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A new algorithm for the diagnosis of celiac disease

Cellular & Molecular Immunology 2011年第2期8卷 146-149页

作者： orit Rozenberg Aaron Lerner Avi Pacht Maya Grinberg Dina Reginashvili Clara Henig Mira Barak Central Laboratory of Haifa and Western Galilee Clalit Health Services and Pediatric GastroenterologyHaifaIsrael Nutrition Unit Carmel Medical CenterHaifaIsrael Technion-Israel Institute of Technology HaifaIsrael

Celiac disease(CD)affects at least 1%of the Western population but remains largely *** our laboratory,we utilize a novel algorithm to diagnose pediatric CD that offers both high sensitivity and high specificity for diagnosis in an outpatient *** aim of the present study was to challenge this algorithm and to test its performance in children and adults suspected of having *** a three-assay algorithm,screening with the most sensitive tissue transglutaminase(tTG)complexed with deamidated gliadin peptide neoepitope immunoglobulin A(IgA)1IgG assay and confirming with the two specific tTG IgA and tTG IgA1IgG assays,we examined the serological results from 112 children aged 0–17 years old and 60 adults in comparison to their respective biopsy *** algorithm performance was calculated by statistical *** use of the new algorithm enabled us to diagnose CD with 98%sensitivity,93%specificity and 95%accuracy in the pediatric group and 94%sensitivity,92%specificity and 93%accuracy in the total population *** false-negative cases in the adult group were attributed to previous adherence to a gluten-free diet,and the single false-negative result in a young child became a true positive after 6 *** have also monitored three celiac patients before and after diagnosis and found that the algorithm may be suitable for disease *** newly proposed three-assay algorithm for celiac detection is very reliable in both children and *** to the high performance of this assay,the further need for confirmatory intestinal biopsies will be reassessed.

关键词： celiac disease diagnosis intestinal histopathology sensitivity specificity tissue transglutaminase

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Metal-dependent anaerobic methane oxidation in marine sediment:insights from marine settings and other systems

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Science China(Life Sciences) 2019年第10期62卷 1287-1295页

作者： Lewen Liang Yinzhao Wang orit Sivan Fengping Wang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240 China Joint International Research Laboratory of Metabolic & Developmental Sciences Shanghai Jiao Tong UniversityShanghai 200240China Department of Geological and Environmental Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel

Anaerobic oxidation of methane(AOM) plays a crucial role in controlling global methane emission. This is a microbial process that relies on the reduction of external electron acceptors such as sulfate, nitrate/nitrite, and transient metal ions. In marine settings, the dominant electron acceptor for AOM is sulfate, while other known electron acceptors are transient metal ions such as iron and manganese oxides. Despite the AOM process coupled with sulfate reduction being relatively well characterized,researches on metal-dependent AOM process are few, and no microorganism has to date been identified as being responsible for this reaction in natural marine environments. In this review, geochemical evidences of metal-dependent AOM from sediment cores in various marine environments are summarized. Studies have showed that iron and manganese are reduced in accordance with methane oxidation in seeps or diffusive profiles below the methanogenesis zone. The potential biochemical basis and mechanisms for metal-dependent AOM processes are here presented and discussed. Future research will shed light on the microbes involved in this process and also on the molecular basis of the electron transfer between these microbes and metals in natural marine environments.

关键词： anaerobic methane oxidation metal-AOM marine sediment archaea electron transfer

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Evaluation of immune response to anti-COVID-19 booster in cancer patients and chronic medical cannabis users and its association with circulating Eosinophils levels

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Cancer Communications 2022年第12期42卷 1417-1420页

作者： Cohen Idan Campisi-Pinto Salvatore Rozenberg orit Abaev Ariel Khoury Marah Agbaria Dana Eitam Harel Colodner Raul Khoury Mona Shalabna Hassan Samih Yousef Mahamid Camel Abu-Amna Mahmoud Bar-Sela Gil Department of Oncology Emek Medical CenterAfula 1834111Israel Research Authority Emek Medical CenterAfula 1834111Israel Clalit Clinical Laboratories Emek Medical CenterAfula 1834111Israel Department of Cancer Science Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifa 320002Israel

Dear Editor On July 29,2021,the Israeli Ministry of Health approved the third anti-Coronavirus disease 2019(COVID-19)vaccination(3rd-BNT162b2-booster-dose),leading to a sharp daily drop in diagnosed positive COVID-19 cases and mortality rates in Israel[1].The booster dose increased severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)neutralization efficiency approximately a hundred-fold compared to individuals receiving only the second dose,providing significant protection against infection[2].

关键词： mortality acute Israel

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Salvage logging versus natural regeneration post-fire practices in a forest: Soil chemical and microbial aspects

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Open Journal of Ecology 2012年第1期2卷 29-37页

作者： orit Ginzburg Yosef Steinberger The Mina & Everard Goodman Faculty of Life Sciences Bar-Ilan University Ramat-Gan Israel

The increase in forest-wildfire events around the world has revived the old debate regarding the practice of salvage logging and its effectiveness in comparison to the unlogged, natural regeneration of burned forests. Since the logging of burned trees may have undesirable outcomes in soil systems, such as soil compaction and nutrient losses, these changes could further cause disturbances to soil microbial-community activity. The aim of this study was to examine chemical and biological changes in soil under two post-fire practices: salvage logging and unlogged, natural regeneration of burned areas, in the recently burned Byria Forest in Israel. Results indicated that salvage logging had a short- lived effect on soil chemical and biological properties that was confined mostly to the first year after logging. Soil moisture was greatly affected by salvage logging, and drier conditions were found in the logged compared to the unlogged burned areas. Moreover, logging had a negative effect on microbial biomass, with reduced biomass in the logged compared to unlogged areas, which was more evident during the first year after fire. These findings support the recommendations in the literature to postpone post-fire practices such as logging or, in turn, to combine the two practices in order to create a mosaic of burned-logged and burned-naturally regenerated areas.

关键词： Microbial community Natural regeneration Post-fire practice Salvage logging Wildfire

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Regulation of hematopoietic stem cell function by nitric oxide signaling

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Blood Science 2020年第2期2卷 66-67页

作者： Tsvee Lapidot orit Kollet Department of Immunology Weizmann Institute of ScienceRehovotIsrael

Mechanisms controlling homing of transplanted hematopoiet-ic stem cells(HSC)to the bone marrow(BM)and their mobilization to the blood have been extensively studied due to their clinical ***,new reports bring new insig... 详细信息

关键词： clinical hematopoietic nitric

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The City Public Transport Overlooked: Analysis of Effective Distances

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Journal of Geographic Information System 2017年第6期9卷 663-684页

作者： orit Rotem-Mindali Eran Feitelson Yaron Michael Department of Geography and Environment Bar Ilan University Ramat Gan Israel Department of Geography The Hebrew University of Jerusalem Jerusalem Israel

Jerusalem is holy to the three main monotheistic religions. Hence Jerusalem is, from a touristic perspective, a world city. Jerusalem is also a highly segmented city. While Jerusalem may seem as an extreme case, it is not unique. Many cities attract large number of tourists to various widely renowned sites within them, in many cases with religious facets. Public transport systems are largely designed to address the demand of local residents. Yet, tourist flows often differ from the travel patterns of local residents, both temporally and spatially. This paper evaluates how Jerusalem’s public transport system serves the global tourist city. To this end, the study focuses on independent tourists, not package-tour tourists. Specifically, we analyze to what extent are the main tourist sites served by the public transportation system. To evaluate accessibility to tourist destinations we use GIS to conduct Least-Cost-Modeling. This methodology measures the effective, rather than the Euclidian distance to tourist destination. We find that the accessibility by public transportation to tourist destinations with high global importance, specifically Christian-religious sites is relatively low. In the final part of the paper we propose a number of explanations for that.

关键词： Accessibility Cities Spatial Planning GIS Urban Transportation

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阻燃剂与环境

阻燃剂与环境

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2006全国阻燃学术年会

作者：郭仁义 orit Manor Pierre Georlette 以色列化工集团ICL-IP

介绍阻燃剂与环境方面的联系以及阻燃剂在合成树脂中的应用

关键词：环境火灾阻燃剂阻燃标准

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Mapping What They Know: Concept Maps as an Effective Tool for Assessing Students’ Systems Thinking

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American Journal of Operations Research 2013年第1期3卷 245-258页

作者： Jaklin Tripto orit Ben-Zvi Assaraf Miriam Amit Department of Science and Technology Education Ben Gurion University of the Negev Beer Sheva Israel

In 2006 anew biology curriculum called “Human Biology: Emphasizing the Role of Homeostasis” was introduced into the Israeli high school system. Complex systems like those that make up the human body have become increasingly important as a focus of high school education. This study examines the effectiveness of the concept map as a assessment tool for students’ systems thinking, a tool that provides researchers with a detailed picture of the systems thinking development taking place within individual students. The content of the students’ concept maps was translated into information about students’ system thinking using the Systems Thinking Hierarchy (STH) model, a model in which system thinking is categorized according to eight hierarchical characteristics or abilities. The goal was to use the maps to characterize Israeli high school students’ understanding of the body’s systemic nature. To do this, we identified the extent to which the students understand three central elements of systems, namely hierarchy, homeostasis, and dynamism, and then analyzed this understanding according to its place within the hierarchical stages of the STH model. The extensive qualitative data analysis of 48 concept maps made by 11th grade biology majors suggest that the strength of the concept map is in its ability to describe the first two levels of system thinking (analysis and synthesis). However, it proved less successful in eliciting evidence of the third and highest level, particularly of students’ understanding of patterns, of homeostasis and their capacity for temporal thinking.

关键词： Human Body System Systems Thinking Concept Map

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Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease

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World Journal of Gastroenterology 2006年第2期12卷 240-245页

作者： Gil Peretz Gabriela Link orit Pappo Rafael Bruck Zvi Ackerman Department of Internal Medicine Hebrew University- Hadassah Medical CenterMount Scopus CampusJerusalemIsrael Department of Human Nutrition and Metabolism Hebrew University Hadassah Medical SchoolJerusalemIsrael Department of Pathology Hebrew University-Hadassah Medical CenterJerusalemIsrael Department of Gastroenterology and Hepatology The EWolfson Medical CenterHolonand Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

瞄准：在肝的纤维变性的前进上与“正常”的肝的铁集中(HIC ) 在老鼠在静脉切开放血术以后估计铁减小的效果，由于胆汁管结扎(BDL ) 。方法：老鼠在假冒的操作或 BDL 前后经历了静脉切开放血术。经历的动物仅仅 BDL 或假冒的操作用作控... 详细信息

瞄准：在肝的纤维变性的前进上与“正常”的肝的铁集中(HIC ) 在老鼠在静脉切开放血术以后估计铁减小的效果，由于胆汁管结扎(BDL ) 。方法：老鼠在假冒的操作或 BDL 前后经历了静脉切开放血术。经历的动物仅仅 BDL 或假冒的操作用作控制。在外科以后的二个星期，肝的损坏和纤维变性的索引被评估。结果：静脉切开放血术降低了 HIC。在 BDL 以后的静脉切开放血术与体重增加，更低的肝的重量，更少的门静脉高血压，更少的仙子门坏死，更少的门发炎，更低的肝的活动索引分数和更高的白朊层次被联系。在另一方面，在 BDL 前的静脉切开放血术与体重减少和肝的活动索引 20 增加被联系。在假冒的操作以后的静脉切开放血术没与任何肝或全身的不利效果被联系。结论：在肝损坏的正式就职以后的 HIC 的减小可以在 BDL 老鼠有有益的效果。然而，铁缺乏能导致肝功能的缺陷并且可以使肝更易受影响到象 BDL 一样的侮辱。

关键词：肝纤维化胆汁郁积肝硬化铁放血术胆官结扎大鼠

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The Effects of Several Types of Induced Abiotic Stress on <i>Cephalaria joppensis</i>Germination under Controlled Conditions

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American Journal of Plant Sciences 2018年第7期9卷 1486-1499页

作者： Miriam Daklo-Keren Waffa Abu-Aklin orit Cohen Valantina Berger Galina Sidan Aharon Bellalou orit Amir-Segev Ran Hovav Shmuel Galili Seed Laboratory Institute of Plant Sciences Agricultural Research Organization The Volcani Center Rishon Le Ziyyon Israel Vegetables & Field Crops Science Department Institute of Plant Sciences Agricultural Research Organization The Volcani Center Rishon Le Ziyyon Israel

The recently domesticated species, Cephalaria joppensis (CJ), is emerging as a new alternative forage crop in Israel. It has high biomass potential and nutritional values that are comparable to forage wheat. However, CJ emerges slowly under cold conditions, which hinders its development as a major winter crop. Additional tolerance for abiotic stress would improve its performance as a forage crop. We examined the effects of several abiotic factors (i.e., cold, salinity, drought and pH) on CJ germination under controlled conditions. The effect of temperature was studied by incubating seeds at different temperatures between 7°C and 35°C. The effects of salinity, osmotic potential and pH were tested by incubating seeds at different NaCl, PEG and pH levels, respectively. Temperature, salinity and osmotic potential significantly affected germination;whereas pH did not. Temperature did not affect the final proportion of germinated seeds, but did affect other germination-rate variables, indicating that germination rate might be the limiting factor under field conditions. Salinity also affected germination-rate variables, but not the proportion of seeds that germinated. Notably, CJ was found to be relatively resistant to high salt concentrations, with a 273 mM NaCl threshold for germination, indicating its potential as a relatively salt-tolerant forage crop. Both the proportion of germinated seeds and the germination rate were highly sensitive to the osmotic-potential treatments, indicating that drought resistance will remain the biggest challenge for CJ. This study provides baseline data for a rapid and efficient system for further screening for abiotic-stress tolerance among wild and cultivated lines of CJ.

关键词： Cephalaria joppensis Abiotic Stress Seed Germination

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