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Evaluating chromosomal segregation in a family where both spouses carry an autosomal translocation

Reproductive and Developmental Medicine 2023年第3期7卷 189-192页

作者： Irina L.Puppo Ziravard N.Tonyan Alsu F.Saifitdinova Julia A.Loginova Anna A.Kinunen Alisa N.Panina Julia R.Pastuhova olga A.Leonteva olga G.Chiryaeva olga v.Malysheva Oleg S.Glotov Irina v.Poliakova Andrey v.Tikhonove Tatyana v.vavilova Irina L.Menshikova Elvira v.Isakova Andrey S.Glotov Natalya K.Bichevaya International Centre for Reproductive Medicine Saint-Petersburg 197350Russia Department of Laboratory Medicine and Genetics Almazov National Medical Research CentreSaint-Petersburg197341Russia Department of Genomic Medicine D.O.Ott's Institute of ObstetricsGynecologyand ReproductologySaint-Petersburg 199034Russia Department of Biology.Herzen State Pedagogical University of Russia Saint-Petersburg 191186Russia DiaCarta Inc.2600 Hilltop DriveRichmondCA 94806 St.Petersburg Centre for Medical Genetics Saint Petersburg194044Russia Department of ExperimentalMedical virology MolecularGenetics and Biobankingof Pediatric Researchand Clinical Center for Infectious DiseasesSaint-Petersburg 197022Russia Medical institute of Surgut State University Surgut 628403 Russia CerbaLab Ltd. Saint-Petersburg 199106Russia

Autosomal reciprocal translocations represent exchanges of chromatin fragments between non-homologous *** are facilitated by the creation of quadrivalent structures during the first meiotic division,which are characterized by the length of the translocated and centric segments,asymmetry,and the presence of terminal breakpoints,all of which may impact segregation ***,we report a rare case of multiple reciprocal translocations within a single *** includes the evaluation of the translocations in each of the spouses and an analysis of their chromosome segregation patterns as determined by the constellation of universal characteristics in each of their *** obtained results will be of interest to fundamental biology,as they will expand the understanding of the factors affecting chromosome segregation during meiosis.

关键词： Embryo viability Genetic counseling Pre-implantation genetic testing Quadrivalent characteristics

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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-Mora valeria García-Zárate Ana varela-Constantino Sergio U villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz victor Mingura-Ledezma Perla R Colunga-Pedraza olga G Cantú-Rodríguez César H Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

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平作条件下不同种植密度对不同株型大豆品种农艺性状及产量的影响

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大豆科技 2024年第4期 7-13页

作者：魏然李阳 СелиховаОльгаАлександровна 张武于晓光吴俊彦崔杰印位昕禹黑龙江省农业科学院黑河分院俄罗斯远东国立农业大学俄罗斯黑龙江省黑河市气象局

文章以俄罗斯无限结荚习性分枝型大豆品种Лидия和亚有限结荚习性主茎型大豆品种Персона为试验材料，设置25万、40万、55万、70万、85万株/hm2这5个种植密度处理，研究平作条件下不同种植密度对2种不同株型大豆品种农艺性状... 详细信息

文章以俄罗斯无限结荚习性分枝型大豆品种Лидия和亚有限结荚习性主茎型大豆品种Персона为试验材料，设置25万、40万、55万、70万、85万株/hm2这5个种植密度处理，研究平作条件下不同种植密度对2种不同株型大豆品种农艺性状及产量的影响。结果表明，种植密度显著影响不同株型大豆品种Лидия和Персона的农艺性状及产量，随着种植密度增加均呈现相似变化趋势。其中，株高和底荚高度随种植密度增加呈升高趋势；有效分枝数、主茎节数、单株荚数、单株粒数和百粒重等农艺性状整体上随种植密度增加呈降低趋势；产量随种植密度增加呈先升高后降低趋势。在平作条件下，无限结荚习性分枝型大豆品种Лидия适宜种植密度为55万株/hm2，产量最高可达2.51 t/hm2；亚有限结荚习性主茎型大豆品种Персона适宜种植密度为40万株/hm2，产量最高可达2.47 t/hm2。

关键词：大豆种植密度株型农艺性状产量

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Growing challenge of post-liver transplantation non-alcoholic fatty liver disease

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World Journal of Transplantation 2022年第9期12卷 281-287页

作者： Maria Styliani Kalogirou olga Giouleme Gastroenterology and Hepatology Division of the Second Propedeutic Department of Internal Medicine Hippokration General HospitalMedical SchoolAristotle University of ThessalonikiThessaloniki 54642Greece

Non-alcoholic fatty liver disease(NAFLD)is one of the leading causes of chronic liver disease,cirrhosis,and hepatocellular carcinoma worldwide,with an estimated prevalence of 25%.Post-liver transplantation(LT)recurrent or de novo hepatic steatosis is a common complication in recipients,irrespective of transplantation *** factors for graft steatosis mainly include obesity,immunosuppression,donor steatosis,and genetic *** transplant recipients are at high risk of developing insulin resistance,new-onset diabetes,and posttransplantation metabolic syndrome that is highly associated with immunosuppressive ***-LT NAFLD is often underdiagnosed due to the poor sensitivity of most routine imaging *** gold standard for the diagnosis of hepatic steatosis is liver biopsy,which is,however,limited to more complex cases due to its invasive *** is no approved pharmacotherapy in *** modification remains the cornerstone in NAFLD *** treatment strategies in post-LT NAFLD include lifestyle modifications,pharmacotherapy,bariatric surgery,and tailored ***,these approaches originate from recommendations in the general population,as there is scarce data regarding the safety and efficacy of current management strategies for NAFLD in liver transplant *** prospective studies are required to achieve tailored treatment for these patients.

关键词： Non-alcoholic fatty liver disease Steatohepatitis Hepatic steatosis Liver transplantation Cirrhosis Metabolic syndrome

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Giant photoinduced reflectivity modulation of nonlocal resonances in silicon metasurfaces

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Advanced Photonics 2023年第6期5卷 83-91页

作者： Andrea Tognazzi Paolo Franceschini olga Sergaeva Luca Carletti Ivano Alessandri Giovanni Finco Osamu Takayama Radu Malureanu Andrei v.Lavrinenko Alfonso C.Cino Domenico de Ceglia Costantino De Angelis University of Palermo Department of EngineeringPalermoItaly National Institute of Optics-National Research Council PalermoItaly University of Brescia Department of Information EngineeringPalermoItaly ITMO University School of Physics and EngineeringSaint-PetersburgRussia ETH Zurich Institute for Quantum ElectronicsDepartment of PhysicsOptical Nanomaterial GroupZurichSwitzerland Technical University of Denmark Department of Electrical and Photonics EngineeringKongens LyngbyDenmark

Metasurfaces offer a unique playground to tailor the electromagnetic field at subwavelength scale to control polarization,wavefront,and nonlinear *** of the optical response of these structures is challenging due to the nanoscale size of their constitutive elements.A long-sought solution to achieve tunability at the nanoscale is all-optical modulation by exploiting the ultrafast nonlinear response of ***,the nonlinear response of materials is inherently very weak,and,therefore,requires optical excitations with large values of *** show that by properly tuning the equilibrium optical response of a nonlocal metasurface,it is possible to achieve sizable variation of the photoinduced out-ofequilibrium optical response on the picosecond timescale employing fluences smaller than 250μJ∕cm^(2),which is 1 order of magnitude lower than previous studies with comparable reflectivity variations in silicon *** results pave the way to fast devices with large modulation amplitude.

关键词： nonlocal metasurface nanophotonics ultrafast modulation Fano resonance

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Polyphony of domestic dog whines and vocal cues to body size

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Current Zoology 2021年第2期67卷 165-176页

作者： olga v.SIBIRYAKOvA Ilya A.vOLODIN Elena v.vOLODINA Department of vertebrate Zoology Faculty of BiologyLomonosov Moscow State UniversityMoscow 119234Russia Department of Behaviour and Behavioural Ecology A.N.Severtsov Institute of Ecology and EvolutionRussian Academy of SciencesMoscow 119071Russia

In domestic dogs Canis familiaris,vocal traits have been investigated for barks and growls,and the relationship between individual body size and vocal traits investigated for growls,with less corre-sponding information for *** this study,we examined the frequency and temporal traits of whines of 20 adult companion dogs(9 males,11 females),ranging in body mass from 3.5 to 70.0 kg and belonging to 16 *** whines(26-71 per individual,824 in total)were recorded in condi-tioned begging contexts modeled by dog *** had 3 independent fundamental fre-quencies:the low,the high and the ultra-high that occurred singly as monophonic calls or simul-taneously as 2-voice biphonic or 3 voice polyphonic *** the smallest to largest dog,the upper frequency limit varied from 0.24 to 2.13 kHz for the low fundamental frequency,from 2.95 to 10.46 kHz for the high fundamental frequency and from 9.99 to 23.26 kHz for the ultra-high funda-mental *** individuals,the low fundamental frequency was lower in monophonic than in biphonic whines,whereas the high fundamental frequency did not differ between those whine *** frequency variables of the low,high,and ultra-high fundamental frequencies cor-related negatively with dog body *** duration,no correlation with body mass was *** discuss potential production mechanisms and sound sources for each fundamental frequency;point to the acoustic similarity between high-frequency dog whines and rodent ultrasonic calls and hypothesize that ultra-high fundamental frequencies function to allow private,"tete-a-tete"com-munication between members of social groups.

关键词： acoustic communication Canis familiaris companion dogs high-frequency calls nonlinear phenomena vocalization

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Changes in permafrost and snow cover in the Boreal and Arctic zones(BAZs)and their impacts

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Advances in Climate Change Research 2023年第2期14卷 157-163页

作者： Hui-Jun JIN Daqing YANG olga MAKARIEvA Liang TANG School of Civil Engineering|Permafrost Institute Northeast Forestry UniversityHarbin 150040China State Key Laboratory of Frozen Soils Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Scientific Observation and Research Station of Permafrost and Cold-Regions Environment in the Da Xing'anling Mountains Northeast ChinaNatural Resources Institute of Heilongjiang ProvinceHarbin 150036China Institute of Tibet Plateau Research Chinese Academy of SciencesBeijing 1000101China National Hydrology Research Centre Environment CanadaSaskatoonSaskatchewan S7N 3H5Canada Institute of Earth Sciences St.Petersburg State UniversitySt.Petersburg199034Russia School of Civil Engineering Harbin Institute of TechnologyHarbin 150090China

*** Amplified climate warming and wetting have been observed in the Boreal and Arctic zones(BAZs).Due to extensive and persistent warming of the climate and the increasing impacts of human activities,we are seeing degradation of the permafrost and rapid shrinkage of the snow cover in the *** attention has been paid to the reconstruction of past permafrost and monitoring,mapping and evaluation of permafrost and snow cover,and the use of models to predict and evaluate future gradual permafrost *** attention,however,has been given to the rapidly changing permafrost and the associated *** may have led to an underestimation of the rapid changes in the cryolithozone and their effects on the climate,ecosystems,and hydrology systems and on *** particular,natural resources and environmental management in northern countries requires better and more systematic understanding of the history,processes,mechanisms and trends of the northern cryosphere and their environmental and engineering impacts.

关键词： Arctic warming ozone

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Searching novel complex solid solution electrocatalysts in unconventional element combinations

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Nano Research 2022年第6期15卷 4780-4784页

作者： olga A.Krysiak Simon Schumacher Alan Savan Wolfgang Schuhmann Alfred Ludwig Corina Andronescu Analytical Chemistry-Center for Electrochemical Sciences(CES) Faculty of Chemistry and BiochemistryRuhr University BochumUniversitätsstr.150D-44780 BochumGermany Chemical Technology Ⅲ Faculty of ChemistryCarl-Benz-Straße 199D-47057 DuisburgGermany CENIDE-Center for Nanointegration University Duisburg Essen Carl-Benz-Straße 199D-47057 DuisburgGermany Chair for Materials Discovery and Interfaces Institute for MaterialsFaculty of Mechanical EngineeringRuhr University BochumUniversitätsstr.150D-44780 BochumGermany ZGH Ruhr University BochumUniversitätsstr.150D-44780 BochumGermany

Despite outstanding accomplishments in catalyst discovery,finding new,more efficient,environmentally neutral,and noble metalfree catalysts remains challenging and ***,complex solid solutions consisting of at least five different elements and often named as high-entropy alloys have emerged as a new class of electrocatalysts for a variety of *** multicomponent combinations of elements facilitate tuning of active sites and catalytic *** optimal catalyst composition remains difficult,making testing of a very high number of them *** present the high-throughput screening of the electrochemical activity of thin film material libraries prepared by combinatorial co-sputtering of metals which are commonly used in catalysis(Pd,Cu,Ni)combined with metals which are not commonly used in catalysis(Ti,Hf,Zr).Introducing unusual elements in the search space allows discovery of catalytic activity for hitherto unknown *** libraries with very similar composition spreads can show different activities *** trends for different *** order to address the inherent challenge of the huge combinatorial material space and the inability to predict active electrocatalyst compositions,we developed a high-throughput process based on co-sputtered material libraries,and performed high-throughput characterization using energy dispersive X-ray spectroscopy(EDS),scanning transmission electron microscopy(SEM),X-ray diffraction(XRD)and conductivity measurements followed by electrochemical screening by means of a scanning droplet *** results show surprising material compositions with increased activity for the oxygen reduction reaction and the hydrogen evolution *** data are important input data for future data-driven materials prediction.

关键词： high-entropy alloys electrocatalysis high-throughput screening thin films hydrogen evolution reaction oxygen reduction reaction

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Response of soil macrofauna to urban park reconstruction

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Soil Ecology Letters 2023年第2期5卷 127-141页

作者： Olexander Zhukov olga Kunakh Nadiia Yorkina Anna Tutova Bogdan Khmelnitsky Melitopol State Pedagogical University Hetmanska st.20Melitopol72318Ukraine Oles Gonchar Dnipro National University Gagarin av.72Dnipro49000Ukraine

This study is based on a park in an industrial city in *** 2019,a 2.8 ha area of the park was *** park’s reconstruction aimed to create a comfortable environment for visitors and to improve the efficiency of ecosystem services,and thereby enhance the quality of life of *** reconstruction of the park was found to cause changes in the physical properties of soils and the structure of the soil macrofauna *** increases of soil compaction in the layers at depth 5-20 cm and the soil electrical conductivity were a consequence of technological operations during *** park reconstruction activities can also explain 29% of the variation in the soil macrofauna *** the variation induced by the park reconstruction from the community variation induced by other causes was a major *** specific changes in the community of soil macrofauna following the reconstruction of the park were *** abundance of soil animal species ***,***,***,***,*** was found to increase after the *** earthworm *** decreased in abundance due to the park reconstruction.

关键词： ecosystem services soil physical properties community ordination urban park management variation partitioning

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Tri-axial accelerometry shows differences in energy expenditure and parental effort throughout the breeding season in long-lived raptors

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Current Zoology 2022年第1期68卷 57-67页

作者： Pascual LOPEZ-LOPEZ Arturo MPERONA olga EGEA-CASAS Jon MORANT vicente URIOS Movement Ecology Laboratory Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of Valencia.C/Catedratico JoseBeltran 2E-46980 PaternaValenciaSpain Department of Ornithology Aranzadi Sciences SocietyDonostia-S.SebastianGuipuzcoa 03690Spain vertebrates Zoology Research Group University of AlicanteApdo.99Alicante E-03080Spain

Cutting-edge technologies are extremely useful to develop new workflows in studying ecological data,particularly to understand animal behavior and movement trajectories at the individual *** parental care is a well-studied phenomenon,most studies have been focused on direct observational or video recording data,as well as experimental ***,what happens out of our sight still remains *** high-frequency GPS/GSM dataloggers and tri-axial accelerometers we monitored 25 Bonelli’s eagles Aquila fasciata during the breeding season to understand parental activities from a broader *** used recursive data,measured as number of visits and residence time,to reveal nest attendance patterns of biparental care with role specialization between *** data interpreted as the overall dynamic body acceleration,a proxy of energy expenditure,showed strong differences in parental effort throughout the breeding season and between ***,males increased substantially their energetic requirements,due to the increased workload,while females spent most of the time on the ***,during critical phases of the breeding season,a low percentage of suitable hunting spots in eagles’territories led them to increase their ranging behavior in order to find food,with important consequences in energy consumption and mortality *** results highlight the crucial role of males in raptor species exhibiting biparental ***,we exemplify how biologging technologies are an adequate and objective method to study parental care in raptors as well as to get deeper insight into breeding ecology of birds in general.

关键词： biologging GPS movement ecology ODBA space use telemetry

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