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Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)

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World Journal of Gastroenterology 2009年第1期15卷 112-116页

作者： Gokhan Adas Soykan Arikan ozgur kemik Ali Oner Nilgun Sahip Oguzhan Karatepe Okmeydani Training Hospital Okmeydani/SisliIstanbul 34715 Turkey

AIM： TO establish which scolicidal agents are superior and more suitable for regular use. METHODS： Echinococcus granu/osus protoscoleces were obtained from 25 patients with liver hydatid cysts. Various concentrations of albendazole sulfone, albendazole sulfoxide, and albendazole sulfone and albendazole sulfoxide mixed together in concentrations of 50 μg/mL, and H202 in a concentration of 4%, NaCI 20%, and 1.5% cetrimide-0.15% chlorhexidine （10% Savlon-Turkey） were used to determine the scolicidal effects. Albendazole （ABZ） derivatives and other scolicidal agents were applied to a minimum of 100 scoleces for 5 and 10 min. The degree of viability was calculated according to the number of living scolices per field from a total of 100 scolices observed under the microscope. RESULTS： After 5 min, ABZ sulfone was 97.3% effective, ABZ sulfoxide was 98.4% effective, and the combined solution was 98.6% effective. When sulfone, sulfoxide and the combined solutions were compared, the combined solution seemed more effective than sulfone. However, there was no difference when the combined solution was compared with sulfoxide. After 10 min, hypertonic salt water, sulfone, sulfoxide, and the combined solution compared to other solutions looked more effective and this was statistically significant on an advanced level. When sulfone, sulfoxide, and the combined solutions were compared with each other, the combined solution appeared more effective than sulfone. When the combined solution was compared with sulfoxide, there was no difference. CONCLUSION： Despite being active, ABZ metabolites did not provide a marked advantage over 20% hypertonic saline. According to these results, we think creating a newly improved and more active preparation is necessary for hydatid cyst treatment.

关键词： Hydatid disease AIbendazole In vitrostudy Combined solution Scolicidal agents

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Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer

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World Journal of Gastroenterology 2011年第16期17卷 2109-2112页

作者： ozgur kemik Ahu Sarbay kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan Department of General Surgery Yuzuncu Y1l University Medical Faculty Department of Biochemistry Cerrahpasa Medical Faculty University of Istanbul Department of Gastroenterology Medical FacultyUniversity of Yüzüncü Y1l Department of Endocrinology Okmeydani Education and Research Hospital Department of Internal Medicine Medical FacultyUniversity of Yüzüncü Y1l Department of Biostatistics Istanbul Medical FacultyUniversity of Istanbul II.General Surgery Haseki Education and Research Hospital

AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric ***:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this *** serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent ***:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological *** were not significantly associated with age,gender,tumor location,or histological ***:Increased MMP-1 and TIMP-1 were associated with gastric *** these markers are not good markers for diagnosis,these markers show in advanced gastric cancer.

关键词： Gastric cancer Matrix metalloproteinase-1 Tissue matrix metalloproteinase-1

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