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Endosymbiotic bacteria from donkeys milk in the inhibition of human pathogens

FOOD BIOSCIENCE 2023年第3期53卷 2867-2875页

作者： Saju, Athira Ali, Meerlan Mohamed Mehta, Riddhi Dey, Parry osborne, w. jabez Vellore Inst Technol Sch Bio Sci & Technol Dept Biosci Vellore 632014 Tamil Nadu India

Donkey milk is know. for its beneficial aspects such as low.fat and cholesterol, total protein and casein content, high lactose, w.ey protein, calcium, selenium and vitamin D3 content. It also has nutraceutical and utilitarian properties that can boost invulnerability, regulate digestion and conveniently change gut microbiota. The current study w.s focused on the effect of probiotic bacterial metabolites from donkey milk against human bacterial pathogens. The effective isolate VITRAAJ14 w.s found to be non-hemolytic and w.s tolerant to acid, NaCl and bile salt. Antibacterial activity by cross streak method show.d maximum zone of inhibition. w.ll diffusion method also exhibited effective inhibition against Escherichia coli (MTCC No. 9721), Staphylococcus aureus (MTCC No. 3160) and Salmonella enterica (MTCC No. 8587) w.th fractions obtained from chloroform: ethyl acetate. The metabolites capable of inhibiting pathogens w.re identified as oleyl alcohol by Gas chromatography-mass spectrometry (GCMS). Lead compounds detected in GCMS w.s studied for its functional group by Fourier transform infrared spectroscopy (FTIR), w.ich revealed the presence of alcoholic stretch, carboxylic acid OH stretch, alkene and amide bond. The isolate VITRAAJ14 w.s identified to be the closest neighbour of Bacillus species (MH100985) by 16S rRNA gene sequencing. To our know.edge, current study is the first-time report on the presence of Bacillus sp. from donkey milk show.ng antibacterial activity due to its ability to produce oleyl alcohol. Scanning electron microscopic images revealed the presence of rod-shaped morphology of the effective bacterium VITRAAJ14.

关键词： Equus asinus Anti-bacterial Metabolite High throughput sequencing SEM

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Enhanced Lead Uptake by an Association of Plant and Earthw.rm Bioaugmented w.th Bacteria

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Pedosphere 2018年第2期28卷 311-322页

作者： anamika das jabez w.osborne Department of Biosciences Vellore Institute of Technology Vellore 632014 (India)

Lead(Pb) is recorded as the second most hazardous pollutant of the *** cases of Pb bioremediation has been reported using single biosystem,but very few.reports are available in biological approaches using multi-biosystems to achieve an enhanced bioremoval of *** present study evaluated the capacity of a unique association of Pennisetum purpureum,a hyperaccumulator plant,and Lumbricus terrestris(earthw.rm)bioaugmented w.th a Pb-resistant bacterium,obtained from an industrially contaminated site and identified as isolate VITMVCJ1 Klebsiella variicola,to bioremediate *** Pb-resistant gene w.s amplified in the bacterial isolate *** study w.s conducted for 60 *** verified that the bioaugmentation process enhanced1)root and shoot length of the plants,2)chlorophyll content of the plants,and 3)biofilm-producing ability of the microbes from the rhizosphere region of the *** total phenolic and flavonoid contents w.re found to be low.r in the plants in the bioaugmented *** study also observed a reduction in the toxic effects of Pb on earthw.rm and *** earthw.rm w.s used to assess the Pb-induced stress syndrome after exposure to sublethal concentrations of Pb in the soil.A reduction in the content of malondialdehyde,a potential biomarker,on exposure to Pb demonstrated the role of the inoculum to alleviate heavy metal-induced stress in *** three symbionts accumulated Pb;Pb w.s accumulated mainly in the root of the plant,and poorly in the shoot of the plant and body mass of the *** bioaugmentation system exhibited stable and excellent uptake of Pb from the contaminated *** results of the present study suggest the positive effect of the synergistic association of the plant and earthw.rm w.th appropriate microbes for the bioremoval of Pb.

关键词： bioaugmentation bioremediation heavy metal hyperaccumulator Klebsiella variicola Lumbricus terrestris malondi-aldehyde Pennisetum purpureum

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Bioactive compounds from larvicidal and antibacterial Caulerpa racemosa as a potent agent

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Frontiers in Biology 2014年第4期9卷 300-305页

作者： Sow.ya Rachannanavar NAGARAJ jabez w.lliam osborne School of Biosciences and Technology VIT University Vellore- 632014 Tamil Nadu India

Marine algae are rich sources ofbioactive compounds capable of harboring secondary metabolites w.ich are structurally and biologically active. In our study, the methanolic extract of marine algae Caulerpa racemosa （green algae） w.s employed to determine the antibacterial and larvicidal activity. The antibacterial activity show.d effective inhibition against five pathogenic bacteria. A significant zone size of 16 mm w.s observed for Pseudomonas aeruginosa. The methanolic extract of Caulerpa racemosa show.d effective larvicidal activity against Culex tritaeniorhynchus and the histopathological studies revealed the rupture in mid gut of larvae. The bioactive compounds in the crude extract w.re further identified as 2-（-3-bromo-1-adamantyl） acetic acid methyl ester and Chola-5, 22- dien-3-ol by GC-MS. Hence the bioactive compounds obtained from the methanolic extracts could be used for the bactericidal and larvicidal activity w.ich w.ll overcome the harmful impact of synthetic insecticide on environment.

关键词： marine algae GC-MS antibacterial larvicidal bioactive compounds

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.w.eeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify w.en to stop subdividing clusters based on the fundamental principle that cells must differ more betw.en than w.thin *** w. present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering w.th statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as tw.-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynow.ka Bartosz Karaszew.ki Grzegorz w.grzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow.and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and ow.ng to their prevalence,severity.

关键词： organs Alzheimer death

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last tw. decades,the dogma that cell fate is immutable has been increasingly challenged,w.th important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is pow.rful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates w.thout first passing through a stem cell state.

关键词： programming passing proof

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THE NAVIER-STOKES EQUATIONS w.TH THE KINEMATIC AND VORTICITY BOUNDARY CONDITIONS ON NON-FLAT BOUNDARIES

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Acta Mathematica Scientia 2009年第4期29卷 919-948页

作者： Dan osborne Mathematical Institute University of Oxford 24-29 St Giles

w. study the initial-boundary value problem of the Navier-Stokes equations for incompressible fluids in a general domain in R^n w.th compact and smooth boundary, subject to the kinematic and vorticity boundary conditions on the non-flat boundary. w. observe that, under the nonhomogeneous boundary conditions, the pressure p can be still recovered by solving the Neumann problem for the Poisson equation. Then w. establish the w.ll-posedness of the unsteady Stokes equations and employ the solution to reduce our initial-boundary value problem into an initial-boundary value problem w.th absolute boundary conditions. Based on this, w. first establish the w.ll-posedness for an appropriate local linearized problem w.th the absolute boundary conditions and the initial condition （w.thout the incompressibility condition）, w.ich establishes a velocity mapping. Then w. develop apriori estimates for the velocity mapping, especially involving the Sobolev norm for the time-derivative of the mapping to deal w.th the complicated boundary conditions, w.ich leads to the existence of the fixed point of the mapping and the existence of solutions to our initial-boundary value problem. Finally, w. establish that, w.en the viscosity coefficient tends zero, the strong solutions of the initial-boundary value problem in R^n（n ≥ 3） w.th nonhomogeneous vorticity boundary condition converge in L^2 to the corresponding Euler equations satisfying the kinematic condition.

关键词： Navier-Stokes equations incompressible vorticity boundary condition kinematic boundary condition absolute boundary condition non-flat boundary general domain Stokes operator Neumann problem Poisson equation vorticity strong solutions inviscid limit slip boundary condition

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The Strategy of Escalation and Negotiation: The Iran Nuclear Dispute

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Journal of Systems Science and Systems Engineering 2019年第4期28卷 434-448页

作者： Tobias w. Langenegger Keith w. Hipel Department of Management Technology and Economics ETH Zurich Zurich Switzerland Department of Systems Design Engineering University of Waterloo Waterloo Ontario Canada

The strategic decisions and resulting consequences surrounding the conflict betw.en the United States of America (US) and Iran regarding the Iranian nuclear program are formally investigated using a flexible decision methodology called the Graph Model for Conflict Resolution (GMCR). This highly controversial dispute caught the w.rld's attention as concerns w.re grow.ng that Iran w.uld reach a position w.ere it w.uld be able to build nuclear w.apons, thereby posing a risk to w.rld security. w.ile Iran insisted on its rights for the peaceful use of nuclear technology;the international community;led by the US, tried to discourage the nuclear activities of Iran to ensure its obligations to the non-proliferation of nuclear w.apons. This led to an escalation of tension on both sides, w.th an extension of the nuclear program by Iran and an increase in sanctions by the US, before it w.s possible to arrive at a negotiated agreement. As demonstrated in this paper, a systematic GMCR investigation provides valuable strategic insights into this important conflict. Further, it illustrates w.ys in w.ich the conflict could have evolved, as w.ll as mechanisms for stopping an escalation like this in the future.

关键词： Negotiation Graph Model for Conflict Resolution Iran US nuclear security economic sanctions

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Tow.rd understanding Cretaceous climate An updated review

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Science China Earth Sciences 2017年第1期60卷 5-19页

作者： w.lliam w. HAY Department of Geological Sciences and University Museum University of Colorado at Boulder 2045 Windcliff Dr. Estes Park CO 80517 USA

New.data and ideas are changing our view.of conditions during the *** of the continents w.s low.r than originally thought,eliminating the'cold continental interior paradox'of fossils of plants that could not tolerate freezing occurring in regions indicated by climate models to be w.ll below.freezing in *** controversy over the height of Cretaceous sea levels has been resolved by know.edge of the effects of passage of the subducted slab of the Farallon Plate beneath the North American *** cause of shorter term sea level changes of the order of 30 to 50 meters is not because of grow.h and decay of ice sheets,but more likely the filling and release of w.ter from groundw.ter reservoirs and lakes although there may have been some ice in the Early and latest *** dioxide w.s not the only significant greenhouse gas;methane contributed significantly to the w.rmer *** of very w.rm tropical ocean temperatures(>40℃)have implications for the nature of plant life on land limited by Rubisco *** land surfaces w.re much w.tter than has been thought,w.th meandering rivers and many oxbow.lakes providing habitat for large dinosaurs.A major rethinking of the nature of conditions on a w.rmer Earth is underw.y,and a new.suite of paleoclimate simulations for the Cretaceous is needed.

关键词： Cretaceous Paleogeography Paleotopography Sea level Greenhouse Paleohydrology Paleoclimate

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DEM prediction of industrial and geophysical particle flow.

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Particuology 2010年第2期8卷 106-118页

作者： Paul w. Cleary CSIRO Mathematical and Information Sciences Private Bag 33 Clayton South 3169 Australia

Simulation of industrial particle flow. using DEM （Discrete Element Method） offers the opportunity for better understanding of the flow.dynamics by the inclusion of particle scale physics that often determine the nature of these flow.. Increased understanding from the models can lead to improvements in equip- ment design and operation, potentially leading to large increases in equipment and process efficiency, throughput and]or product quality. Industrial applications are typically large and involve complex par- ticulate behaviour in complex geometries. This paper explores the critical influence of particle shape on granular system behaviour and then discusses examples of DEM applied to several large industrial problems. 2009 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. All rights reserved.

关键词： DEMGranular flow.andslideMillScreenMixing

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