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Contemporary treatment approaches for metastatic colorectal cancer driven by BRAF V600 mutations

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1080-1090页

作者： ozkan kanat Hulya Ertas Burcu Caner Department of Medical Oncology Acıbadem Bursa HospitalBursa 16059Turkey Department of Medical Oncology Bursa City HospitalBursa 16059Turkey Department of Medical Oncoloy Balıkesir Ataturk City HospitalBursa 16059Turkey

The treatment of metastatic colorectal cancer(mCRC)harboring BRAF V600 mutations is *** tumors are often refractory to standard ***,the patients may exhibit rapid clinical deterioration,depriving them of the chance to receive salvage *** newly diagnosed patients with good performance status,the administration of an intensive chemotherapy regimen like FOLFOXIRI(5-fluorouracil,leucovorin,oxaliplatin,and irinotecan)along with the antiangiogenic agent bevacizumab can modify this aggressive behavior of the disease and improve patient clinical *** recently published results of the BEACON(Binimetinib,Encorafenib,and Cetuximab Combined to Treat BRAF-Mutant Colorectal Cancer)study demonstrated that a combination therapy consisting of BRAF,epidermal growth factor receptor,and mitogen-activated protein kinase kinase inhibitors could be a useful second-or third-line *** review summarizes the current treatment strategies for BRAF-mutant mCRC.

关键词： BRAF mutation V600 mutations Metastatic colorectal cancer Targeted therapies

Shattering the castle walls: Anti-stromal therapy for pancreatic cancer

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World Journal of Gastrointestinal Oncology 2018年第8期10卷 202-210页

作者： ozkan kanat Hulya Ertas Department of Medical Oncology Faculty of Medicine Uludag University

Despite the availability of potent chemotherapy regimens, such as 5-fluorouracil, folinic acid, irinotecan, and oxaliplatin(FOLFIRINOX) and nab-paclitaxel plus gemcitabine, treatment outcomes in metastatic pancreatic cancer(PC) remain unsatisfactory. The presence of an abundant fibrous stroma in PC is considered a crucial factor for its unfavorable condition. Apparently, stroma acts as a physical barrier to restrict intratumoral cytotoxic drug penetration and creates a hypoxic environment that reduces the efficacy of radiotherapy. In addition, stroma plays a vital supportive role in the development and progression of PC, which has prompted researchers to assess the potential benefits of agents targeting several cellular(e.g., stellate cells) and acellular(e.g., hyaluronan) elements of the stroma. This study aims to briefly review the primary structural properties of PC stroma and its interaction with cancer cells and summarize the current status of antistromal therapies in the management of metastatic PC.

关键词： Pancreatic cancer Stroma Stellate cells Hyaluronan Secreted protein acidic and rich in cysteine

Targeted therapy for advanced gastric cancer: A review of current status and future prospects

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 401-410页

作者： ozkan kanat Bert O'Neil Safi Shahda Department of Medical Oncology Uludag University faculty of Medicine Simon Cancer Center Indiana University School of Medicine

In the West in particular, the vast majority of gastric cancer(GC) patients present with advanced-stage disease. Although combination chemotherapy is stillthe most important component of treatment for these patients, it confers a modest survival advantage. Recently, increased knowledge of the key molecular signaling pathways involved in gastric carcinogenesis has led to the discovery of specific molecular-targeted therapeutic agents. Some of these agents such as trastuzumab and ramucirumab have changed the treatment paradigm for this disease. In this paper, we will summarize the current clinical status of targeted drug therapy in the management of GC.

关键词： Gastric cancer Targeted therapy Angiogenesis Epide

Dual HER2 inhibition strategies in the management of treatment-refractory metastatic colorectal cancer:History and status

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World Journal of Clinical Cases 2018年第11期6卷 418-425页

作者： ozkan kanat Hulya Ertas Burcu Caner Department of Medical Oncology Faculty of MedicineUludag University

Human epidermal growth factor receptor 2(HER2) signaling pathway activation has been identified as a contributor to de novo or acquired resistance to epidermal growth factor receptor(EGFR) inhibitors in a small subset of patients with metastatic colorectal cancer(mCRC). Dual anti-HER2-targeted treatment exhibits strong antitumor activity in preclinical models of HER2-positive mCRC, supporting its testing in clinical trials. The HERACLES trial at four Italian academic cancer centers has confirmed the effectiveness of dual blockage of HER2 with trastuzumab plus lapatinib in patients with heavily pretreated HER2-positive mCRC, refractory to the anti-EGFR antibodies cetuximab or panitumumab. Here, we reviewed the preclinical studies exploring the role of HER2 signaling in the development of anti-EGFR therapy resistance and discussed the status of clinical trials assessing the activity of HER2 inhibitors in this setting.

关键词： Epidermal growth factor receptor Cetuximab Panitumumab Human epidermal growth factor receptor 2 Anti-epidermal growth factor receptor resistance Trastuzumab Dual inhibition

Platinum-induced neurotoxicity: A review of possible mechanisms

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World Journal of Clinical Oncology 2017年第4期8卷 329-335页

作者： ozkan kanat Hulya Ertas Burcu Caner Department of Medical Oncology Uludag University Faculty of Medicine

Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despitediscontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is the most common presentation of platinum neurotoxicity. DNA damage-induced apoptosis of dorsal root ganglion(DRG) neurons seems to be the principal cause of neurological symptoms. However, DRG injury alone cannot explain some unique symptoms such as cold-aggravated burning pain affecting distal extremities that is observed with oxaliplatin administration. In this article, we briefly reviewed potential mechanisms for the development of platinum drugs-associated neurological manifestations.

关键词： Cisplatin Dorsal root ganglion Mechanism Oxaliplatin Neurotoxicity Neuropathic pain Sodium channel

Existing anti-angiogenic therapeutic strategies for patients with metastatic colorectal cancer progressing following first-line bevacizumab-based therapy

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World Journal of Clinical Oncology 2019年第2期10卷 52-61页

作者： ozkan kanat Hulya Ertas Department of Medical Oncology Faculty of Medicine Uludag University

Continuous inhibition of angiogenesis beyond progression is an emerging treatment concept in the management of metastatic colorectal cancer patients with prior bevacizumab exposure. Treatment options include the continuation or reintroduction of bevacizumab during the second-line chemotherapy or switching to a different antiangiogenic monoclonal antibody such as aflibercept or ramucirumab. In the selection of treatment, patient-based factors such as performance status, age, tumor burden, and tolerance and sensitivity to the firstline bevacizumab-based therapy, as well as treatment-related factors such as toxicity, efficacy, and cost, should be taken into consideration.

关键词： Angiogenesis inhibition Second-line chemotherapy Colorectal cancer Bevacizumab Aflibercept Ramucirumab

Splenic hemangiopericytoma and serosal cavernous hemangiomatosis of the adjacent colon

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World Journal of Gastroenterology 2005年第26期11卷 4111-4113页

作者： Tuncay Yilmazlar Turkay Kirdak Omer Yerci Saduman B.Adim ozkan kanat Osman Manavoglu Department of General Surgery Uludag University School of Medicine Gorukle Bursa 16059 Turkey Department of Pathology Uludag University School of Medicine Gorukle Bursa 16059 Turkey Department of Medical Oncology Uludag University School of Medicine Gorukle Bursa 16059 Turkey

A healthy 31-years-old man presented with a three-year history of abdominal discomfort. Radiological examinations revealed multifocal tumoral lesions in the spleen. The patient underwent splenectomy for differential diagnosis and treatment. During the operation, in addition to the splenic masses, there were also multiple milimetric purpuric-like lesions on the colonic serosal surfaces adjacent to the splenic hilus. One of them was excised. Histologic examination showed hemangiopericytoma of the spleen and cavernous hemangioma of the adjacent colon. This is the first report showing the close association of these two distinct lesions with vascular origin in the literature. Despite not having any apparent evidence, there may be a sequential relationship between the hemangiopericytoma of the spleen and cavernous hemangiomas.

关键词： Hemangiopericytoma of the spleen Cavernous hemangiomatosis

Singular and non-topological soliton solutions for nonlinear fractional differential equations

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Chinese Physics B 2015年第10期24卷 10-15页

作者： ozkan Guner Cankiri Karatekin University Faculty of Economics and Administrative SciencesDepartment of International Trade

In this article, the fractional derivatives are described in the modified Riemann-Liouville sense. We propose a new approach, namely an ansatz method, for solving fractional differential equations（FDEs） based on a fractional complex transform and apply it to solve nonlinear space-time fractional equations. As a result, the non-topological as well as the singular soliton solutions are obtained. This method can be suitable and more powerful for solving other kinds of nonlinear fractional FDEs arising in mathematical physics.

关键词： solitons ansatz method the space-time fractional Boussinesq equation the space-time fractional(2+l)-dimensional breaking soliton equations

Exp-Function Method and Fractional Complex Transform for Space-Time Fractional KP-BBM Equation

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Communications in Theoretical Physics 2017年第8期67卷 149-154页

作者： ozkan Guner Cankiri Karatekin University Faculty of Economics and Administrative Sciences Department of International Trade

In the present article, He＇s fractional derivative, the ansatz method, the （ C / G）-expansion method, and the exp-function method are used to construct the exact solutions of nonlinear space-time fractional Kadomtsev-Petviashvili- Benjamin-Bona Mahony （KP-BBM）. As a result, different types of exact solutions are obtained. Also we have examined the relation between the solutions obtained from the different methods. These methods are an efficient mathematical tool for solving fractional differential equations （FDEs） and it can be applied to other nonlinear FDEs.

关键词： ansatz method exp-function method He's fractional derivative (G'/G)-expansion method spacetime fractional KP-BBM equation