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Genetic and Demographic Outcomes in a Population of Patients with Headache and Facial Pain

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Journal of Behavioral and Brain Science 2018年第6期8卷 339-350页

作者： Jonathan Eskenazi Miriam nuno Steven Graff-Radford Oana M. Dumitrascu Department of Neurology Cedars-Sinai Medical Center Los Angeles CA USA Department of Public Health Sciences Division of Biostatistics University of California Davis Davis CA USA The Pain Center Cedars-Sinai Medical Center Los Angeles CA USA

Background: Pharmacogenetics information about cytochrome p450 (CYP450) polymorphism in patients with headaches is limitedly reported. Similarly, the genetic factors linking various headache types and vascular disorders are poorly described. We aimed to characterize the genetic profile of a cohort of headache and facial pain subjects. Methods: Medical records of consecutive headache subjects that underwent PersonaGeneTM testing were reviewed. PersonaGeneTM panel assessed CYP450, apolipoprotein E (ApoE), methylene tetrahydrofolate reductase (MTHFR), Factor II, Factor V Leiden and Vitamin K epoxide reductase complex subunit 1 (VKORC1). Demographic information, headache diagnosis and genetic profiling were analyzed and compared with data obtained from the general population. Results: Out of 130 headache patients, 91.3% were Caucasian and 70.8% had migraine. Compared to the general Caucasian population, our Caucasian headache patients were significantly different for CYP3A4/A5 and CYP2D6 (p < 0.001) and comparable regarding CYP2C9 and CYPC19. Whereas MTHFR genotype was similar, ApoE and Factor V Leiden were different in headache patients (p = 0.001). Less headache patients showed intermediate sensitivity to warfarin (p = 0.009) based on VQORC1 genotyping. No differences were noticed between migraine and other headache type diagnoses for all the genetic tests. Conclusion: Distinctive profiles for CYP450, ApoE, Factor V Leiden and VQORC1 were observed in our Caucasian headache cohort. These results may impact headache subjects’ pharmacological treatment options and vascular risk ascertainment.

关键词： Headache Pharmacogenetics Cytochrome P450 Cerebrovascular Risk Cardiovascular Risk

Nocardia infections among immunomodulated inflammatory bowel disease patients:A review

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World Journal of Gastroenterology 2015年第21期21卷 6491-6498页

作者： Candida Abreu nuno Rocha-Pereira António Sarmento Fernando Magro Department of Infectious Diseases Faculty of MedicineCentro Hospitalar S.Joao4200 PortoPortugal Nephrology Research and Development Unit University of Porto Department of Gastroenterology Faculty of MedicineCentro Hospitalar S.Joao4200 PortoPortugal Department of Pharmacology and Therapeutics Faculty of MedicineUniversity of Porto MedInUP Center for Drug Discovery and Innovative MedicinesUniversity of Porto

Human nocardiosis,caused by Nocardia spp.,an ubiquitous soil-borne bacteria,is a rare granulomatous disease close related to immune *** can occur as an acute life-threatening disease,with lung,brain and skin being commonly *** infection was classically diagnosed in HIV infected persons,organ transplanted recipients and long term corticosteroid treated *** the widespread use of immunomodulators and immunossupressors in the treatment of inflammatory diseases changed this *** purpose is to review all published cases of nocardiosis in immunomodulated patients due to inflammatory diseases and describe clinical and laboratory *** reviewed the literature concerning human cases of nocardiosis published between 1980 and 2014 in peer reviewed *** cases of nocardiosis associated with anti-tumor necrosis factor(TNF) prescription(9 related with infliximab and 2 with adalimumab) were identified; 7 patients had inflammatory bowel disease(IBD),4 had rheumatological conditions; nocardia infection presented as cutaneous involvement in 3 patients,lung disease in 4 patients,hepatic in one and disseminated disease in 3 *** the 10 cases described in IBD patients 7 were associated with anti-TNF and 3 with steroids and *** conclusion,nocardiosis requires high levels of clinical suspicion and experience of laboratory staff,in order to establish a timely diagnosis and by doing so avoid worst *** for long periods tailored by the susceptibility of the isolated species whenever possible is *** safety of restarting immunomodulators or anti-TNF after the disease or the value of prophylaxis with cotrimoxazole is still debated.

关键词： Nocardiosis Immunomodulation Nocardiaspp. Inflammatory diseases

Barriers and facilitators to mexican-american participation in clinical trials: physician and patient focus group perspectives

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Health 2010年第7期2卷 742-752页

作者： Jesse Nodora Tomas nuno Ken O’Day Virginia Yrun Francisco Garcia National Center of Excellence in Women’s Health and the Arizona Cancer Center University of ArizonaTucsonUSA National Center of Excellence in Women’s Health and the Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Xcenda Palm HarborUSA

Racial/ethnic minority populations are under- represented in clinical trials and Hispanic participation rates are particularly low. This study assessed barriers and facilitators to clinical trials participation by Medicaid eligible Mexican- Americans and their serving physicians. Qualitative data from two focus groups conducted among Mexican-American Medicaid eligible patients and four physician focus groups were analyzed. Mexican-American patients have a basic understanding of clinical trials. While most are open to participating in clinical research, not speaking English, time, and transportation were identified as barriers. Physicians believe that desperation and financial need are the primary patient motivators for participation. Barriers to physician recruitment and referral include: lack of information about clinical trials, concern that study participation may not be in the patient’s best interest, and lack of staffing and time to conduct trials. Ample opportunities exist to engage providers and patients in future efforts to increase Mexican-American patient recruitment into clinical trials.

关键词： Clinical Trials Participation Mexican-American Hispanic Medicaid Patients Medicaid Physicians Focus Groups Qualitative Methods

Huge Recalcitrant Warts Treated with Pulse Dye Laser after Conventional Therapies and Others Destructive Physical Modalities Failed

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第3期1卷 47-49页

作者： nuno Menezes Paulo Varela Rita Guedes Inês Leite Armando Baptista 不详

Cutaneous infections with the human papilloma virus, despite being almost always asymptomatic, can induce slow-growing lesions knowed as warts that can remain subclinical for long periods of time. There are several therapeutical options namely keratolytics, retinoids, imiquimod, cryotherapy, electrosurgery, lasers and classic surgery, but none has antiviral effects. We describe the case of a patient with large warts located on the dorsal surface of the right hand, treated with cryotherapy, CO2 laser and topical imiquimod having either no clinical response or quick relapse. Treatment with PDL was started and after 13 sessions, the patient was without lesions, with a good cosmetic result and so far without relapse. This case report is relevant to us and deserves to be published because of the size of the lesions and the great response to PDL despite all the failures with the other treatments.

关键词： Pulse Dye laser Recalcitrant Warts

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将“控制面板”控制在手中

电脑应用文萃（电脑界配套光盘） 2002年第7期 32-33页

作者： nuno

战斗中总要想方设法抢占制高点或摧毁敌人的指挥部,因为那是要害所在。那么Windows系统有没有这样的要害部门呢答案是肯定的,"控制面板"就称得上是Windows的大本营,系统的很多设置都是由它来决定的。为了让你的Windows更听话,我们今天... 详细信息

战斗中总要想方设法抢占制高点或摧毁敌人的指挥部,因为那是要害所在。那么Windows系统有没有这样的要害部门呢答案是肯定的,"控制面板"就称得上是Windows的大本营,系统的很多设置都是由它来决定的。为了让你的Windows更听话,我们今天就要对"控制面板"发起一场冲锋,攻陷这个系统堡垒。

关键词： “控制面板” Windows 操作系统

Chlorophyll-a Fluorescence in Ecology： Theoretical Considerations and Examples around Marine Macroalgae

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Journal of Environmental Science and Engineering(A) 2013年第10期2卷 606-616页

作者： Vinicius Peruzzi de Oliveira nuno Tavares Martins Yocie Yoneshigue-Valentin Alex Enrich-Prast Biogeochemistry Laboratory Department of Ecology Biology Institute Federal University of Rio de Janeiro Rio de Janeiro 21941-902. Brazil Macroalgae Laboratory Department of Botany Biology Institute Federal University of Rio de Janeiro Rio de Janeiro 21941-902 Brazil

Over the last decades, the usage of PAM （pulse amplitude modulated） fluorometers for assessment of chlorophyll-a fluorescence variations became widely applied on marine macroalgae physiology and ecophysiology researches. Due to the increased use of these methods, a large number of studies, mainly relating to macroalgae ecology and physiology were worldwide reported. In this context, it was also created a mismatch of concepts about fluorescence of the chlorophyll-a and its application. Under this background, this study compile and summarize the state of the art knowledge regarding to the chlorophyll fluorescence, contextualizing the use of the PAM method with the main factors regulating photosynthesis （light, temperature, salinity nitrogen and phosphorus） in marine macroalgae. Moreover, this study also references the most used terms and shows some examples found in literature about the applicability of fluorescence parameters. The herein findings and the discussed examples, helps to emphasize the importance of fluorescence usage, that highlights the understanding of photosynthetic responses in macroalgal physiology and ecology.

关键词： Fluorometry PAM quenching analysis stress.

交叉污染和过敏原:如果无法避免,那么管理它们!

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食品安全导刊 2018年第16期 35-36页

作者： nuno Soares

交叉污染（如表1所示）是食品工业应该慎重处理的一种相关危害——发生交叉污染时,微生物或其它污染物（物理或化学物质）会无意间从一种食品转移到另一种食品上。当污染通过两种食品产品之间的接触产生时,通常称之为直接交叉污染;间接... 详细信息

交叉污染（如表1所示）是食品工业应该慎重处理的一种相关危害——发生交叉污染时,微生物或其它污染物（物理或化学物质）会无意间从一种食品转移到另一种食品上。当污染通过两种食品产品之间的接触产生时,通常称之为直接交叉污染;间接交叉污染的产生则需要通过某种载体（空气或气体,液体或物体）来携带或运输污染物。

关键词：交叉污染过敏原食品工业管理化学物质污染物微生物空气

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食品工业水质管理的六个步骤

食品安全导刊 2019年第7期231卷 40-42页

作者： nuno Soares 不详

水是万物之本源,滋养万物而不争夺。但在许多情况下,水也是疾病的传播媒介,可能致人死亡。据世界卫生组织(WHO)估计,每年约50.2万人因饮用受污染的水而腹泻致死,至少有20亿人正在使用或饮用受粪便污染的饮用水。更为重要的是,人们通常... 详细信息

水是万物之本源,滋养万物而不争夺。但在许多情况下,水也是疾病的传播媒介,可能致人死亡。据世界卫生组织(WHO)估计,每年约50.2万人因饮用受污染的水而腹泻致死,至少有20亿人正在使用或饮用受粪便污染的饮用水。更为重要的是,人们通常会认为由水引起的疾病是第三世界国家所独有的。然而,2018年美国发生的两起罗马生菜疫情都与被大肠杆菌污染的水源有关。2018年6月28日,第一次疫情调查宣布最终结果——5人死亡,96人住预防中心宣布了这一消息,但疫情的其他可能来源仍在调查中……通常来说,食品安全体系包括水质管理的指导方针,其制度建设均来自食品法典对SQF、BRC、IFS、ISO 22000、FSSC 22000的实践。此外,许多国家和地区的水务局执行水质管理计划,其实施水质控制系统时主要考虑以下6个步骤。

关键词：水质管理食品工业世界卫生组织粪便污染疫情调查食品安全体系致人死亡饮用水

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食品欺诈与食品安全计划大反击

食品安全导刊 2018年第13期 36-37页

作者： nuno Soares

近年来,一些食品欺诈案件屡被曝光。正如《管理委员会：应该被惩罚!》一文中所述,2013年的＂马肉风波＂让人们对供应商的诚信颇感担忧,他们以马肉充替牛肉,但不在标签上标注表明,以此赚取中间的差价利润。不幸的是,这样的案例还有很多... 详细信息

近年来,一些食品欺诈案件屡被曝光。正如《管理委员会：应该被惩罚!》一文中所述,2013年的＂马肉风波＂让人们对供应商的诚信颇感担忧,他们以马肉充替牛肉,但不在标签上标注表明,以此赚取中间的差价利润。不幸的是,这样的案例还有很多。同年,中国又爆发了和蜂蜜生产有关的丑闻。据南华早报报道,这些问题蜂蜜并不含有任何真正的蜂蜜成分,而是由水、糖、明矾粉和着色剂合成。

关键词：安全计划食品欺诈蜂蜜生产管理委员会供应商着色剂马肉