Targeted therapy for advanced gastric cancer: A review of current status and future prospects

作     者：Ozkan Kanat Bert O'Neil Safi Shahda 

作者机构：Department of Medical Oncology Uludag University faculty of Medicine Simon Cancer Center Indiana University School of Medicine 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2015年第7卷第12期

页      面：401-410页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastric cancer Targeted therapy Angiogenesis Epide 

摘      要：In the West in particular, the vast majority of gastric cancer(GC) patients present with advanced-stage disease. Although combination chemotherapy is stillthe most important component of treatment for these patients, it confers a modest survival advantage. Recently, increased knowledge of the key molecular signaling pathways involved in gastric carcinogenesis has led to the discovery of specific molecular-targeted therapeutic agents. Some of these agents such as trastuzumab and ramucirumab have changed the treatment paradigm for this disease. In this paper, we will summarize the current clinical status of targeted drug therapy in the management of GC.