Positron emission tomography complete metabolic response as a favorable prog-nostic predictor in esophageal cancer following neoadjuvant chemotherapy with docetaxel/cis-platin/5-fluorouracil

作     者：Kosuke Suzuki Tsuyoshi Etoh Tomotaka Shibata Kohei Nishiki Shoichi Fumoto Yoshitake Ueda Hidefumi Shiroshita Norio Shiraishi Masafumi Inomata 

作者机构：Department of Gastroenterological and Pediatric SurgeryOita UniversityYufu 879-5593OitaJapan Department of SurgeryOita Nakamura HospitalOita 870-0022Japan 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2021年第12卷第4期

页      面：249-261页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Esophageal cancer Neoadjuvant chemotherapy Positron emission tomography/computed tomography Complete metabolic response Prognostic factor Docetaxel,cisplatin plus 5-fluorouracil 

摘      要：BACKGROUND 18F-fluorodeoxyglucose-positron emission tomography(PET)/computed tomography is useful in diagnosing lymph node and distant metastases of esophageal ***,its value for predicting survival is *** To evaluate the value of PET complete metabolic response(CMR)as a prognostic predictor for esophageal *** Between June 2013 and December 2017,58 patients with squamous cell esophageal cancer who underwent neoadjuvant chemotherapy(NAC)in Oita University were enrolled in this retrospective cohort *** were clinically staged using fluorodeoxyglucose-PET/computed tomography before and after *** NAC,maximal standardized uptake value≤2.5 was defined as PET-CMR,and maximal standardized uptake value2.5 was defined as *** compared short-term outcomes between the PET-CMR group and non-PET-CMR group and evaluated prognostic factors by univariate and multivariate *** The PET-CMR group included 22 patients,and the non-PET-CMR group included 36 *** were no significant differences in intraoperative and post operative complications between the two ***-year relapse-free survival and overall survival in the PET-CMR group were significantly more favorable than those in the non-PET-CMR group(38.6 mo vs 20.8 mo,P=0.021;42.8 mo vs 25.1 mo,P=0.011,respectively).PET-CMR was a significant prognostic factor in terms of relapse-free survival by univariate analysis(hazard ratio:2.523;95%confidence interval:1.034–7.063;P0.041).Particularly,PET-computed tomography negative N was an independent prognostic factor of relapse-free survival and overall survival by multivariate *** PET-CMR after NAC is considered a favorable prognostic factor for esophageal *** by PET-computed tomography could be useful in clinical decision making for esophageal cancer.