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RbC aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from L-Arginine and sodium nitroprusside

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Journal of Innovative optical Health Sciences 2024年第5期17卷 53-65页

作者： M.K.Maksimov P.b.Ermolinskiy o.n.Scheglovitova n.n.Sklyankina A.v.Muravyov A.E.Lugovtsov A.v.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya national Research Center for Epidemiology and Microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State Pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RbCs)are the most abundant human blood *** aggregation and deformation strongly determine blood viscosity which impacts hemorheology and *** turn,RbC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(no),which is mainly produced by endothelial cells(EC)from L-arginine amino acid in the circulatory *** the mechanisms of the RbC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The e®ect of L-arginine induced no on RbC aggregation and adhesion to endothelium;(2)the no e®ect on RbC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the *** RbC aggregation and adhesion to a monolayer of EC were studied using optical tweezers(oT).The RbC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and Myrenne *** con¯rmed that no increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only no signaling pathway *** the samples with the endothelium,the\bell-shaped"dependence of RbC aggregation force on L-arginine concentration was observed,which improves our knowledge about the process of no production by ***,data related to L-arginine accumulation by endothelium were obtained:necessity of the presence of extracellular L-arginine stated by other authors was put under *** our study,no decreased the RbC-endothelium adhesion,however,the tendency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RbC adhesion to endothelium monolayer with oT.

关键词： Red blood cells aggregation L-arginine endothelium optical tweezers Myrenne flow chamber

Astrophysical S-factor and reaction rate for 15n(p,γ)16o within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： S.b.Dubovichenko A.S.Tkachenko R.Ya.Kezerashvili n.A.burkova b.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan new York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate School and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh national University 050040 AlmatyKazakhstan

We study radiative p^(15)n capture on the ground state of ^(16)o at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)n(p,γ0)^(16)o reaction includes the consideration of ^(3)S_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)n channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy S-factor,and the extrapolated S(0)turned out to be within 34.7−40.4 kev·*** important role of the asymptotic constant(AC)for the ^(15)n(p,γ0)16o process with interfering ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances is elucidated.A comparison of our calculation for the S-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances in reference to the Cno Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)n(p,γ)^(13)o,^(13)n(p,γ)^(14)o,^(14)n(p,γ)^(15)o,and ^(15)n(p,γ)^(16)o obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)n system thermonuclear reaction rate potential cluster model Cno-cycle

Detailed seismic zoning of the East Kazakhstan region in the Republic of Kazakhstan

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Geodesy and Geodynamics 2024年第2期15卷 156-165页

作者： natalya v.Silacheva n.P.Stepanenko o.K.Kurilova A.D.Kudabayeva A.T.Danabayeva Institute of Seismology Ministry of Emergency SituationsAlmaty 050060Kazakhstan

Kazakhstan is currently drafting new construction regulations that comply with the major provisions of the *** regulations are created on the basis of seismic zoning maps of various degrees of detail,developed by our Institute of Seismology using a new methodological approach for *** article is about creating the first normative map of the Detailed Seismic Zoning on a probabilistic foundation for the Republic of Kazakhstan’s East Kazakhstan *** carried out the probabilistic assessment of seismic hazard using a methodology consistent with the main provisions of Eurocode 8and updated compared with that used in developing maps of Kazakhstan’s General Seismic Zoning and seismic microzoning of *** most thorough and current data accessible for the area under consideration were combined with contemporary analytical *** have been done to not only the databases being used but also the way seismic sources were shown,including active faults *** a scale of 1:1000000,precise seismic zoning maps of the East Kazakhstan region were created for two probabilities of exceedance:10%and 2%in 50 years in terms of peak ground accelerations and macroseismic *** obtained seismic hazard distribution is generally consistent with the General Seismic Zoning of Kazakhstan’s previous ***,because active faults were included and a thoroughly revised catalog was used,there are more pronounced zones of increased danger along the fault in the western part of the *** the west of the territory,acceleration values also increased due to a more accurate consideration of seismotectonic *** maps are the basis for developing new state building regulations of the Republic of Kazakhstan.

关键词： Probabilistic seismic hazard assessment Detailed seismic zoning Peak ground acceleration Microseismical intensity

Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： v.A.KRUPIn M.R.nURGALIEv A.R.nEMETS I.A.ZEMTSov S.D.SUnTSov T.b.MYALTon D.S.SERGEEv n.A.SoLovEv D.v.SARYCHEv D.v.RYJAKov S.n.TUGARInov n.n.nAUMEnKo national Research Centre“Kurchatov Institute” Moscow 123182Russia bauman Moscow State Technical University Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SoLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECRH power. The EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

Highly Defective Dark Tio_(2) Modified with Pt: Effects of Precursor nature and Preparation Method on Photocatalytic Properties

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Transactions of Tianjin University 2024年第2期30卷 198-209页

作者： E.D.Fakhrutdinova o.A.Reutova T.A.bugrova I.Yu.ovsyuk L.S.Kibis o.A.Stonkus D.b.vasilchenko o.v.vodyankina v.A.Svetlychnyi national Research Tomsk State University TomskRussia 634050 novosibirsk State University NovosibirskRussia 630090 boreskov Institute of Catalysis NovosibirskRussia 630090 nikolaev Institute of Inorganic Chemistry NovosibirskRussia 630090

The study focused on the modification with platinum of dark defective titania obtained via pulsed laser ablation. both the method of Pt introduction and the nature of the Pt precursor were varied. All samples exhibited similar phase compositions, specific surface areas, and Pt contents. High-resolution transmission electron microscopy coupled with pulsed Co adsorption revealed increased dispersity when photoreduction and the hydroxonitrate complex (Me _(4) n) _(2) [Pt _(2) (oH) _(2) (no _(3) ) _(8) ] were used. The sample featured a high content of single-atom species and subnano-sized Pt clusters. The X-ray photoelectron spectroscopy results showed that the photoreduction method facilitated the appearance of a larger number of Pt ^(2+) states, which appeared owing to the strong metal-support interaction (SMSI) eff ect of the transfer of electron density from the electron-saturated defects on the Tio _(2) surface to Pt ^(4+) . In the hydrogen evolution reaction, samples with a significant fraction of the Pt ^(2+) ionic component, capable of generating short-lived Pt^(0) single-atom sites under irradiation due to the SMSI eff ect, exhibited the highest photocatalytic activity. The 0.5Pt(C)/Tio_(2) -Ph sample exhibited the highest hydrogen yield with a quantum efficiency of 0.53, retaining its activity even after 8 h of operation.

关键词： Dark(black)Tio_(2) Pulsed laser ablation Platinum reduction method Precursor type Photocatalysis Hydrogen evolution reaction

Phase composition,conductivity,and sensor properties of cerium-doped indium oxide

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nano Materials Science 2024年第2期6卷 193-200页

作者： M.I.Ikim G.n.Gerasimov v.F.Gromov o.J.Ilegbusi L.I.Trakhtenberg n.n.Semenov Federal Research Center for Chemical Physics of RAS MoscowRussia University of Central Florida OrlandoFLUSA Moscow Institute of Physics and Technology(State University) DolgoprudnyMoscow RegionRussia Lomonosov Moscow State University MoscowRussia

The hydrothermal synthesis of In_(2)o_(3)and Ceo_(2)–In_(2)o_(3)is investigated as well as the properties of sensor layers based on these *** the synthesis of In_(2)o_(3),intermediate products In(oH)_(3)and InooH are formed,which are the precursors of stable cubic(c-In_(2)o_(3))and metastable rhombohedral(rh-In_(2)o_(3))phases,respectively.A transition from c-In_(2)o_(3)to rh-In_(2)o_(3)is observed with the addition of Ceo_(2).The introduction of cerium into rh-In_(2)o_(3)results in a decrease in the sensor response to hydrogen,while it increases in composites based on c-In_(2)o_(3).The data on the sensor activity of the composites correlate with XPS results in which Ceo_(2)causes a decrease in the concentrations of chemisorbed oxygen and oxygen vacancies in rh-In_(2)o_(3).The reverse situation is observed in composites based on c-In_(2)o_(3).Compared to In_(2)o_(3)and Ceo_(2)–In_(2)o_(3)obtained by other methods,the synthesized composites demonstrate maximum response to H_(2)at low temperatures by 70–100℃,and have short response time(0.2–0.5 s),short recovery time(6–7 s),and long-term stability.A model is proposed for the dependence of sensitivity on the direction of electron transfer between In_(2)o_(3)and Ceo_(2).

关键词： Cerium oxide Indium oxide nanocomposite Hydrothermal method Cubic phase Rhombohedral phase Sensor response Conductivity Hydrogen Response/recovery time

Unsupervised intrusion detection system for in-vehicle communication networks

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Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan n vinayakumar Ravi v Sowmya Center for Computational Engineering and networking(CEn) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Center for Artificial Intlligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(CAn)is used as a standard communication method because of its efficient and reliable ***,CAn is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining the optimal feature extracting ability of autoencoders and more precise clustering using fuzzy C-means(FCM).The proposed method is light weight and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the ML35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WnS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDCup with accuracy 60.63%,UnSW_nb15 with accuracy 73.62%and Information Security Center of Excellence(Iscx)with accuracy 74.83%.overall,the proposed method outperforms the existing methods and avoids labeled datasets when training an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is generalized and robust in detecting intrusions and can be effectively deployed in real time to monitor CAn traffic in vehicles and proactively alert during attacks.

关键词： Controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy C-means

Prompt neutron emission in ^(250)no spontaneous fission associated with ground and isomeric state decays

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Chinese Physics C 2024年第6期48卷 112-117页

作者： R.S.Mukhin A.v.Isaev A.v.Andreev M.L.Chelnokov v.I.Chepigin H.M.Devaraja I.n.Izosimov A.A.Kuznetsova o.n.Malyshev A.G.Popeko Yu.A.Popov A.Rahmatinejad b.Sailaubekov T.M.Shneidman E.A.Sokol A.I.Svirikhin M.S.Tezekbayeva M.A.bychkov A.v.Yeremin o.Dorvaux b.Gall K.Kessaci K.Hauschild A.Lopez-Martens Joint Institute for nuclear Research Dubna141980Russia Dubna State University Dubna141982Russia Institute of nuclear Physics Almaty050032Kazakhstan L.n.Gumilyov Eurasian national University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde Strasbourg CNRSStrasbourg67000France IJCLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion reaction^(204)Pb(^(48)Ca,2n)^(250)no was used to study two activities of^(250)no with distinct half-lives.A total of 1357 events were observed in the SFinx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)no was determined to be(4.1±0.1).The unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide

Measurement of yields and angular distributions ofγ-quanta from the interaction of 14.1 Mev neutrons with oxygen,phosphorus,and sulfur

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Chinese Physics C 2024年第3期48卷 79-92页

作者： D.n.Grozdanov n.A.Fedorov S.b.Dabylova Yu.n.Kopatch I.n.Ruskov v.R.Skoy T.Yu.Tretyakova C.Hramco P.I.Kharlamov G.v.Pampushik P.G.Filonchik A.v.Andreev Joint Institute for nuclear Research(JInR) DubnaRussia Institute for nuclear Research and nuclear Energy Bulgarian Academy of SciencesSofiaBulgaria Faculty of Physics Lomonosov Moscow State UniversityMoscowRussia L.n.Gumilyov Eurasian national University AstanaKazakhstan Skobeltsyn Institute of nuclear Physics Moscow State UniversityMoscowRussia Institute of Chemistry of Moldova ChisinauRepublic of Moldova Moscow Institute of Physics and Technology MoscowRussia

A study of the inelastic scattering of neutrons with an energy of 14.1 Mev on the nuclei of oxygen,phosphorus,and sulfur was performed at the TAnGRA facility at JInR(Dubna).The experiment aimed to refine existing data and obtain new data on the yields and angular distributions ofγ-quanta emitted by the studied nuclei due to neutron-induced nuclear reactions using the tagged neutron *** types of detector systems were used to registerγ-***γ-ray yields were measured using a high-purity germanium(HPGe)*** angular distributions ofγ-rays were obtained using a system of 18 scintillation detectors based on bismuth germanite bi_(4)Ge_(3)o_(12)(bGo)located around the *** performed experiments measured the yields of two transitions for the reaction of tagged neutrons with 16o,nine transitions for the reaction with ^(31)P,and nine transitions for the reaction with ^(32)S for the first *** angular anisotropy of theγ-radiation accompanying the inelastic scattering of neutrons with an energy of 14.1 Mev on ^(31)P nuclei was also measured for the first time.

关键词： tagged neutron method yields of gamma-quanta high-resolution gamma-spectrometry neutron-nuclear reactions neutron scattering