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采油工艺情报 1995年第3期 78-83页

作者： osma.,ms 吕佳祥

Chronic hepatitis B virus infection in Eastern Ethiopia:Clinical characteristics and determinants of cirrhosis

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World Journal of Hepatology 2024年第7期16卷 995-1008页

作者： Nejib Y Ismael Semir A Usmael Nega B Belay Hailemichael Desalegn Mekonen Asgeir Johannessen Stian ms Orlien Haramaya University College of Health and Medical SciencesHarar 252Ethiopia Aklilu Lemma Institute of Pathobiology Addis Ababa UniversityAddis Ababa 1000Ethiopia Regional Centre for Imported and Tropical Diseases Oslo University HospitalOslo 0450UllevålNorway Internal Medicine Gastroenterology and Hepatology UnitSaint Paul’s Hospital Millennium Medical CollegeAddis Ababa 1000Ethiopia Department of Infectious Disease Vestfold Hospital TrustTønsberg 3103Norway Institute of Clinical Medicine Oslo UniversityOslo 0318Norway Department of PediatricsOslo UniversityOslo 0450UllevålNorway

BACKGROUND Chronic hepatitis B(CHB)virus infection is a major cause of liver-associated morbidity and mortality,particularly in low-income countries.A better understanding of the epidemiological,clinical,and virological characteristics of CHB will guide appropriate treatment strategies and improve the control and management of CHB in *** To investigate the characteristics of CHB in Eastern Ethiopia and assess the efficacy and safety of antiviral *** This cohort study included 193 adults who were human immunodeficiency virus-negative with CHB between June 2016 and December *** assessments included chemistry,serologic,and viral markers.χ^(2) tests,Mann-Whitney U tests,and logistic regression analyses were used to identify the determinants of *** disoproxil fumarate(TDF)was initiated using treatment criteria from the Ethiopian CHB pilot *** A total of 132 patients(68.4%)were men,with a median age of 30 years[interquartile range(IQR):24-38].At enrollment,60(31.1%)patients had cirrhosis,of whom 35(58.3%)had decompensated *** use,hepatitis B envelope antigen positivity,and a high viral load were independently associated with ***,66 patients(33.4%)fulfilled the treatment criteria and 59(30.6%)started *** 29 patients who completed 24 months of treatment,the median aspartate aminotransferase to platelet ratio index declined from 1.54(IQR:0.66-2.91)to 1.10(IQR:0.75-2.53)(P=0.002),and viral suppression was achieved in 80.9%and 100%of patients after 12 months and 24 months of treatment,*** the treated patients,12(20.3%)died within the first 6 months of treatment,of whom 8 had decompensated *** This study highlights the high prevalence of cirrhosis,initial mortality,and the efficacy of TDF *** up measures to prevent and control CHB infections in Ethiopia is crucial.

关键词： Chronic hepatitis B Cirrhosis Cohort study Resource-limited settings Sub-Saharan Africa

高特异性σ2R/TMEM97配体FEM-1689可减轻神经病理性疼痛并抑制整合应激反应

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中国疼痛医学杂志 2024年第3期30卷 161-165页

作者：龙沙沙(译) 韩清见(校) 复旦大学脑科学研究院

在药理学界,σ2受体(σ2R)早在30多年前就被描述过,但其分子特征仍模糊不清,直到最近才被确认为跨膜蛋白97 (TMEM97)。经研究证明σ_(2)R/TMEM97配体可减轻小鼠神经病理性疼痛模型的机械超敏反应,其最大抗痛作用的时间为给药后24 h。该... 详细信息

在药理学界,σ2受体(σ2R)早在30多年前就被描述过,但其分子特征仍模糊不清,直到最近才被确认为跨膜蛋白97 (TMEM97)。经研究证明σ_(2)R/TMEM97配体可减轻小鼠神经病理性疼痛模型的机械超敏反应,其最大抗痛作用的时间为给药后24 h。该研究试图通过解决2个关键问题来了解其抗神经病理性疼痛效应:σ_(2)R/TMEM97化合物是否通过受体选择性地发挥作用,以及它们对痛觉神经元的下游机制是什么?该研究使用了一种Tmem97全身基因敲除小鼠,发现σ_(2)R/TMEM97结合化合物FEM-1689,需要该基因才能在小鼠神经损伤模型中产生抗痛作用。利用小鼠背根神经节原代神经元证明,FEM-1689能抑制整合应激反应(ISR),并通过σ_(2)R/TMEM97特异性作用促进神经元生长。随后,该研究扩展了其临床转化价值,证明FEM-1689可降低人类感觉神经元中的整合应激反应(ISR)和p-eIF2α水平,并可减轻甲基乙二醛对ISR的致病作用。同时,研究还证明了σ_(2)R/TMEM97在人类痛觉感受器和卫星胶质细胞中均有表达。这些结果证实了σ_(2)R/TMEM97有希望成为治疗神经病理性疼痛的靶点。

关键词：抗痛作用特异性作用受体选择性痛觉感受器甲基乙二醛神经病理性疼痛痛觉神经高特异性

Carbon dioxide fixation into cyclic carbonates at room temperature catalyzed by heteroscorpionate aluminum complexes

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Green Chemical Engineering 2022年第3期3卷 280-287页

作者： Felipe de la Cruz-Martinez Jose A.Castro-osma.Agustin Lara-Sanchez Universidad de Castilla-La Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de Ciencias y Tecnologias QuimicasCiudad Real13071Spain Instituto de Investigaciones Quimicas(IIQ) Departamento de Quimica Inorganica and Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Consejo Superior de Investigaciones Cientificas(CSIC)and University of SevillaSevilla41092Spain Universidad de Castilla-La Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de FarmaciaAlbacete02071Spain

Novel mono-and bimetallic scorpionate aluminum compounds have been designed and characterized by spec-troscopic *** organometallics complexes,in combination with tetrabutylammonium bromide as cocatalyst,displayed good catalytic activity for the cycloaddition of styrene oxide and CO_(2) under ambient *** the compounds tested,monometallic complex 3 featuring diethylamino groups showed the highest catalytic *** catalytic system catalyzed the formation of cyclic carbonate products from their corresponding epoxides at room temperature and 1 bar of CO_(2) pressure in the absence of a solvent in good yields and excellent selectivities.

关键词： CO_(2) Epoxides Cyclic carbonates Aluminum complexes

Early Childhood Care and Education Policies ——A Comparative Analysis between China and Zambia

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Early Childhood Care and Education Policies ——A Comparativ...

作者： Siabalima osma.Nzila（奥斯马）东北师范大学

学位级别：硕士

The purpose of this study was to analyze, compare and contrast similarities and differences of current government policies of ECCE in China and Zambia. The research has argued that, policy development is a major step to implementing equitable programs for young children. Therefore, governments need to fully support ECCE initiatives to help all children realize their full potential and accord them an opportunity to lead better and productive adult life. The main instrument for the exploration of the study was a comparative and interpretive analysis based on data collected using semi-structured interviews with senior government officials and high ranking stakeholders in ECCE as well as reviewed literature and personal reflections.Findings from this study concur with published literature that investing in the young offers outstanding returns both in human, financial and economic returns. Findings show increased access and recognition of ECCE although in country differences prevail and are mostly dominated by the private sector. However, there are no stand alone ECCE policy documents, though recognized and recommended in both countries, it is not free and compulsory. A lot of work remains pending on government's agenda and civil society to achieve this EFA goal. The study also revealed that the major setback has been the absence and fragmented policies to inform practice (Zambia), the inadequate allocation of resources to early childhood work, cultural and traditional preferences of raising children and the general low political will to put children first. The research therefore recommends that the ministries of education guide policy formulation, coordination and improve practice, scale up participation of the private sector and enhance promotion of ECCE and its core values.

关键词： Early Childhood Policy Education Care China Zambia

Collapse period of degrading SDOF systems

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Earthquake Engineering and Engineering Vibration 2014年第4期13卷 681-694页

作者： Borekci M Kircil ms Ekiz I Yildiz Technical University

Seismic demand estimation for a structure is a critical issue for seismic performance assessment so that the potential damage can be estimated realistically. Many researchers proposed simplified methods to estimate the demand of a structure under strong ground motions. However, most of them did not consider degradation and collapse potential of the structures. Even some of theme considered the degradation effect, stiffness and strength degradation effects were considered separately without collapse potential caused by dynamic instability. In this study, collapse potential of SDOF systems caused by dynamic instability with stiffness and strength degradation has been investigated. Nonlinear time history analyses were performed, using an energy-based, strength and stiffness degraded hysteretic model that considers the collapse potential, with 160 earthquake acceleration time histories. An equation was proposed for the estimation of collapse period of SDOF systems as a function of certain strength reduction factor, ductility level and post-capping stiffness ratio. Finally, effects of parameters of the considered hysteretic model and local site conditions on the collapse period were investigated.

关键词： collapse degradation dynamic instability hysteretic types,earthquake

Maternal and Perinatal Prognosis of Arterial Hypertension and Pregnancy in a Peripheral Health Center in Mali

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 855-867页

作者： Samaké Alou Diarra Lasseny Keita Mamadou Haidara Dramane Haidara Mamadou Diallo Mamadou Konaté Moussa Maiga Mariam ms Ag Med Elméhdi Elansari Kassogue Djibril Dao Seydou Zana Samake Hawa Konate Karim Dembele Bertin Coulibaly Moussa Mariko Seydou Colette Dohinnon Reference Health Center in Commune VI of the Bamako District Bamako Mali Bamako Dermatology Hospital (HDB) Bamako Mali Kalaban Coro Reference Health Center Bamako Mali Timbuktu Hospital Timbuktu Mali Reference Health Center of Commune II of the Bamako district Bamako Mali Reference Health Center in Commune V of the Bamako district Bamako Mali National Institute for Training in Health Sciences Bamako Mali Mali Hospital Bamako Mali

Introduction: Maternal mortality constitutes a public health problem and its rate is an indicator of a country’s development. Among the causes of maternal and perinatal death, high blood pressure associated with pregnancy occupies a significant part. It represents 5% of direct maternal deaths. Objective: to study the maternal and perinatal prognosis of high blood pressure during pregnancy in the Tenenkou reference health center in Mali. Methodology: This was a descriptive, analytical and retrospective cross-sectional study over a period of twelve months from January 1, 2021 to December 31, 2021 and involving 144 cases of high blood pressure associated with pregnancy. Results: We obtained a frequency of 11.75%. The majority of patients 70.9% were aged between 20 - 35 years. The important risk factor found was young age. During our study, 46.5% of patients had performed at least one CPN and only 13.9% performed 04 CPN. Pre-eclampsia was the most common type of high blood pressure during pregnancy, i.e. 61.1%. Eclampsia and retroplacental hematoma were the most common maternal complications, respectively 27.8% and 11.1%. The most common fetal complications were premature births and fetal distress with 20.9% and 17.4% respectively. Conclusion: Hypertension associated with pregnancy still remains a major cause of maternal-fetal morbidity and mortality in our context where diagnosis is often late. The main clinical form was preeclampsia. Eclampsia and retroplacental hematoma were the most frequent maternal complications. Fetal complications were mainly prematurity and fetal distress.

关键词： Pregnancy High Blood Pressure Prognosis

Rheological Behavior of Polymer Melts and Concentrated SolutionsPart V: A New Molecular Theory of Non-linear Viscoelasticity for Polymeric Suspensions

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Journal of Materials Science & Technology 1999年第2期15卷 169-177页

作者： Song, ms Zhou, W Hu, GX Hu, LJ Beijing Univ Chem Technol Inst Polymer Mat Beijing 100029 Peoples R China Harbin Inst Technol Dept Appl Chem Harbin 150001 Peoples R China

A double-network model is established, which consists of the segments, E and A-constituent chains, the polymeric chains entangled with other ones by multi-entanglement and polymeric chains connected to a great number of destructible particles by multi-adsorption, based on which the E and A-constituent chains can be recreated and released dynamically. The distribution function of the end-to-end vector, the statistical distribution function of conformation for two kinds of chains in the multi-entanglement and multi-adsorption states and their number of polymeric chains are calculated by the combination of statistical mechanics and kinetics. Then the viscoelastic free energies of deformation for two kinds of the networks and suspensions are calculated by Boltzmann's statistical theory. Also, elastic modulus and memory function for two kinds of the network and suspensions are derived. Consequently, a new molecular theory df the non-linear viscoelasticity for polymeric suspensions is proposed, and the constitutive equation and material function with yielding and thinning for the polymeric suspensions in different flow fields are derived from this theory.

关键词： Polymers

Two New Sesquiterpenes from Ligularia Intermedia

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Chinese Chemical Letters 1996年第12期7卷 1100-1102页

作者： Chen, HM Cai, ms Jia, ZJ BEIJING MED UNIV SCH PHARMACEUT SCIBEIJING 100083PEOPLES R CHINA LANZHOU UNIV DEPT CHEMLANZHOU 730000PEOPLES R CHINA

Two new sesquiterpenes were isolated from the rhizomes of Ligularia intermedia. Their structures were determined as eremophil-7(8)-en-12,8(4 beta, 6 alpha)-diolide(1) and eremophil-7(8)-en-12,8(4 beta, 6 beta)-diolide... 详细信息

关键词： New Sesquiterpenes from Ligularia Intermedia Two

Liver inflammatory pseudotumor or parasitic granuloma?

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World Journal of Gastroenterology 2000年第3期6卷 458-460页

作者： Ji XL Shen ms Yin T Gen Hosp Chinese PLA Dept Pathol Beijing 100853 Peoples R China

INTRODUCTION Liver pseudotumor is a very rare benign *** the first case reported by Pack and Baker in1953,only 40 cases had been reported up to *** diagnostic challenge of hepatic inflammatorypseudotumor is emphasized... 详细信息

关键词： inflammatory pseudotumor parasitic granuloma ascariasis larva liver disease