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Analytic algorithms for Some Models of Nonlinear Age–Structured population Dynamics and Epidemiology

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Journal of Modern physics 2011年第4期2卷 236-247页

作者： Vipul K. Baranwal Ram K. pandey Manoj p. Tripathi om. p. Singh 不详

Three analytic algorithms based on Adomian decomposition, homotopy perturbation and homotopy analysis methods are proposed to solve some models of nonlinear age-structured population dynamics and epidemiology. Truncating the resulting convergent infinite series, we obtain numerical solutions of high accuracy for these models. Three numerical examples are given to illustrate the simplicity and accuracy of the methods.

关键词： Age-Structured population Models population Dynamics SIS Epidemic Models Adomian Decomposition Method Homotopy perturbation and Homotopy Analysis Methods

Intestinal permeability and its association with the patient and disease characteristics in Crohn's disease

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World Journal of Gastroenterology 2008年第9期14卷 1399-1405页

作者： Jaya Benjamin Govind K Makharia Vineet ahuja Mani Kalaivan Yogendra K Joshi Department of Gastroenterology & Human Nutrition All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India Department of Biostatistics All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India Department of Gastroenterology & Human Nutrition All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

AIM:To assess the intestinal permeability (Ip) in patients with Crohn's disease (CD) and study the association of Ip with the patient and disease characteristics. METHODS: One hundred and twenty five consecutive patients of CD (Males: 66) were diagnosed on the basis of a combination of standard clinical, endoscopic, imaging and histological features. CD activity index (CDAI) was used to calculate the activity of the disease while the behavior of the disease was assessed by the modified Montreal classification. Ip was measured by the ratio of the percentage excretion of ingested doses of lactulose and mannitol in urine (LMR). The upper limit of normality of LMR (0.037) was derived from 22 healthy controls. RESULTS: Thirty six percent of patients with CD had increased Ip. There was no significant difference in mannitol excretion (patients vs controls = 12.5% vs 14.2%, p = 0.4652), but lactulose excretion was significantly higher in patients compared to healthy controls (patients vs controls = 0.326% vs 0.293%, p = 0.0391). The mean LMR was also significantly higher in the patients as compared to healthy controls [0.027 (0.0029-0.278) vs 0.0164 (0.0018-0.0548), p = 0.0044]. Male patients had a higher LMR compared to females [0.036 (95% CI 0.029, 0.046) vs 0.022 (95% CI 0.0178, 0.028) (p = 0.0024), though there was no difference in the number of patients with abnormal Ip in boththe sexes. patients with an ileo-colonic disease had a higher LMR than those with only colonic disease [0.045 (95% CI 0.033, 0.06) vs 0.021 (95% CI 0.017, 0.025) (p patients with ileo-colonic disease, 57.8% had an abnormal Ip, compared to 26.7% with colonic and 15.6% with small intestinal disease. patients with a stricturing disease had significantly higher LMR compared to non-fistulising non-stricturing disease [0.043 (95% CI 0.032, 0.058) vs 0.024 (95% CI 0.019, 0.029) (p = 0.0062)]. There was no correlation of Ip with age, disease activity, duration of illness, D-xylose absorptio

关键词： Lactulose mannitol ratio Crohn's disease Inflammatory bowel disease Intestinal barrier Crohn's disease activity index Intestinal permeability

Hepatic endogenous defense potential of propolis after mercury intoxication

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Integrative Zoology 2008年第4期3卷 311-321页

作者： Monika BHADAURIA Sangeeta SHUKLA Ramesh MATHUR om pAGRAWAL Sadhana SHRIVASTAVA Sonia JOHRI Deepmala JOSHI Varsha SINGH Deepak MITTAL Satendra Kumar NIRALA Reproductive Biology and Toxicology Laboratory Insect physiology and Biochemistry School of Studies in ZoologyJiwaji UniversityGwaliorIndia Boston College for professional Studies GwaliorIndia

Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LpO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in *** with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LpO and the formation of GSSG and increased the level of GSH in the *** of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis *** activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis *** observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent.

关键词： antioxidant enzymes glutathione hepatoprotection mercuric chloride propolis.

Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective

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Infectious Diseases of poverty 2016年第1期5卷 165-179页

作者： om prakash Singh Bhawana Singh Jaya Chakravarty Shyam Sundar Infectious Disease Research Laboratory Department of MedicineInstitute of Medical SciencesBanaras Hindu UniversityVaranasiIndia

Visceral leishmaniasis(VL)is a serious parasitic disease causing considerable mortality and major disability in the Indian *** is most neglected tropical disease,particularly in terms of new drug development for the lack of financial *** elimination campaign has been running in India since 2005 that aim to reduce the incidence of VL to below 1 per 10,000 people at sub-district *** of the major components in this endeavor is reducing transmission through early case detection followed by complete *** progress has been made during the recent years in the area of VL treatment,and the VL elimination initiatives have already saved many lives by deploying them effectively in the endemic ***,many challenges remain to be overcome including availability of drugs,cost of treatment(drugs and hospitalization),efficacy,adverse effects,and growing parasite ***,better emphasis on implementation research is urgently needed to determine how best to deliver existing interventions with available anti-leishmanial *** is essential that the new treatment options become truly accessible,not simply available in endemic areas so that they may promote healing and save *** this review,we highlight the recent advancement and challenges in current treatment options for VL in disease endemic area,and discuss the possible strategies to improve the therapeutic outcome.

关键词： Visceral leishmaniasis Treatment Drug resistance Multidrug therapy

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The potential Bioeffects of Extremely Low Frequency Electromagnetic Fields on Melatonin Levels &Related Oxidative Stress in Electric Utility Workers Exposed to 132 kV Substation

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Journal of Electromagnetic Analysis and Applications 2013年第11期5卷 393-403页

作者： Ravindra Tiwari Suresh Chandra Bhargava Yog Raj ahuja Department of Electrical and Electronic Engineering Sree Nidhi Institute of Science and Technology Hyderabad India Genetics Unit Vasavi Medical and Research Centre Hyderabad India University Grants Commission (UGC) Research Unit Bhavan’s New Science College Hyderabad India

Electricity substations take electricity from power lines and transformer lines to transform it from high to low voltage and distribute to the consumers. These substations generate low frequency electromagnetic fields similar to those emitted from over head power lines and electrical appliances at home. The present study is focused on assessing the potential bioeffects of Extremely Low Frequency Electromagnetic Fields (ELF-EMFs) on melatonin level and oxidative stress biomarkers, in subjects occupationally exposed to 132 kV high voltage substation in Hyderabad, India. These subjects are involved in maintenance and installation of power line distribution at electricity transmission network. The ELFEMFs exposed subjects (n = 142) included the electric utility workers, who were compared with age, and socioeconomic status matched controls (n = 151). The subjects were professionally categorized based on their job titles, with different exposure levels, as administrative workers (low exposure), maintenance workers (medium exposure) and liveline workers (high exposure). The plasma melatonin levels were significantly suppressed in the high exposed subjects i.e., hotline workers (p 0.05). The oxidant status levels of plasma Malondialdehyde (MDA) and Nitric Oxide (NO) showed significantly increased levels in all the exposed subjects (p 0.05). The activity levels of erythrocyte antioxidative enzyme when compared to control subjects were significantly reduced in the exposed subjects of all the categories (p 0.05).

关键词： Melatonin Oxidative Stress 132 kV Live-Line Workers

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CTA对大脑中动脉动脉瘤形态学研究

CTA对大脑中动脉动脉瘤形态学研究

作者： HARI om JOSHI 吉林大学

学位级别：硕士

研究背景：尽管已有很多学者研究了颅内动脉瘤，但是在动脉瘤破裂的危险因素间的多重相关性的研究仍然不多。近几十年来，许多研究者通过研究动脉瘤的形态学参数来预测动脉瘤破裂的风险，但是仍没有找到可以确切预测动脉瘤破裂风险... 详细信息

研究背景：尽管已有很多学者研究了颅内动脉瘤，但是在动脉瘤破裂的危险因素间的多重相关性的研究仍然不多。近几十年来，许多研究者通过研究动脉瘤的形态学参数来预测动脉瘤破裂的风险，但是仍没有找到可以确切预测动脉瘤破裂风险的独立参数。从这些研究中，我们已经了解了很多关于动脉瘤的知识。在很多研究人员中，动脉瘤的形态被认为是一个潜在的颅内动脉瘤破裂的因素。本研究致力于研究已被多名学者定义的不同形态学参数对动脉瘤破裂风险的预测。本文中动脉瘤形态的多个参数都显示与动脉瘤的破裂风险有相关性。在很多已经被认为可能预测动脉瘤破裂风险的形态学参数中，结果显示这些形态学参数可以作为预测动脉瘤破裂风险的因素。本研究通过研究动脉瘤患者CTA图像，比较不同形态学参数在预测动脉瘤破裂风险上的差异及统计学意义。研究目的：通过CT血管造影（CTA）研究大脑中动脉（MCA）动脉瘤的形态学特征。材料与方法：本研究搜集2011年1月至2012年1月到吉林大学第一医院就诊的患者，共62例患者，其中26例患者中，发现27个未破裂动脉瘤，另外36例患者，发现36个破裂动脉瘤。其中11例患者为双侧大脑中动脉动脉瘤，其他患者为单发或多发动脉瘤。只有发生在大脑中动脉的动脉瘤计入统计，其他部位动脉瘤不计入统计。除囊状动脉瘤外，梭形与霉菌性动脉瘤不计入本研究。医院计算机系统pACS（图片存档和通信系统）记录了每个病人的医疗记录，包括既往病史、影像学检查、治疗过程及结果。该系统通过回顾性分析为我们提供有用的信息。本研究通过CTA工作站后处理获得动脉瘤的形态学参数，并统计分析动脉瘤形态参数对动脉瘤破裂风险评估的意义。结果：统计发现，动脉瘤的各种形态学参数在评价预测动脉瘤破裂风险上均有显著性差异。 1.动脉瘤尺寸比SR作为唯一一个预测动脉瘤破裂风险的独立指标，也是最重要的形态学参数（p＜0.001，AUC0.78）。 2.动脉瘤其他形态学参数也可以预测其破裂风险，如最大动脉瘤高度Hmax（p≤0.001, AUC0.78）,、深度Hpr（p≤0.001, AUC0.77）,、高宽比AR （p=0.002,AUC0.73）及动脉瘤体积（p≤0.001, AUC0.75）。然而，Logistic回归分析显示这些形态参数不能作为预测动脉瘤破裂的独立指标。 3.动脉瘤（包括破裂及未破裂动脉瘤）好发于女性，右侧多于左侧。动脉瘤患者年龄大多分布在51-60岁，未破裂动脉瘤平均年龄55.59岁，破裂动脉瘤平均年龄52.56岁。结论：基于动脉瘤多种形态学参数的研究，CTA是预测动脉瘤破裂风险的重要影像学方法。尺寸比SR是最重要且最有意义的一个形态学参数。

关键词： CTA 大脑中动脉动脉瘤

二维XO_(2)(X=Ni,pd,pt) 弹性、电子结构和热导率

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物理学报 2021年第24期70卷 241-251页

作者：方文玉陈粤叶盼魏皓然肖兴林黎明锴 ahuja Rajeev 何云斌湖北大学材料科学与工程学院铁电压电材料与器件湖北省重点实验室高分子材料湖北省重点实验室功能材料绿色制备与应用教育部重点实验室武汉430062 乌普萨拉大学物理与天文系凝聚态理论组瑞典乌普萨拉S-751-20

基于第一性原理计算方法,研究了二维XO_(2)(X=Ni,pd,pt)的稳定性、弹性、电子结构和热导率.计算结果显示,二维XO_(2)同时具备较好的机械和动力学稳定性.此外,二维NiO_(2),pdO_(2)和ptO_(2)的杨氏模量分别为124.69 N/m,103.31 N/m和116.5... 详细信息

基于第一性原理计算方法,研究了二维XO_(2)(X=Ni,pd,pt)的稳定性、弹性、电子结构和热导率.计算结果显示,二维XO_(2)同时具备较好的机械和动力学稳定性.此外,二维NiO_(2),pdO_(2)和ptO_(2)的杨氏模量分别为124.69 N/m,103.31 N/m和116.51 N/m,泊松比分别为0.25,0.24和0.27,并呈现各向同性.电子能带结构表明,二维XO_(2)(X=Ni,pd,pt)为间接带隙半导体,计算能隙分别为2.95 eV,3.00 eV和3.34 eV,且价带顶和导带底的能级主要由Ni-3d,pd-4d,pt-5d和O-2p轨道电子组成.通过畸变势理论计算载流子迁移率,结果显示二维XO_(2)(X=Ni,pd,pt)沿armchair和zigzag方向的有效质量和形变势表现出明显的各向异性,电子/空穴的迁移率最高分别为13707.96/53.25 cm^(2)·V^(-1)·s^(-1),1288.12/19.18 cm^(2)·V^(-1)·s^(-1)和404.71/270.60 cm^(2)·V^(-1)·s^(-1).此外,在300 K温度下,二维XO_(2)(X=Ni,pd,pt)的晶格热导率分别为53.55 W·m^(-1)·K^(-1),19.06 W·m^(-1)·K^(-1)和17.43 W·m^(-1)·K^(-1),这表明二维XO_(2)(X=Ni,pd,pt)在纳米电子材料和导热器件方面具备应用潜力.

关键词：二维XO_(2)(X=Ni,pd,pt) 电子结构载流子迁移率热导率

自身免疫性甲状腺疾病患者外周血淋巴细胞端粒长度的研究

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中华微生物学和免疫学杂志 2001年第5期21卷 504-507页

作者：陈健萌戴为信任韵钊崔巍T om.Jus 中国医学科学院中国协和医科大学北京协和医院丹麦DAKO公司

目的　研究自身免疫性甲状腺疾病 (ATD)患者外周血淋巴细胞端粒长度的变化。方法　用流式原位杂交法检测 3 8例ATD患者和 4 8例健康对照者外周血淋巴细胞的端粒长度。结果　患者组外周血淋巴细胞端粒长度明显短于健康对照组 (p <0 .0 0 ... 详细信息

目的　研究自身免疫性甲状腺疾病 (ATD)患者外周血淋巴细胞端粒长度的变化。方法　用流式原位杂交法检测 3 8例ATD患者和 4 8例健康对照者外周血淋巴细胞的端粒长度。结果　患者组外周血淋巴细胞端粒长度明显短于健康对照组 (p <0 .0 0 1 ) ,端粒长度与病程、发病时间、甲状腺激素水平不相关。健康对照组端粒长度随年龄增加而变短 ,病人组端粒长度与年龄不相关。结论ATD病人的外周血淋巴细胞端粒长度比正常人短 ,且与年龄不相关 ,提示其外周血淋巴细胞复制、分裂增多及凋亡异常。

关键词：端粒自身免疫性甲状腺疾病淋巴细胞

达比加群治疗非瓣膜性心房颤动患者后凝血功能变化及其与出血事件的相关性研究

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达比加群治疗非瓣膜性心房颤动患者后凝血功能变化及其与出血事件...

作者： om pRAKASH ADHIKARI(欧明杰) 广西医科大学

学位级别：硕士

目的:探讨达比加群治疗非瓣膜性心房颤动患者凝血功能与出血事件的相关性。研究方法:在这项观察性研究中,从心房颤动患者中纳入符合入选标准的达比加群药物治疗的非瓣膜性心房颤动患者。纳入2018年9月至2020年12月在广西医科大学第一附... 详细信息

目的:探讨达比加群治疗非瓣膜性心房颤动患者凝血功能与出血事件的相关性。研究方法:在这项观察性研究中,从心房颤动患者中纳入符合入选标准的达比加群药物治疗的非瓣膜性心房颤动患者。纳入2018年9月至2020年12月在广西医科大学第一附属医院心血管内科住院的诊断为房颤的患者。所有患者均按我院房颤患者常规临床路径进行综合诊断评估。从医院的住院病历和门诊病历中获取临床特征和人口学数据,比较出血组和无出血组的基线特征。结果:共有80名NVAF患者(51名男性,65±11)8例患者发生出血事件。其中56例使用DE110mg,24例使用DE150mg。出血组用药前后凝血指标比较,ApTT轻度延长(p值为0.03),TT轻度延长(p值0.05)。无出血组ApTT延长(pppT(p值0.1)、INR(p值0.36)、ApTT(p值0.49)、TT(p值0.41)、pTA(p值0.55)均无统计学意义。在本研究中,Spearman相关分析未能发现出血组和无出血组凝血参数之间的相关性。在比较DE110mg和DE150mg两种剂量时,接受DE150mg治疗的患者比接受DE110mg治疗的患者相对年轻。DE150mg的HAS-BLEED和CHA2DS2VASc评分较低,肾功能较好。经spearman相关分析,用药剂量与年龄(ppppppTT延长和显著的TT延长是达比加群酯引起的凝血功能改变,不会增加出血的风险。由于常规凝血参数不能准确反映达比加群的出血风险,因此不建议用于监测达比加群的出血风险。因此,轻度ApTT延长和显著TT延长不是停止服用达比加群的指征。根据患者的年龄、体重、肾功能和出血评分分层选择达比加群的个体化剂量有助于减少出血事件的发生。

关键词：心房颤动凝血功能出血事件达比加群