI: 0.28-0.51) and radioembolization(HR = 0.36, 95%CI: 0.18-0.74) provided a comparable survival benefit in the real life setting. Surgical treatments as resection and transplantation were found to be associated with the best survival compared with loco-regional treatments(log-rank, P < 0.001).CONCLUSION Baseline liver function, oncologic features including AFP level and primary treatment modality determines overall survival in patients with hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Cirrhosis Alfafetoprotein Prognosis Treatment Survival

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Psychiatric comorbidity has a negative impact on quality of life in epileptic adolescents

Psychiatric comorbidity has a negative impact on quality of ...

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第十九届世界儿童及青少年精神卫生与相关学科学术会议

作者： Erdem Beyoglu Yesim Taneli ozlem Ozdemir Mehmet S Okan Suna Taneli Uludag University School of Medicine Department of Child and Adolescent Psychiatry Bursa Turkey Uludag University School of Medicine Department of Child Neurology Bursa Turkey

＜正＞Background Study aim was to investigate impact of psychiatric comorbidity on quality of life（QoL） in epileptic adolescents. Methods Forty-two epileptic adolescents（52.1%female;mean age 15.3±1.7 years） with min.1 seizure in the past 2 years were included. Severity of epilepsy（Clinical Global Impression- Severity;CGI-S）,psychiatric comorbidity（DSM-IV psychiatric interview and Brief Symptom Inventory;BSI） and QoL（Pediatric Quality of Life Inventory - Child and Parents Report;PedsQL） were assessed.

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Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

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Chinese Journal of Cancer Research 2015年第4期27卷 408-416页

作者： Nedim Turan Mustafa Benekli Olcun Umit Unal ?lkay Tugba Unek Didem Tastekin Faysal Dane Efnan Alg?n Sukran Ulger Tulay Eren Turkan Ozturk Topcu Esma Turkmen Nalan Akgül Babacan Gulnihal Tufan Zuhat Urakci Basak Oven Ustaalioglu ozlem Sonmez Uysal ozlem Balvan Ercelep Burcu Yapar Taskoylu Asude Aksoy Mustafa Canhoroz Umut Demirci Erkan Dogan Veli Berk Ozan Balakan Ahmet ?iyar Ekinci Mukremin Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?nder Tonyal? Bülent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman Buyukberber Department of Medical Oncology Faculty of Medicine Cumhuriyet University Department of Medical Oncology Faculty of Medicine Gazi University Department of Medical Oncology Faculty of Medicine Dokuz Eylul University Department of Medical Oncology Faculty of Medicine Necmettin Erbakan University Department of Medical Oncology Faculty of Medicine Marmara University Department of Radiation Oncology Faculty of Medicine Gazi University Department of Medical Oncology Numune Education and Research Hospital Department of Medical Oncology Faculty of Medicine Karadeniz Technical University Department of Medical Oncology Faculty of Medicine Trakya University Department of Medical Oncology Rize Education and Research Hospital Department of Medical Oncology Faculty of Medicine Dicle University Department of Medical Oncology Dr.Lutfi Kirdar Kartal Education and Research Hospital Department of Medical Oncology Sakarya Education and Research Hospital Department of Medical Oncology Faculty of Medicine Pamukkale University Department of Medical Oncology Faculty of Medicine Inonu University Department of Medical Oncology Faculty of Medicine Firat University Department of Medical Oncology Dr.Abdurrahman Yurtaslan Education and Research Hospital Department of Medical Oncology Faculty of Medicine Yuzuncu Yil University Department of Medical Oncology Faculty of Medicine Erciyes University Department of Medical Oncology Faculty of Medicine Sutcu Imam University Department of Medical Oncology Diyarbakir Education and Research Hospital Department of Medical Oncology Faculty of Medicine Kocatepe University Department of Medical Oncology Dr.Ersin Arslan State Hospital Department of Medical Oncology Education and Research Hospital Ad?yaman University Department of Medical Oncology Faculty of Medicine Mustafa Kemal University Department of Medical Oncology Faculty of Medicine Ataturk University

Background： We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma（PAC）.Methods： A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and ***： Of 563 patients, 472 received adjuvant chemotherapy（CT） alone, chemoradiotherapy（CRT） alone, and chemoradiotherapy plus chemotherapy（CRT-CT） were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival（RFS） and overall survival（OS） were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were ***： Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.

关键词： Pancreatic adenocarcinoma adjuvant chemotherapy(adjuvant CT) adjuvant radiotherapy

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Novel variant syndrome associated with congenital hepatic fibrosis

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World Journal of Clinical Cases 2015年第10期3卷 904-910页

作者： Yusuf Bayraktar ozlem Yonem Kubilay Varl? Hande Taylan Ali Shorbagi Cenk Sokmensuer Department of Gastroenterology Faculty of MedicineHacettepe University Department of Gastroenterology Cumhuriyet University Department of Neurology Hacettepe University Department of Ophthalmology Hacettepe University Department of Pathology Hacettepe University

Congenital hepatic fibrosis is part of many different malformation syndromes, of which oculo-encephalohepato-renal syndrome is the most common. These syndromes largely overlap, and so accurate classification of individual patients may be difficult. We present herein three syndromic siblings who were products of a consanguineous marriage. We investigated in detail at least six organ systems in these patients, namely the liver, brain, eye, kidneys, skeleton, and gonads. The common features observed in these three cases were congenital hepatic fibrosis, retinitis pigmentosa, truncal obesity, rotatory nystagmus, mental retardation, advanced myopia, and high-arched palate. The clinical dysmorphology in these patients was distinct and lacked the major features of the known syndromes associated with congenital hepatic fibrosis. Although some features of these presented cases are similar to those found in Bardet-Biedl syndrome(BBS), the absence of some major criteria of BBS(polydactyly, renal abnormality, and hypogonadism) suggests that this may be a new syndrome. All three patients remain under follow-up in the departments of Gastroenterology, Ophthalmology, and Neurology at Hacettepe University.

关键词： Congenital hepatic fibrosis Nystagmus Mental retardation Retinitis pigmentosa High-arched palate

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The predictors of long-COVID in the cohort of Turkish Thoracic Society-TURCOVID multicenter registry:One year follow-up results

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Asian Pacific Journal of Tropical Medicine 2022年第9期15卷 400-409页

作者： Serap Argun Baris Oya Baydar Toprak Pelin Duru Cetinkaya Fusun Fakili Nurdan Kokturk Seval Kul Ozgecan Kayalar Yildiz Tutuncu Emel Azak Mutlu Kuluozturk Pinar Aysert Yildiz Pelin Pinar Deniz Oguz Kilinc Ilknur Basyigit Hasim Boyaci Ismail Hanta Neslihan Kose Gulseren Sagcan Caglar Cuhadaroglu Hacer Kuzu Okur Hasan Selcuk Ozger Begum Ergan Mehtap Hafizoglu Abdullah Sayiner Esra Nurlu Temel Onder Ozturk Tansu Ulukavak Ciftci Ipek Kivilcim Oguzulgen Vildan Avkan Oguz Firat Bayraktar ozlem Ataoglu Merve Ercelik Pinar Yildiz Gulhan Aysegul Tomruk Erdem Muge Meltem Tor Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Koc University Research Center for Translational Medicine(KUTTAM) Koc University School of MedicineIstanbulTurkey Department of Immunology Koc University Research Center for Translational Medicine(KUTTAM)Koc University School of MedicineIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeli Turkey Department of Pulmonary Medicine Faculty of MedicineFirat UniversityElazigTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineEge UniversityIzmirTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Internal Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZongu

Objective:To evaluate long-term effects of COVID-19,and to determine the risk factors in long-COVID in a cohort of the Turkish Thoracic Society(TTS)-TURCOVID multicenter ***:Thirteen centers participated with 831 patients;504 patients were enrolled after *** study was designed in three-steps:(1)Phone questionnaire;(2)retrospective evaluation of the medical records;(3)face-to-face ***:In the first step,93.5%of the patients were hospitalized;61.7%had a history of pneumonia at the time of diagnosis.A total of 27.1%reported clinical symptoms at the end of the first ***(17.00%),fatigue(6.30%),and weakness(5.00%)were the most prevalent long-term *** incidence of long-term symptoms was increased by 2.91 fold(95%CI 1.04-8.13,P=0.041)in the presence of chronic obstructive pulmonary disease and by 1.84 fold(95%CI 1.10-3.10,P=0.021)in the presence of pneumonia at initial diagnosis,3.92 fold(95%CI 2.29-6.72,P=0.001)of dyspnea and 1.69 fold(95%CI 1.02-2.80,P=0.040)fatigue persists in the early-post-treatment period and 2.88 fold(95%CI 1.52-5.46,P=0.001)in the presence of emergency service admission in the post COVID *** step 2,retrospective analysis of 231 patients revealed that 1.4%of the chest X-rays had not significantly improved at the end of the first year,while computed tomography(CT)scan detected fibrosis in 3.4%.In step 3,138(27.4%)patients admitted to face-to-face visit at the end of first year;at least one symptom persisted in 49.27%*** most common symptoms were dyspnea(27.60%),psychiatric symptoms(18.10%),and fatigue(17.40%).Thorax CT revealed fibrosis in 2.4%***:COVID-19 symptoms can last for extended lengths of time,and severity of the disease as well as the presence of comorbidities might contribute to increased ***-term clinical issues should be regularly evaluated after COVID-19.

关键词： Long COVID-19 Dyspnea Fatigue Comorbidity

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Treatment of Massive Low-Grade Chondrosarcoma of Nasal Septum with Helical Tomotherapy: A Case Report

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第4期5卷 263-269页

作者： Hamit Basaran Timur Koca Sibel Karaca ozlem Eser K&iota l&iota nc Fikriye Gul Karauc Okan Ö zdemir Ozan Kuduban Arzu Tatar Sare Ş ipal Department of Radiation Oncology Regional Training and Research Hospital Erzurum Turkey Department of Otorhinolaryngology Regional Training and Research Hospital Erzurum Turkey Department of Otorhinolaryngology Ataturk University Faculty of Medicine Erzurum Turkey Department of Pathology Ataturk University Faculty of Medicine Erzurum Turkey

Chondrosarcomas are malignant bone tumors which develop as a cartilaginous differentiation of primary mesenchymal cells and the second most frequently seen malignant tumor of the bone after osteosarcoma. These malignancies are slowly growing non-epithelial tumors with unknown etiology and most frequently seen during the 4 decades of life. They are frequently localized on pelvis, ribs and long bones. Nasal septum CSs are very rarely seen malignancies. They originate from septal mucosa or cartilage and it is difficult to make a diagnosis unless they reach a certain size. A few cases of CSs with nasal septum have been reported in the literature. In cases of CSs, surgery is the gold standard treatment modality;however in surgically unresectable cases or close to margins, radiotherapy plays a significant role in primary and adjuvant treatment. Based on the position of the tumor in head and neck and extremely closeness of the tumor to vital organs as optic nerve, chiasm and brain, image guided-intensity modulated radiation therapy (IG-IMRT) becomes very effective and reliable modalities and may be a favorable treatment alternative.

关键词： Chondrosarcoma Image Guided Intensity Modulated Radiation Therapy

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Possible Mechanism of Action of Neurokinin-1 Receptors （NK1R） Antagonists

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Journal of Pharmacy and Pharmacology 2017年第11期5卷 787-797页

作者： Ozum Ozturk Esin Aki-Yalcin Tugba Ertan-Bolelli Kayhan Bolelli Andry Nur-Hidayat ozlem Bingol-Ozakpinar Filiz Ozdemir Ismail Yalcin Pharmacy Chemistry Department Faculty of Pharmacy Ankara University Ankara 06100 Turkey Bioinformatics Department Biotechnology Institution Ankara University Ankara 06100 Turkey Biochemistry Department Faculty of Pharmacy Marmara University Istanbu134722 Turkey Analytical Chemistry Department Faculty of Pharmacy Marmara University Istanbu134722 Turkey

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Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey

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Asian Pacific Journal of Tropical Biomedicine 2013年第9期3卷 743-747页

作者： Aysegül Copur Cicek Azer Ozad Düzgün Aysegül Saral Tuba Kayman Zeynep Cizmeci Pervin ozlem Balci Tuba Dal Mehmet Firat Ismail Tosun Yasemin Ay Alitntop Ahmet Caliskan Yelda Yazici Cemal Sandalli Department of Medical Microbiology Faculty of MedicineRecep Tayyip Erdogan University Department of Genetics and Bioengineering Faculty of Engineering and Natural SciencesGümüshane University Department of Biology Faculty of Arts and SciencesArtvin Coruh University Clinical Microbiology Laboratory Research and Training Hospital Clinical Microbiology Laboratory Kecioren Research and Training Hospital Clinical Microbiology Laboratory General State Hospital Department of Medical Microbiology Faculty of MedicineDicle University Clinic of Infectious Diseases and Clinical Microbiology PrivateOSM Ortadogu Hospital Microbiology Laboratory Kirikkale Highly Specialized Hospital General State Hospital Microbiology Laboratory Necip Fazil City Hospital Clinical Microbiology Laboratory Ahi Evren Chest and Cardiovascular Surgery Research and Training Hospital Department of Biology Faculty of Arts and SciencesRecep Tayyip Erdogan University

Objective:To investigate the antibiotic resistance genes inserted into class I and class 2integrons in Acinetobacler baumannii[***)isolates obtained from nine different cities in ***:A collection of 281 *** clinical isolates were collected from nine diferenl state hospitals in Turkey and were confirmed as *** by conventional biochemical,API testing and bla_(-OXA-51)specific *** isolates were examined by PCR for existence of class I and2 integron gene ***:They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin(90.03%),ciprofloxacin(87.54%),cefepime and trimethoprim/sulfamethoxazole(81.13%).The lowest resistance rates was for cefotaxime(3.55%).class 1 integrons were detected in 6.4%(18/281)of *** strains and no class 2 integron was *** gene casselles of class 1 inlegrons AacCI-AAC(3)l-aadAI,AacCI-aadA1,AAC(3)-I,AAC(3)-I-AAC(3)-I-aadA1,***(3)-I-aadA1-AAC(3)-I-AAC(3)-I,AAC(3)-I-AAC(3)-I-AAC(3)-I-aadA1,AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I,AAC(3)-I-aadA1-AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen *** aac genes family were most frequently found integrated into the class 1 inlegrons and it was followed by aadA genes and TEM-1 ***:This is an extensive study on the distribulion of class 1 integron among *** in *** addition to these,two new alleles were *** percentage rates of similarity to other cassettes are 95%aadA1(TK A18)and 89%,aadA 1(ANKA3).

关键词： Acinetobacter baumannii Class 1 integron Gene cassette Resistance

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无压熔渗AlN-Si-Al复合材料的热性能(英文)

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Transactions of Nonferrous Metals Society of China 2013年第5期23卷 1304-1313页

作者： Ayse KALEMTAS Gulsum TOPATES ozlemBAHADIR Pinar KAYAISCI Hasan MANDAL Department of Metallurgical and Materials Engineering Mugla Sitki Kocman University Department of Materials Science and Engineering Anadolu University Material Science and Engineering Programme Sabanci University

采用无压熔渗法将Al/Al合金渗透到多孔α-Si3N4中,并对AlN-Si-Al复合材料在50~300°C的热性能进行研究。SEM和TEM结果表明,AlN的晶粒尺寸小于1μm,另外,AlN-Si-Al复合材料还表现出较高的热导率55~107W/（m·K）。采用热导率为107W/（m·... 详细信息

采用无压熔渗法将Al/Al合金渗透到多孔α-Si3N4中,并对AlN-Si-Al复合材料在50~300°C的热性能进行研究。SEM和TEM结果表明,AlN的晶粒尺寸小于1μm,另外,AlN-Si-Al复合材料还表现出较高的热导率55~107W/（m·K）。采用热导率为107W/（m·K）的商用Al得到的AlN-Si-Al复合材料的热膨胀系数为6.5×10-6K-1。Al的热膨胀系数高达23.6×10-6K-1,而AlN-Si-Al复合材料却具有低的热膨胀系数,其原因是在渗透过程中形成了Si和AlN。

关键词： A1N 陶瓷基复合材料热性能金属溶渗

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