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Positron emission tomography complete metabolic response as a favorable prog-nostic predictor in esophageal cancer following neoadjuvant chemotherapy with docetaxel/cis-platin/5-fluorouracil

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World Journal of Clinical Oncology 2021年第4期12卷 249-261页

作者： Kosuke Suzuki Tsuyoshi Etoh Tomotaka Shibata Kohei Nishiki Shoichi Fumoto Yoshitake Ueda Hidefumi Shiroshita norio Shiraishi Masafumi Inomata Department of Gastroenterological and Pediatric Surgery Oita UniversityYufu 879-5593OitaJapan Department of Surgery Oita Nakamura HospitalOita 870-0022Japan

BACKGROUND 18F-fluorodeoxyglucose-positron emission tomography(PET)/computed tomography is useful in diagnosing lymph node and distant metastases of esophageal ***,its value for predicting survival is *** To evaluate the value of PET complete metabolic response(CMR)as a prognostic predictor for esophageal *** Between June 2013 and December 2017,58 patients with squamous cell esophageal cancer who underwent neoadjuvant chemotherapy(NAC)in Oita University were enrolled in this retrospective cohort *** were clinically staged using fluorodeoxyglucose-PET/computed tomography before and after *** NAC,maximal standardized uptake value≤2.5 was defined as PET-CMR,and maximal standardized uptake value>2.5 was defined as *** compared short-term outcomes between the PET-CMR group and non-PET-CMR group and evaluated prognostic factors by univariate and multivariate *** The PET-CMR group included 22 patients,and the non-PET-CMR group included 36 *** were no significant differences in intraoperative and post operative complications between the two ***-year relapse-free survival and overall survival in the PET-CMR group were significantly more favorable than those in the non-PET-CMR group(38.6 mo vs 20.8 mo,P=0.021;42.8 mo vs 25.1 mo,P=0.011,respectively).PET-CMR was a significant prognostic factor in terms of relapse-free survival by univariate analysis(hazard ratio:2.523;95%confidence interval:1.034–7.063;P<0.041).Particularly,PET-computed tomography negative N was an independent prognostic factor of relapse-free survival and overall survival by multivariate *** PET-CMR after NAC is considered a favorable prognostic factor for esophageal *** by PET-computed tomography could be useful in clinical decision making for esophageal cancer.

关键词： Esophageal cancer Neoadjuvant chemotherapy Positron emission tomography/computed tomography Complete metabolic response Prognostic factor Docetaxel,cisplatin plus 5-fluorouracil

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一种运动图像无色乱的新型场序彩色LCD

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现代显示 2003年第6期 40-44页

作者： norio Koma Tatsuo Uchida 代永平东北大学工程研究院电子工程系南开大学

本文针对场序彩色液晶显示器(FS-LCD)研发了一种新的显示方法,它可以降低FS-LCD中色乱的负面影响。这种方法称为眼上色元素调节(ACE,AdjustmentofColorElementontheEyes),与RGB子场图形在眼球的成像位置相关。并证实了使用ACE方法时,周... 详细信息

本文针对场序彩色液晶显示器(FS-LCD)研发了一种新的显示方法,它可以降低FS-LCD中色乱的负面影响。这种方法称为眼上色元素调节(ACE,AdjustmentofColorElementontheEyes),与RGB子场图形在眼球的成像位置相关。并证实了使用ACE方法时,周围非移动图像没有产生色乱现象。

关键词：场序彩色液晶显示器色乱眼上色元素调节运动图像 FS-LCD

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Effects of Darbepoetin-<i>α</i>on Oxidative Stress Marker in Patients with Chronic Renal Failure

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Open Journal of Nephrology 2014年第1期4卷 8-12页

作者： norio Nakamura Michiko Shimada Ikuyo Narita Yuko Shimaya Takeshi Fujita Reiichi Murakami Hiroshi Osawa Hideaki Yamabe Ken Okumura Community Medicine Hirosaki University Gradu-ate School of Medicine Japan Department of Cardiology Respiratory Medicine and Nephrology Hirosaki University Graduate School of Medicine Hirosaki Japan Department of General Medicine Hirosaki Uni-versity Hospital Hirosaki Japan

Objective: Long-acting darbepoetin-α (DA) has recently been used to treat renal anemia in patients with chronic renal failure. It is considered clinically useful because its duration of action is longer than that of conventional epoetin-α. In this study, we investigated changes in the levels of the oxidative stress marker malondialdehyde-modified low density lipoprotein (MDA-LDL), renal anemia, and renal function when patients were treated for chronic renal failure switched from epoetin-α to DA. Materials and Methods: The subjects included nine patients with chronic renal failure and renal anemia who were treated with epoetin-α on an outpatient basis at our department. Blood was sampled prior to the switch and at 3, 6, and 12 months after the switch. We then investigated changes in MDA-LDL, hemoglobin (Hb), and creatinine (Cr) levels. Results: There were no significant changes in MDA-LDL and Hb levels after switching to DA. A significant increase was observed in Cr levels after 12 months compared with those prior to switching. Conclusion: Once-a-month administration of DA did not result in an increase in oxidative stress, and therefore, DA is considered capable of controlling renal anemia.

关键词： Chronic Renal Failure Darbepoetin-α Epoetin-α Indoxyl Sulfate MDA-LDL Renal Anemia

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A Mixture of Glycosylated proBNP and BNP-32 Is a Suitable Calibrator for BNP Immunoassays

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Open Journal of Clinical Diagnostics 2019年第2期9卷 51-63页

作者： Keiichi Masuta Kenzo Funatsuki Youko Inoue Izuru Masuda Toshio Nishikimi Yasuaki Nakagawa Kazukiyo Horii Hiroshi Nishi Masayo Igarashi norio Ota Biomarker R & D Department Shionogi & Co. Ltd. Toyonaka Japan Takeda Hospital Medical Examination Center Kyoto Japan Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan Department of Medicine Wakakusa-Tatsuma Rehabilitation Hospital Daito Japan Horii Planning Yokohama Japan

Aim: Measurement of B-type natriuretic peptide (BNP) is widely used as a diagnostic and risk assessment tool for cardiovascular disease. Recent studies have demonstrated that BNP-32 and its precursor proBNP circulate in the blood stream, and that most commercial BNP immunoassays measure both forms. However, recombinant or synthetic BNP-32 is used as the standard for those BNP immunoassays. This gap between clinical samples and the standard might be a potential source of variation in BNP measurements among assays. The purpose of this study is to validate a more suitable calibrator for BNP immunoassays. Methods: External BNP calibrators containing both BNP-32 and glycosylated proBNP were prepared at two concentration levels. Target BNP concentrations of the low and high levels were 40 and 160 pg/mL, respectively. And to reflect clinical samples, the molar ratios of BNP-32 to glycosylated proBNP in these concentration levels were adjusted to 50:50 and 25:75, respectively. BNP concentrations of plasma samples along with the external BNP calibrators were measured at two commercial labs and using an automated analyzer MI02 Shionogi®BNP (MI02). These samples and the calibrators were also measured using an immunoradiometric assay (IRMA) as a standard assay procedure. Concentrations of the plasma samples measured at the labs or using the MI02 were adjusted according to a comparison of the measured concentrations of the external BNP calibrators with the IRMA. Results: After measured concentrations of the plasma samples were adjusted using the external BNP calibrators, the correlation between each measurement and the IRMA was improved. The range of the slopes according to Passing-Bablok regression analysis narrowed from 0.628 - 0.955 to 0.911 - 1.005. Conclusions: Our data suggests that a mixture of BNP-32 and glycosylated proBNP at different ratios by concentration level is suitable for calibration to minimize variations in BNP measurements among immunoassays.

关键词： B-Type Natriuretic Peptide (BNP) proBNP Calibrator

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Safety and Efficacy of Once-Daily Administration of Mycophenolate Mofetil in Kidney Transplant Patients—A New Treatment Option for Non-Adherence

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Journal of Biomedical Science and Engineering 2014年第10期7卷 788-791页

作者： Naotsugu Ichimaru Kazuaki Yamanaka Taigo Kato Yoichi Kakuta Toyofumi Abe Jun-ya Kaimori Ryoichi Imamura norio Nonomura Shiro Takahara Department of Advanced Technology for Transplantation Osaka University Graduate School of Medicine Suita Japan Department of Specific Organ Regulation (Urology) Osaka University Graduate School of Medicine Suita Japan

Non-adherence to immunosuppressive therapy is associated with reduced graft survival. Fifteen long-term follow up kidney transplant patients with stable post-transplant clinical courses were enrolled in the study. All patients were prescribed to tacrolimus prolonged release, mycophenolate mofetil (MMF) and corticosteroid at the time of enrolment. Twice-daily administration of MMF was then converted to a single daily dose. As a result, all immunosuppressive agents were administered simultaneously at one time in the morning. The daily total doses of the three immunosuppressants were identical during the study period. No acute rejection or adverse event was observed during the study period. Blood urea nitrogen and estimated glomerular filtration rate did not change significantly after conversion to once-daily administration. The blood tacrolimus trough level and the Mycophenolic acid (MPA) trough level also did not change significantly after conversion to once-daily administration. Interestingly, the meanmedian MPA trough level remained >3 μg/ml even after conversion to once-daily administration. A sufficient plasma MPA level was maintained after conversion to once-daily administration, and no acute rejection was observed during the study period. To our knowledge, this study is the first to report that the plasma MPA concentration can be maintained after once-daily administration of MMF in long-term kidney transplant patients. Once-daily administration of immunosuppressive agents may improve long-term graft survival because of better treatment adherence due to the reduced dosing frequency. The safety or efficacy of conversion to once-daily administration of MMF should be evaluated in a future randomized controlled large-scale clinical study.

关键词： Once-Daily Administration Mycophenolate Mofetil Treatment Adherence

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亚微米颗粒对铝基复合材料基体显微结构的影响

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稀有金属材料与工程 2007年第6期36卷 1002-1004页

作者：姜龙涛武高辉河野纪雄齐藤秀雄哈尔滨工业大学黑龙江哈尔滨150001 日本千叶工业大学金属工学科

选用0.15μm和5μm的Al2O3颗粒,采用挤压铸造法制备了体积分数为40%的铝基复合材料。利用选区电子衍射和高分辨电子显微技术研究了Al2O3P/1070Al界面附近基体的显微组织。结果表明,复合材料增强体颗粒为5μm时,基体存在大量的由热错配... 详细信息

选用0.15μm和5μm的Al2O3颗粒,采用挤压铸造法制备了体积分数为40%的铝基复合材料。利用选区电子衍射和高分辨电子显微技术研究了Al2O3P/1070Al界面附近基体的显微组织。结果表明,复合材料增强体颗粒为5μm时,基体存在大量的由热错配应力引发的位错,颗粒粒径为0.15μm时,基体表现为近无位错的组织特征,其缺陷形式为1～5nm的“微畸变区”,这主要是由于粒径小、分布弥散,微区应力均匀所致。

关键词：金属基复合材料 Al2O3P/Al 亚微米级Al2O3 显微组织

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用新的VLSI片子步进机提高电路图形的微细加工水平

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电子工业专用设备 1986年 78-82页

作者： norio Shiotaka ,Kiyoshi Lizuka ,童志义

投影透镜系统的改进,使片子步进机实现了更高的图形微细加工水平,且普遍改进了片子步进机在超大规模集成电路制造中对于更高集成度片子的加工精度和通用性。

关键词：对准系统 NSR 透镜系统 VLSI 光刻设备曝光面积光学曝光投影光学系统微细加工

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Effect of chlorine dioxide on avian influenza A(H7N9)virus

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Biosafety and Health 2022年第1期4卷 53-57页

作者： Zhiping Sun Yun Qian norio Ogata Xia Cai Wendong Han Youhua Xie Hirofumi Morino Koushirou Sogawa Takashi Shibata Di Qu BSL-3 Laboratory of Fudan University School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China R&D Center Taiko Pharmaceutical Co.LtdKyotoJapan Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Department of Medical Microbiology and ParasitologySchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Avian influenza remains a threat to human *** derivatives are commonly used as disinfectants to prevent the spread of the *** World Health Organization(WHO)has listed chlorine dioxide(ClO_(2))as an A1‐level,safe,and efficient *** this study,we tested the efficacy of ClO_(2),in aqueous solution and gas forms,against avian influenza A(H7N9)*** virus suspension was mixed with ClO_(2) aqueous solutions of various concentrations and for various time *** of the mixture were then serially diluted,and the 50%tissue culture infective dose(TCID50)was measured with a hemagglutination test on MDCK ***_(2) gas produced from generators was introduced in a chamber containing the virus suspension in a Petri *** infective activity of the surviving virus was measured by the hemagglutination *** aqueous solution of ClO_(2) at 126μg/mL for 15 s was effective given that no surviving virus was detected with the hemagglutination ***_(2) gas at>5μL/L sustained for 1 h inactivated the virus effectively,while at 2.5μL/L for 1 h,it only partially inactivated the ***_(2) as gas or aqueous solution at a certain concentration is effective in inactivating the H7N9 virus,and can be applied for the decontamination and disinfection of environments.

关键词： Chlorine dioxide Influenza virus A H7N9 Disinfection Aqueous solution Gas ClO_(2)

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Glycinebetaine enhances the tolerance of tomato plants to high temperature during germination of seeds and growth of seedlings

Glycinebetaine enhances the tolerance of tomato plants to hi...

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山东植物生理学会第七次代表大会暨植物生物学与现代农业研讨会

作者： Shufen Li Feng Li Jianwei Wang Wen Zhang Qingwei Meng Tony HH Chen norio Murata Xinghong Yang College of Life Science State Key Laboratory of Crop BiologyShandong Key Laboratory of Crop BiologyShandong Agricultural University

Tomato(Lycopersicon esculentum cv.’Moneymaker’) was transformed with a codA gene,from Arthrobacter globiformis,for choline oxidase that had been modified to allow targeting to both chloroplasts and the ***(GB) accumulated in seeds of transformed plants up to 1μmol g DW,while no detectable GB was found in wild-type *** incubation at temperatures from 25℃to 55℃for 90 min during imbibition,codA-transgenic seeds germinated faster and at higher frequency than wild-type *** the exposure of imbibed seeds to 40°/30℃(12 h/12 h) or 34°/34℃(16 h/8 h), transgenic seeds germinated faster and developed more vigorous seedlings than wild-type *** compared the expression of genes for a mitochondrial small heat-shock protein(MT-sHSP),heat-shock protein 70(HSP70),and heat shock cognate 70(HSC70) between wild-type and transgenic seeds after heat stress at 34℃.Levels of expression of all three genes were higher in transgenic seeds than in wild-type seeds during heat stress,and the accumulation of HSP70 was more prominent in codA-transgenic seeds than in wild-type *** of GB at 0.1 mM to 5 mM to the germination medium or imbibition of seeds in a solution of GB enhanced the tolerance of wild-type seeds to high ***-type seeds that had been soaked in 1 mM GB for 20 h before high-temperature treatment also expressed heat-shock genes at elevated levels and accumulated more HSP70 than *** results suggest that GB,either applied exogenously or accumulated in vivo in codA-transgenic seeds,enhanced the expression of heat-shock genes in and improved the tolerance to high temperature of tomato seeds during germination.

关键词： Glycinebetaine heat-shock protein high temperature seed germination tomato

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Assessing optimal Roux-en-Y reconstruction technique after total gastrectomy using the Postgastrectomy Syndrome Assessment Scale-45

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World Journal of Clinical Oncology 2022年第5期13卷 376-387页

作者： Masami Ikeda Masashi Yoshida norio Mitsumori Tsuyoshi Etoh Chikashi Shibata Masanori Terashima Junya Fujita Kazuaki Tanabe Nobuhiro Takiguchi Atsushi Oshio Koji Nakada Department of Surgery Asama General HospitalNagano 385-8558Japan Department of Surgery International University of Health and Welfare HospitalTochigi 329-2763Japan Department of Surgery The Jikei University School of MedicineTokyo 105-8461Japan Department of Gastroenterological Surgery Oita UniversityOita 879-5593Japan Department of Surgery Tohoku Medical and Pharmaceutical UniversityMiyagi 983-8512Japan Division of Gastric Surgery Shizuoka Cancer CenterShizuoka411-8777Japan Department of Surgery Yao Municipal HospitalOsaka 581-0069Japan Department of Gastroenterological and Transplant Surgery Institute of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8551Japan Department of Gastroenterological Surgery Chiba Cancer CenterChiba 260-8717Japan Faculty of Letters Arts and SciencesWaseda UniversityTokyo 162-8644Japan Department of Laboratory Medicine The Jikei University School of MedicineTokyo 105-8461Japan

BACKGROUND Following a total gastrectomy,patients suffer the most severe form of postgastrectomy *** is a significant clinical problem as it reduces quality of life(QOL).Roux-en-Y reconstruction,which is regarded as the gold standard for post-total gastrectomy reconstruction,can be performed using various *** the technique used could affect postoperative QOL,there are no previous reports regarding the *** To investigate the effect of different techniques on postoperative *** data was collected from the registry of the postgastrectomy syndrome assessment study(PGSAS).METHODS In the present study,we analyzed 393 total gastrectomy patients from those enrolled in *** were divided into groups depending on whether antecolic or retrocolic jejunal elevation was performed,whether the Roux limb was“40 cm”,“shorter”(≤39 cm),or“longer”(≥41 cm),and whether the device used for esophageal and jejunal anastomosis was a circular or linear ***,we comparatively investigated postoperative QOL of the *** Reconstruction route:Esophageal reflux subscale(SS)occurred significantly less frequently in patients who underwent antecolic *** limb length:“Shorter”Roux limb did not facilitate esophageal reflux SS and somewhat attenuated indigestion SS and abdominal pain *** technique:In terms of esophagojejunostomy techniques,no differences were *** The techniques used for total gastrectomy with Roux-en-Y reconstruction significantly affected postoperative *** results suggest that elevating the Roux limb,which is not overly long,through an antecolic route may improve patients’QOL.

关键词： Total gastrectomy Roux-en-Y Postgastrectomy syndrome Quality of life Postgastrectomy Syndrome Assessment Scale-45

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