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Effectiveness of vedolizumab treatment in two different anti-tumor necrosis factor alpha refractory pouchitis: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2316-2321页

作者： ozlem ozer cakir Department of Gastroenterology and Hepatology Alanya Alaaddin Keykubat University School of Medicine

BACKGROUND Refractory pouchitis is a common cause of pouch failure,which may require surgical excision of the pouch or permanent *** aimed to show the effect of vedolizumab on treatment of the patient with refractory *** SUMMARY A 32-year-old male with pancolonic ulcerative colitis since the age of 25 with primary failure of infliximab and mesalamine and intolerance of azathioprine,underwent a total proctocolectomy with ileal pouch-anal anastomosis in *** developed chronic diarrhea in 2014,which was watery,30 per day and accompanied with blood and mucus affecting his quality of *** Vedolizumab is safe and effective in the management of anti-tumor necrosis factor alpha refractory pouchitis.

关键词： Anti-tumor necrosis factor alpha Refractory pouchitis Vedolizumab Ulcerative colitis

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Leucocyte-and platelet-rich fibrin as a rescue therapy for small-to-medium-sized complex wounds of the lower extremities

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Burns & Trauma 2019年第1期7卷 98-106页

作者： Kadri ozer ozlem Colak Aydin State Hospital PlasticReconstructive and Aesthetic Surgery Clinic09100 AydinTurkey Istanbul Okmeydani Training and Research Hospital PlasticReconstructive and Aesthetic Surgery Clinic34384 IstanbulTurkey

Background:Generally,advanced wound care resources are applied for complex wounds that pose a challenge to the medical and nursing *** this report,the use of leukocyte-and platelet-rich fibrin(L-PRF)is emphasized for complex wounds as an alternative,simple,inexpensive,time-saving process that does not require hospitalization and has a healing potential over that of bare soft tissue,including bone,tendon,and *** aim of this study is to extend the use of L-PRF in small-to-moderate-sized complex wounds of lower extremities in which L-PRF maintains the sensitive structures ***:Between January 2016 and December 2017,17 small-to-moderate-sized complex wounds of lower extremities treated with L-PRF were recruited from the plastic and reconstructive surgery clinic in Aydin State Hospital,*** treatment was administered twice per week in the outpatient *** on the size and extension of the complex wound,two to five blood samples were collected into 8.5 ml dry,glass vacuum tubes with no anticoagulant,and samples were immediately centrifuged at 1630×g for 5 min to obtain *** healing was defined as the day of complete wound ***:The median values of the initial wound size and wound duration were 12 cm^(2)(interquartile range,6 to 23 cm^(2))and 8 months before first admission(interquartile range,4 to 18 months),*** wounds showed significant improvements after L-PRF therapy and full closure after a median of 18months,with an interquartile range of 11 to 34 months of L-PRF *** were recurrences of wounds during the first 6 months after *** adverse events were ***:Our results add to the growing evidence that L-PRF treatments protect and maintain bare soft tissue structures viable,facilitate the formation of granulation tissue and epithelization,and remarkably reduce the need for additional soft tissue surgeries in small-to-medium-sized complex wounds.

关键词： Leukocyte-and platelet-rich fibrin Complex wound Bare bone Bare tendon

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Does crossover innervation really affect the clinical outcome？ A comparison of outcome between unilateral and bilateral digital nerve repair

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Neural Regeneration Research 2016年第9期11卷 1499-1505页

作者： Melike Oruc Kadri ozer ozlem Colak Yüksel Kankaya Ugur Kocer Ankara Training and Research Hospital Plastic Reconstructive and Aesthetic Surgery Clinic Ankara Turkey Aydin State Hospital Plastic Reconstructive and Aesthetic Surgery Clinic Aydin Turkey Istanbul Okmeydani Training and Research Hospital Plastic Reconstructive and Aesthetic Surgery Clinic Istanbul Turkey

Digital nerve injuries are the mostly detected nerve injury in the upper extremity. However, since the clinical phenomenon of crossover innervation at some degree from uninjured digital nerve to the in- jured side occurs after digital nerve injuries is sustained, one could argue that this concept might even result in the overestimation of the outcome of the digital nerve repair. With this knowledge in mind, this study aimed to present novel, pure, focused and valuable clinical data by comparing the outcomes of bilateral and unilateral digital nerve repair. A retrospective review of 28 fingers with unilateral or bilateral digital nerve repair using end-to-end technique in 19 patients within 2 years was performed. Weber＇s two-point discrimination, sharp/dull discrimination, warm/cold sensation and Visual Analog Scale scoring were measured at final 12-month follow ups in all patients. There was no significant difference in recovery of sensibility after unilateral and bilateral digital nerve repairs. Though there is crossover innervation microscopically, it is not important in the clinical evaluation period. According to clinical findings from this study, crossover innervations appear to be negligible in the estimation of outcomes of digital neurorrhaphy.

关键词： nerve regeneration digital nerve repair unilateral bilateral crossover innervation sensibility neurorrhaphy nerve sprouting neural regeneration

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吸烟,血清抗氧化维生素水平和老年性黄斑变性之间的关系(英文)

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国际眼科杂志 2014年第5期14卷 790-796页

作者： Sezen Akkaya cakir ozlem Sahin Haluk Kazokoglu Feyza Tekeli Goncagul Haklar Yelda Ozkurt 法提赫苏丹穆罕默德培训和研究医院土耳其伊斯坦布尔34742 马尔马拉大学医学院眼科土耳其伊斯坦布尔34747 马尔马拉大学医学院生物化学系土耳其伊斯坦布尔34747

目的:研究老年性黄斑变性(AMD)等级、血清抗氧化维生素水平(维生素A、C和E)和吸烟的关系。方法:对84例患者行黄斑彩色眼底成像,根据AMD损伤率和损伤程度将其分为五组(等级I^V)。应用高效液相色谱法(HPLC)测量血清抗氧化维生素水平。根... 详细信息

目的:研究老年性黄斑变性(AMD)等级、血清抗氧化维生素水平(维生素A、C和E)和吸烟的关系。方法:对84例患者行黄斑彩色眼底成像,根据AMD损伤率和损伤程度将其分为五组(等级I^V)。应用高效液相色谱法(HPLC)测量血清抗氧化维生素水平。根据吸烟状况分不吸烟者、已戒烟者和吸烟者三组,并统计吸烟者每年的吸烟总量。结果:对照组中,维生素A、E、C水平分别为0.874±0.326mg/L,10.739±4.874mg/L和1.737±0.447mg/L,AMD组中分别为0.880±0.305mg/L,9.487±6.060mg/L和1.870±2.191mg/L,无显著差异(P>0.05)。AMD不同等级分组间维生素A(P=0.881)和E(P=0.293)水平差异无统计学意义,维生素C水平(P=0.044)随AMD程度的加深而增加。根据吸烟状况,AMD组与对照组之间无显著差异。根据每年的吸烟总量,两组之间有显著差异(P=0.02)。AMD越严重,年吸烟总量越高(P=0.007)。结论:研究结果显示AMD与维生素A、E血清水平无关,但和维生素C的血清水平相关,并与吸烟量有关。

关键词：吸烟抗氧化维生素老年性黄斑变性

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