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Treatment strategy for metastatic prostate cancer with extremely high PSA level： reconsidering the value of vintage therapy

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Asian Journal of Andrology 2018年第5期20卷 432-437页

作者： Yasutaka Yamada Shinichi Sakamoto Yoshiyasu Amiya Makoto Sasaki Takayuki Shima Akira Komiya noriyuki suzuki Koichiro Akakura Tomohiko Ichikawae Hiroomi Nakatsu Department of Urology Asahi General Hospital Asahi 289-2511 Japan Department of Urology Chiba University Graduate School of Medicine Chiba 260-8677 Japan Department of Urology Japan Community Healthcare Organization Tokyo Shinjuku Medical Center Tokyo 162-8543 Japan

The prognostic significance of initial prostate-specific antigen （PSA） level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metastatic prostate cancer patients according to initial PSA levels. We analyzed 184 patients diagnosed with metastatic prostate cancer and divided them into three PSA level groups as follows： low （〈100 ng ml-1）, intermediate （100–999 ng ml-1）, and high （≥1000 ng ml-1）. All patients received androgen deprivation therapy （ADT） immediately. We investigated PSA progression-free survival （PFS） for first-line ADT and overall survival （OS） within each of the three groups. Furthermore, we analyzed response to antiandrogen withdrawal （AW） and alternative antiandrogen （AA） therapies after development of castration-resistant prostate cancer （CRPC）. No significant differences in OS were observed among the three groups （P = 0.654）. Patients with high PSA levels had significantly short PFS for first-line ADT （P = 0.037）. Conversely, patients in the high PSA level group had significantly longer PFS when treated with AW than those in the low PSA level group （P = 0.047）. Furthermore, patients with high PSA levels had significantly longer PFS when provided with AA therapy （P = 0.049）. PSA responders to AW and AA therapies had significantly longer survival after CRPC development than nonresponders （P = 0.011 and P 〈 0.001, respectively）. Thus, extremely high PSA level predicted favorable response to vintage sequential ADT and AW. The current data suggest a novel aspect of extremely high PSA value as a favorable prognostic marker after development of CRPC.

关键词： alternative antiandrogen therapy antiandrogen withdrawal hormonal therapy metastatic prostate cancer prostate-specificantigen

Metallacyclic Compounds Derived from Group 4 Metals and [n]Cumulenes （n=3,5）

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Metallacyclic Compounds Derived from Group 4 Metals and [n]C...

Outcomes of patients older than 75 years with non-metastatic prostate cancer

中国化学会第27届学术年会

作者： noriyuki suzuki Department of Materials and Life Sciences Faculty of Science and Technology Sophia University

＜正＞We recently reported that five-membered metallacycloalkynes, 1-metallacyclopent-3-ynes, could be synthesized from group 4 metallocenes and [3]cumulenes （= butatrienes）（eq 1）.1 These molecules are

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Asian Journal of Urology 2017年第2期4卷 102-106页

作者： Yoshiyasu Amiya Yasutaka Yamada Masahiro Sugiura Makoto Sasaki Takayuki Shima noriyuki suzuki Hiroomi Nakatsu Shino Murakami Jun Shimazaki Department of Urology Asahi General HospitalAsahiJapan Department of Urology Graduate School of MedicineChiba UniversityChibaJapan

Objective:Prostate cancer in elderly patients was formerly treated with androgen deprivation *** the latter of the 1990s new technologies were introduced into treatments,then strategies have *** aimed to observe the outcomes of elderly patients treated during transition period and compare each stage with ***:During 2008 and 2010,255 patients with prostate cancer older than 75 years were sequentially *** exception of patients with bone and/or visceral metastasis,outcomes of 199 patients with localized and locally advanced stages were *** records were obtained by the end of ***:In total,122(61%),28(14%),37(19%)and 12(6%)of patients were in stages T1c-T2a,T2b-c,T3 and T4,*** generally presented with abnormal screening or lower urinary tract ***-one percent of patients received androgen deprivation therapy as monotherapy and 22% of the radiation-treated patients added androgen deprivation *** in stage T1c-T2a and T2b-c showed a favorable *** cancer death appeared in patients with T3 and T4 during observation ***-seven percent of patients died from prostate cancer-independent complications:pneumonia,heart disease,and brain vascular *** is similar to that of Japanese elderly male *** remarkable side effects from androgen deprivation therapy were noticed.

关键词： Prostate cancer Elderly Androgen deprivation Non-metastatic prostate cancer Radiation therapy

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陆相沉积岩中的无定形干酪根的特征

地球与环境 1986年第7期 8-13页

作者： noriyuki suzuki ,房敬彤,朱抱荃石油勘探开发科学研究院地质所石油勘探开发科学研究院地质所

干酪根,即沉积物中的不溶于有机溶剂的有机质,在显微镜下大致可分为两部分:结构型的和无定形的。通过扫描电镜和透射光显微镜可从形态上将结构型干酪根作进一步分类。结构型干酪根主要来源于植物碎屑、孢子、花粉等,而大多数无定形干酪... 详细信息

干酪根,即沉积物中的不溶于有机溶剂的有机质,在显微镜下大致可分为两部分:结构型的和无定形的。通过扫描电镜和透射光显微镜可从形态上将结构型干酪根作进一步分类。结构型干酪根主要来源于植物碎屑、孢子、花粉等,而大多数无定形干酪根是实际上在显微镜下难以鉴别的有机残体,被认为起源于生物

关键词：无定形干酪根结构型皂化陆源有机质岩中

Therapeutic potential of stem cells in subarachnoid hemorrhage

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Neural Regeneration Research 2025年第4期20卷 936-945页

作者： Hideki Kanamaru Hidenori suzuki Department of Neurosurgery Mie University Graduate School of MedicineTsuJapan

Aneurysm rupture can result in subarachnoid hemorrhage,a condition with potentially severe consequences,such as disability and *** the acute stage,early brain injury manifests as intracranial pressure elevation,global cerebral ischemia,acute hydrocephalus,and direct blood–brain contact due to aneurysm *** may subsequently cause delayed cerebral infarction,often with cerebral vasospasm,significantly affecting patient *** complications such as brain volume loss and chronic hydrocephalus can further impact *** the mechanisms of subarachnoid hemorrhage-induced brain injury is paramount for identifying effective *** cell therapy,with its multipotent differentiation capacity and anti-inflammatory effects,has emerged as a promising approach for treating previously deemed incurable *** review focuses on the potential application of stem cells in subarachnoid hemorrhage pathology and explores their role in neurogenesis and as a therapeutic intervention in preclinical and clinical subarachnoid hemorrhage studies.

关键词： delayed cerebral ischemia early brain injury matricellular protein neurogenesis stem cell therapy subarachnoid hemorrhage

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油电混合/电动汽车驱动马达用硅钢片

油电混合/电动汽车驱动马达用硅钢片

Rapidly deforming gastric carcinosarcoma with osteoblastic component:An autopsy case report

第十一届中国钢铁年会

作者：藪本政男開道力脇坂岳顕李军锋 Kubota Takeshi suzuki noriyuki 日本钢铁研究所加工技术研究开发中心深圳市荣昌盛金属科技有限公司

硅钢片用于油电混合汽车（HEV）及电动汽车（EV）驱动马达铁芯,对HEV/EV的性能造成影响。为了实现驱动马达的小型轻量化、高效率,硅钢片中有很多的要求。满足这些要求,在进行最佳性能硅钢片开发的同时,优质的技术应用也是必要的。

关键词：驱动马达硅钢片

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World Journal of Gastroenterology 2012年第30期18卷 4064-4068页

作者： Hiroshi Yoshida noriyuki Tanaka Naobumi Tochigi Yoshio suzuki Department of Pathology Asahi General HospitalChiba 289-2511Japan

Carcinosarcomas are rare,malignant,biphasic tumors simultaneously comprising carcinoma and sarcoma in a single *** present an extremely rare case of gastric carcinosarcoma with an osteoblastic component that drastically changed its shape within 2 mo.A 59-year-old male patient presented to the emergency outpatient unit with a complaint of black *** endoscopy showed an ulcerated mass in the cardia of the lesser curvature of the *** specimens revealed only *** months later,the ulcerated lesion drastically changed its shape into an exophytic *** gastrectomy was *** the resected specimen,the gastric tumor contained both adenocarcinoma and sarcoma components with lace-like *** patient died 7 mo after the operation,and an autopsy was *** the autopsy,widespread metastases were present in the liver,lung,lymph nodes and *** this report,we describe a case of gastric carcinosarcoma and presume its tumorigenesis based on the autopsy findings.

关键词： Carcinosarcoma Stomach Osteoblastic differentiation Autopsy Tumorigenesis

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

Design Method of Guide Vane for Wells Turbine

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Journal of Thermal Science 2006年第2期15卷 126-131页

作者： Masami suzuki Department of Mechanical Engineering Graduate School of Engineering The University of Tokyo

Guide vanes are installed in the Wells turbine in order to improve its efficiency, self-rotating characteristics and off design performance with stall. This work attempts to explain the role of these guide vanes on the basis of momentum theory. It is shown that the upstream vanes are more effective in enhancing efficiency than the downstream ones. A design method for guide vanes is suggested based on experimental data and potential theory. Experimental studies carried out by the author confirm the theory proposed.

关键词： wells turbine guide vane cascade potential flow wave energy converter ocean engineering

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