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Neuro.nflammatio. revisited thro.gh the micro.lial lens

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Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.B.Relvas Institute o. Research and Inno.atio. in Health(i3S)and Institute fo. Mo.ecular and Cell Bio.o.y(IBMC) University of PortoPortoPortugal department o. Bio.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues between the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,beyo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship between neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elabo.ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(Ad).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist but a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. brain diseases.

关键词： inflammatio. simplified activatio.

Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3d cellular mo.ility mechanisms

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to.o.anges:enviro.mentally derived,dynamic regulatio. o. sero.o.in neuro. subpo.ulatio.s in adultho.d?

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Neural Regeneratio. Research 2025年第9期20卷 2596-2597页

作者： Christo.her J.o.Co.nell Matthew J.Ro.so. department o. Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle Co.lege o. Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuro.cience Graduate Pro.ram College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health pro.lem with an undue eco.o.ic burden that impacts nearly every age,ethnic,and gender gro.p acro.s the glo.e(Capizzi et al.,2020).TBIs are o.ten sustained during a dynamic range o. expo.ures to.energetic enviro.mental fo.ces and as such o.tco.es are typically hetero.eneo.s regarding severity and patho.o.y(Capizzi et al.,2020).

关键词： sustained o.ange dynamic

dynamic stress co.centratio. in an infinitely lo.g cylindrical cavity due to.a po.nt spherical so.rce embedded within a fluid-saturated po.o.lastic fo.matio. o. infinite extent

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Applied Mathematics and Mechanics(English Editio.) 2025年第1期46卷 139-156页

作者： H.Ho.SEINI o.BALILASHAKI department o. Mechanical Engineering Faculty of EngineeringGolestan University

The effects o. a harmo.ically exciting mo.o.o.e so.rce o. an infinitely lo.g cylindrical cavity embedded entirely within a fluid-saturated po.o.lastic fo.matio. o. infinite extent are examined theo.etically. It is assumed that the so.rce is lo.ated o.tside the cavity at a specified distance fro. the bo.eho.e axis. The magnitudes o. the ho.p and radial stresses beside the po.e pressures exerted o. the interface and inside the po.o.s medium surro.nding the bo.eho.e are calculated and discussed. Bio.'s po.o.lastic mo.eling alo.g with three types o. bo.ndary co.ditio.s fo. the cylindrical interface including the ideal fluid, empty bo.eho.e, and rigid inclusio. with a hard bo.ndary is emplo.ed fo. the analysis. Utilizing a pro.er translatio.al additio. theo.em fo. expressing the incident spherical wave in terms o. cylindrical wave expansio.s, the pro.o.ed bo.ndary co.ditio.s at the interface are satisfied. Stresses are fo.mulated by means o. wave po.ential functio.s in a three-dimensio.al(3d) manner. The effects o. the frequency and the radial distance between the so.rce and bo.eho.e o. the induced stresses are examined fo. the first cylindrical mo.es o.er frequency spectra. Two.permeability co.ditio.s fo. the interface and three types o. so.ls fo. the po.o.s fo.matio. are co.sidered thro.gho.t the analysis. To.give an o.erall o.tline o. the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has co.siderable effects o. the induced stress values. In additio., the interface permeability co.ditio. and so.l characteristics play an impo.tant ro.e in determining the dynamic respo.se o. the bo.eho.e. Finally,the o.tained results are co.pared with the relevant analyses existing in the literature fo. so.e limit cases, and go.d agreement is achieved.

关键词： po.nt so.rce cylindrical cavity po.o.s medium wave-field transfo.matio. stress co.centratio. o.53.4

Po.yethylene glyco. has immuno.ro.ective effects o. sciatic allo.rafts, but behavio.al reco.ery and graft to.erance require neuro.rhaphy and axo.al fusio.

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Neural Regeneratio. Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zho. Camero. L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley o.Tucker JuliAnne Allgo.d Jared S.Bushman Geo.ge d.Bittner department o. Mo.ecular Bio.ciences University of Texas at AustinAustinTXUSA department o. Neuro.cience University of Texas at AustinAustinTXUSA divisio. o. Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavio.al reco.ery using(viable)peripheral nerve allo.rafts to.repair ablatio.-type(segmental-lo.s)peripheral nerve injuries is delayed o. po.r due to.slo. and inaccurate axo.al ***,such peripheral nerve allo.rafts undergo.immuno.o.ical rejectio. by the ho.t immune *** co.trast,peripheral nerve injuries repaired by po.yethylene glyco. fusio. o. peripheral nerve allo.rafts exhibit excellent behavio.al reco.ery within weeks,reduced immune respo.ses,and many axo.s do.no. undergo.Wallerian *** relative co.tributio. o. neuro.rhaphy and po.yethylene glyco.-fusio. o. axo.s versus the effects o. po.yethylene glyco. per se was unkno.n prio. to.this *** hypo.hesized that po.yethylene glyco. might have so.e immune-pro.ective effects,but po.yethylene glyco.-fusio. was necessary to.prevent Wallerian degeneratio. and functio.al/behavio.al *** examined ho. po.yethylene glyco. so.utio.s per se affect functio.al and behavio.al reco.ery and peripheral nerve allo.raft mo.pho.o.ical and immuno.o.ical respo.ses in the absence o. po.yethylene glyco.-induced axo.al ***-type sciatic nerve injuries in o.tbred Sprague–dawley rats were repaired acco.ding to.a mo.ified pro.o.o. using the same so.utio.s as po.yethylene glyco.-fused peripheral nerve allo.rafts,but peripheral nerve allo.rafts were lo.se-sutured(lo.se-sutured po.yethylene glyco.)with an intentio.al gap o. 1–2 mm to.prevent fusio. by po.yethylene glyco. o. peripheral nerve allo.raft axo.s with ho.t *** to.negative co.tro. peripheral nerve allo.rafts no. treated by po.yethylene glyco. and in co.trast to.po.yethylene glyco.-fused peripheral nerve allo.rafts,animals with lo.se-sutured po.yethylene glyco. peripheral nerve allo.rafts exhibited Wallerian degeneratio. fo. all axo.s and myelin degeneratio. by 7 days po.to.eratively and did no. reco.er sciatic-mediated behavio.al functio.s by 42 days *** mo.pho.o.ical signs o. rejectio.,such as co.

关键词： allo.raft rejectio. axo.o.y macro.hage myelin nerve repair po.yethylene glyco.(PEG) sciatic nerve T cell transplantatio. Wallerian degeneratio.

Thermo.ynamic analysis fo. a third grade fluid thro.gh a vertical channel with internal heat generatio.

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Jo.rnal o. Hydro.ynamics 2015年第2期27卷 264-272页

作者： AdESANYA Samuel o. MAKINdE o.uwo.e d. department o. Mathematical Sciences Redeemer's University Faculty o. Military Science Stellenbosch University

This paper makes the thermo.ynamic analysis in fo.ced co.vective flo. o. a third grade fluid thro.gh a vertical channel. due to.the reactive nature o. the fluid, the effect o. internal heat generatio. is co.sidered and assumed to.be a linear functio. o. temperature. The co.pled no.linear dimensio.less o.dinary differential equatio.s go.erning the fluid flo. are so.ved by using the Ado.ian deco.po.itio. metho.（AdM）. The effects o. vario.s physical parameters such as third grade material parameter, buo.ancy parameter and heat generatio. parameter o. the thermal structure o. flo. are presented and discussed.

关键词： energy co.servatio. vertical channel third grade fluid internal heat generatio. Ado.ian deco.po.itio. metho.(AdM)

Irreversibility analysis o. unsteady co.ette flo. with variable visco.ity

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Jo.rnal o. Hydro.ynamics 2015年第2期27卷 304-310页

作者： EEGUNJo.I A.S. MAKINdE o.d. TSHEHLA M.S. FRANKS o. department o. Mathematics and Statistics Namibia University of Science and Technology Faculty o. Military Science Stellenbosch University Faculty o. Engineering Built Enviro.ment and Info.matio. Techno.o.y Nelson Mandela Metropolitan University Faculty o. Military Science Stellenbosch University

This paper investigates numerically the inherent irreversibility in unsteady generalized Co.ette flo. between two.parallel plates with variable visco.ity. The no.linear go.erning equatio.s are derived fro. the Navier-Sto.es equatio.s and so.ved numerically using a semi-discretizatio. finite difference metho. to.ether with the Runge-Kutta-Fehlberg integratio. scheme. The pro.iles o. velo.ity and the temperature o.tained are used to.co.pute the entro.y generatio. number, Bejan number, skin frictio. and Nusselt number. The effects o. embedded parameters o. entire flo. structure are presented graphically and discussed quantitatively.

关键词： parallel plates variable visco.ity heat transfer Co.ette flo. entro.y generatio.

No.relativistic Lamb shift in a nano.sized co.ducting ring

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Science China(Physics,Mechanics & Astro.o.y) 2012年第8期55卷 1383-1388页

作者： o.ESEN d. S. KELLER o. Institute o. Physics and Nano.echno.o.y Aalborg University

A theo.etical calculatio. o. the no.relativistic Lamb shift in nano.sized semico.ducting （GaAs） and metallic （AI） circular rings is carried o.t. o. the basis o. a flat o.e-electro. po.ential with infinitely high barriers, the radiative back-actio. is o.tained to.seco.d o.der in perturbatio. theo.y. Numerical results are presented fo. the radiative co.rectio. to.the transitio. frequency between the gro.nd state and first excited radial quantum states （initial state：（1,1,0）, final state：（2,1,0）） neglecting the curvature term in the Schr6dinger equatio.. Lamb shifts are calculated as functio.s o. the inner ring radius, the ring thickness, and the temperature.

关键词： Lamb shift nano.ring meso.co.ic quantum electro.ynamics

Pro.o.tio.al-integral-derivative co.tro. o. no.linear half-car electro.hydraulic suspensio. systems

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Jo.rnal o. Zhejiang University-Science A(Applied Physics & Engineering) 2013年第6期14卷 401-416页

作者： Jo.n E. d. EKo.U Jimo. o. PEdRo Scho.l o. Mechanical Aeronautical and Industrial Engineering University of the Witwatersrand Private Bag 03 WITS 2050 Johannesburg South Africa

This paper presents the develo.ment o. a pro.o.tio.al-integral-derivative (PId)-based co.tro. metho. fo. applicatio. to.active vehicle suspensio. systems (AVSS). This metho. uses an inner PId hydraulic actuato. fo.ce co.tro. lo.p, in co.binatio. with an o.ter PId suspensio. travel co.tro. lo.p, to.co.tro. a no.linear half-car AVSS. Ro.ustness to.mo.el uncertainty in the fo.m o. variatio. in suspensio. damping is tested, co.paring perfo.mance o. the AVSS with a passive vehicle suspensio. system (PVSS), with similar mo.el parameters. Spectral analysis o. suspensio. system mo.el o.tput data, o.tained by perfo.ming a ro.d input disturbance frequency sweep, pro.ides frequency respo.se plo.s fo. bo.h no.linear vehicle suspensio. systems and time do.ain vehicle respo.ses to.a sinuso.dal ro.d input disturbance o. a smo.th ro.d. The results sho. the greater ro.ustness o. the AVSS o.er the PVSS to.parametric uncertainty in the frequency and time do.ains.

关键词： Fo.ce co.tro. Pro.o.tio.al-integral-derivative (PId) co.tro. No.linear half-car Active vehicle suspensio. system (AVSS) Hydraulic actuato. dynamics Mo.el uncertainty