PARK16 locus:Differential effects of the non-coding rs823114 on Parkinson's disease risk,RNA expression,and DNA methylation

作     者：Orly Goldstein Mali Gana-Weisz Fergal Casey Hila Meltzer-Fridrich Or Yaacov Yedael Y.Waldman Dongdong Lin Yael Mordechai Jing Zhu Patrick F.Cullen Nurit Omer Tamara Shiner Avner Thaler Anat Bar-Shira Anat Mirelman Sally John Nir Giladi Avi Orr-Urtreger Orly Goldstein;Mali Gana-Weisz;Fergal Casey;Hila Meltzer-Fridrich;Or Yaacov;Yedael Y.Waldman;Dongdong Lin;Yael Mordechai;Jing Zhu;Patrick F.Cullen;Nurit Omer;Tamara Shiner;Avner Thaler;Anat Bar-Shira;Anat Mirelman;Sally John;Nir Giladi;Avi Orr-Urtreger

作者机构：The Genomic Research Laboratory for NeurodegenerationNeurological InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael BiogenIncCambridgeMAUSA NRGene Ltd.Ness-ZionaIsrael Sackler Faculty of MedicineTel Aviv UniversityIsrael Sackler Faculty of MedicineSagol School of NeuroscienceTel Aviv UniversityIsrael 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2021年第48卷第4期

页      面：341-345页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by Chaya Charitable Fund Alrov Fund supported by the Common Fund of the Office of the Director of the National Institutes of Health by NCI NHGRI NHLBI NIDA NIMH NINDS 

主　　题：PARK al. identification 

摘      要：Understanding the genetic basis of Parkinson’s disease(PD)has dramatically progressed since the identification of the first genetic mutation in alpha-synuclein,to become a highly complex model of oligogenic disease(Lubbe et al.,2016;Keogh et al.,2018).