Macular carotenoid supplementation improves disability glare performance and dynamics of photostress recovery

作     者：James M.Stringham Kevin J.O’Brien Nicole T.Stringham 

作者机构：Nutritional Neuroscience LaboratoryDepartment of Physiology and PharmacologyUniversity of GeorgiaAthensGA 30602USA Vision Sciences LaboratoryDepartment of PsychologyUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Neuroscience ProgramBiomedical Health Sciences InstituteUniversity of GeorgiaAthensGA 30602USA 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2016年第3卷第1期

页      面：231-238页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This study was funded by Omniactive Health Technologies Inc. who had no role in study design data collection or analysis 

主　　题：Lutein Zeaxanthin Mesozeaxanthin Visual performance Photostress recovery Disability glare Macular pigment Visual cycle 

摘      要：Background:The so-called macular carotenoids(MC)lutein(L),zeaxanthin(Z),and meso-zeaxanthin(MZ)comprise the diet-derived macular pigment(MP).The purpose of this study was to determine effects of MC supplementation on the optical density of MP(MPOD),repeated-exposure photostress recovery(PSR),and disability glare(DG)***:This was a double-blind,placebo-controlled ***-nine young(mean age=21.7),healthy volunteers participated in this *** supplemented their daily diet with either 10 mg L+2 mg total Z(1 mg Z+1 mg MZ;n=24),20 mg L+4 mg total Z(2 mg Z+2 mg MZ;n=25),or placebo(n=10)for 12 *** primary outcome was a composite measure of visual performance in glare,defined by change in DG and *** outcomes included MPOD and visual *** primary endpoint for outcomes was 12 *** was assessed with customized heterochromatic flicker *** times for an 8 cycle/degree,15%contrast Gabor patch target were determined after each of five successive exposures to intense LED *** threshold was defined as the intensity of a ring of lights through which subjects were able to maintain visibility of the aforementioned *** of all parameters were conducted at baseline,6 months,and 12 ***-measures ANOVA,and Pearson product-moment correlations were used to determine statistically significant correlations,and changes within and between ***:MPOD for subjects in both supplementation groups increased significantly versus placebo at both 6-and 12-month visits(p0.001 for all).Additionally,PSR times and DG thresholds improved significantly from baseline compared to placebo at 6-and 12-month visits(p0.001 for all).At baseline,MPOD was significantly related to both DG thresholds(r=0.444;p=0.0021)and PSR times(r=-0.56;p0.001).As a function of MPOD,the repeated-exposure PSR curves became more asymptotic,as opposed to *** change in subjects’DG thresholds were significantly related to chang