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Transfer of single dose of intravitreal injection of ranibizumab and bevacizumab into milk of sheep

International Journal of Ophthalmology(English edition) 2017年第7期10卷 1069-1075页

作者： Tugba Cakmak Argun ozlem Yalcin Tok Levent Tok Gulsen Yilmaz Fatma Meric Yilmaz Alime Gunes Mehmet Argun Osman Butuner Department of Ophthalmology Hatay Dortyol State Hospital Faculty of Medicine Ophthalmology Suleyman Demirel University Ministry of Health Ankara HospitalBiochemistry Biochemistry Department Faculty of MedicineYildirim Beyazit University The Management of Veterinary Service

AIM： To investigate whether single-dose intravitreal injections of bevacizumab and ranibizumab transfer into milk. METHODS： This study included lactating 12 sheep and a single 3-month old suckling lamb of each sheep. Two groups consisting of 6 sheep and their lambs were constituted; the ranibizumab group and the bevacizumab group before the administration of intravitreal injections, blood and milk samples were obtained from all sheep and, following the injections, blood and milk samples of all sheep and blood samples of all lambs were collected at regular time points. Serum and milk concentrations of bevacizumab and ranibizumab were measured using an enzyme-linked immunosorbent assay（ELISA） kit. The limit of determination was 0.9 ng/m L for bevacizumab and 0.62 ng/m L for ***： At 6h after intravitreal injections, bevacizumab concentration was above the limit of determination in the blood of all sheep. At 3wk, when the study was terminated, bevacizumab concentrations were high in 4 sheep. Even though bevacizumab concentrations in milk showed fluctuations, the drug transferred into the milk of all sheep at detectable concentrations. Ranibizumab drug concentrations in the blood and milk of sheep and those in the blood of lambs were below the limit of determination by the ELISA ***： This sheep model study demonstrate that intravitreal injection of ranibizumab, which did not transfer into the milk of sheep and suckling lambs, is safer than bevacizumab during lactation period.

关键词： bevacizumab ranibizumab lactation milk vascular endothelial growth factor

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Post-discharge mortality in the first wave of COVID-19 in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 479-484页

作者： Fusun Fakili Pelin Duru Cetinkaya Oya Baydar Serap Argun Baris Nurdan Kokturk Seval Kul Oguz Karcioglu Pinar Aysert Yildiz Ilim Irmak Yonca Sekibag Emel Azak Sait Mulamahmutoglu Caglar Cuhadaroglu Bugra Kerget Burcu Baran Ketencioglu Hasan Selcuk Ozger Gulcihan Ozkan Zeynep Ture Merve Ercelik Tansu Ulukavak Ciftci ozlem Alici Esra Nurlu Temel ozlem Ataoglu Neslihan Kose Muge Meltem Tor Gulsah Gunluoglu Sedat Altin Onder Ozturk Pinar Yildiz Gulhan Ilknur Basyigit Hasim Boyaci I Kivilcim Oguzulgen Sermin Borekci Bilun Gemicioglu Ismail Hanta Hacer Kuzu Okur Gulseren Sagcan Metin Akgun Ali Fuat Kalyoncu Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalFaculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Halil Sivgin Cubuk State HospitalAnkaraTurkey Department of Infectious Disease Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Pulmonary Medicine Cerrahpasa Faculty of MedicineIstanbul University−CerrahpasaIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineAtaturk UniversityErzurumTurkey Department of Pulmonary Medicine Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Maslak Acibadem HospitalIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Infectious Disease Faculty of MedicineTurkiye Gazetesi Private HospitalIstanbulTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Universi

Objective:To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society(TTD)-TURCOVID ***:In this retrospective cohort study,we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study,and 1112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the *** causes of death after COVID-19 discharge were ***:The mean age of the patients was(51.07±16.93)years,with 57.6%male *** the cohort group,89.1%of COVID-19 treatment locations were hospital wards,3.6%were intensive care units(ICUs),and 7.2%were community *** the longterm follow-up,the in-hospital mortality rate was 3.6%(95%CI 2.6-4.8),the post-discharge mortality rate was 2.8%(95%CI 1.9-3.9),and the total mortality was 6.3%(95%CI 5.0-7.8).After discharge,63.3%of mortality overall occurred during the first six *** rates in post-discharge follow-ups were 12.7%(95%CI 8.0-30.6)in cancer patients,10.8%(95%CI 6.3-22.9)in chronic obstructive pulmonary disease patients,11.1%(95%CI 4.4-22.7)in heart failure patients,7.8(95%CI 3.8-14.3)in atherosclerotic heart disease patients,and 2.3%(95%CI 0.8-5.6)in diabetes mellitus *** smokers/ex-smokers,the all-mortality rates were higher than in ***:This multicenter study showed that patients over 65 years of age,males,former/active smoker,ICU stay,lung,heart disease,and malignancy should be followed up for at least the first six months after discharge due to COVID-19.

关键词： COVID-19 Post-discharge Mortality Comorbidity

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Comparison of the Effects of Physiotherapy Group Exercise and Basketball on Quality of Life of Obese Children

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Open Journal of Therapy and Rehabilitation 2017年第1期5卷 1-10页

作者： Zehra Guchan Topcu ozlem Ulger Department of Physiotherapy and Rehabilitation Faculty of Health SciencesEastern Mediterranean UniversityFamagustaCyprus Department of Physiotherapy and Rehabilitation Faculty of Health SciencesHacettepe UniversityAnkaraTurkey

Aim: To compare the effects of group exercises under physiotherapist control and basketball program on the quality of life of obese children. Methods: 45 obese children aged 10 years were randomly included to the physiotherapy (n=14), basketball (n:15), and control group (n:16). The children were assessed before and after 12-week study duration. The Pediatric Quality of Life Inventory (PedsQL) was used to determine and compare their quality of life (QoL). Results: No difference was found when the subheadings of the PedsQL were compared among the groups (p>0.05). When the changes were investigated within the groups, only significant increase was determined in the physical and emotional subheadings of the physiotherapy group (pConclusion: Although no change was determined in the quality of life, physiotherapy group exercise was found to be more successful to affect physical and emotional status of obese children.

关键词： Physiotherapy Basketball Quality of Life Obese Children

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Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 339-344页

作者： Düriye Betül Yilmaz Zeynep Bayramoglu Gülsah Ünay Erdem Ayik Cumhur Ibrahim Bassorgun Gülsüm ozlem Elpek Department of Pathology Akdeniz University Medical SchoolKonyaalti/AntalyaTurkey

The composite tumors of the liver are very rare,including the coexistence of HCC(hepatocellular carcinoma)with NEC(neuroendocrine carcinoma).The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics,behaviors and *** is described an incidental collision tumor of HCC-NEC,along with a review of the literature focusing on their clinicopathological findings and *** tumor presented here was found incidentally in the hepatectomy specimen of a 56-yearold man who had undergone liver transplantation for rapidly progressive liver failure because of alcoholic hepatitis and *** and laboratory examinations did not demonstrate tumor-related *** macroscopic examination,two sharply defined and distinctive areas(1.7 cm and 0.6 cm dimension respectively)were detected among the cirrhotic *** characteristic histopathological features and immunohistochemical findings allowed a diagnosis of HCCNEC to be *** was no evidence of recurrence and metastasis after 10months following *** present case and review revealed that these tumors are frequently found in older ages and *** serum markers are valuable in the discrimination of malignant tumors,their absence cannot completely rule out composite *** requires a comprehensive histopathological evaluation together with *** NEC component might influence the treatment strategy and eventually the outcome of the *** conclusion,the rare occurrence of HCC-NEC and the lack of diagnostic clinical signs and symptoms do not exclude their consideration in the differential diagnosis of liver tumors,especially in patients with the chronic liver disease.

关键词： Liver neoplasm Hepatocel ular carcinoma Neuroendocrine carcinoma

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An adult case of celiac sprue triggered after an ileal resection for perforated Meckel's diverticulum

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World Journal of Gastroenterology 2009年第32期15卷 4075-4076页

作者： Firdevs Topal Sabiye Akbulut Ismail Cagatay Topcu Yasemin Dolek ozlem Yonem Department of Gastroenterology Cumhuriyet University Cumhuriyet Universitesi Hastanesi 58140 Sivas Turkey Department of Gastroenterology ankiri State HospitalCankiri Devlet Hastanesi18200 CankiriTurkey Department of Gastroenterology Kartal Kosuyolu High Speciality Education and Research HospitalKartal Kosuyolu Devlet Hastanesi34846 IstanbulTurkey Department of Surgery Cankiri State HospitalCankiri Devlet Hastanesi18200 CankiriTurkey Department of Pathology Cankiri State HospitalCankiri Devlet Hastanesi18200 CankiriTurkey

Celiac disease can be triggered by upper abdominal surgery, such as vagotomy, oesophagectomy, pancreatico-duodenectomy, and gastrojejunal anastomosis. Here we report a case of a 24 year-old woman who developed celiac disease after an ileal resection for perforated Meckel's diverticula. This is the first reported celiac case that has been triggered, not by upper abdominal surgery, but after ileal resection for Meckel's diverticula.

关键词：切除术腹腔回肠穿孔直浇道成人迷走神经十二指肠

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Post-Varicella Disciform Keratitis: Case Report

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Open Journal of Ophthalmology 2012年第3期2卷 83-84页

作者： ozlem G. Sahin The World Eye Center Department of Uveitis Ankara Turkey

The purpose of this study is to report a rare condition of post-varicella disciform keratitis in a 4-year-old child. It is a prospective study of the follow-up of a 4 year-old girl who was diagnosed as post-varicella stromal disciform keratitis related to high serum antibody titers five months after the skin lesions. Rapid response to topical steroids, topical and oral antivirals have been observed in 6 weeks of treatment. There was no recurrence in the 6 months of follow-up. Total resolution of the disciform stromal keratitis in a short period of time was disclosed with an effective treatment of both topical and oral antivirals and topical steroids.

关键词： Acyclovir Disciform Keratitis Trifluridine Varicella Zoster

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Comparison between primary angioplasty and thrombolytic therapy on erectile dysfunction after acute ST elevation myocardial infarction

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Asian Journal of Andrology 2012年第5期14卷 784-787页

作者： Ramazan Akdemir ozlem Karakurt Salih Orcan Nihat Karakoyunlu Mustafa Mucahit Balci Levent Sagnak Hamit Ersoy Mehmet Bulent Vatan Harun Kilic Ekrem Yeter Department of Cardiology Faculty of MedicineSakarya UniversitySakarya 54054Turkey Department of Cardiology Batikesir Government HospitalBalikesir 10100Turkey Department of Urology Diskapr Yildinm Beyazpt Research and Education HospitalAnkara 06110Turkey Department of Cardiology Yuksek I htisas Research and EducationAnkara 06590Turkey Department of Cardiology Diskapl Yddtnm Beyazlt Research and Education HospitalAnkara 06110Turkey

Acute ST elevation myocardial infarction has high mortality and morbidity rates. The majority of patients with this condition face erectile dysfunction in addition to other health problems. In this study, we aimed to investigate the effects of two different reperfusion strategies, primary angioplasty and thrombolytic therapy, on the prevalence of erectile dysfunction after acute myocardial infarction. Of the 71 patients matching the selection criteria, 45 were treated with primary coronary angioplasty with stenting, and 26 were treated with thrombolytic agents. Erectile function was evaluated using the International Index of Erectile Function in the hospital to characterize each patient＇s sexual function before the acute myocardial infarction and 6 months after the event. The time required to restore blood flow to the artery affected by the infarct was found to be associated with the occurrence of erectile dysfunction after acute myocardial infarction. The increase in the prevalence of erectile dysfunction after acute myocardial infarction was 44.4% in the angioplasty group and 76.9% in the thrombolytic therapy group （P= 0.008）. In conclusion, this study has shown that reducing the time of reperfusion decreases the erectile dysfunction prevalence, and primary angioplasty is superior to thrombolytic therapy for decreasing the prevalence of erectile dysfunction after acute myocardial infarction.

关键词： coronary angioplasty erectile dysfunction fibrinolysis myocardial infarction myocardial reperfusion

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Learning outcomes of nursing curriculum in Turkey:a cross-sectional study

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Frontiers of Nursing 2020年第2期7卷 129-134页

作者： Sevinc Mersin Hulya Saray Kilic ozlem Ibrahimoglu School of Health Nursing DepartmentBilecik Seyh Edebali UniversityGulumbe campusBilecik 11210Turkey

Objective:To assess the nursing curriculum and point out learning outcomes in ***:A cross-sectional design was used in this *** study was conducted between May and June 2017 from 23 undergraduate nursing schools'education programs for one education and academic year's *** public information of the universities collected from their web sites and learning outcomes of the schools were classified as cognitive,psychomotor,and affective ***:It appears that half of the basic nursing courses are in the psychomotor domain,and the majority of basic medical sciences courses are in the cognitive *** outcomes about the affective domain mostly take place in basic nursing ***:The findings of the results of this study can provide insight into current nursing education and guide new curricula to be developed.

关键词： curriculum learning outcomes nursing care nursing courses nursing education

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Effect of basic life support training on the knowledge and skills of first aid of first year medical students

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Journal of Acute Disease 2021年第4期10卷 169-172,I0002-I0005页

作者： Esra Karaman Nazire Avcu ozlem Guneysel Department of Emergency Medicine Faculty of MedicineMaltepe UniversityIstanbulTurkey

Objective:To determine the timing of first aid training in the medical school curriculum and the training method with the 8-hour first aid training given to the first-grade students of the faculty of ***:The study was conducted prospectively with 168 first year medical students at Faculty of Medicine,Maltepe University in October *** 8-hour course plan consisting of theoretical and practical applications was *** courses included cardiopulmonary resuscitation,basic life supports,epileptic seizures,heatstroke,aspiration,and drowning issues,while practical applications included cardiopulmonary resuscitation techniques,basic life support scenarios,Heimlich’s Maneuver and the coma *** were sent a link consisting of 17 questions created with Google forms at the beginning and the end of the *** knowledge was measured with the posttest,and pre-and post-training results were ***:A significant increase was found in the rate of correct answers compared to the pre-training *** the rate of correct post-test answers increased significantly in all questions;the increase in the questions related to the subjects supported by practical applications was more *** was found that more incorrect answers were given to questions about environmental ***:It is possible to improve the public recognition of first aid,even with one day of theoretical and practical ***,adding first aid practical courses to the first-year medical school curriculum and raising awareness at an earlier age will play an essential role in medical education.

关键词： Medical education First aid Basic life support Medical school curriculum

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The Application of Ultra High Voltage in the World

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Journal of Power and Energy Engineering 2015年第4期3卷 453-457页

作者： Metin Candas ozlem Sahin Meric Faculty of Aeronautics and Astronautics Eskisehir Turkey

With rapidly growth in industrial sectors, in order to meet the demand, the usage of Ultra High Voltage (UHV) is needed. High voltage (HV) is between the range of 52 kV and 300 kV. In case of voltage above 800 kV, it can be defined as UHV. With the development of technologies in the world, it could be seen that Japan, Russia, Italy, Brazil, America (U.S), and Canada began to improve UHV in the 1960s and 1970s. In addition, China, a leader developing country for UHV technologies in the world, started UHV technologies in transmission, in 1980s. Nowadays, seven transmission lines are in operation in China. In this study, the concept of HV and UHV will be introduced. Especially, UHV transmission in the worldwide will be researched. Then, the historical development and current situation of UHV will be analyzed and the assessment for Turkey will be done.

关键词： The Application of Ultra High Voltage in the World

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