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Localized,non-viral delivery of nucleic acids:Opportunities,challenges and current strategies

Asian Journal of Pharmaceutical Sciences 2015年第3期10卷 159-175页

作者： oliver germershaus Kira Nultsch Institute for Pharma Technology School of Life SciencesUniversity of Applied Sciences and Arts Northwestern SwitzerlandGründenstrasse 40CH 4132MuttenzSwitzerland

Localized delivery of drugs is an emerging field both with regards to drug delivery during disease as well as in tissue *** significant achievements made in the last decades,the efficient delivery of proteins and peptides remains challenging,especially in cases requiring long-term release of proteins after *** localized delivery of nucleic acids(NA)represents an interesting alternative due to higher physicochemical stability of NA,increased efficiency by harnessing cells as bioreactors for the production of required proteins and improved versatility with regards to expression of specific proteins through plasmid DNA or repression of gene products through ***,unlike most proteins and peptides,NA must be delivered to the cytoplasm or nucleus to be efficacious,resulting in significant delivery *** herein describe frequently used non-viral vectors for the delivery of NA including polyplexes,lipoplexes and lipopolyplexes and summarize recent developments in the field of nucleic acid delivery systems for local application based on hydrogels,solid scaffolds and physical delivery *** challenges associated with the different approaches are identified and options to address these challenges are discussed.

关键词： Gene delivery Topical application Tissue engineering Controlled release SiRNA DNA

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Recent advances in crystalline and amorphous particulate protein formulations for controlled delivery

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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 469-477页

作者： Sebastian Puhl Lorenz Meinel oliver germershaus Institute for Pharmacy and Food Chemistry University of WuerzburgAm Hubland97074 WuerzburgGermany Institute for Pharma Technology University of Applied Sciences Northwestern SwitzerlandGruendenstrasse 404132 MuttenzSwitzerland

The number of particulate delivery systems for biologics is negligible compared to liquid dosage forms, signifying the complications associated with development of solid protein delivery systems. Particulate protein delivery systems can improve stability, reduce viscosity of suspensions at high protein concentration and allow for controlled drug release. This review discusses current advances in controlled delivery of particulate protein formulations. While the focus lies on protein crystals and delivery systems employing protein crystals,amorphous protein particles will also be addressed. Crystallization and precipitations methods and modifications allowing controlled delivery with and without encapsulation are summarized and discussed.

关键词： Protein crystals Protein particles Protein delivery Controlled release

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