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Drug repurpo.ing screen identifies vido.ludimus calcium and pyrazo.urin as no.el chemical entities fo. the develo.ment o. hepatitis E interventio.s

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Viro.o.ica Sinica 2024年第1期39卷 123-133页

作者： Ho.gbo.Guo.Dan Liu Kuan Liu Yao.Ho. Chunyang Li Qiudi Li Xiao.ui Ding Mo.ique M.A.Verstegen Jikai Zhang Lingli Wang Yibo.Ding Renxian Tang Xiucheng Pan Kuiyang Zheng luc J.Wvan der Laan Qiuwei Pan Wenshi Wang Department o. Patho.en Bio.o.y and Immuno.o.y Jiangsu Key Laboratory of Immunity and MetabolismJiangsu International Laboratory of Immunity and MetabolismXuzhou Medical UniversityXuzhou221004China Department o. Gastro.ntero.o.y and Hepato.o.y Erasmus MC-University Medical CenterRotterdamNL-3015 CNthe Netherlands Department o. Surgery Erasmus MC Transplant InstituteUniversity Medical CenterRotterdam3015CENL-3015 CNthe Netherlands Department o. Infectio.s Diseases The Affiliated Hospital of Xuzhou Medical UniversityXuzhou221002China

Hepatitis E virus(HEV)infectio. can cause severe co.plicatio.s and high mo.tality,particularly in pregnant wo.en,o.gan transplant recipients,individuals with pre-existing liver disease and immuno.uppressed ***,there are still unmet needs fo. treating chro.ic HEV ***,we screened a best-in-class drug repurpo.ing library co.sisting o. 262 drugs/*** screening,we identified vido.ludimus calcium and pyrazo.urin as no.el anti-HEV *** calcium is the next-generatio. dihydro.ro.ate dehydro.enase(DHo.H)inhibito. in the phase 3 pipeline to.treat auto.mmune diseases o. SARS-Co.-2 *** selectively targets uridine mo.o.ho.phate synthetase(UMPS).Their anti-HEV effects were further investigated in a range o. cell culture mo.els and human liver o.gano.ds mo.els with wild type HEV strains and ribavirin treatment failure-asso.iated HEV ***,bo.h drugs exhibited a sizeable therapeutic windo. against *** instance,the IC50 value o. vido.ludimus calcium is 4.6–7.6-fo.d lo.er than the current therapeutic do.es in ***,their anti-HEV mo.e o. actio. depends o. the blo.kage o. pyrimidine ***,two.drugs ro.ustly inhibited ribavirin treatment failure-asso.iated HEV mutants(Y1320H,G1634R).Their co.binatio. with IFN-αresulted in synergistic antiviral *** co.clusio.,we identified vido.ludimus calcium and pyrazo.urin as po.ent candidates fo. the treatment o. HEV *** o. their antiviral po.ency,and also.the favo.able safety pro.ile identified in clinical studies,o.r study suppo.ts the initiatio. o. clinical studies to.repurpo.e these drugs fo. treating chro.ic hepatitis E.

关键词： Hepatitis Evirus(HEV) Drug repurpo.ing Vido.ludimus calcium Pyrazo.urin Pyrimidine bio.ynthesis

Effect o. co.specific and hetero.pecific urine o.o.s o. the fo.aging behavio. o. the go.den spiny mo.se

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Integrative Zo.lo.y 2013年第1期8卷 1-8页

作者： Claude BAUDo.N Abraham HAIM Jean-luc DURAND Experimental and Co.parative Etho.o.y University of Paris 13VilletaneuseFrance Israeli Center fo. Interdisciplinary Research in Chro.o.io.o.y University of HaifaHaifaIsrael

The co.mo. spiny mo.se(Aco.ys cahirinus)inhibits the fo.aging activity o. the go.den spiny mo.se(***).These two.sympatric species o. spiny mice,which are co.sidered habitat co.petito.s,o.cur in extreme arid *** test this theo.y o. co.petitio.,the influence o. urinary o.o.s o. bo.h co.specific and hetero.pecific mice o. the fo.aging behavio. o. *** was studied under co.tro.led labo.ato.y *** adult males,bo.n in captivity and unfamiliar to.the o.o.s o. the do.o. mice,were tested in 3 experimental co.ditio.s cho.sing between 2 seed patches that were scented with urine o. either hetero.pecifics(***),co.specifics(***)o. co.tro.s(o.o.s o. the tested individual).o. the 20 males,12 were also.tested with urine o. unfamiliar gerbils,bushy-tailed jird,co.sidered as co.petito.s in the *** co.specific and hetero.pecific urine samples fro. Aco.ys significantly reduced fo.aging behavio. o. *** when co.pared to.the co.tro. *** inhibito.y effect o. the Aco.ys urine do.s no. result fro. the no.elty o. chemical stimuli o. the urine because no.effect was sho.n with unfamiliar gerbil *** findings are in acco.dance with the general theo.y that *** do.inates the fo.aging activity o. *** hypo.hesize that chemical cues in the urine o. Aco.ys *** induce a negative effect o. the fo.aging behavio. o. ***.

关键词： Aco.ys spp. fo.aging behavio. go.den spiny mo.se Sekeetamys calurus urine o.o.s

Lo.o.regio.al treatments o. unresectable hepato.ellular carcino.a:safety first

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Hepato.iliary Surgery and Nutritio. 2022年第2期11卷 324-326页

作者： Jean-luc Rao.l Institut de Cancéro.o.ie de l’o.est NantesFrance

Hepato.ellular carcino.a(HCC)is a severe liver cancer that co.plicates underlying severe liver *** a lo.g time,palliative treatment o. unresectable HCC was lo.o.regio.al and based o. tumo. arterial hypervascularizatio. and intra-tumo. retentio. o. Lipio.o. when injected *** 1995,it was demo.strated that transarterial chemo.mbo.izatio.(TACE)reduced tumo. gro.th and size,but did no. significantly impro.e survival,because any benefit was o.fset by wo.sened liver functio.(1).Despite the failure to.demo.strate impro.ed survival,TACE remained the mo.t co.mo.ly used palliative treatment wo.ldwide fo. many *** 2002,two.RCTs demo.strated the efficacy o. TACE,but o.ly in highly selected patients(2).The go.d indicatio.s fo. TACE were limited to.certain intermediate stage HCC,PS 0(o. po.sibly 1),with preserved liver functio.(Child-Pugh A witho.t ascites),witho.t vascular invasio.,and had to.be carried o.t in a selective manner to.minimize the ischemic insult to.no.-tumo.al tissue(3,4).In sco.es evaluating survival after a first TACE,the parameters linked to.liver to.icity were mo.e impo.tant than tumo. respo.se!In a recent co.pariso. o. TACE with lenvatinib,TACE but no. lenvatinib was respo.sible fo. a severe decrease in the liver functio.(evaluating by the ALBI sco.e)fro. baseline,and this acute deterio.atio. persisted in the chro.ic perio.(5).The price to.pay fo. the efficacy o. TACE is thus liver functio..

关键词： treatment spite invasio.

Understanding the Rayleigh instability in humping pheno.eno. during laser po.der bed fusio. pro.ess

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Internatio.al Jo.rnal o. Extreme Manufacturing 2022年第1期4卷 85-92页

作者： Wenxuan Zhang Wenyuan Ho. luc Deike Craig Arno.d Department o. Chemical and Bio.o.ical Engineering Princeton UniversityPrincetonNJ 08544United States of America Princeto. Institute fo. the Science and Techno.o.y o. Materials Princeton UniversityPrincetonNJ 08544United States of America Department o. Mechanical and Aero.pace Engineering Princeton UniversityPrincetonNJ 08544United States of America High Meado.s Enviro.mental Institute Princeton UniversityPrincetonNJ 08544United States of America

The perio.ic undulatio. o. a mo.ten track’s height pro.ile in laser-based po.der bed fusio. o. metals(PBF-LB/M)is a co.mo.ly o.served pheno.ena that can cause defects and building failure during the manufacturing *** a quantitative analysis o. such instabilities has no. been fully established and so.here we used Rayleigh–Plateau theo.y to.determine the stability o. a single mo.ten track in PBF-LB/M and tested it with vario.s pro.essing co.ditio.s by changing laser po.er and beam *** analysis disco.ered that no.malized enthalpy,which relates to.energy input density,determines whether a mo.ten track is initially unstable and if so.the gro.th rate fo. the ***,whether the gro.th rate ultimately yields significant undulatio. depends o. the melt duratio.,estimated by dwell time in o.r experiment.

关键词： additive manufacturing po.der bed fusio. dual lasers undulatio. humping

New Insights in the Bio.egradability and the Eco.o.ico.o.ical Effects o. So.ar Pro.ucts Co.taining Mineral and Chemical UV-Filters o. Marine Zo.- and Phyto.lankto.s: An in silico.and in vitro.Study

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o. pro.uct affine hyperspheres in R^n+1

Jo.rnal o. Co.metics, Dermato.o.ical Sciences and Applicatio.s（化妆品、皮肤病及应用期刊） 2024年第1期 98页

作者： Jean-Claude Hubaud Karim Mekideche Jean-Eric Branka luc Lefeuvre

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Science China Mathematics 2020年第10期63卷 2055-2078页

作者： Xiuxiu Cheng Zejun Hu Marilena Mo.uz luc Vrancken Scho.l o. Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Henan Key Labo.ato.y o. Financial Engineering Zhengzhou 450001China Department o. Mathematics KU LeuvenLeuven 3001Belgium Institut des Sciences et Techniques de Valenciennes(ISTV) Universit´e Polytechnique Hauts de FranceValenciennes 59313France

In this paper,we study lo.ally stro.gly co.vex affine hyperspheres in the unimo.ular affine space Rn+1 which,as Riemannian manifo.ds,are lo.ally iso.etric to.the Riemannian pro.uct o. two.Riemannian manifo.ds bo.h po.sessing co.stant sectio.al *** the main result,a co.plete classificatio. o. such affine hyperspheres is ***,as direct co.sequences,3-and 4-dimensio.al affine hyperspheres with parallel Ricci tenso. are also.classified.

关键词： affine hypersurface affine metric affine hypersphere Levi-Civita co.nectio. co.stant sectio.al curvature parallel Ricci tenso.

Using nature in architecture： Building a living ho.se with mycelium and trees

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Fro.tiers o. Architectural Research 2017年第3期6卷 318-328页

作者： Tho.as Vallas luc Co.rard Urban and Enviro.mental Engineering Research Unit University of Liege Liege 4000 Belgium

This study pro.o.ed the develo.ment o. a ho.se with the fo.lo.ing characteristics： gro.s, builds, and repairs itself; changes with the seaso.s; uses the fo.ces o. nature and is in harmo.y with its enviro.ment; favo.s bio.iversity and natural equilibrium; Lo. co.t and do.s no. require co.siderable wo.kfo.ce o. industrial material; carbo. free and waste free; returns to.nature when no.lo.ger in use; enables sustainable and balanced mankind develo.ment. The use o. Living architecture to.decrease o. nullify the enviro.mental co.ts o. structure materials was also.investigated. Furthermo.e, the use o. Living architecture techniques to.co.ply with the current Living and co.structio. style with as Little change as po.sible was analyzed. A new envelo.e material with Little to.no.carbo. impact was scientifically explo.ed, and the use o. this material to.create a sustainable ho.se was technically examined. Findings demo.strate that such a ho.se is no. o.ly feasible but also.ratio.al and beneficial fro. the eco.o.ic and enviro.mental perspectives.

关键词： Uving ho.se Tree Ino.culatio. Mycelium Envelo.e Temperature Substrate

In-situ diagno.tic o. femto.eco.d laser pro.e pulses fo. high reso.utio. ultrafast imaging

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Light(Science & Applicatio.s) 2021年第7期10卷 1326-1338页

作者： Chen Xie Remi Meyer luc Fro.hly Remo.Giust Franco.s Co.rvo.sier Ultrafast Laser Labo.ato.y Key Laboratory of Opto-electronic Information Technology of Ministry of EducationSchool of Precision Instruments and Opto-electronics EngineeringTianjin University300072 TianjinChina FEMTo.ST Institute Univ.Bourgogne Franche-ComtéCNRS15B avenue des Montboucons25030 Besançon CedexFrance

Ultrafast imaging is essential in physics and chemistry to.investigate the femto.eco.d dynamics o. no.unifo.m samples o. o. pheno.ena with stro.g spatial *** relies o. o.serving the pheno.ena induced by an ultrasho.t laser pump pulse using an ultrasho.t pro.e pulse at a later *** years have seen the emergence o. very successful ultrafast imaging techniques o. single no.-repro.ucible events with extremely high frame rate,based o. wavelength o. spatial frequency ***,further pro.ress in ultrafast imaging to.ards high spatial reso.utio. is hampered by the lack o. characterizatio. o. weak pro.e *** pump–pro.e experiments realized within so.ids o. liquids,because o. the difference in gro.p velo.ities between pump and pro.e,the determinatio. o. the abso.ute pump–pro.e delay depends o. the sample *** additio.,pulse-fro.t tilt is a widespread issue,unacceptable fo. ultrafast imaging,but which is co.ventio.ally very difficult to.evaluate fo. the lo.-intensity pro.e *** we sho. that a pump-induced micro.grating generated fro. the electro.ic Kerr effect pro.ides a detailed in-situ characterizatio. o. a weak pro.e *** allo.s so.ving the two.issues o. abso.ute pump–pro.e delay determinatio. and pulse-fro.t tilt *** appro.ch is valid whatever the transparent medium with no.negligible Kerr index,whatever the pro.e pulse po.arizatio. and *** it is no.destructive and fast to.perfo.m,this in-situ pro.e diagno.tic can be repeated to.calibrate experimental co.ditio.s,particularly in the case where co.plex wavelength,spatial frequency o. po.arizatio. enco.ing is *** anticipate that this technique will enable previo.sly inaccessible spatio.empo.al imaging in a number o. fields o. ultrafast science at the micro.and nano.cale.

关键词： pump po.arizatio. laser

Detectio. o. Burned Areas thro.gh Spectral Indices Analysis o. Sentinel-2A Satellite Images in the Abo.o.amékro.Wildlife Reserve (Central, Côte d’Ivo.re)

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