Role of natural products and intestinal flora on type 2 diabetes mellitus treatment
作者机构：Department of Medical PharmacologyErzincan Mengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of RadiologyErzincan Binali Yıldırım UniversityMengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Medical PharmacologyGazi University Faculty of MedicineAnkara 06500Turkey
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2023年第11卷第1期
页 面：65-72页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Diabetes mellitus Intestinal flora Natural products Endotoxemia Bioactive compounds Probiotics
摘 要：Diabetes mellitus(DM)is a complicated,globally expanding disease that is influenced by hereditary and environmental *** in modern society’s food choices,physical inactivity,and obesity are significant factors in the development of type 2 DM(T2DM).The association between changes in intestinal flora and numerous disorders,including obesity,diabetes,and cardiovascular diseases,has been studied in recent *** purpose of this review is to analyze the mechanisms underlying the alteration of the diabetic patients’intestinal flora,as well as their therapeutic *** included is a summary of the antidiabetic benefits of natural compounds demonstrated by *** short-chain fatty acids theory,the bile acid theory,and the endotoxin theory are all potential methods by which intestinal flora contributes to the establishment and progression of *** to an intestinal flora imbalance,abnormalities in shortchain fatty acids and secondary bile acids have been found in diabetic ***,metabolic endotoxemia with altering flora induces a systemic inflammatory response by stimulating the immune system via bacterial *** agenda for diabetes treatment includes the use of short-chain fatty acids,probiotics,prebiotics in the diet,fecal bacteria transplantation,and *** studies have proven the antidiabetic benefits of numerous bioactive substances,including Flavonoids,Alkaloids,Saponin,and ***,further research is required to contribute to the treatment of diabetes.
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