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4号染色体短臂微卫星多态性与鼻咽癌相关性的研究

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遗传 2006年第7期28卷 783-790页

作者：郭秀婵 o’brien stephen j WINKLER Cheryl SCoTT Kevin HUTCHESoN Holli DAVID Victor KESSING Bailey 郑裕明廖建刘彦 GUY de The 曾毅中国疾病预防控制中心病毒病预防控制所北京100052 美国国家癌症研究所基因组多样性研究室 frederickmd21702 广西梧州市肿瘤防治研究所梧州543002 广西苍梧县鼻咽癌防治所苍梧543100 法国巴士德研究所 parisfrance75724

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发... 详细信息

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异，即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者（IgA／VCA＋）288例和EB病毒壳抗原IgA抗体阴性者（IgA／VCA—）346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂（4p15．1～q12）进行了微卫星精细扫描，在18Mb的范围内选择34个微卫星标记，包括319个等位基因，对其进行基因分型。比较分析NPC组和IgA／VCA＋组等位基因频率结果显示，9个等位基因与鼻咽癌呈相关，其中5个为易感等位基因（oR=1．51～5．36，P=0．01～0．03），4个为限制性等位基因（oR值为0．3～0．71，P值为0．02～0．045）。比较分析IgA／VCA＋组和IgA／VCA-组及比较所有IgA／VCA＋者（包括NPC患者）和IgA／VCA-者等位基因频率的结果显示，12个等位基因与EB病毒壳抗原IgA抗体持续存在相关，其中3个在两组比较中均呈显著相关。等位基因D4S3241～136（P=0．004，oR=1．9，95％CI=1．2～3．0）和D4S3347-213（P=0．001，oR=1．6，95％CI=1．2～2．1）可增加EB病毒IgA／VCA抗体形成的危险，为易感基因；而等位基因D4S174．202（P=0．001，oR=0．5，95％CI=0．3～0．7）可限制IgA／VCA抗体的形成。但上述结果经多因素比较校正后，均失去相关性。结果不能确定该区域与非家族性鼻咽癌的形成相关，但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。

关键词：鼻咽癌 4号染色体微卫星相关研究

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Characterizing objective and self-report habitual physical activity and sedentary time in outpatients with an acquired brain injury

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Sports Medicine and Health Science 2024年第4期6卷 338-343页

作者： Liam P.Pellerine Katerina Miller Ryan j.Frayne Myles W.o'brien Division of Kinesiology School of Health and Human PerformanceFaculty of HealthDalhousie UniversityHalifaxNova ScotiaCanada Acquired Brain Injury NeuroCommons Nova Scotia Health AuthorityHalifaxNova ScotiaCanada School of Physiotherapy(Faculty of Health)&Department of Medicine(Faculty of Medicine) Dalhousie UniversityHalifaxNova ScotiaCanada Geriatric Medicine Research Dalhousie University&Nova Scotia HealthHalifaxNova ScotiaCanada Centre de Formation Medicale Du Nouveau-Brunswick New Brunswick&Department of MedicineUniversite de SherbrookeSherbrookeQuebecCanada

outpatients with an acquired brain injury(ABI)experience physical,mental,and social *** can be classified into two subgroups based on mechanism of injury:mild traumatic brain injury(mTBI;e.g.,concussion)and other ABI(e.g.,stroke,brain aneurysm,encephalitis).our understanding of habitual activity levels within ABI populations is limited because they are often collected using self-report *** purpose of this study was to,1)describe the habitual activity levels of outpatients with ABI using objective and self-report monitoring,and 2)compare the activity levels of outpatients with mTBI *** *** outpatients with other ABI(mean±standard deviation:[58±13]years,9 females)and 12 outpatients with mTBI([48±11]years,9 females)wore a thigh-worn activPAL 24 h/day(h/day)for *** with ABI averaged(6.0±2.3)h/day of upright time,(10.6±2.2)h/day of sedentary time,(5.6±2.7)h/day in prolonged sedentary bouts>1 h,(5960±3037)steps/day,and(11±13)minutes/day(min/day)of moderate-vigorous physical activity(MVPA).There were no differences between activPAL-derived upright,sedentary,prolonged sedentary time,and physical activity between the mTBI and other ABI groups(all,p>0.31).outpatients with ABI overestimated their MVPA levels(t138 min/week)and underestimated sedentary time(-4.3 h/day)compared to self-report(all,porting high activity levels,outpatients with ABI objectively exhibit highly inactive and sedentary *** habitual movement behaviours of our sample did not differ by mechanism of injury(i.e.,mTBI versus other ABI).Targeting reductions in objectively measured sedentary time are needed to progressively improve the habitual movement behaviours of outpatients with ABI.

关键词： Accelerometry Stroke Brain aneurysm Encephalitis Mild traumatic brain injury Rehabilitation

Taxonomic species recognition should be consistent

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National Science Review 2022年第12期9卷 17-18页

作者： stephen j.o'brien Shu-jin Luo Guy Harvey oceanographic Center Halmos College of Arts and Sciences Nova Southeastern University The State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University

Criteria for species naming have been contentious since the time of Carl *** no clear’right or wrong’convention for species naming,biologists strive to simply convince their *** NSR compendium offers detailed guidance [1-6] that adds quantitative genomic inference to the *** taxonomic assemblages (***,fish,fungi,insects,terrestrial and marine invertebrates,plants,bacteria) are sufficiently distinctive that any generalization is fraught with natural exceptions.

关键词： PHYLoGEoGRAPHY

Applying molecular genetic tools to tiger conservation

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Integrative Zoology 2010年第4期5卷 351-362页

作者： Shu-jin LUo Warren E.joHNSoN stephen j.o’brien School of Life Sciences Peking UniversityBeijingChina Laboratory of Genomic Diversity National Cancer InstituteFrederickMDUSA

The utility of molecular genetic approaches in conservation of endangered taxa is now commonly *** the past decade,conservation genetic analyses based on mitochondrial DNA sequencing and microsatellite genotyping have provided powerful tools to resolve taxonomy uncertainty of tiger subspecies,to define conservation units,to reconstruct phylogeography and demographic history,to examine the genetic ancestry of extinct subspecies,to assess population genetic status non-invasively,and to verify genetic background of captive tigers *** genetic status of tiger subspecies and populations and implications for developing strategies for the survival of this charismatic species both in situ and ex situ are discussed.

关键词： conservation genetics mitochondrial DNA microsatellite subspecies tiger

Parallel loop recovery with quiescent compensation for high performance feedback control of systems with imperfect actuators

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Control Theory and Technology 2019年第3期17卷 201-215页

作者： Y.V.o'brien j.F.o'brien Department of Electrical and Computer Engineering University of Wyoming Laramie WY 82073 U.S.A.

Actuator limits and imperfections introduce multiple nonlinearities in a feedback *** standard mild-feedback systems (e.g.,PID) are intrinsically robust to such nonlinearities,the stability of large feedback systems is *** eliminates from consideration the usage of imperfect actuators in large feedback applications and available disturbance rejection as a result is not *** implementation of multiple-path nonlinear dynamic compensation (NDC),however,allows the combination of large feedback and imperfect actuation and is the focus of this *** nonlinearities due to actuator imperfection are often difficult to model,the stability of the NDC systems is assessed using multivariable absolute stability *** features of a parallel loop recovery system with loop transmission modulus reduction compensation in the quiescent condition are compared to an alternative approach of strict modulus reduction via nonlinear compensation for stability *** of the loop recovery approach is illustrated using experimental data from a voice-coil actuated disturbance rejection system.

关键词： Feedback control imperfect actuators nonlinear dynamic compensation

Tipping points among social learners： Tools from varied disciplines

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Current Zoology 2012年第2期58卷 298-306页

作者： R. Alexander BENTLEY Michael j. o＇brien Department of Archaeology and Anthropology University of Bristol Bristol BS8 1UU UK Department of Anthropology University of Missouri Columbia MO 65211 USA

There is a long and rich tradition in the social sciences of using models of collective behavior in animals as jump- ing-off points for the study of human behavior, including collective human behavior. Here, we come at the problem in a slightly different fashion. We ask whether models of collective human behavior have anything to offer those who study animal behavior. our brief example of tipping points, a model first developed in the physical sciences and later used in the social sciences, suggests that the analysis of human collective behavior does indeed have considerable to offer

关键词： Networks Social learning Thresholds Time series Tipping points

A near infrared spectroscopy calibration for the prediction of fresh grass quality on Irish pastures

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Information Processing in Agriculture 2022年第2期9卷 243-253页

作者： Darren j.Murphy Bernadette o’brien Michael o’Donovan Tomas Condon Michael D.Murphy Teagasc Animal&Grassland Research and Innovation CentreMooreparkFermoyCo.CorkIreland Department of Process Energy and Transport EngineeringMunster Technological UniversityCorkIreland

The aim of this study was to develop near infrared spectroscopy(NIRS)calibrations to predict quality parameters,dry matter(DM,g kg1)and crude protein(CP,g kg1 DM),in fresh un-dried *** of these parameters would enable more precise allocation of quality herbage to grazing *** ryegrass samples(n=1615)were collected over the 2017 and 2018 grazing seasons at Teagasc Moorepark to develop a NIRS calibration *** samples were collected for an independent validation dataset(n=197)during the 2019 grazing *** were scanned using a FoSS 6500 spectrometer at 2 nm intervals in the range of 1100~2500 nm and absorption was recorded as log 1/Reflec*** wet chemistry analysis was carried out for both parameters and the resultant data were calibrated against spectral data by means of modified partial least squares regression.A range of mathematical spectral treatments were examined for each calibration,which were ranked in order of standard error of prediction(SEP)and ratio of percent deviation(RPD).Best performing calibrations achieved high predictive precision for DM(R2=0.86 SEP=9.46 g kg1,RPD=2.60)and moderate precision for CP(R2=0.84 SEP=20.38 g kg1 DM,RPD=2.37).These calibrations will aid the optimisation of grassland management and the development of precision agricultural technologies.

关键词： Near infrared spectroscopy Fresh grass analysis Grassland management Grass quality Precision agriculture

Macular carotenoid supplementation improves disability glare performance and dynamics of photostress recovery

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Eye and Vision 2016年第1期3卷 231-238页

作者： james M.Stringham Kevin j.o’brien Nicole T.Stringham Nutritional Neuroscience Laboratory Department of Physiology and PharmacologyUniversity of GeorgiaAthensGA 30602USA Vision Sciences Laboratory Department of PsychologyUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Neuroscience Program Biomedical Health Sciences InstituteUniversity of GeorgiaAthensGA 30602USA

Background:The so-called macular carotenoids(MC)lutein(L),zeaxanthin(Z),and meso-zeaxanthin(MZ)comprise the diet-derived macular pigment(MP).The purpose of this study was to determine effects of MC supplementation on the optical density of MP(MPoD),repeated-exposure photostress recovery(PSR),and disability glare(DG)***:This was a double-blind,placebo-controlled ***-nine young(mean age=21.7),healthy volunteers participated in this *** supplemented their daily diet with either 10 mg L+2 mg total Z(1 mg Z+1 mg MZ;n=24),20 mg L+4 mg total Z(2 mg Z+2 mg MZ;n=25),or placebo(n=10)for 12 *** primary outcome was a composite measure of visual performance in glare,defined by change in DG and *** outcomes included MPoD and visual *** primary endpoint for outcomes was 12 *** was assessed with customized heterochromatic flicker *** times for an 8 cycle/degree,15%contrast Gabor patch target were determined after each of five successive exposures to intense LED *** threshold was defined as the intensity of a ring of lights through which subjects were able to maintain visibility of the aforementioned *** of all parameters were conducted at baseline,6 months,and 12 ***-measures ANoVA,and Pearson product-moment correlations were used to determine statistically significant correlations,and changes within and between ***:MPoD for subjects in both supplementation groups increased significantly versus placebo at both 6-and 12-month visits(por all).Additionally,PSR times and DG thresholds improved significantly from baseline compared to placebo at 6-and 12-month visits(por all).At baseline,MPoD was significantly related to both DG thresholds(r=0.444;p=0.0021)and PSR times(r=-0.56;pon of MPoD,the repeated-exposure PSR curves became more asymptotic,as opposed to *** change in subjects’DG thresholds were significantly related to chang

关键词： Lutein Zeaxanthin Mesozeaxanthin Visual performance Photostress recovery Disability glare Macular pigment Visual cycle

Neurological heterotopic ossification:novel mechanisms,prognostic biomarkers and prophylactic therapies

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Bone Research 2020年第4期8卷 379-392页

作者： Ker Rui Wong Richelle Mychasiuk Terence j.o’brien Sandy R.Shultz Stuart j.McDonald Rhys D.Brady Department of Neuroscience Central Clinical SchoolMonash UniversityMelbourneVICAustralia Department of Medicine Royal Melbourne HospitalThe University of MelbourneParkvilleVICAustralia Department of Physiology Anatomy and MicrobiologySchool of Life SciencesLa Trobe UniversityBundooraVICAustralia

Neurological heterotopic ossification(NHo)is a debilitating condition where bone forms in soft tissue,such as muscle surrounding the hip and knee,following an injury to the brain or spinal *** abnormal formation of bone can result in nerve impingement,pain,contractures and impaired *** are often diagnosed with NHo after the bone tissue has completely mineralised,leaving invasive surgical resection the only remaining treatment *** resection of NHo creates potential for added complications,particularly in patients with concomitant injury to the central nervous system(CNS).Although recent work has begun to shed light on the physiological mechanisms involved in NHo,there remains a significant knowledge gap related to the prognostic biomarkers and prophylactic treatments which are necessary to prevent NHo and optimise patient *** article reviews the current understanding pertaining to NHo epidemiology,pathobiology,biomarkers and treatment *** particular,we focus on how concomitant CNS injury may drive ectopic bone formation and discuss considerations for treating polytrauma patients with *** conclude that understanding of the pathogenesis of NHo is rapidly advancing,and as such,there is the strong potential for future research to unearth methods capable of identifying patients likely to develop NHo,and targeted treatments to prevent its manifestation.

关键词： such has likely

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