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Structural Restoration of Carbonate Platform in the Southern Part of Central Luconia, Malaysia

Journal of Earth Science 2018年第1期29卷 155-168页

作者： Siti nur Fathiyah Jamaludin Manuel Pubellier David Menier Faculty of Geosciences & Petroleum Engineering Universiti Teknologi PETRONAS Bandar Seri Iskandar 32610 Perak Malaysia UMR 8538 du CNRS Ecole Normale Supérieure 24 rue Lhomond 75231 Paris Cedex 05 France Geosciences Marines et Geomorphologie du Littoral Universite Europeenne de Bretagne UMR CNRS 6538 rue Yves Mainguy 56017 Vannes Cedex France

Carbonates of Central Luconia, Malaysia, had been serving as hydrocarbon reservoirs for more than 25 years. However, the relationship and impacts of extensive tectonic events to the growth of Miocene carbonates in Central Luconia have not been revealed sufficiently. In this work, two carbonates platforms in the southern part of Central Luconia were used for detailed interpretation and seismic based structural restoration. This work had provided new insight for the interpreta- tion of carbonate growth in Central Luconia and its association with the surrounding tectonic. This work suggested three possible tectonic evolutions from Late Oligocene to Pliocene are responsible for the growth of carbonates in Central Luconia. These stages are equivalent with pre-carbonate stage （Late Oligocene-Early Miocene）, syn-carbonate stage （Middle-Late Miocene） and post-carbonate stage （Pliocene）. Rifting of the South China Sea and subduction of proto-South China Sea are believed to be responsible for the development of faulting during pre-carbonate stage, while movement of the ancient Baram Line is thought to control the parallel striking direction of normal faults during syn- carbonate stage. Finally, subsidence and compaction due to the overburden clastic materials from the prograding deltas is considered as the main reason for the impacts of gravitational tectonics in this area, which corresponding to the post-carbonate stage.

关键词： carbonate platforms structural restoration carbonate growth seismic interpretation,Central Luconia Province.

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Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

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Neuroscience Bulletin 2017年第5期33卷 535-542页

作者： Weidong Le Jie Dong Song Li amos D. Korczyn Liaoning Provincial Center for Clinical Research on Neurological Diseases The First Affiliated HospitalDalianMedical UniversityDalian 116021China Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated HospitalDalian Medical UniversityDalian 116021China Collaborative Innovation Center for Brain Science The First Affiliated HospitalDalian Medical UniversityDalian 116021China Department of Neurology Sackler School of MedicineTel Aviv University69978 Ramat-AvivIsrael

Parkinson＇s disease （PD） is a complex neurode- generative disease with progressive loss of dopamine neurons. PD patients usually manifest a series of motor and non-motor symptoms. In order to provide better early diagnosis and subsequent disease-modifying therapies for PD patients, there is an urgent need to identify sensitive and specific biomarkers. Biomarkers can be divided into four categories： clinical, imaging, biochemical, and genetic. Ideal biomarkers not only improve our under- standing of PD pathogenesis and progression, but also provide benefits for early risk evaluation and clinical diagnosis of PD. Although many efforts have been made and several biomarkers have been extensively investigated, few if any have been found useful for early diagnosis. Here, we summarize recent developments in the discovered biomarkers of PD and discuss their merits and limitations for the early diagnosis of PD.

关键词： Parkinson's disease· Biomarker Early diag-nosis - Molecular imaging Biochemical markers

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Performance of GPS and IMU sensor fusion using unscented Kalman filter for precise i-Boat navigation in infinite wide waters

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Geodesy and Geodynamics 2023年第3期14卷 265-274页

作者： Mokhamad nur Cahyadi Tahiyatul Asfihani Ronny Mardiyanto Risa Erfianti Department of Geomatics Engineering Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Research Center of Marine and Earth Science-Technology Directorate of Research and Community ServiceInstitut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Department of Mathematics Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Department of Electrical Engineering Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia

The Unmanned Surface Vehicle(USV)navigation system needs an accurate,firm,and reliable performance to avoid obstacles,as well as carry out automatic movements during *** Global Positioning System(GPS)is often used in these systems to provide absolute position ***,the GPS measurements are affected by external conditions such as atmospheric bias and multipath *** leads to the inability of the stand-alone GPS to provide accurate positioning for the USV *** of the solutions to correct the errors of this sensor is by conducting GPS and Inertial Measurement Unit(IMU)*** IMU sensor is complementary to the GPS and not affected by external ***,it accumulates noise as time ***,this study aims to determine the fusion of the GPS and IMU sensors for the i-Boat navigation system,which is a USV developed by Institut Teknologi Sepuluh Nopember(ITS)*** the Unscented Kalman filter(UKF),sensor fusion was carried out based on the state equation defined by the dynamic and kinematic mathematical model of ship motion in 6 degrees of *** the performance of this model was tested through several simulations using different combinations of attitude measurement *** scenarios were conducted in the simulations:attitude measurement inclusion and exclusion(Scenarios I and II,respectively).The results showed that the position estimation in Scenario II was better than in Scenario I,with the Root Mean Square Error(RMSE)value of 0.062 *** simulations showed that the presence of attitude measurement data caused a decrease in the fusion *** UKF simulation with eight measurement parameters(Scenarios A,B and C)and seven measurement parameters(Scenarios D,E and F),as well as analytical attitude movement,indicated that yaw data had the largest noise accumulation compared to roll and pitch.

关键词： GPS IMU Fusion sensor 6 DOF USV motion Unscented Kalman filte

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Illness perception and cardiovascular health behaviour among persons with ischemic heart disease in Indonesia

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International Journal of nursing Sciences 2018年第2期5卷 174-180页

作者： Kholid Rosyidi Muhammad nur Department of Community Health nursing Faculty of NursingUniversity of JemberEast JavaIndonesia

Objective:A study was conducted to explore the level of illness perception,the level of cardiovascular health behaviour and the relationship between illness perception and cardiovascular health behaviour among persons with ischemic heart disease(IHD)in a community ***:The participants comprised 235 persons with *** instruments used were as follows:1)Demographic Data and Health Information,2)The Brief Illness Perception Questionnaire(Brief IPQ),3)The Open-ended Questionnaire(OEQ),and 4)The Modified Cardiac Health Behaviour Scale(MCHBS).Findings from the OEQ are used to assess in-depth illness perception and to extend the information obtained from the Brief *** design of the study was descriptive *** data were analysed using descriptive statistics to present the demographic data and health *** statistics was used to resolve the relationship between illness perception and cardiovascular health behaviour by using Pearson's Product Moment ***:The mean score of illness perception was at a moderate level(M=43.65,SD=3.93),whereas the mean score of cardiovascular health behaviour was at a high level(M=80.29,SD=5.42).A significant positive relationship existed between illness perception and cardiovascular health behaviour among persons with IHD(r=0.38,Pnurses to develop an intervention program to promoting appropriate illness perception and cardiovascular health behaviour among persons with IHD.

关键词： Illness perception Cardiovascular health behaviour Ischemic heart disease

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Evolution of specific RNA aptamers via SELEX targeting recombinant human CD36 protein:A candidate therapeutic target in severe malaria

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Asian Pacific Journal of Tropical Biomedicine 2020年第1期10卷 23-32页

作者： Nik Abdul Aziz Nik Kamarudin Judy nur Aisha Sat nur Fatihah Mohd Zaidi Khairul Mohd Fadzli Mustaffa Institute for Research in Molecular Medicine(INFORMM) Health CampusUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Objective:To isolate and characterize RNA aptamers that are specific to human CD36 protein using systematic evolution of ligands by exponential enrichment(SELEX)technology to identify candidates for adjunct therapy to reverse the binding of Plasmodiuminfected ***:RNA aptamers were isolated using nitrocellulose membrane-based SELEX and binding analysis was screened using an electrophoretic mobility shift assay and enzyme-linked oligonucleotide ***:Thirteen cycles of nitrocellulose membrane-based SELEX yielded three aptamers(RC60,RC25,RC04)exhibiting high binding against CD36 protein as shown on electrophoretic mobility shift *** sequence analysis revealed a G-quadruplex sequence within all the isolated aptamers that might contribute to aptamer binding and thermodynamic *** specificity assay further showed that RC60 and RC25 were highly specific to *** competitive inhibition assay demonstrated that RC60 and RC25 shared a similar binding epitope recognized by m Ab FA6-152,a specific monoclonal antibody against ***:RC60 and RC25 are promising candidates as anticytoadherence for severe malaria adjunct therapy.

关键词： RNA aptamers SELEX CD36 protein Severe malaria Adjunct therapy Cytoadherence

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Faecal sterols as sewage markers in the Langat River,Malaysia:Integration of biomarker and multivariate statistical approaches

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Journal of Environmental Sciences 2012年第9期24卷 1600-1608页

作者： nur Hazirah Adnan Mohamad Pauzi Zakaria Hafizan Juahir Masni Mohd Ali Centre of Excellence for Environmental Forensics Faculty of Environmental StudiesUniversiti Putra Malaysia 43400 SerdangSelangorMalaysia Department of Environmental Sciences Faculty of Environmental StudiesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia School of Environmental and Natural Resource Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia

The Langat River in Malaysia has been experiencing anthropogenic input from urban, rural and industrial activities for many years. Sewage contamination, possibly originating from the greater than three million inhabitants of the Langat River Basin, were examined. Sediment samples from 22 stations （SL01-SL22） along the Langat River were collected, extracted and analysed by GC-MS. Six different sterols were identified and quantified. The highest sterol concentration was found at station SL02 （618.29 ng/g dry weight）, which situated in the Balak River whereas the other sediment samples ranged between 11.60 and 446.52 ng/g dry weight. Sterol ratios were used to identify sources, occurrence and partitioning of faecal matter in sediments and majority of the ratios clearly demonstrated that sewage contamination was occurring at most stations in the Langat River. A multivariate statistical analysis was used in conjunction with a combination of biomarkers to better understand the data that clearly separated the compounds. Most sediments of the Langat River were found to contain low to mid-range sewage contamination with some containing ＇significant＇ levels of contamination. This is the first report on sewage pollution in the Langat River based on a combination of biomarker and multivariate statistical approaches that will establish a new standard for sewage detection using faecal sterols.

关键词： sterols biomarkers surface sediments sewage pollution Langat River principal component analysis

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Real-life experience of ranibizumab therapy for neovascular age-related macular degeneration from Turkey

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 267-273页

作者： Zafer Cebeci Yusuf Cem Yilmaz nur Kir Department of Ophthalmology Istanbul Faculty of Medicine Istanbul University

AIM： To report the real-life experience and clinical results of intravitreal ranibizumab injections to neovascular agerelated macular degeneration（nAMD） in a single institution in ***： A total of 101 eyes of 89 patients with nAMD treated with intravitreal ranibizumab injection, followed up for at least 24 mo between 2009 and June 2014, which were evaluated retrospectively. A pro re nata（PRN） treatment protocol was performed after the patients had received three, monthly loading injections. Best corrected visual acuity（BCVA） and central macular thickness measurements were evaluated at baseline and 3, 6, 12, 18, and 24 mo. Number of injections and visits were also ***： Of the 89 patients, 34（38.2%） were male and 55（61.8%） were female and the mean age was 74.0±9.5（52-91）y. The mean follow-up period was 24.82±4.4（24-29）mo. Mean number of visits was 8.4±1.12（7-12） in the first year and 6.6±1.33（4-12） in the second year. The mean number of injections was 5.8±1.6（3-10） and 4.2±2.2（0-9） in the first and second year, respectively. The mean BCVA was 59±15.8 letters at baseline by the Early Treatment Diabetic Retinopathy Study（ETDRS） chart. The mean BCVA at 3, 12, and 24 mo was 70.3±15.9, 67.9±14.3 and 67.3±16.9 letters, respectively. Improvement in visual acuity for each of the visits from baseline was found to be statistically significant（P〈0.01）. Visual acuity in 9 eyes at month 3, 7 eyes at month 12, and 13 eyes at month 24 did not change. The mean central macular thickness（CMT） was 437.99±164.78 μm at baseline. The mean CMT was 348.05±138.47 μm, 349.27±139.79 μm, and 344.13±146.30 μm at months 3, 12, and 24, respectively. The decrease in CMT for each of the visits from baseline was found to be statistically significant（P〈0.01）.CONCLUSION： Anatomical and functional achievement are obtained in our study, but the mean number of injections and visits are found to be lower than the findings reported in randomized controlled clinical trials in the litera

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Surpassing the advanced comes from continuous accumulation

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Protein & Cell 2014年第6期5卷 409-410页

作者： Baoyuan Zhang Jing Qu nur Estya Binte Rahman Beijing Institutes of Life Science Chinese Academy of Sciences Beijing 100101 China Temasek Life Sciences Laboratory 1 Research Link National University of Singapore Singapore 117604 Singapore

As a famous Chinese saying goes, ＂A journey of a thousand miles begins with a single step＂. It teaches us that perse- verance and steadfastness are absolutely essential for success and progress. This philosophy has ... 详细信息

关键词： accumulation Institutes Science

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The Tertiary： a proposal for its formal definition

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Episodes 2008年第2期31卷 248-250页

作者： Martin J. Head Philip Gibbard amos Salvador Department of Earth Sciences Brock University 500 Glenridge Avenue St. Catharines Ontario L2S 3A1 Canada. Cambridge Quaternary Department of Geography University of Cambridge Downing Place Cambridge CB2 3EN United Kingdom. Department of Geological Sciences University of Texas at Austin Austin Texas 78712 U.S.A.

The term Tertiary, subdivided into the Paleogene and Neogene, is traditionally used to represent the interval of geological time between the Cretaceous and Quaternary. In the 1990s, however, the Neogene and Paleogene were ratified by the International Union of Geological Sciences as periods/systems of the Cenozoic Era/Erathem, leaving the Tertiary officially undefined. The Tertiary nonetheless remains a formal term that has never been officially eliminated, and its widespread use today implies a long future.

关键词：地球第三纪地质时代清晰度地质学

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Food poisoning associated methemoglobinemia: Time to wake up

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World Journal of Emergency Medicine 2020年第2期11卷 127-128页

作者： Kamal Kant Sahu amos Lal Ajay Mishra Susan George Department of Internal Medicine Saint Vincent HospitalWorcesterMassachusetts 01608USA

Dear editor,With interest we read the recent article on methemoglobinemia by Chan et al.[1]Through this letter,we would like to add few additional comments regarding methemoglobinemia and its relevance in medicine practice with regards to food *** Chan et al[1]successfully managed their patient of methemoglobinemia and could pinpoint choy sum as the responsible agent,we wonder if there were any more cases of choy sum related to methemoglobinemia detected at the same time in the community?

关键词： letter 1] editor

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