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Heart rate response and recovery during exercise predict future delirium risk——A prospective cohort study in middle-to older-aged adults

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Journal of Sport and Health Science 2023年第3期12卷 312-323页

作者： Lei Gao Aden Gaba Peng Li Richa Saxena Frank A.J.LScheer oluwaseun Akeju Martin K.Rutter Kun Hu Department of Anesthesia Critical Care and Pain MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Medical Biodynamics Program Brigham and Women's HospitalBostonMA 02115USA Division of Sleep Medicine Harvard Medical SchoolBostonMA 02115USA Broad Institute of Massachusetts Institute of Technology and Harvard CambridgeMA 02142USA Center for Genomic Medicine Massachusetts General HospitalBostonMA 02114USA Division of Diabetes Endocrinology and GastroenterologySchool of Medical SciencesFaculty of BiologyMedicine and HealthManchester Academic Health Science CentreUniversity of ManchesterManchester M139PLUK Diabetes Endocrinology and Metabolism CentreManchester University National Health Service Foundation TrustManchester M139WLUK

Background:Delirium is a neurocognitive disorder characterized by an abrupt decline in attention,awareness,and cognition after surgical/illness-induced stressors on the *** is now an increasing focus on how cardiovascular health interacts with neurocognitive disorders given their overlapping risk factors and links to subsequent dementia and *** common indicator for cardiovascular health is the heart rate response/recovery(HRR)to exercise,but how this relates to future delirium is ***:Electrocardiogram data were examined in 38,740 middle-to older-aged UK Biobank participants(mean age=58.1 years,range:40-72 years;47.3%males)who completed a standardized submaximal exercise stress test(15-s baseline,6-min exercise,and 1-min recovery)and required hospitalization during *** HRR index was derived as the product of the heart rate(HR)responses during exercise(peak/resting HRs)and recovery(peak/recovery HRs)and categorized into low/average/high groups as the bottom quartile/middle 2 quartiles/top quartile,*** between 3 HRR groups and new-onset delirium were investigated using Cox proportional hazards models and a2-year landmark analysis to minimize reverse *** factors,lifestyle factors/physical activity,cardiovascular risk,comorbidities,cognition,and maximal workload achieved were included as ***:During a median follow-up period of 11 years,348 participants(9/1000)newly developed *** with the high HRR group(16/1000),the risk for delirium was almost doubled in those with low HRR(hazard ratio=1.90,95%)confidence interval(95%CI):1.30-2.79,p=0.001)and average HRR(hazard ratio=1.54,95%CI:1.07-2.22,p=0.020)).Low HRR was equivalent to being 6 years older,a current smoker,or>3 additional cardiovascular disease *** were robust in sensitivity analysis,but the risk appeared larger in those with better cognition and when only postoperative delirium was considered(n=1

关键词： Brain health Delirium Exercise stress test UK Biobank

Antioxidant and chemical properties of essential oil extracted from blend of selected spices

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Journal of Coastal Life Medicine 2015年第7期 575-578页

作者： Ochuko Lucky Erukainure Funmi Olabisi Kayode Olubanke Adetutu Adeyoju Sunday oluwaseun Adenekan Godfrey Asieba Atinuke ajayi Mosebolatan Victoria Adegbola Bolanle Basirat Sarumi Department of Food Technology Federal Institute of Industrial ResearchLagosNigeria Analytical Division Federal Institute of Industrial ResearchLagosNigeria Department of Biochemistry University of LagosLagosNigeria Department of Laboratory Technology Federal PolytechnicEdeNigeria

Objective:To investigate the chemical properties of essential oil extracted from blends of selected Nigerian spices as well as its antioxidant protective potentials against free radical in ***:Essential oil was extracted from selected spices blend consisting of Monodora myristica,Myristica fragrans,Tetrapleura tetraptera,and Aframomum sceptrum using a Clevenger type *** obtained was subjected to phytochemical and gas chromatography-mass spectrometer analysis as well as analyzed for antioxidant activity which covers for 1,1-diphenyl-2 picrylhydrazyl,nitric oxide scavenging activities and reducing ***:Gas chromatography-mass spectrometer analysis revealed over 50 compoundfs withα-phellandrene being the most predominant compound(27.32%),which was followed by(-)-β-bourbonene(15.78%)and 5-(1-methylethyl)-α-phellandrene(11.80%).Phytochemical analysis showed high flavonoid content and a lower phenolic *** oil showed a dose like dependent effect on the1-diphenyl-2 picrylhydrazyl and nitric oxide scavenging activities,these activities increased with increasing *** same was also observed for the reducing power properties of the ***:The antioxidant activities exhibited by the essential oil in vitro signify its protective potential against free *** chemical constituents,α-phellandrene in particular and the studied phytochemicals may be responsible for these ***,in vivo study is needed to further authenticate this potency.

关键词： α-phellandrene Antioxidant DPPH Nitric oxidant Spices

Predictive modeling of COVID-19 death cases in Pakistan

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Infectious Disease Modelling 2020年第1期5卷 897-904页

作者： Muhammad Daniyal Roseline oluwaseun Ogundokun Khadijah Abid Muhammad Danyal Khan Opeyemi Eyitayo Ogundokun Department of Statistics Islamia University of BahawalpurPakistan Department of Computer Science Landmark University Omu AranNigeria Research Evaluation Unit College of Physicians&SurgeonsPakistan Gillani Law College BZU MultanPakistan Directoriate Department Audit SectionAgricultural and Rural Management Training InstituteIlorinNigeria

Background:The world is presently facing the challenges posed by COVID-19(2019-nCoV),especially in the public health sector,and these challenges are dangerous to both health and *** disease results in an acute respiratory infection that may result in pain and *** Pakistan,the disease curve shows a vertical trend by almost 256K established cases of the diseases and 6035 documented death cases till August 5,***:The primary purpose of this study is to provide the statistical model to predict the trend of COVID-19 death cases in *** age and gender of COVID-19 victims were represented using a descriptive ***:ology:Three regression models,which include Linear,logarithmic,and quadratic,were employed in this study for the modelling of COVID-19 death cases in *** three models were compared based on R2,Adjusted R2,AIC,and BIC *** data utilized for the modelling was obtained from the National Institute of Health of Pakistan from February 26,2020 to August 5,***:The finding deduced after the prediction modelling is that the rate of mortality would decrease by the end of *** total number of deaths will reach its maximum point;then,it will gradually *** indicates that the curve of total deaths will continue to be flat,i.e.,it will shift to be constant,which is also the upper bound of the underlying function of absolute death.

关键词： Coronavirus COVID-19 Public health Epidemic Modelling Model selection criteria

Two-stage capacity optimization approach of multi-energy system considering its optimal operation

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能源与人工智能(英文) 2020年第1期1卷 35-63页

作者： X.J.Luo Lukumon O.Oyedele Olugbenga O.Akinade Anuoluwapo O.ajayi Big Data Enterprise and Artificial Intelligence Laboratory(Big-DEAL) University of the West of England(UWE)Frenchay CampusBristolUnited Kingdom

With the depletion of fossil fuel and climate change,multi-energy systems have attracted widespread attention in ***-energy systems,fuelled by renewable energy,including solar and biomass energy,are gain-ing increasing adoption in commercial *** of previous capacity design approaches are formulated based upon conventional operating schedules,which result in inappropriate design capacities and ineffective operating schedules of the multi-energy ***,a two-stage capacity optimization approach is pro-posed for the multi-energy system with its optimal operating schedule taken into *** demonstrate the effectiveness of the proposed capacity optimization approach,it is tested on a renewable energy fuelled multi-energy system in a commercial *** primary energy devices of the multi-energy system consist of biomass gasification-based power generation unit,heat recovery unit,heat exchanger,absorption chiller,elec-tric chiller,biomass boiler,building integrated photovoltaic and photovoltaic thermal hybrid solar *** variable efficiency owing to weather condition and part-load operation is also *** algorithm is adopted to determine the optimal design capacity and operating capacity of energy devices for the first-stage and second-stage optimization,*** two optimization stages are interrelated;thus,the optimal design and operation of the multi-energy system can be obtained simultaneously and *** the adoption of the proposed novel capacity optimization approach,there is a 14%reduction of year-round biomass consumption compared to one with the conventional capacity design approach.

关键词： Multi-energy system Renewable energy Biomass Genetic algorithm Capacity design Optimization

Assessment of Noise Exposure of Sawmill Workers in Southwest,Nigeria

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Sound & Vibration 2021年第1期55卷 69-85页

作者： Abiola O.Ajayeoba Adewoye A.Olanipekun Wasiu A.Raheem oluwaseun O.Ojo Ayowumi R.Soji-Adekunle Department of Mechanical Engineering Ladoke Akintola University of TechnologyOgbomosoNigeria Department of Civil Engineering Ladoke Akintola University of TechnologyOgbomosoNigeria Department of Systems Engineering University of LagosLagosNigeria Department of Mechanical Engineering Adeleke UniversityEdeNigeria

Economic wood processing employs the use of industrial machines for cutting,shaping,milling,and sawing timber,thereby leading to the generation of high levels of *** data from empirical studies have categorized noise as an environmental hazard of global ***,noise exposure limits for different industries and all the industrial machines available has not been formally established as it presently exists in developed nations around the ***,this study assessed the daily exposure of sawmills workers to noise in Southwestern *** surveys were first carried out in Osun,Oyo,Ondo,Ekiti,Lagos,and Ogun States to select sawmills that were fully operational and fit for the *** fully functional sawmills in two cities of each State were eventually selected for data collection,making a total of 24 sawmills,while the Circular Machines(CM),Planer Machines(PM),and Band-saw Machines(BM)were the machines in each sawmill *** machines each of CM,PM,and BM were considered in each sawmill,making a total of forty-eight(48)machines each of CM,PM,and *** data were collected between 7 am and 7 pm each day for six days(between Monday and Saturday)using Extech 407732 sound level meter and all stabilized measurements were taken three times at different *** data collected were in three different periods:Machine No-work Period(NPm),Machine Idle Period(IPm),and Machine Working Period(WPm).A two–way Analysis of Variance(ANOVA)was carried out at P<0.05 to determine whether there is a significant difference in the sound level average before and after the break,for both the idle and working periods of the three machines *** was also done to determine whether there is a signifi-cant difference between the sound level average of the results collected during idle and working periods of the three *** Pollution Levels(Lnp)ranged from 83.20 dB(PM)to 107.65(BM)and 93.42(CM and PM)–116.00(BM)resp

关键词： Sawmills machines noise exposure pollution wood

Knowledge and awareness of human mpox infection among healthcare workers:A cross-sectional study in southwestern Nigeria

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 245-252,I0001页

作者： Paul Oladapo ajayi Deborah Tolulope Esan Tope Michael Ipinnimo Moronkeji Temitope Olanrewaju Oluremi Olayinka Solomon Olajumoke Oyewumi Atanda-Owoeye Department of Community Medicine Faculty of Clinical SciencesEkiti State UniversityAdo-EkitiEkiti StateNigeria Department of Nursing Science College of Health SciencesBOWEN UniversityIwoOsun StateNigeria Department of Community Medicine Federal Teaching HospitalIdo-EkitiEkiti StateNigeria Department of Family Medicine Federal Teaching HospitalIdo-EkitiEkiti StateNigeria Department of Community Medicine Ekiti State University Teaching HospitalAdo-EkitiEkiti StateNigeria

Objective:To identify the knowledge and awareness level of human mpox viral infection among healthcare workers in southwestern ***:A cross-sectional study was conducted in Ekiti State,southwest Nigeria among 316 healthcare workers that were selected through a systematic random *** were collected with the aid of a semi-structured,self-administered *** Chi-square test and binary logistic regression were used to find the association between the independent and dependent *** significance level was set at P-value<***:Two hundred and twenty-two(70.3%)of the respondents were aged≤40 years,mean age(36±9)years,189(59.8%)were female,306(96.8%)were Christians,and 203(64.2%)were *** hundred and fourteen(99.4%)of the respondents were aware of mpox *** sources of information about mpox were medical education(44.0%),radio/television(32.0%)and newspaper(21.0%).However,among those aware of the disease,209(67.0%)demonstrated poor knowledge *** than 5 years’experience of medical practice was the only significant predictor of higher knowledge level of the disease(OR 1.76,95%CI 1.01-3.06;P=0.046).Conclusions:Despite the high awareness level of mpox infection among healthcare workers,there still exists a huge knowledge *** is recommended that targeted intervention could be directed towards continuous medical education and simulation exercises on re-emerging infectious diseases like mpox to improve the knowledge of the healthcare workers.

关键词： Awareness Knowledge Human mpox viral infection Healthcare workers Nigeria

Kaposi Sarcoma in HIV Positive Nigerian Children: A Case Series

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World Journal of AIDS 2011年第3期1卷 63-69页

作者： Regina Oladokun Bamidele Kolude Gabriel Ogun Biobele Brown kikelomo Osinusi 不详

Background: HIV associated KS is relatively rare in children and has been reported to be higher in East Africa compared to other regions. Literature on cases of histologically proven Kaposi sarcoma in children with HIV infection in West Africa is scanty. Case presentation: This communication presents three cases of KS seen among children in a paediatric HIV unit. The first case was an eleven year old HIV positive boy who had oral candidiasis that resolved with treatment and subsequently developed a painless, erythematous swelling at the middle of the dorsum of the tongue with central loss of papillae. He also had multiple discoid hyperpigmented flat lesions on the legs and soles of the feet. In addition to switching to second line antiretroviral therapy, he had chemotherapy. The lesions regressed. The second case was a double orphan who had KS involvement of the right eye, nasal cavity and lymph nodes. The tumour rapidly progressed and the child died before ART and chemotherapy could be commenced. The last case was a five year old girl with mild KS of the skin but also had other manifestations of severe HIV disease which she succumbed to. Incisional biopsies of the lesions revealed an invasive epithelial lined vascular tumour destroying the upper layers of skeletal fibres within the connective tissue stroma in keeping with KS. Human Herpes Virus type 8 (HHV8) screen was also positive for all the cases. Conclusion: A high index of suspicion must be entertained and biopsy of suspicious muco-cutaneous lesions is necessary to exclude a diagnosis of KS which is an indicator of severity and progression of HIV.

关键词： Kaposi Sarcoma HIV Infection Children West Africa

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coinfection with Malaria in Selected States in Nigeria

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Advances in Infectious Diseases 2024年第2期14卷 442-455页

作者： Oluwagbemiga Olanrewaju Aina Olufemi Samuel Amoo Kazeem Adewale Osuolale Adewale Kayode Ojogbede Azuka Patrick Okwuraiwe David Ayoola Oladele Adesola Zaidat Musa Tajudeen Akanji Bamidele Celestina Onyinye Okoyenta Abideen Olurotimi Salako Toyosi Yekeen Raheem Ifeoma Eugenia Idigbe Fehintola Anthonia Ige Joseph Ojonugwa Shaibu Gregory Aigbe Ohihoin kikelomo Wright Bisola Adebayo Hussein Abdu-Razzaq Abdulrahman Ahmad Mustapha Imam Bashir Bello Tambuwal Muhammad Shuaibu Gobir Richard Ikwuogu Christian Tetsola Gloria Patrick-Ferife Nathaniel Enamuotor Mildred Okowa William Nwachukwu Cornelius Ohonsi Magdalene Egede Chinwe Ochu Ehimario Igumbor Oliver Chukwujekwu Ezechi Babatunde Lawal Salako Rosemary Ajuma Audu Biochemistry and Nutrition Department Nigerian Institute of Medical Research Lagos Nigeria Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Lagos Nigeria Monitoring and Evaluation Unit Nigerian Institute of Medical Research Lagos Nigeria Public Health and Epidemiology Department Nigerian Institute of Medical Research Lagos Nigeria Clinical Sciences Department Nigerian Institute of Medical Research Lagos Nigeria Molecular Biology and Biotechnology Department Nigerian Institute of Medical Research Lagos Nigeria Department of Community Health & Primary Health Care Lagos State University College of Medicine Lagos State University Teaching Hospital Lagos Nigeria Research Unit Lagos State Ministry of Health Lagos Nigeria Sokoto State Ministry of Health Sokoto Nigeria Department of Medical Biochemistry Usmanu Danfodiyo University Sokoto Nigeria Centre for Advanced Medical Research and Training Usmanu Danfodiyo University Sokoto Nigeria Delta State Ministry of Health Asaba Nigeria Nigeria Centre for Disease Control Abuja Nigeria Center for Infectious Disease Research Nigerian Institute of Medical Research Lagos Nigeria

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Plasmodium species are the causative agents of coronavirus disease 2019 (COVID-19) and malaria respectively with similar clinical presentations. The objective of this study is to determine the burden of co-infection of SARS-CoV-2 and malaria in the general population. Five (5 mLs) of blood samples were collected for SARS-CoV-2 and malaria parasite test. The malaria test was performed using a commercially available one-step malaria antigen Plasmodium falciparum histidine-rich protein 2 (Pf HRP-II) rapid test kit. The results of the study showed that the participants that were coinfected with SARS-CoV-2 IgG and malaria were 13 (2.5%) in Lagos, 1114 (39.1%) in Delta and 49 (2.3%) in Sokoto States. The prevalence of coinfection of SARS-CoV-2 and malaria in urban areas in Lagos, Delta and Sokoto States were 7 (2.2%), 1373 (48.1%), and 5 (0.2%) respectively. In rural areas, the prevalence of coinfection of SARS-CoV-2 and malaria in Lagos, Delta and Sokoto States were 6 (0.3%), 365 (12.8%), and 44 (2.1%) respectively in this study. This suggests that participants in the urban areas were more prone to co-infections than the rural areas in Lagos and Delta states, while it was otherwise in Sokoto State. In conclusion, the co-infection of SARS-CoV-2 and malaria was very high in Delta State compared to the other States. It is important for clinics to screen for both diseases when patients present with symptoms of malaria. This is because the infections have similar symptoms and the public is quick to assume malaria infection without diagnosing for COVID-19 and vice versa.

关键词： SARS-CoV-2 Malaria Coinfection

The microstructural effects of aqueous extract of Garcinia kola(Linn) on the hippocampus and cerebellum of malnourished mice

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 261-265页

作者： Sunday A ajayi David A Ofusori Gideon B Ojo Oladele A Ayoka Taiwo A Abayomi Adekilekun A Tijani Department of Anatomy College of Health SciencesOsun State UniversityOsogbo Osun State Department of Anatomy & Cell Biology Faculty of Basic Medical SciencesObafemi Awolowo UniversityIle-IfeOsun State Department of Anatomy College of Health SciencesBowen UniversityIwoOsun State Department of Physiological Sciences Faculty of Basic Medical SciencesObafemi Awolowo UniversityIle-IfeOsun State

Objective:To assess the neuroprotective effects of aqueous extract of Garcinia kola on neurotoxin administered malnourished mice adopting histological ***:The study was carried out using thirty-two adult malnourished mice which were randomly assigned into four groups(n=8):A,B,C and *** A served as control,while the other groups served as the experimental *** in group A were fed malnourished diet ad libitum and given water *** in group B were administered with 3-Nitropropionic acid(3-NP)(neurotoxin)only at 20 rag/kg body weight,group C were given only Garcinia kola extracts,and group D were pre-treated with Garcinia kola extracts at 200 mg/kg for seven days prior to administration of neurotoxin at 20 mg/kg body *** three days of neurotoxins administration in the relevant groups,the brains were excised and fixed in formal calcium for histological ***:The study showed that hippocampal and cerebellar neurons of animals in group B exhibited some cellular degeneration and blood vessel blockage,which were not seen in groups A,C and *** violet staining was least intense in group B than in groups A,C and *** the fact that animals in group D has equal administration of 3-Nitropropionic acid concentration,there were no traces of neural degeneration as it was evidenced in group ***:It is concluded that Garcinia kola has protective effects on the neurons of the hippocampus and cerebellum of malnourished mice.

关键词： Garcinia kola 3-Nitropropionic acid Neurons Hippocampus Malnourished mice Cerebellum Microstructural effect Neuroprotective effect Aqueous extract Neurotoxin