检索结果-南通市图书馆

Interactions of primary insult biomechanics and secondary cascades in spinal cord injury： implications for therapy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第10期12卷 1618-1619页

作者： Michael B.orr john C.Gensel Spinal Cord and Brain Injury Research Center and the Department of Physiology the University of KentuckyLexingtonKYUSA Integrated Biomedical Sciences Graduate Program the University of KentuckyLexingtonKYUSA

The complex and variable nature of traumatic spinal cord inju- ry （SCI） presents a unique challenge for translational research. SCI is not bound by any demographic nor is it limited to specific injury biomechanics.

关键词： SCI Interactions of primary insult biomechanics and secondary cascades in spinal cord injury:implications for therapy

Effect of Hepatitis C Treatment on Renal Function in Liver Transplant Patients

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2018年第4期6卷 391-395页

作者： Mohamed Shoreibah john Romano Ornar T.Sims Yuqi Guo DeAnn Jones Krishna Venkata Vishnu Kommineni Jordan orr Paul Fitzmorris Omar I.Massoud Division of Gastroenterology&Hepatology School of MedicineUniversity of Alabama at BirminghamBirminghamALUSA Department of Internal Medicine School of MedicineUniversity of Alabama at BirminghamBirminghamALUSA Department of Social Work College of Arts and SciencesUniversity of Alabama at BirminghamBirminghamALUSA Department of Health Behavior School of Public HealthUniversity of Alabama at BirminghamBirminghamALUSA Center for AIDS Research School of MedicineUniversity of Alabama at BirminghamBirminghamALUSA School of Social Work University of AlabamaTuscaloosaALUSA Department of Pharmacology University of Alabama at BirminghamBirminghamALUSA Division of Gastroenterology and Hepatology Department of MedicineVanderbilt UniversityNashvilleTNUSA

Background andAims:Hepatitis C Virus(HCV)is uniformly recurrent after liver transplant(LT)and recurrence is associated with an increased risk of *** medications increase the risk of chronic kidney disease,and the presence of chronic kidney disease presents a challenge for HCV treatment in LT *** aim of this study was to assess changes in glomerular filtration rates(GFRs)of LT recipients receiving HCV ***:This is a retrospective study of LT patients who received HCV treatment between 2015 and 2016(n=60).The outcomes of interest were differences in serum creatinine levels and in GFR,measured at treatment initiation and at 24 weeks after *** average age of the patients was 59 years-old,and 17%were cirrhotic and 67%were *** patients received sofosbuvir/ledipasvir without ***:All patients achieved sustained virologic response at 12 weeks after treatment(SVR12).At baseline,55%of patients had GFR60 mL/min per 1.73 *** those patients,GFR did not change in 81%,and 19%had worsened *** the entire cohort,65%of patients had improved or stable GFR and 35%had worsened *** average change in serum creatinine between baseline and 24 weeks was 0.10(p=0.18).Conclusions:This study showed improved or unchanged GFR in 65%and worsened GFR in 35%of LT recipients who achieved *** of GFR was more frequently encountered in those with impaired renal function at *** should be used when treating HCV in LT recipients,especially those with baseline status of renal impairment.

关键词： Hepatitis C Renal function Direct-acting antivirals Liver transplant Treatment

Six steps for building a technological knowledge base for future taxonomic work

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第12期9卷 19-21页

作者： Michael C.orr Anderson Feijó Douglas Chesters Alfried P.Vogler Silas Bossert Rafael R.Ferrari Mark john Costello Alice C.Hughes Lars Krogmann john S.Ascher Xin Zhou De-Zhu Li Ming Bai Jun Chen Deyan Ge Arong Luo Gexia Qiao Paul H.Williams Ai-bing Zhang Keping Ma Feng Zhang Chao-Dong Zhu Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Entomologie Staatliches Museum für Naturkunde Stuttgart Department of Life Sciences Silwood Park Campus Imperial College London Natural History Museum Department of Entomology Washington State University Department of Entomology National Museum of Natural History Smithsonian Institution Faculty of Biosciences and Aquaculture Nord University School of Biological Sciences University of Hong Kong Department of Biological Sciences National University of Singapore Department of Entomology China Agricultural University Germplasm Bank of Wild Species Kunming Institute of Botany Chinese Academy of Sciences College of Life Sciences Capital Normal University Institute of Botany Chinese Academy of Sciences Department of Entomology College of Plant Protection Nanjing Agricultural University State Key Laboratory of Integrated Pest Management Institute of Zoology Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences

Species are the principal category we use to study,understand,and conserve the natural world,so how we define species has a cascading impact across fields,well beyond biology [1].Despite such importance,debate on species concepts continues to this day ([2] 2020),with consequences for what organisms we recognize,study and *** the wealth of life forms on our planet,

关键词：

PARK16 locus:Differential effects of the non-coding rs823114 on Parkinson's disease risk,RNA expression,and DNA methylation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2021年第4期48卷 341-345页

作者： Orly Goldstein Mali Gana-Weisz Fergal Casey Hila Meltzer-Fridrich Or Yaacov Yedael Y.Waldman Dongdong Lin Yael Mordechai Jing Zhu Patrick F.Cullen Nurit Omer Tamara Shiner Avner Thaler Anat Bar-Shira Anat Mirelman Sally john Nir Giladi Avi orr-Urtreger The Genomic Research Laboratory for Neurodegeneration Neurological InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael Biogen IncCambridgeMAUSA NRGene Ltd. Ness-ZionaIsrael Sackler Faculty of Medicine Tel Aviv UniversityIsrael Sackler Faculty of Medicine Sagol School of NeuroscienceTel Aviv UniversityIsrael

Understanding the genetic basis of Parkinson’s disease(PD)has dramatically progressed since the identification of the first genetic mutation in alpha-synuclein,to become a highly complex model of oligogenic disease(L... 详细信息

关键词： PARK al. identification

Bifunctional Oxygen Electrocatalyst of Mesoporous Ni/NiO Nanosheets for Flexible Rechargeable Zn–Air Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2020年第5期12卷 165-176页

作者： Peitao Liu Jiaqi Ran Baorui Xia Shibo Xi Daqiang Gao john Wang Key Laboratory for Magnetism and Magnetic Materials of MOE Key Laboratory of Special Function Materials and Structure Design of MOELanzhou UniversityLanzhou 730000People’s Republic of China Institute of Chemical and Engineering Sciences A*STAR1 Pesek RoadJurong Island 627833Singapore Department of Material Science and Engineering National University of SingaporeEngineering Drive 3Singapore 117575Singapore

One approach to accelerate the stagnant kinetics of both the oxygen reduction and evolution reactions(orr/OER)is to develop a rationally designed multiphase nanocomposite,where the functions arising from each of the constituent phases,their interfaces,and the overall structure are properly ***,we successfully synthesized an oxygen electrocatalyst consisting of Ni nanoparticles purposely interpenetrated into mesoporous NiO nanosheets(porous Ni/NiO).Benefiting from the contributions of the Ni and NiO phases,the well-established pore channels for charge transport at the interface between the phases,and the enhanced conductivity due to oxygen-deficiency at the pore edges,the porous Ni/NiO nanosheets show a potential of 1.49 V(10 mA cm^-2)for the OER and a half-wave potential of 0.76 V for the orr,outperforming their noble metal *** significantly,a Zn-air battery employing the porous Ni/NiO nanosheets exhibits an initial charging-discharging voltage gap of 0.83 V(2 mA cm^-2),specific capacity of 853 mAh gZn^-1 at 20 mA cm^-2,and long-time cycling stability(120 h).In addition,the porous Ni/NiO-based solid-like Zn-air battery shows excellent electrochemical performance and flexibility,illustrating its great potential as a next-generation rechargeable power source for flexible electronics.

关键词： Porous Ni/NiO Oxygen reduction reaction Oxygen evolution reaction Electrocatalysis Flexible Zn–air battery

Identifying the Zn-Co binary as a robust bifunctional electrocatalyst in oxygen reduction and evolution reactions via shifting the apexes of the volcano plot

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第4期30卷 162-168页

作者： Jing Wang Rui Xu Yuling Sun Qian Liu Meirong Xia Yan Li Faming Gao Yufeng Zhao john S.Tse Key Laboratory of Applied Chemistry Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource ReuseSchool of Environmental and Chemistry EngineeringYanshan UniversityNo.438Hebei St(W)Qinhuangdao 066004HebeiChina Institute of Sustainable Energy/College of Science Shanghai UniversityShanghai 200444China Department of Physics and Engineering Physics University of SaskatchewanSaskatoonSK S7N 5B2Canada

The performance of an electrocatalyst is closely correlated with the binding strength of key oxygencontaining intermediates,i.e.,*OOH,*O and*OH,in the oxygen reduction reaction(orr)and oxygen evolution reaction(OER).Facile strategies to achieve favorable binding strength of these oxygen-containing species are urgently demanded,yet it still remains great ***,the Zn-Co bimetallic isolation,which serves as an ideal model,is studied systematically by the density functional theory(DFT).Reaction activity volcano plots are built from 48 models,among them the ZnCoN6-gra(I)configuration is confirmed to be the most stable,featured of the strongest interaction with the oxygen-containing *** △G*O(free energy change of an atomic oxygen containing intermediate)is facilitated,which effectively drifts the volcano peaks of orr and OER closer to each other,enabling promising bifunctional ***,the small overpotential in the simulation of protonation and oxidation by hydroxy groups rationalizes the durability of the catalyst in both acid and alkaline media.

关键词： Single-atom catalyst Oxygen reduction Electrocatalysis DFT Reaction volcano

Management and prevention of acute and chronic lateral ankle instability in athletic patient populations

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2015年第2期6卷 161-171页

作者： Brendan J Mc Criskin Kenneth L Cameron Justin D orr Brian R Waterman Department of Orthopaedic Surgery and Rehabilitation William Beaumont Army Medical Center the john A. Feagin Jr Sports Medicine Fellowship Keller Army HospitalUS Military AcademyWest Point

Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance.

关键词： Ankle instability Athlete Treatment Epidemiology Prevention Lateral Sprain

Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2020年第4期7卷 815-822页

作者： Alida M.Bailleul Wenxia Zheng john R.Horner Brian K.Hall Casey M.Holliday Mary H.Schweitzer Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences CAS Center for Excellence in Life and Paleoenvironment Department of Biological Sciences North Carolina State University Department of Geology University of Lund Honors Program Chapman University Department of Pathology and Anatomical Sciences University of Missouri North Carolina Museum of Natural Sciences Department of Biology Dalhousie University

A histological ground-section from a duck-billed dinosaur nestling(Hypacrosaurus stebingeri) revealed microstructures morphologically consistent with nuclei and chromosomes in cells within calcified *** hypothesized that this exceptional cellular preservation extended to the molecular level and had molecular features in common with extant avian cartilage. Histochemical and immunological evidence supports in situ preservation of extracellular matrix components found in extant cartilage, including glycosaminoglycans and collagen type II. Furthermore, isolated Hypacrosaurus chondrocytes react positively with two DNA intercalating stains. Specific DNA staining is only observed inside the isolated cells, suggesting endogenous nuclear material survived fossilization. Our data support the hypothesis that calcified cartilage is preserved at the molecular level in this Mesozoic material, and suggest that remnants of once-living chondrocytes, including their DNA, may preserve for millions of years.

关键词： cartilage dinosaur nuclei chromosomes collagen Ⅱ DNA markers

High-performance oxygen reduction and evolution carbon catalysis： From mechanistic studies to device integration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2017年第4期10卷 1163-1177页

作者： john W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao Department of Chemical Engineering Stan ford University Stanford CA 94305 USA Institute of Chemical and Engineering Sciences Agency for Science Technology and Research Jurong Island 627833 Singapore Stanford Nano Shared Facilities Stanford University Stanford CA 94305 USA Department of Physics Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798 Republic of Korea Department of Chemical and Biological Engineering Colorado School of Mines Golden CO 80401 USA UNIST Central Research Facilities (UCRF) Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798 Republic of Korea SUNCAT Center for Interface Science and Catalysis SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA Institute of Catalysis Research and Technology Karlsruhe Institute of Technology Hermann-von-Helmholtz Platz 1 76344 Eggenstein-Leopoldshafen Germany Institute for Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology Engesserstr. 18 76131 Karlsruhe Germany

The development of high-performance and low-cost oxygen reduction and evolution catalysts that can be easily integrated into existing devices is crucial for the wide deployment of energy storage systems that utilize O2-H2O chemistries, such as regenerative fuel cells and metal-air batteries. Herein, we report an NHB-activated N-doped hierarchical carbon （NHC） catalyst synthesized via a scalable route, and demonstrate its device integration. The NHC catalyst exhibited good performance for both the oxygen reduction reaction （orr） and the oxygen evolution reaction （OER）, as demonstrated by means of electrochemical studies and evaluation when integrated into the oxygen electrode of a regenerative fuel cell. The activities observed for both the orr and the OER were comparable to those achieved by state-of-the-art Pt and Ir catalysts in alkaline environments. We have further identified the critical role of carbon defects as active sites for electrochemical activity through density functional theory calculations and high-resolution TEM visualization. This work highlights the potential of NHC to replace commercial precious metals in regenerative fuel cells and possibly metal-air batteries for cost-effective storage of intermittent renewable energy.

关键词： electrocatalysis porous carbon density functional theory