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Post-discharge mortality in the first wave of COVID-19 in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 479-484页

作者： Fusun Fakili Pelin Duru Cetinkaya Oya Baydar Serap Argun Baris Nurdan Kokturk Seval Kul Oguz Karcioglu Pinar Aysert Yildiz Ilim Irmak Yonca Sekibag Emel Azak Sait Mulamahmutoglu Caglar Cuhadaroglu Bugra Kerget Burcu Baran Ketencioglu Hasan Selcuk Ozger Gulcihan Ozkan Zeynep Ture Merve Ercelik Tansu Ulukavak Ciftci ozlem Alici Esra Nurlu Temel ozlem ataoglu Neslihan Kose Muge Meltem Tor Gulsah Gunluoglu Sedat Altin Onder Ozturk Pinar Yildiz Gulhan Ilknur Basyigit Hasim Boyaci I Kivilcim Oguzulgen Sermin Borekci Bilun Gemicioglu Ismail Hanta Hacer Kuzu Okur Gulseren Sagcan Metin Akgun Ali Fuat Kalyoncu Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalFaculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Halil Sivgin Cubuk State HospitalAnkaraTurkey Department of Infectious Disease Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Pulmonary Medicine Cerrahpasa Faculty of MedicineIstanbul University−CerrahpasaIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineAtaturk UniversityErzurumTurkey Department of Pulmonary Medicine Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Maslak Acibadem HospitalIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Infectious Disease Faculty of MedicineTurkiye Gazetesi Private HospitalIstanbulTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Universi

Objective:To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society(TTD)-TURCOVID ***:In this retrospective cohort study,we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study,and 1112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the *** causes of death after COVID-19 discharge were ***:The mean age of the patients was(51.07±16.93)years,with 57.6%male *** the cohort group,89.1%of COVID-19 treatment locations were hospital wards,3.6%were intensive care units(ICUs),and 7.2%were community *** the longterm follow-up,the in-hospital mortality rate was 3.6%(95%CI 2.6-4.8),the post-discharge mortality rate was 2.8%(95%CI 1.9-3.9),and the total mortality was 6.3%(95%CI 5.0-7.8).After discharge,63.3%of mortality overall occurred during the first six *** rates in post-discharge follow-ups were 12.7%(95%CI 8.0-30.6)in cancer patients,10.8%(95%CI 6.3-22.9)in chronic obstructive pulmonary disease patients,11.1%(95%CI 4.4-22.7)in heart failure patients,7.8(95%CI 3.8-14.3)in atherosclerotic heart disease patients,and 2.3%(95%CI 0.8-5.6)in diabetes mellitus *** smokers/ex-smokers,the all-mortality rates were higher than in ***:This multicenter study showed that patients over 65 years of age,males,former/active smoker,ICU stay,lung,heart disease,and malignancy should be followed up for at least the first six months after discharge due to COVID-19.

关键词： COVID-19 Post-discharge Mortality Comorbidity

Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： ozlem Dogan Hayriye Sahinli Yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of Medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of Radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of Medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGROUND Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(P<0.001).A significant relationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass Muscle density

The predictors of long-COVID in the cohort of Turkish Thoracic Society-TURCOVID multicenter registry:One year follow-up results

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Asian Pacific Journal of Tropical Medicine 2022年第9期15卷 400-409页

作者： Serap Argun Baris Oya Baydar Toprak Pelin Duru Cetinkaya Fusun Fakili Nurdan Kokturk Seval Kul Ozgecan Kayalar Yildiz Tutuncu Emel Azak Mutlu Kuluozturk Pinar Aysert Yildiz Pelin Pinar Deniz Oguz Kilinc Ilknur Basyigit Hasim Boyaci Ismail Hanta Neslihan Kose Gulseren Sagcan Caglar Cuhadaroglu Hacer Kuzu Okur Hasan Selcuk Ozger Begum Ergan Mehtap Hafizoglu Abdullah Sayiner Esra Nurlu Temel Onder Ozturk Tansu Ulukavak Ciftci Ipek Kivilcim Oguzulgen Vildan Avkan Oguz Firat Bayraktar ozlem ataoglu Merve Ercelik Pinar Yildiz Gulhan Aysegul Tomruk Erdem Muge Meltem Tor Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Koc University Research Center for Translational Medicine(KUTTAM) Koc University School of MedicineIstanbulTurkey Department of Immunology Koc University Research Center for Translational Medicine(KUTTAM)Koc University School of MedicineIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeli Turkey Department of Pulmonary Medicine Faculty of MedicineFirat UniversityElazigTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineEge UniversityIzmirTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Internal Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZongu

Objective:To evaluate long-term effects of COVID-19,and to determine the risk factors in long-COVID in a cohort of the Turkish Thoracic Society(TTS)-TURCOVID multicenter ***:Thirteen centers participated with 831 patients;504 patients were enrolled after *** study was designed in three-steps:(1)Phone questionnaire;(2)retrospective evaluation of the medical records;(3)face-to-face ***:In the first step,93.5%of the patients were hospitalized;61.7%had a history of pneumonia at the time of diagnosis.A total of 27.1%reported clinical symptoms at the end of the first ***(17.00%),fatigue(6.30%),and weakness(5.00%)were the most prevalent long-term *** incidence of long-term symptoms was increased by 2.91 fold(95%CI 1.04-8.13,P=0.041)in the presence of chronic obstructive pulmonary disease and by 1.84 fold(95%CI 1.10-3.10,P=0.021)in the presence of pneumonia at initial diagnosis,3.92 fold(95%CI 2.29-6.72,P=0.001)of dyspnea and 1.69 fold(95%CI 1.02-2.80,P=0.040)fatigue persists in the early-post-treatment period and 2.88 fold(95%CI 1.52-5.46,P=0.001)in the presence of emergency service admission in the post COVID *** step 2,retrospective analysis of 231 patients revealed that 1.4%of the chest X-rays had not significantly improved at the end of the first year,while computed tomography(CT)scan detected fibrosis in 3.4%.In step 3,138(27.4%)patients admitted to face-to-face visit at the end of first year;at least one symptom persisted in 49.27%*** most common symptoms were dyspnea(27.60%),psychiatric symptoms(18.10%),and fatigue(17.40%).Thorax CT revealed fibrosis in 2.4%***:COVID-19 symptoms can last for extended lengths of time,and severity of the disease as well as the presence of comorbidities might contribute to increased ***-term clinical issues should be regularly evaluated after COVID-19.

关键词： Long COVID-19 Dyspnea Fatigue Comorbidity

Assessment of the potential interactions between favipiravir and radiocontrast agents

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World Journal of Radiology 2024年第5期16卷 128-135页

作者： Sonay Aydin ozlem Celik Aydin Mesut Furkan Yazar Huseyin Aydemir Mecit Kantarci Sureyya Barun Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Pharmacology Gazi UniversityFaculty of MedicineErzincan 24100Türkiye Department of Radiology Bilecik Education and Reseach HospitalBilecik 11230Türkiye Department of Radiology Atatürk UniversityFaculty of MedicineErzurum 25030Türkiye

BACKGROUND In cases of coronavirus disease 2019(COVID-19),favipiravir is commonly included to the therapy *** interactions between favipiravir and other COVID-19 therapy drugs are frequently ***,no research on possible drug interactions between Favipiravir and radiocontrast agents,which have become almost crucial in diagnostic processes while not being part of the treatment,has been *** To determine potential medication interactions between Favipiravir and radiocontrast *** The study comprised patients who were taking Favipiravir for COVID-19 therapy and underwent a contrast-enhanced computed tomography(CT)or magnetic resonance imaging(MRI)test while taking the *** computerized patient files of the cases included in the study,as well as the pharmacovigilance forms in the designated hospital,were evaluated for this *** The study included the evaluation of data from 1046 *** study sample's mean age was 47.23±9.48 *** mean age of cases with drug interactions was statistically significant greater than that of cases with no drug interactions(P=0.003).When evaluated with logistic regression analysis,a 1-year raises in age increases the risk of developing drug interactions by 1.63 times(P=0.023).There was no statistically significant difference in the occurrence of medication interactions between the sexes(P=0.090).Possible medication interactions were discovered in 42 cases(4%).CONCLUSION The findings of this study revealed that the most notable findings as a result of the combined use of contrast agents and favipiravir were increased creatinine and transaminase values,as well as an increase in the frequency of nausea and *** majority of drug interactions discovered were modest enough that they were not reflected in the *** interactions become more common as people get older.

关键词： Favipiravir Iohexol Gadoxetic acid Meglumine gadoterate Drug interactions

Prognostic significance of tumor budding,desmoplastic reaction,and lymphocytic infiltration in patients with gastric adenocarcinoma

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 9-25页

作者： Aysen Yavuz Kubra Simsek Anil Alpsoy Busra Altunay Elif Ocak Gedik Betul Unal Cumhur Ibrahim Bassorgun Ali Murat Tatli Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye Department of Medical Oncology Akdeniz University Medical SchoolAntalya 07070Türkiye

BACKGROUND Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid *** this context,Accumulated data suggests that pathological evaluation of tumor budding(TB),desmoplastic reaction(DR),and tumor-infiltrating lymphocytes(TILs)may be crucial in determining tumor behavior in the gastrointestinal *** gastric adenocarcinoma(GAC),although some results suggest that TB and TILs may be effective in determining the course of the disease,the data do not ***,very few studies have investigated the relationship between DR and *** present,the associations between tumor TB,DR and TILs in GAC patients have not been *** To establish the relationships between TB,DR,and TILs in patients with GAC and to assess their influence on *** Our study group comprised 130 patients diagnosed with *** definition of TB was established based on the International TB Consensus *** DR was categorized into three groups according to the level of tumor stroma *** assessment of TILs was conducted using a semiquantitative approach,employing a cutoff value of 5%.The statistical analysis of the whole group and 100 patients with an intestinal subtype of GAC was performed using SPSS version *** A significant correlation between peritumoral budding(PTB)and intratumoral budding(ITB)was noted(r=0.943).Tumors with high PTBs and ITBs had a greater incidence of immature DRs and low TILs(P<0.01).PTB and ITB were associated with histological subtype,lymph node metastasis(LNM),and stage(P<0.01).ITB,PTB,LNM,DR,and stage were significant risk factors associated with poor *** multivariate Cox regression analysis identified ITB,PTB,and LNM as independent prognostic variables(P<0.05).In intestinal-type adenocarcinomas,a positive correlation between PTB and ITB was noted(r=0.972).While univariate analysis revealed that LNM,stage,PTB,ITB,and DR were strong parameters for pred

关键词： Gastric cancer Tumor budding Desmoplastic stroma Tumor-infiltrating lymphocytes Prognosis

Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system:An update

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World Journal of Gastroenterology 2022年第8期28卷 794-810页

作者： Gulsum ozlem Elpek Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Mixed neuroendocrine-nonneuroendocrine neoplasms(Mi NENs)of the digestive tract are a rare heterogeneous group of tumors that present many challenges in terms of diagnosis and *** the years,the diagnostic criteria,classification,and clinical behavior of these tumors have been the subjects of ongoing debate,and the various changes in their nomenclature have strengthened the challenges associated with Mi *** review is performed to provide an understanding of the key factors involved in the evolution of the designation of these tumors as Mi NEN,highlight the current diagnostic criteria,summarize the latest data on pathogenesis and provide information on available ***,this work seeks to increase the awareness about these rare neoplasms by presenting the clinicopathological features and prognostic factors that play important roles in their behavior and discussing their different regions of origin in the gastrointestinal system(GIS).Currently,the Mi NEN category also includes tumors in the GIS with a nonneuroendocrine component and epithelial tumors other than adenocarcinoma,depending on the organ of *** is based on the presence of both morphological components in more than 30%of the ***,this value needs to be reconfirmed with further studies and may be a limiting factor in the diagnosis of Mi NEN by ***,available clinicopathological data suggest that the inclusion of amphicrine tumors in the definition of Mi NEN is not supportive and warrants further *** diagnosis of these tumors is not solely based on immunohistochemical *** are not hybrid tumors and both components can act independently;thus,careful grading of each component separately is *** addition to parameters such as the metastatic state of the tumor at the time of diagnosis and the feasibility of surgical resection,the aggressive potential of both components has paramount importance in the choice of treatment.R

关键词： Mixed neuroendocrine–nonneuroendocrine neoplasms Mixed adeno neuroendocrine carcinoma Gastrointestinal system Liver Pancreas Gallbladder

Epidemiology and etiology of chemical ocular injury:A brief review

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World Journal of Clinical Cases 2023年第6期11卷 1245-1251页

作者： Zeynep Akgun ozlem Barut Selver Department of Ophthalmology Ege University Faculty of MedicineIzmir 35100Turkey

Chemical ocular injury is one of the common ophthalmologic emergencies that can cause vision loss and serious *** all protective measures,it continues to be a serious public health problem,especially in young male *** it is known that injuries occur most frequently in the workplace and in young male patients,there is a variable frequency and distribution in different regions around the *** addition,with the coronavirus disease 2019 pandemic,there are changing trends in ocular chemical *** review aims to specify an update on the epidemiological and etiological features of ocular chemical injuries.

关键词： Chemical ocular injury Alkaline Acid COVID-19 Epidemiology Etiology

Role of natural products and intestinal flora on type 2 diabetes mellitus treatment

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World Journal of Clinical Cases 2023年第1期11卷 65-72页

作者： ozlem Celik Aydin Sonay Aydın Sureyya Barun Department of Medical Pharmacology Erzincan Mengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Radiology Erzincan Binali Yıldırım UniversityMengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Medical Pharmacology Gazi University Faculty of MedicineAnkara 06500Turkey

Diabetes mellitus(DM)is a complicated,globally expanding disease that is influenced by hereditary and environmental *** in modern society’s food choices,physical inactivity,and obesity are significant factors in the development of type 2 DM(T2DM).The association between changes in intestinal flora and numerous disorders,including obesity,diabetes,and cardiovascular diseases,has been studied in recent *** purpose of this review is to analyze the mechanisms underlying the alteration of the diabetic patients’intestinal flora,as well as their therapeutic *** included is a summary of the antidiabetic benefits of natural compounds demonstrated by *** short-chain fatty acids theory,the bile acid theory,and the endotoxin theory are all potential methods by which intestinal flora contributes to the establishment and progression of *** to an intestinal flora imbalance,abnormalities in shortchain fatty acids and secondary bile acids have been found in diabetic ***,metabolic endotoxemia with altering flora induces a systemic inflammatory response by stimulating the immune system via bacterial *** agenda for diabetes treatment includes the use of short-chain fatty acids,probiotics,prebiotics in the diet,fecal bacteria transplantation,and *** studies have proven the antidiabetic benefits of numerous bioactive substances,including Flavonoids,Alkaloids,Saponin,and ***,further research is required to contribute to the treatment of diabetes.

关键词： Diabetes mellitus Intestinal flora Natural products Endotoxemia Bioactive compounds Probiotics

A 3D in vitro co-culture model for evaluating biomaterial-mediated modulation of foreign-body responses

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Bio-Design and Manufacturing 2022年第3期5卷 465-480页

作者： Betul Cakmak Pelin Saglam-Metiner Goze Beceren Yu S.Zhang ozlem Yesil-Celiktas Department of Bioengineering Faculty of EngineeringEge University35100 IzmirTurkey Division of Engineering in Medicine Brigham and Women’s HospitalDepartment of MedicineHarvard Medical SchoolCambridgeMAUSA

The immune response after implantation of a biomaterial may shorten the functional life of the implant,depending on the degree of the *** this study,we used a polyacrylamide-alginate(PAAm-Alg)hydrogel,which has been previously characterized as a biocompatible material and shown to enhance regeneration of cartilage in vivo,along with a graphiteenhanced hydrogel(PAAm-Alg-G)as a non-biocompatible counterpart,to evaluate macrophage attachment and polarization to pro-or anti-inflammatory *** performance of each biomaterial in the presence of fibroblasts and chondrocytes was validated by an in vitro model which demonstrated modulation of the foreign-body response.A blend of 5%gelatin methacryloyl and 0.1%methacrylated hyaluronic acid was optimized to mimic the extracellular matrix(ECM)and support cell viability,proliferation,migration,and functionality at an initial concentration of 3.25×10^(5) cells/*** PAAm-Alg-G hydrogel localized in the simulated ECM showed cytotoxic and genotoxic effects for both fibroblasts and chondrocytes,while exhibiting a proliferative effect on macrophages with elevated immune *** M1/M2 ratio was 0.73 for PAAm-Alg hydrogel but 2.64 for PAAm-Alg-G,leading to significant M1 dominance(p0.05).The interleukin-6(IL-6)concentration secreted in the presence of PAAm-Alg hydrogel(4.58 pg/mL)significantly decreased(p<0.0001)on day 13,while the increase(p<0.0001)in interleukin-10(IL-10)concentration(120.73 pg/mL)confirmed the switch from a pro-inflammatory to an anti-inflammatory *** immune responses by developing a simplistic yet powerful three-dimensional in vitro model provides advantages in preparing for clinical use of biomaterials.

关键词： Biomaterial Macrophage polarization Genotoxicity Biocompatibility Immune response